RU93005332A - Производные 4,1-бензоксазепина, фармацевтическая композиция, способ лечения - Google Patents
Производные 4,1-бензоксазепина, фармацевтическая композиция, способ леченияInfo
- Publication number
- RU93005332A RU93005332A RU93005332/04A RU93005332A RU93005332A RU 93005332 A RU93005332 A RU 93005332A RU 93005332/04 A RU93005332/04 A RU 93005332/04A RU 93005332 A RU93005332 A RU 93005332A RU 93005332 A RU93005332 A RU 93005332A
- Authority
- RU
- Russia
- Prior art keywords
- optionally substituted
- hydrogen atom
- derivatives
- benzoxazepina
- treatment
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- VTYJANRVLSSNCJ-UHFFFAOYSA-N 4,1-benzoxazepin-2-one Chemical class O=C1COC=C2C=CC=CC2=N1 VTYJANRVLSSNCJ-UHFFFAOYSA-N 0.000 claims 1
- 108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Claims (1)
- Предложены производные 4, 1-бензоксазепин-2-она общей формулы
где R1 является атомом водорода или необязательно замещенной углеводородной группой; R2 и R3 независимо являются атомом водорода, необязательно замещенным низшим алкилом, необязательно замещенным фенилом или необязательно замещенной ароматической гетероциклической группой; X является связью или спейсером, имеющим длину цепи от 1 до 7 атомов; Y является необязательно этерифицированным или тиоэтерифицированным карбоксилом, необязательно замещенным гидроксилом, необязательно замещенной аминогруппой, необязательно замещенным фенилом, необязательно замещенным карбамоилом или N - содержащим гетероциклическим остатком, имеющим атом водорода, способный быть депротонированным; при условии, что когда X является метиленом и R1 не является алкилом, содержащим больше 4 атомов углерода, Y не является ни карбоксилом, ни алкоксикарбонилом; кольцо A может быть необязательно замещенным, или его соли, которые являются полезными для ингибирования скваленсинтетазы и роста грибов.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP04-099541 | 1992-04-20 | ||
| JP9954192 | 1992-04-20 | ||
| JP33994792 | 1992-12-21 | ||
| JP04-339947 | 1992-12-21 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99118298/04A Division RU2170732C2 (ru) | 1993-04-19 | 1993-04-19 | Производные 4,1-бензоксазепина |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93005332A true RU93005332A (ru) | 1996-02-27 |
| RU2145603C1 RU2145603C1 (ru) | 2000-02-20 |
Family
ID=26440672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93005332/04A RU2145603C1 (ru) | 1992-04-20 | 1993-04-19 | Производные 4,1-бензоксазепина, фармацевтическая композиция, способ ингибирования скваленсинтетазы у млекопитающих, способ ингибирования роста грибков у млекопитающих |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0567026B1 (ru) |
| KR (1) | KR100293338B1 (ru) |
| CN (1) | CN1044237C (ru) |
| AT (1) | ATE235474T1 (ru) |
| AU (1) | AU659543B2 (ru) |
| CA (1) | CA2094335C (ru) |
| DE (1) | DE69332792T2 (ru) |
| FI (1) | FI119022B (ru) |
| HU (1) | HUT71482A (ru) |
| NO (1) | NO304520B1 (ru) |
| NZ (1) | NZ247429A (ru) |
| RU (1) | RU2145603C1 (ru) |
| SG (2) | SG48855A1 (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2337100C2 (ru) * | 2003-08-01 | 2008-10-27 | Такеда Фармасьютикал Компани Лимитед | Производные бензоксазепина, способ их получения, лекарственное средство на их основе и их применение |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5726306A (en) * | 1992-04-20 | 1998-03-10 | Takeda Chemical Industries, Ltd. | 4,1-benzoxazepin derivatives and their use |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| WO1995021834A1 (en) * | 1994-02-09 | 1995-08-17 | Takeda Chemical Industries, Ltd. | Optically active 4,1-benzoxazepine derivatives useful as squalene synthase inhibitors |
| ATE246927T1 (de) * | 1994-03-24 | 2003-08-15 | Merrell Pharma Inc | Cholesterin senkende mercaptoacetylamiddisulfidderivate |
| TW401301B (en) * | 1994-10-07 | 2000-08-11 | Takeda Chemical Industries Ltd | Antihypertriglyceridemic composition |
| CA2161849A1 (en) * | 1994-11-01 | 1996-05-02 | Kazuo Nakahama | Production of optically active compounds |
| JPH10500702A (ja) * | 1994-12-23 | 1998-01-20 | ファイザー・インコーポレーテッド | スクアレンシンテターゼ阻害剤としてのナフチル−ベンゾキサゼピンまたは−ベンゾチアゼピン |
| DK0862562T3 (da) * | 1995-09-13 | 2001-09-24 | Takeda Chemical Industries Ltd | Benzoxazepinforbindelser, fremstilling deraf og anvendelse deraf som lipidniveauformindskende midler |
| CN1072649C (zh) * | 1995-09-13 | 2001-10-10 | 武田药品工业株式会社 | 苯并氧杂吖庚因化合物,其生产方法和用途 |
| WO1997048701A1 (en) * | 1996-06-20 | 1997-12-24 | Pfizer Inc. | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors |
