RU2003117016A - Способ получения латентного антитромбина iii - Google Patents
Способ получения латентного антитромбина iii Download PDFInfo
- Publication number
- RU2003117016A RU2003117016A RU2003117016/13A RU2003117016A RU2003117016A RU 2003117016 A RU2003117016 A RU 2003117016A RU 2003117016/13 A RU2003117016/13 A RU 2003117016/13A RU 2003117016 A RU2003117016 A RU 2003117016A RU 2003117016 A RU2003117016 A RU 2003117016A
- Authority
- RU
- Russia
- Prior art keywords
- range
- concentration
- buffer
- antithrombin iii
- sulfate ions
- Prior art date
Links
- 102000004411 Antithrombin III Human genes 0.000 title claims 4
- 108090000935 Antithrombin III Proteins 0.000 title claims 4
- 229960005348 antithrombin iii Drugs 0.000 title claims 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 17
- 239000000872 buffer Substances 0.000 claims 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 5
- 230000002779 inactivation Effects 0.000 claims 4
- 102000029797 Prion Human genes 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- 229910052936 alkali metal sulfate Inorganic materials 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- -1 alkaline earth metal sulfates Chemical class 0.000 claims 1
- 238000001728 nano-filtration Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Psychiatry (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004086A SE0004086D0 (sv) | 2000-11-08 | 2000-11-08 | Preparation process |
| SE0004086-5 | 2000-11-08 | ||
| US25214800P | 2000-11-20 | 2000-11-20 | |
| US60/252,148 | 2000-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003117016A true RU2003117016A (ru) | 2004-12-10 |
Family
ID=26655296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003117016/13A RU2003117016A (ru) | 2000-11-08 | 2001-11-08 | Способ получения латентного антитромбина iii |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1332159A1 (cs) |
| JP (1) | JP2004522707A (cs) |
| KR (1) | KR20030057545A (cs) |
| AU (1) | AU2002214468A1 (cs) |
| BR (1) | BR0115188A (cs) |
| CA (1) | CA2428055A1 (cs) |
| CZ (1) | CZ20031277A3 (cs) |
| EE (1) | EE200300218A (cs) |
| HU (1) | HUP0301766A3 (cs) |
| IL (1) | IL155539A0 (cs) |
| MX (1) | MXPA03004030A (cs) |
| NO (1) | NO20032048L (cs) |
| PL (1) | PL360410A1 (cs) |
| RU (1) | RU2003117016A (cs) |
| WO (1) | WO2002038610A1 (cs) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| SE0203770D0 (sv) * | 2002-12-19 | 2002-12-19 | Biovitrum Ab | Method of separation |
| WO2006086200A1 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Plasma concentrator device |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| JP5479319B2 (ja) | 2007-04-12 | 2014-04-23 | バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー | ブイ式懸濁液分画システム |
| WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| WO2009111338A1 (en) | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
-
2001
- 2001-11-08 RU RU2003117016/13A patent/RU2003117016A/ru not_active Application Discontinuation
- 2001-11-08 CZ CZ20031277A patent/CZ20031277A3/cs unknown
- 2001-11-08 WO PCT/SE2001/002473 patent/WO2002038610A1/en not_active Ceased
- 2001-11-08 EP EP01983012A patent/EP1332159A1/en not_active Withdrawn
- 2001-11-08 PL PL36041001A patent/PL360410A1/xx unknown
- 2001-11-08 JP JP2002541941A patent/JP2004522707A/ja active Pending
- 2001-11-08 KR KR10-2003-7005757A patent/KR20030057545A/ko not_active Ceased
- 2001-11-08 MX MXPA03004030A patent/MXPA03004030A/es unknown
- 2001-11-08 CA CA002428055A patent/CA2428055A1/en not_active Abandoned
- 2001-11-08 IL IL15553901A patent/IL155539A0/xx unknown
- 2001-11-08 AU AU2002214468A patent/AU2002214468A1/en not_active Abandoned
- 2001-11-08 EE EEP200300218A patent/EE200300218A/xx unknown
- 2001-11-08 BR BR0115188-6A patent/BR0115188A/pt not_active Application Discontinuation
- 2001-11-08 HU HU0301766A patent/HUP0301766A3/hu unknown
-
2003
- 2003-05-07 NO NO20032048A patent/NO20032048L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1332159A1 (en) | 2003-08-06 |
| IL155539A0 (en) | 2003-11-23 |
| CZ20031277A3 (cs) | 2003-08-13 |
| MXPA03004030A (es) | 2004-02-12 |
| NO20032048D0 (no) | 2003-05-07 |
| JP2004522707A (ja) | 2004-07-29 |
| HUP0301766A3 (en) | 2005-12-28 |
| NO20032048L (no) | 2003-05-07 |
| PL360410A1 (en) | 2004-09-06 |
| BR0115188A (pt) | 2004-02-03 |
| KR20030057545A (ko) | 2003-07-04 |
| EE200300218A (et) | 2003-08-15 |
| CA2428055A1 (en) | 2002-05-16 |
| AU2002214468A1 (en) | 2002-05-21 |
| WO2002038610A1 (en) | 2002-05-16 |
| HUP0301766A2 (hu) | 2003-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20050301 |