RU2006125497A - Экспрессионные единицы pgro - Google Patents

Экспрессионные единицы pgro Download PDF

Info

Publication number: RU2006125497A
Authority: RU; Russia
Prior art keywords: activity; nucleic acids; expression; acids encoding; microorganism
Prior art date: 2003-12-18

Application number

RU2006125497/13A

Other languages

English (en)

Russian (ru)

Inventor

Буркхард КРЕГЕР (DE)

Буркхард КРЕГЕР

Оскар ЦЕЛЬДЕР (DE)

Оскар Цельдер

Коринна КЛОППРОГГЕ (DE)

Коринна КЛОППРОГГЕ

Хартвиг ШРЕДЕР (DE)

Хартвиг ШРЕДЕР

Штефан ХЭФНЕР (DE)

Штефан ХЭФНЕР

Original Assignee

БАСФ Акциенгезельшафт (DE)

Басф Акциенгезельшафт

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-18

Filing date

2004-12-15

Publication date

2008-01-27

2004-12-15 Application filed by БАСФ Акциенгезельшафт (DE), Басф Акциенгезельшафт filed Critical БАСФ Акциенгезельшафт (DE)

2008-01-27 Publication of RU2006125497A publication Critical patent/RU2006125497A/ru

Links

230000014509 gene expression Effects 0.000 title claims 126
230000000694 effects Effects 0.000 claims 236
150000007523 nucleic acids Chemical class 0.000 claims 201
108020004707 nucleic acids Proteins 0.000 claims 179
102000039446 nucleic acids Human genes 0.000 claims 179
108090000623 proteins and genes Proteins 0.000 claims 129
244000005700 microbiome Species 0.000 claims 86
235000018102 proteins Nutrition 0.000 claims 53
102000004169 proteins and genes Human genes 0.000 claims 53
238000013518 transcription Methods 0.000 claims 29
230000035897 transcription Effects 0.000 claims 29
230000006696 biosynthetic metabolic pathway Effects 0.000 claims 27
108091028043 Nucleic acid sequence Proteins 0.000 claims 24
238000000034 method Methods 0.000 claims 23
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 15
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 13
239000004473 Threonine Substances 0.000 claims 13
102000001253 Protein Kinase Human genes 0.000 claims 12
102000011848 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Human genes 0.000 claims 11
108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 claims 10
101000889837 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) Protein CysO Proteins 0.000 claims 9
108010055400 Aspartate kinase Proteins 0.000 claims 9
101710088194 Dehydrogenase Proteins 0.000 claims 9
108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims 9
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 9
108010053763 Pyruvate Carboxylase Proteins 0.000 claims 9
102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 claims 9
102000019394 Serine hydroxymethyltransferases Human genes 0.000 claims 9
229940024606 amino acid Drugs 0.000 claims 9
235000003704 aspartic acid Nutrition 0.000 claims 9
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 9
OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 claims 8
108010064711 Homoserine dehydrogenase Proteins 0.000 claims 8
239000004472 Lysine Substances 0.000 claims 8
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 8
230000001105 regulatory effect Effects 0.000 claims 8
108010017464 Fructose-Bisphosphatase Proteins 0.000 claims 7
102000027487 Fructose-Bisphosphatase Human genes 0.000 claims 7
108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims 7
108010022394 Threonine synthase Proteins 0.000 claims 7
102000006843 Threonine synthase Human genes 0.000 claims 7
102100033451 Thyroid hormone receptor beta Human genes 0.000 claims 7
102000014701 Transketolase Human genes 0.000 claims 7
108010043652 Transketolase Proteins 0.000 claims 7
230000001419 dependent effect Effects 0.000 claims 7
108010071598 homoserine kinase Proteins 0.000 claims 7
239000002773 nucleotide Substances 0.000 claims 7
125000003729 nucleotide group Chemical group 0.000 claims 7
OAJLVMGLJZXSGX-SLAFOUTOSA-L (2s,3s,4r,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7 Chemical compound [Co+3].O[C@H]1[C@@H](O)[C@@H]([CH2-])O[C@@H]1N1C2=NC=NC(N)=C2N=C1.[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-SLAFOUTOSA-L 0.000 claims 6
108010023317 1-phosphofructokinase Proteins 0.000 claims 6