| DE69832376T2 (de) | 1997-04-21 | 2006-08-03 | Takeda Pharmaceutical Co. Ltd. | 4,1-benzoxazepine, ihre analoga, und ihre verwendung als somatostatin-agonisten |
| CA2303295A1 (en) * | 1997-09-02 | 1999-03-11 | Dupont Pharmaceuticals Company | 5,5-disubstituted-1,5-dihydro-4,1-benzoxazepin-2(3h)-ones useful as hiv reverse transcriptase inhibitors |
| US6063921A (en) * | 1997-11-20 | 2000-05-16 | Pharm-Eco Laboratories, Inc. | Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines |
| US6207664B1 (en) | 1998-11-25 | 2001-03-27 | Pfizer Inc. | Squalene synthetase inhibitor agents |
| HUP0301301A2 (hu) * | 2000-06-23 | 2003-08-28 | Takeda Chemical Industries Ltd. | Benzoxazepinon-származékok és szkvalén szintáz inhibitorként való alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| JO2390B1 (en) | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
| EP1407782A4 (en) * | 2001-06-28 | 2004-10-20 | Takeda Chemical Industries Ltd | AGENTS FOR PREVENTION / TREATMENT OF FUNCTIONAL ORGANIC DISEASES AND ORGANIC DYSFUNCTION |
| GB0125532D0 (en) * | 2001-10-24 | 2001-12-12 | Burton Michael | Enzyme activity indicators |
| UA79300C2 (en) | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
| CA2514547A1 (en) * | 2003-01-28 | 2004-08-12 | Takeda Pharmaceutical Company Limited | Receptor agonists |
| EP1689383B1 (en) | 2003-11-19 | 2012-10-31 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| US7323455B2 (en) | 2004-03-24 | 2008-01-29 | Wyeth | 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators |
| RU2008119687A (ru) | 2005-10-21 | 2009-11-27 | Новартис АГ (CH) | Комбинации органических соединений |
| US20120046364A1 (en) | 2009-02-10 | 2012-02-23 | Metabasis Therapeutics, Inc. | Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| CN103965185B (zh) * | 2014-03-28 | 2016-06-29 | 河北师范大学 | 含有噻唑基和酯基的1,5-苯并二氮杂卓化合物及其应用 |
| CN119817591B (zh) * | 2025-01-10 | 2025-11-21 | 河北农业大学 | 一种苯并-1,2,4-三嗪并氧氮杂䓬类化合物的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5572177A (en) * | 1978-11-27 | 1980-05-30 | Shionogi & Co Ltd | 4,1-benzoxazepine or 4,1-benzothiazepine |
| JPS5735596A (en) * | 1980-08-13 | 1982-02-26 | Funai Corp | Ester derivative of deoxyfluorouridine |
| US4374842A (en) * | 1980-04-18 | 1983-02-22 | Shionogi & Co., Ltd. | 4,1-Benzoxazepines and compositions |
| JPS5735576A (en) * | 1980-07-18 | 1982-02-26 | Takeda Chem Ind Ltd | 4,1-benzoxazepin-3-acetic derivative and its production |
| US4590187A (en) * | 1983-11-17 | 1986-05-20 | The Upjohn Company | Phospholipase A2 inhibition using 4,1-benzoxazepine-2-(3H)-ones |
| EP0142361B1 (en) * | 1983-11-17 | 1988-05-11 | The Upjohn Company | N-substituted-5-phenyl-4,1-benzoxazepin-2(3h)-ones having therapeutic utility |
| US4758559A (en) * | 1986-01-21 | 1988-07-19 | Ciba-Geigy Corporation | Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors |
| US5096923A (en) * | 1990-03-21 | 1992-03-17 | Merck & Co., Inc. | Novel squalene synthetase inhibitors |
| NZ239663A (en) * | 1990-09-13 | 1993-07-27 | Merck & Co Inc | Ester derivatives of dioxabicyclo(3,2,1)-octane, medicaments, and a fungus which makes them |
| US5026554A (en) * | 1990-09-13 | 1991-06-25 | Merck & Co., Inc. | Method of inhibiting fungal growth using squalene synthetase inhibitors |
| CA2105655A1 (en) * | 1991-03-08 | 1992-09-09 | Kent Neuenschwander | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
-
1993
- 1993-04-17 DE DE69332792T patent/DE69332792T2/de not_active Expired - Fee Related
- 1993-04-17 AT AT93106276T patent/ATE235474T1/de not_active IP Right Cessation
- 1993-04-17 EP EP93106276A patent/EP0567026B1/en not_active Expired - Lifetime
- 1993-04-17 SG SG1996003103A patent/SG48855A1/en unknown
- 1993-04-17 SG SG9903981A patent/SG82630A1/en unknown
- 1993-04-19 NZ NZ247429A patent/NZ247429A/en not_active IP Right Cessation
- 1993-04-19 RU RU93005332/04A patent/RU2145603C1/ru not_active IP Right Cessation
- 1993-04-19 CA CA002094335A patent/CA2094335C/en not_active Expired - Fee Related
- 1993-04-19 NO NO931433A patent/NO304520B1/no unknown
- 1993-04-19 FI FI931763A patent/FI119022B/fi active IP Right Grant
- 1993-04-19 AU AU37003/93A patent/AU659543B2/en not_active Ceased
- 1993-04-20 KR KR1019930006653A patent/KR100293338B1/ko not_active Expired - Fee Related
- 1993-04-20 HU HU9301164A patent/HUT71482A/hu unknown
- 1993-04-20 CN CN93106358A patent/CN1044237C/zh not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2337100C2 (ru) * | 2003-08-01 | 2008-10-27 | Такеда Фармасьютикал Компани Лимитед | Производные бензоксазепина, способ их получения, лекарственное средство на их основе и их применение |
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