RU2012157473A - Способ выявления или лечения реакции "трансплантат против хозяина" - Google Patents

Способ выявления или лечения реакции "трансплантат против хозяина" Download PDF

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RU2012157473A
RU2012157473A RU2012157473/15A RU2012157473A RU2012157473A RU 2012157473 A RU2012157473 A RU 2012157473A RU 2012157473/15 A RU2012157473/15 A RU 2012157473/15A RU 2012157473 A RU2012157473 A RU 2012157473A RU 2012157473 A RU2012157473 A RU 2012157473A
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reaction
owner
identification
treatment
versus host
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RU2012157473/15A
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RU2632434C2 (ru
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Цукаса ХОРИ
Ясуо КОКАИ
Ясуйоси НАИСИРО
Хироюки ЦУЦУМИ
Кохзох ИМАИ
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Саппоро Медикал Юниверсити
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Publication of RU2632434C2 publication Critical patent/RU2632434C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G01N2333/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1or LDCF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

1. Фармацевтическая композиция для лечения реакции «трансплантат против хозяина», содержащая анти-CCL8 антитело в качестве активного ингредиента.2. Способ лечения реакции «трансплантат против хозяина», включающий введение анти-CCL8 антитела субъекту, у которого имеется реакция «трансплантат против хозяина».

Claims (2)

1. Фармацевтическая композиция для лечения реакции «трансплантат против хозяина», содержащая анти-CCL8 антитело в качестве активного ингредиента.
2. Способ лечения реакции «трансплантат против хозяина», включающий введение анти-CCL8 антитела субъекту, у которого имеется реакция «трансплантат против хозяина».
RU2012157473A 2007-06-22 2012-12-26 Способ выявления или лечения реакции "трансплантат против хозяина" RU2632434C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007165547 2007-06-22
JP2007-165547 2007-06-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2010101909/15A Division RU2479846C2 (ru) 2007-06-22 2008-06-23 Способ выявления или лечения реакции "трансплантат против хозяина"

Publications (2)

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RU2012157473A true RU2012157473A (ru) 2014-07-10
RU2632434C2 RU2632434C2 (ru) 2017-10-04

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ID=40185370

Family Applications (2)

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RU2010101909/15A RU2479846C2 (ru) 2007-06-22 2008-06-23 Способ выявления или лечения реакции "трансплантат против хозяина"
RU2012157473A RU2632434C2 (ru) 2007-06-22 2012-12-26 Способ выявления или лечения реакции "трансплантат против хозяина"

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RU2010101909/15A RU2479846C2 (ru) 2007-06-22 2008-06-23 Способ выявления или лечения реакции "трансплантат против хозяина"

Country Status (8)

Country Link
US (3) US20100183586A1 (ru)
EP (1) EP2163896B1 (ru)
JP (1) JP5403752B2 (ru)
KR (1) KR101432191B1 (ru)
CN (1) CN101743473B (ru)
CA (1) CA2692332C (ru)
RU (2) RU2479846C2 (ru)
WO (1) WO2009001545A1 (ru)

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JP2012233693A (ja) * 2009-08-26 2012-11-29 Sapporo Medical Univ 宿主対移植片疾患の検査方法
JP5786020B2 (ja) 2010-04-16 2015-09-30 アボットジャパン株式会社 関節リウマチを診断する方法および試薬
WO2012018260A1 (en) * 2010-08-05 2012-02-09 Universiteit Utrecht Holding B.V. Epidermal growth factor receptor targeted immune therapy
ES2692833T3 (es) * 2010-09-07 2018-12-05 Stephen G. Marx Kit para controlar, detectar y estadificar GVHD
GB201021149D0 (en) * 2010-12-14 2011-01-26 Georg August Uni Gottingen Stiftung Offentlichen Rechts Use of a skin explant assay for mRNA expression analysis for the identification of new genes and drug targets associated with graft versus host disease
CN102550486B (zh) * 2012-01-10 2013-07-10 浙江大学 一种nod/scid小鼠异种移植物抗宿主病模型的建立方法
US20150099645A1 (en) * 2012-03-14 2015-04-09 Stephen Marx Means and methods for diagnostics and therapeutics of diseases
WO2013168876A1 (ko) 2012-05-11 2013-11-14 가톨릭대학교 산학협력단 이식 후 면역 상태를 모니터링 하는 키트 및 이를 이용한 면역 상태의 모니터링 방법
CN105102612B (zh) 2012-12-06 2020-11-17 恩立夫克治疗有限责任公司 治疗性凋亡细胞制剂、其制备方法以及其用途
JP6947372B2 (ja) * 2015-05-26 2021-10-13 学校法人東京薬科大学 炎症性腸疾患を抑制する抗体および該抗体を含む医薬組成物
CA2995582A1 (en) 2015-08-19 2017-02-23 Children's Research Institute, Children's National Medical Center Compositions and methods for treating graft versus host disease
RU2603461C1 (ru) * 2015-11-27 2016-11-27 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ подбора режима иммуносупрессии после трансплантации печени детям раннего возраста
CN115327118A (zh) * 2022-09-05 2022-11-11 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Cd38+hla-dr+cd8+t细胞在gvhd早期诊断中的应用

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ITMI991299A1 (it) * 1999-06-11 2000-12-11 Consiglio Nazionale Ricerche Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite
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Also Published As

Publication number Publication date
EP2163896A1 (en) 2010-03-17
JPWO2009001545A1 (ja) 2010-08-26
US20140234335A1 (en) 2014-08-21
JP5403752B2 (ja) 2014-01-29
US9631014B2 (en) 2017-04-25
CN101743473A (zh) 2010-06-16
KR20100055390A (ko) 2010-05-26
AU2008268842A1 (en) 2008-12-31
RU2632434C2 (ru) 2017-10-04
US20100183586A1 (en) 2010-07-22
CA2692332C (en) 2019-09-24
US20130065779A1 (en) 2013-03-14
EP2163896B1 (en) 2013-09-25
RU2010101909A (ru) 2011-07-27
CA2692332A1 (en) 2008-12-31
EP2163896A4 (en) 2010-08-04
KR101432191B1 (ko) 2014-08-20
RU2479846C2 (ru) 2013-04-20
US20130267430A2 (en) 2013-10-10
CN101743473B (zh) 2014-03-19
WO2009001545A1 (ja) 2008-12-31

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