108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 claims 6
102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 claims 6
102100031126 6-phosphogluconolactonase Human genes 0.000 claims 6
108010029731 6-phosphogluconolactonase Proteins 0.000 claims 6
108010081616 FAD-dependent malate dehydrogenase Proteins 0.000 claims 6
108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
102000003960 Ligases Human genes 0.000 claims 6
108090000364 Ligases Proteins 0.000 claims 6
108010042687 Pyruvate Oxidase Proteins 0.000 claims 6
108020004530 Transaldolase Proteins 0.000 claims 6
102100028601 Transaldolase Human genes 0.000 claims 6
239000002253 acid Substances 0.000 claims 6
235000001014 amino acid Nutrition 0.000 claims 6
150000001413 amino acids Chemical class 0.000 claims 6
230000015572 biosynthetic process Effects 0.000 claims 6
229940088598 enzyme Drugs 0.000 claims 6
102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 6
108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 6
108060006633 protein kinase Proteins 0.000 claims 6
108091000044 4-hydroxy-tetrahydrodipicolinate synthase Proteins 0.000 claims 5
108030003594 Diaminopimelate decarboxylases Proteins 0.000 claims 5
102000004190 Enzymes Human genes 0.000 claims 5
108090000790 Enzymes Proteins 0.000 claims 5
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 5
101710116000 Phosphoadenosine phosphosulfate reductase Proteins 0.000 claims 5
102000012435 Phosphofructokinase-1 Human genes 0.000 claims 5
108010053816 Sulfite Reductase (Ferredoxin) Proteins 0.000 claims 5
229960002685 biotin Drugs 0.000 claims 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 5
235000020958 biotin Nutrition 0.000 claims 5
239000011616 biotin Substances 0.000 claims 5
108010056578 diaminopimelate dehydrogenase Proteins 0.000 claims 5
230000004952 protein activity Effects 0.000 claims 5
230000037425 regulation of transcription Effects 0.000 claims 5
102000002249 Arginine-tRNA Ligase Human genes 0.000 claims 4
108010014885 Arginine-tRNA ligase Proteins 0.000 claims 4
241000894006 Bacteria Species 0.000 claims 4
241000186146 Brevibacterium Species 0.000 claims 4
241000186216 Corynebacterium Species 0.000 claims 4
108010076010 Cystathionine beta-lyase Proteins 0.000 claims 4
108010014468 Dihydrodipicolinate Reductase Proteins 0.000 claims 4
101710083973 Homocysteine synthase Proteins 0.000 claims 4
102000004316 Oxidoreductases Human genes 0.000 claims 4
108090000854 Oxidoreductases Proteins 0.000 claims 4
108010022684 Phosphofructokinase-1 Proteins 0.000 claims 4
108091022908 Serine O-acetyltransferase Proteins 0.000 claims 4
108010006873 Threonine Dehydratase Proteins 0.000 claims 4
102000005924 Triose-Phosphate Isomerase Human genes 0.000 claims 4
108700015934 Triose-phosphate isomerases Proteins 0.000 claims 4
150000007513 acids Chemical class 0.000 claims 4
239000005515 coenzyme Substances 0.000 claims 4
238000012258 culturing Methods 0.000 claims 4
238000012217 deletion Methods 0.000 claims 4
230000037430 deletion Effects 0.000 claims 4
239000012634 fragment Substances 0.000 claims 4
108010034653 homoserine O-acetyltransferase Proteins 0.000 claims 4
238000003780 insertion Methods 0.000 claims 4
230000037431 insertion Effects 0.000 claims 4
230000014493 regulation of gene expression Effects 0.000 claims 4
238000006467 substitution reaction Methods 0.000 claims 4
108020005199 Dehydrogenases Proteins 0.000 claims 3
108010074122 Ferredoxins Proteins 0.000 claims 3
108010061618 O-succinylhomoserine (thiol)-lyase Proteins 0.000 claims 3
229910019142 PO4 Inorganic materials 0.000 claims 3
108091000080 Phosphotransferase Proteins 0.000 claims 3
102000004357 Transferases Human genes 0.000 claims 3
108090000992 Transferases Proteins 0.000 claims 3
150000001491 aromatic compounds Chemical class 0.000 claims 3
150000001720 carbohydrates Chemical class 0.000 claims 3
235000014633 carbohydrates Nutrition 0.000 claims 3
235000014113 dietary fatty acids Nutrition 0.000 claims 3
150000002009 diols Chemical class 0.000 claims 3
229930195729 fatty acid Natural products 0.000 claims 3
239000000194 fatty acid Substances 0.000 claims 3
