RU2012120343A - Морфогенные белки кости (bmp), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы - Google Patents
Морфогенные белки кости (bmp), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы Download PDFInfo
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- RU2012120343A RU2012120343A RU2012120343/15A RU2012120343A RU2012120343A RU 2012120343 A RU2012120343 A RU 2012120343A RU 2012120343/15 A RU2012120343/15 A RU 2012120343/15A RU 2012120343 A RU2012120343 A RU 2012120343A RU 2012120343 A RU2012120343 A RU 2012120343A
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- Prior art keywords
- bmp
- antagonist
- glaucoma
- treatment
- proteins
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Links
- 208000010412 Glaucoma Diseases 0.000 title claims abstract 6
- 102000029877 BMP binding proteins Human genes 0.000 title 1
- 108091014778 BMP binding proteins Proteins 0.000 title 1
- 102000001893 Bone Morphogenetic Protein Receptors Human genes 0.000 title 1
- 108010040422 Bone Morphogenetic Protein Receptors Proteins 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 230000000921 morphogenic effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 claims abstract 14
- 102000016970 Follistatin Human genes 0.000 claims abstract 6
- 108010014612 Follistatin Proteins 0.000 claims abstract 6
- 102100038367 Gremlin-1 Human genes 0.000 claims abstract 6
- 101001032872 Homo sapiens Gremlin-1 Proteins 0.000 claims abstract 6
- 102000006533 chordin Human genes 0.000 claims abstract 6
- 108010008846 chordin Proteins 0.000 claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
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- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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Abstract
1. Композиция для лечения глаукомы, содержащая антагонист хордина, антагонист гремлина или антагонист фоллистатина.2. Композиция по п.1, в которой антагонист хордина, гремлина или фоллистатина представляет собой антитело или олигонуклеотид.3. Применение композиции, содержащей антагонист хордина, антагонист гремлина или антагонист фоллистатина для лечения глаукомы.4. Применение по п.3, где антагонист хордина, гремлина или фоллистатина представляет собой антитело или олигонуклеотид.
Claims (4)
1. Композиция для лечения глаукомы, содержащая антагонист хордина, антагонист гремлина или антагонист фоллистатина.
2. Композиция по п.1, в которой антагонист хордина, гремлина или фоллистатина представляет собой антитело или олигонуклеотид.
3. Применение композиции, содержащей антагонист хордина, антагонист гремлина или антагонист фоллистатина для лечения глаукомы.
4. Применение по п.3, где антагонист хордина, гремлина или фоллистатина представляет собой антитело или олигонуклеотид.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33485201P | 2001-10-31 | 2001-10-31 | |
| US60/334,852 | 2001-10-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008122296/15A Division RU2008122296A (ru) | 2001-10-31 | 2008-06-03 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012120343A true RU2012120343A (ru) | 2013-11-27 |
Family
ID=23309139
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004116308/15A RU2336902C2 (ru) | 2001-10-31 | 2002-10-31 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
| RU2008122296/15A RU2008122296A (ru) | 2001-10-31 | 2008-06-03 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
| RU2012120343/15A RU2012120343A (ru) | 2001-10-31 | 2012-05-16 | Морфогенные белки кости (bmp), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004116308/15A RU2336902C2 (ru) | 2001-10-31 | 2002-10-31 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
| RU2008122296/15A RU2008122296A (ru) | 2001-10-31 | 2008-06-03 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US20050118585A1 (ru) |
| EP (2) | EP1440159B1 (ru) |
| JP (2) | JP4255382B2 (ru) |
| KR (4) | KR101072867B1 (ru) |
| CN (2) | CN1966725A (ru) |
| AT (1) | ATE349554T1 (ru) |
| BR (1) | BR0213738A (ru) |
| CA (1) | CA2463143A1 (ru) |
| DE (1) | DE60217152T2 (ru) |
| ES (1) | ES2278079T3 (ru) |
| MX (1) | MXPA04003697A (ru) |
| PL (2) | PL214839B1 (ru) |
| RU (3) | RU2336902C2 (ru) |
| WO (1) | WO2003055443A2 (ru) |
| ZA (1) | ZA200402662B (ru) |
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