RU2012146433A - ANTI-HEATING PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING IT - Google Patents
ANTI-HEATING PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING IT Download PDFInfo
- Publication number
- RU2012146433A RU2012146433A RU2012146433/15A RU2012146433A RU2012146433A RU 2012146433 A RU2012146433 A RU 2012146433A RU 2012146433/15 A RU2012146433/15 A RU 2012146433/15A RU 2012146433 A RU2012146433 A RU 2012146433A RU 2012146433 A RU2012146433 A RU 2012146433A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- regulator
- methylpyrrolidone
- azelaic acid
- hydrophobic component
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 7
- 238000010438 heat treatment Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims abstract 12
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 6
- 239000003995 emulsifying agent Substances 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 4
- 229920000642 polymer Polymers 0.000 claims abstract 4
- 239000003755 preservative agent Substances 0.000 claims abstract 4
- 230000002335 preservative effect Effects 0.000 claims abstract 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000003125 aqueous solvent Substances 0.000 claims abstract 3
- 239000002260 anti-inflammatory agent Substances 0.000 claims abstract 2
- 239000007864 aqueous solution Substances 0.000 claims abstract 2
- 229940008099 dimethicone Drugs 0.000 claims abstract 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract 2
- 239000000243 solution Substances 0.000 claims abstract 2
- 229940032094 squalane Drugs 0.000 claims abstract 2
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Фармацевтическая композиция для наружного применения в виде геля, которая включает азелаиновую кислоту, гидрофобный компонент, неводный растворитель, эмульгатор, гелеобразующий полимер, консервант и регулятор рН, отличающаяся тем, что дополнительно включает метилпирролидон в следующем соотношении, масс.ч.:Азелаиновая кислота - 1,Метилпирролидон - 0,025-4.2. Фармацевтическая композиция по п.1, отличающаяся тем, что содержит в качестве гидрофобного компонента комбинацию сквалана и диметикона.3. Фармацевтическая композиция по п.1, отличающаяся тем, что дополнительно содержит противовоспалительное вещество.4. Способ получения композиции, охарактеризованной в п.1, по которому в водный раствор консерванта вводят гелеобразующий полимер, метилпирролидон, неводный растворитель, эмульгатор, азелаиновую кислоту, гомогенизируют, затем последовательно добавляют гидрофобный компонент, регулятор рН и гомогенизируют полученную смесь.5. Способ по п.4, по которому регулятор рН вводят в виде раствора1. The pharmaceutical composition for external use in the form of a gel, which includes azelaic acid, a hydrophobic component, a non-aqueous solvent, an emulsifier, a gel-forming polymer, a preservative and a pH regulator, characterized in that it further includes methylpyrrolidone in the following ratio, parts by weight: azelaic acid - 1, Methylpyrrolidone - 0.025-4.2. The pharmaceutical composition according to claim 1, characterized in that it contains a combination of squalane and dimethicone as a hydrophobic component. The pharmaceutical composition according to claim 1, characterized in that it further comprises an anti-inflammatory substance. A method for preparing the composition described in claim 1, wherein a gelling polymer, methylpyrrolidone, a nonaqueous solvent, an emulsifier, azelaic acid are introduced into an aqueous solution of a preservative, homogenized, then a hydrophobic component, a pH regulator are added sequentially, and the resulting mixture is homogenized. 5. The method according to claim 4, in which the pH regulator is introduced in the form of a solution
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012146433/15A RU2530644C2 (en) | 2012-11-01 | 2012-11-01 | Comedolytic pharmaceutical composition and method for preparing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012146433/15A RU2530644C2 (en) | 2012-11-01 | 2012-11-01 | Comedolytic pharmaceutical composition and method for preparing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012146433A true RU2012146433A (en) | 2014-05-10 |
| RU2530644C2 RU2530644C2 (en) | 2014-10-10 |
Family
ID=50629306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012146433/15A RU2530644C2 (en) | 2012-11-01 | 2012-11-01 | Comedolytic pharmaceutical composition and method for preparing it |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2530644C2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230346661A1 (en) * | 2020-04-16 | 2023-11-02 | Baek Clinical Inc. | Anhydrous Azelaic Acid Topical Formulations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6387383B1 (en) * | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| FR2867684B1 (en) * | 2004-03-18 | 2006-05-05 | Galderma Sa | CREAM GEL CONTAINING IVERMECTIN |
| DE602005020912D1 (en) * | 2004-03-18 | 2010-06-10 | Galderma Sa | IVERMECTIN CONTAINING CREAM |
-
2012
- 2012-11-01 RU RU2012146433/15A patent/RU2530644C2/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230346661A1 (en) * | 2020-04-16 | 2023-11-02 | Baek Clinical Inc. | Anhydrous Azelaic Acid Topical Formulations |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2530644C2 (en) | 2014-10-10 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20171102 |