150000004665 fatty acids Chemical class 0.000 claims 3
230000002068 genetic effect Effects 0.000 claims 3
150000002632 lipids Chemical class 0.000 claims 3
101150052246 lrwd1 gene Proteins 0.000 claims 3
239000002777 nucleoside Substances 0.000 claims 3
125000003835 nucleoside group Chemical group 0.000 claims 3
150000007524 organic acids Chemical class 0.000 claims 3
235000005985 organic acids Nutrition 0.000 claims 3
239000010452 phosphate Substances 0.000 claims 3
-1 phosphate aminosulfonate phosphate aminomethane serine Chemical compound 0.000 claims 3
102000020233 phosphotransferase Human genes 0.000 claims 3
239000011782 vitamin Substances 0.000 claims 3
235000013343 vitamin Nutrition 0.000 claims 3
229940088594 vitamin Drugs 0.000 claims 3
229930003231 vitamin Natural products 0.000 claims 3
102000015790 Asparaginase Human genes 0.000 claims 2
108010024976 Asparaginase Proteins 0.000 claims 2
108010005694 Aspartate 4-decarboxylase Proteins 0.000 claims 2
108010046335 Ferredoxin-NADP Reductase Proteins 0.000 claims 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 2
102000005954 Methylenetetrahydrofolate Reductase (NADPH2) Human genes 0.000 claims 2
241000005308 Orsa Species 0.000 claims 2
102100021762 Phosphoserine phosphatase Human genes 0.000 claims 2
102000004523 Sulfate Adenylyltransferase Human genes 0.000 claims 2
108010022348 Sulfate adenylyltransferase Proteins 0.000 claims 2
230000037007 arousal Effects 0.000 claims 2
229960003272 asparaginase Drugs 0.000 claims 2
DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 claims 2
230000001851 biosynthetic effect Effects 0.000 claims 2
229930182817 methionine Natural products 0.000 claims 2
102000030592 phosphoserine aminotransferase Human genes 0.000 claims 2
108010088694 phosphoserine aminotransferase Proteins 0.000 claims 2
108010076573 phosphoserine phosphatase Proteins 0.000 claims 2
229920002477 rna polymer Polymers 0.000 claims 2
238000013519 translation Methods 0.000 claims 2
ISJHUKIGBLJDNA-DKWTVANSSA-N (2s)-2-amino-3-phosphonooxypropanoic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)[C@@H](N)COP(O)(O)=O ISJHUKIGBLJDNA-DKWTVANSSA-N 0.000 claims 1
UWOCFOFVIBZJGH-UHFFFAOYSA-N 2,3-dihydrodipicolinic acid Chemical compound OC(=O)C1CC=CC(C(O)=O)=N1 UWOCFOFVIBZJGH-UHFFFAOYSA-N 0.000 claims 1
XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 claims 1
108030003650 6-phosphofructokinases Proteins 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
108010000700 Acetolactate synthase Proteins 0.000 claims 1
102000001967 Branched-chain aminotransferases Human genes 0.000 claims 1
108050009223 Branched-chain aminotransferases Proteins 0.000 claims 1
108090000489 Carboxy-Lyases Proteins 0.000 claims 1
102000004031 Carboxy-Lyases Human genes 0.000 claims 1
101710155796 Malate:quinone oxidoreductase Proteins 0.000 claims 1
101710141619 Meso-diaminopimelate D-dehydrogenase Proteins 0.000 claims 1
108030006431 Methionine synthases Proteins 0.000 claims 1
FCXZBWSIAGGPCB-YFKPBYRVSA-N O-acetyl-L-homoserine Chemical compound CC(=O)OCC[C@H]([NH3+])C([O-])=O FCXZBWSIAGGPCB-YFKPBYRVSA-N 0.000 claims 1
108700027408 O-acetylhomoserine (thiol)-lyase Proteins 0.000 claims 1
239000005922 Phosphane Substances 0.000 claims 1
102000003929 Transaminases Human genes 0.000 claims 1
108090000340 Transaminases Proteins 0.000 claims 1
229950006137 dexfosfoserine Drugs 0.000 claims 1
239000013604 expression vector Substances 0.000 claims 1
239000001963 growth medium Substances 0.000 claims 1
GMKMEZVLHJARHF-SYDPRGILSA-N meso-2,6-diaminopimelic acid Chemical compound [O-]C(=O)[C@@H]([NH3+])CCC[C@@H]([NH3+])C([O-])=O GMKMEZVLHJARHF-SYDPRGILSA-N 0.000 claims 1
230000037361 pathway Effects 0.000 claims 1
229910000064 phosphane Inorganic materials 0.000 claims 1
YXJYBPXSEKMEEJ-UHFFFAOYSA-N phosphoric acid;sulfuric acid Chemical compound OP(O)(O)=O.OS(O)(=O)=O YXJYBPXSEKMEEJ-UHFFFAOYSA-N 0.000 claims 1
238000011084 recovery Methods 0.000 claims 1
210000003705 ribosome Anatomy 0.000 claims 1
230000002103 transcriptional effect Effects 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

RU2006125497/13A 2003-12-18 2004-12-15 Экспрессионные единицы pgro RU2006125497A (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10359595.3		2003-12-18
DE10359595A DE10359595A1 (de)	2003-12-18	2003-12-18	Pgro-Expressionseinheiten

Publications (1)

Publication Number	Publication Date
RU2006125497A true RU2006125497A (ru)	2008-01-27

Family

ID=34683544

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2006125497/13A RU2006125497A (ru)	2003-12-18	2004-12-15	Экспрессионные единицы pgro

Country Status (16)

Country	Link
US (1)	US20090246836A1 (2)
EP (2)	EP1921150B1 (2)
JP (2)	JP2007536908A (2)
KR (1)	KR100876655B1 (2)
CN (2)	CN101230352B (2)
BR (1)	BRPI0417770A (2)
CA (1)	CA2548306A1 (2)
CY (1)	CY1114595T1 (2)
DE (1)	DE10359595A1 (2)
IN (2)	IN2006CH02600A (2)
PL (1)	PL1921150T3 (2)
PT (1)	PT1921150E (2)
RU (1)	RU2006125497A (2)
TW (1)	TW200533749A (2)
WO (1)	WO2005059143A1 (2)
ZA (1)	ZA200605862B (2)

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DE10359594A1 (de)	2003-12-18	2005-07-28	Basf Ag	PEF-TU-Expressionseinheiten
DE102004061846A1 (de)	2004-12-22	2006-07-13	Basf Ag	Mehrfachpromotoren
US20100041107A1 (en) *	2006-10-24	2010-02-18	Basf Se	Method of reducing gene expression using modified codon usage
CN101646687A (zh) *	2007-02-19	2010-02-10	赢创德固赛有限责任公司	通过过表达戊糖磷酸途径的酶在棒状细菌中生产甲硫氨酸的方法
JP5444323B2 (ja) *	2008-03-27	2014-03-19	イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー	高発現ザイモモナス（Ｚｙｍｏｍｏｎａｓ）プロモーター
US8647642B2 (en)	2008-09-18	2014-02-11	Aviex Technologies, Llc	Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US10676723B2 (en)	2015-05-11	2020-06-09	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en)	2016-12-07	2021-09-28	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11136586B2 (en) *	2016-12-30	2021-10-05	Ntxbio, Llc	Cell-free expression system having novel inorganic polyphosphate-based energy regeneration
EP3415622A1 (en)	2017-06-14	2018-12-19	Evonik Degussa GmbH	Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases

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US7270984B1 (en) *	1999-06-25	2007-09-18	Basf Aktiengesellschaft	Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum
KR100878336B1 (ko) *	1999-06-25	2009-01-14	백광산업 주식회사	탄소 대사 및 에너지 생산과 관련된 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자
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JP4623825B2 (ja) *	1999-12-16	2011-02-02	協和発酵バイオ株式会社	新規ポリヌクレオチド
DE10046870A1 (de)	2000-09-20	2002-03-28	Basf Ag	Verfahren zur Veränderung des Genoms von Corynebakterien
US7141388B2 (en) *	2000-11-15	2006-11-28	Archer-Daniels-Midland Company	Nucleotide sequences for transcriptional regulation in corynebacterium glutamicum
CN100334213C (zh) *	2000-12-22	2007-08-29	巴斯福股份公司	棒状杆菌基因
DE10112992A1 (de) *	2001-03-17	2002-09-26	Degussa	Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
US7005031B2 (en) *	2002-01-16	2006-02-28	3M Innovative Properties Company	Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods

2003
- 2003-12-18 DE DE10359595A patent/DE10359595A1/de not_active Withdrawn
2004
- 2004-12-15 CN CN2008100020226A patent/CN101230352B/zh not_active Expired - Lifetime
- 2004-12-15 CN CNA2004800380880A patent/CN1898388A/zh active Pending
- 2004-12-15 TW TW93139001A patent/TW200533749A/zh unknown
- 2004-12-15 RU RU2006125497/13A patent/RU2006125497A/ru unknown
- 2004-12-15 WO PCT/EP2004/014263 patent/WO2005059143A1/de not_active Ceased
- 2004-12-15 JP JP2006544324A patent/JP2007536908A/ja not_active Withdrawn
- 2004-12-15 EP EP07123783.8A patent/EP1921150B1/de not_active Expired - Lifetime
- 2004-12-15 KR KR1020067014365A patent/KR100876655B1/ko not_active Expired - Lifetime
- 2004-12-15 BR BRPI0417770-3A patent/BRPI0417770A/pt not_active IP Right Cessation
- 2004-12-15 PT PT71237838T patent/PT1921150E/pt unknown
- 2004-12-15 US US10/582,822 patent/US20090246836A1/en not_active Abandoned
- 2004-12-15 PL PL07123783T patent/PL1921150T3/pl unknown
- 2004-12-15 EP EP04803884A patent/EP1697524A1/de not_active Withdrawn
- 2004-12-15 CA CA002548306A patent/CA2548306A1/en not_active Abandoned
2006
- 2006-07-17 ZA ZA200605862A patent/ZA200605862B/xx unknown
- 2006-07-17 IN IN2600CH2006 patent/IN2006CH02600A/en unknown
2008
- 2008-02-21 IN IN439CH2008 patent/IN2008CH00439A/en unknown
- 2008-04-02 JP JP2008095696A patent/JP4808742B2/ja not_active Expired - Fee Related
2013
- 2013-11-11 CY CY20131100999T patent/CY1114595T1/el unknown

Also Published As

Publication number	Publication date
ZA200605862B (en)	2008-06-25
EP1697524A1 (de)	2006-09-06
CN101230352B (zh)	2013-02-13
KR100876655B1 (ko)	2009-01-09
PT1921150E (pt)	2013-10-08
JP4808742B2 (ja)	2011-11-02
CN101230352A (zh)	2008-07-30
JP2007536908A (ja)	2007-12-20
JP2008237218A (ja)	2008-10-09
IN2006CH02600A (2)	2007-06-08
DE10359595A1 (de)	2005-07-28
BRPI0417770A (pt)	2007-04-17
CY1114595T1 (el)	2016-10-05
IN2008CH00439A (2)	2008-09-19
PL1921150T3 (pl)	2014-03-31
KR20070004579A (ko)	2007-01-09
EP1921150A1 (de)	2008-05-14
US20090246836A1 (en)	2009-10-01
EP1921150B1 (de)	2013-09-18
TW200533749A (en)	2005-10-16
CN1898388A (zh)	2007-01-17
WO2005059143A1 (de)	2005-06-30
CA2548306A1 (en)	2005-06-30

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