RU93046319A - NEW DERIVATIVES OF 3,4-DIHYDROISOCHINOLINE, METHOD FOR PRODUCING THEM, AND NEW PHARMACEUTICAL APPLICATION OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNELATED DIGYDROPYRIDINES - Google Patents
NEW DERIVATIVES OF 3,4-DIHYDROISOCHINOLINE, METHOD FOR PRODUCING THEM, AND NEW PHARMACEUTICAL APPLICATION OF CARBOCYCLICALLY AND HETEROCYCLICALLY ANNELATED DIGYDROPYRIDINESInfo
- Publication number
- RU93046319A RU93046319A RU93046319/14A RU93046319A RU93046319A RU 93046319 A RU93046319 A RU 93046319A RU 93046319/14 A RU93046319/14 A RU 93046319/14A RU 93046319 A RU93046319 A RU 93046319A RU 93046319 A RU93046319 A RU 93046319A
- Authority
- RU
- Russia
- Prior art keywords
- annelated
- new
- dihydroisochinoline
- digydropyridines
- carbocyclically
- Prior art date
Links
- NKSZCPBUWGZONP-UHFFFAOYSA-N 3,4-dihydroisoquinoline Chemical class C1=CC=C2C=NCCC2=C1 NKSZCPBUWGZONP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Claims (1)
а также их таутомерных форм формулы II
где A является одной из аннелированных кольцевых систем
и X является группой OR1, NHR2 или NR3R4 в качестве средства для защиты головного мозга, средства для лечения хронических воспалительных процессов и в качестве средства для торможения свертываемости крови. Изобретение касается также новых соединений общей формулы Iе, которые определены в тексте описания изобретения и приведенной выше общей формулой I.The invention relates to the use of carbocyclic or heterocyclic annelated dihydropyridines of the formula I
as well as their tautomeric forms of formula II
where A is one of the annelated ring systems
and X is a group of OR 1 , NHR 2 or NR 3 R 4 as an agent for protecting the brain, an agent for treating chronic inflammatory processes, and as an agent for inhibiting blood coagulation. The invention also relates to new compounds of the general formula Ie, which are defined in the text of the description of the invention and the above general formula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4041482A DE4041482A1 (en) | 1990-12-22 | 1990-12-22 | NEW PHARMACEUTICAL USE OF CARBOCYCLIC AND HETEROCYCLICALLY ANNELATED DIHYDROPYRIDINE |
| DEP4041482.5 | 1990-12-22 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94046320/14A Division RU2149000C1 (en) | 1990-12-22 | 1991-12-20 | Use of carbocyclic and heterocyclic anellated dihydropyridines and their pharmaceutically acceptable salts as blocker of nonselective channel of cations in protection of brain and for treatment of patients with chronic bronchial asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93046319A true RU93046319A (en) | 1997-01-27 |
| RU2115647C1 RU2115647C1 (en) | 1998-07-20 |
Family
ID=6421218
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93046319A RU2115647C1 (en) | 1990-12-22 | 1991-12-20 | 3,4-dihydroisoquinoline derivatives or pharmaceutically acceptable salts thereof, method of preparation thereof, and pharmaceutical composition based thereon |
| RU94046320/14A RU2149000C1 (en) | 1990-12-22 | 1991-12-20 | Use of carbocyclic and heterocyclic anellated dihydropyridines and their pharmaceutically acceptable salts as blocker of nonselective channel of cations in protection of brain and for treatment of patients with chronic bronchial asthma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94046320/14A RU2149000C1 (en) | 1990-12-22 | 1991-12-20 | Use of carbocyclic and heterocyclic anellated dihydropyridines and their pharmaceutically acceptable salts as blocker of nonselective channel of cations in protection of brain and for treatment of patients with chronic bronchial asthma |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US6034094A (en) |
| EP (2) | EP0563128B1 (en) |
| JP (1) | JP3283877B2 (en) |
| KR (1) | KR100227953B1 (en) |
| AT (1) | ATE177948T1 (en) |
| AU (1) | AU666107B2 (en) |
| BR (1) | BR1100520A (en) |
| CA (1) | CA2098917A1 (en) |
| CZ (3) | CZ284695A3 (en) |
| DE (3) | DE9017900U1 (en) |
| DK (1) | DK0563128T3 (en) |
| ES (1) | ES2129040T3 (en) |
| FI (1) | FI105026B (en) |
| GR (1) | GR3030341T3 (en) |
| HR (1) | HRP940721B1 (en) |
| HU (1) | HU217819B (en) |
| ID (1) | ID16001A (en) |
| IE (3) | IE914486A1 (en) |
| IL (1) | IL100450A (en) |
| MX (1) | MX9102765A (en) |
| NO (1) | NO179515C (en) |
| NZ (1) | NZ241140A (en) |
| PL (1) | PL172262B1 (en) |
| PT (1) | PT99901B (en) |
| RU (2) | RU2115647C1 (en) |
| SG (1) | SG43064A1 (en) |
| SI (1) | SI9111975B (en) |
| SK (1) | SK281017B6 (en) |
| TW (1) | TW283145B (en) |
| WO (1) | WO1992011010A1 (en) |
| YU (1) | YU48063B (en) |
| ZA (1) | ZA9110116B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957092A1 (en) * | 1992-06-22 | 1999-11-17 | Boehringer Ingelheim Pharma KG | Ring-closed dihydropyridines and their use in the preparation of pharmaceutical compositions |
| ES2152379T3 (en) * | 1993-12-21 | 2001-02-01 | Boehringer Ingelheim Pharma | CONDENSED DIHYDROPIRIDINS AND ITS USE FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS. |
| DE4343683A1 (en) * | 1993-12-21 | 1995-06-22 | Boehringer Ingelheim Kg | Anellated dihydropyridines and their use for the preparation of pharmaceutical preparations |
| GB2341318A (en) * | 1998-09-14 | 2000-03-15 | Boehringer Ingelheim Pharma | A Dihydroisoquinoline (LOE 908) and Traumatic Brain Injury. |
| IT1318650B1 (en) * | 2000-07-28 | 2003-08-27 | Dompe Spa | 1,3-DIOSSOLANS WITH ANTI-TOXIC ACTIVITY. |
| CA2475761C (en) * | 2002-02-11 | 2011-07-12 | Gold-T Tech, Inc. | An implantable device which provides high frequency ultrasound energy to provide acoustical streaming to prevent thrombus formation |
| AU2004224156B2 (en) * | 2003-03-26 | 2010-08-12 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists |
| RU2355686C2 (en) * | 2003-10-16 | 2009-05-20 | Ф.Хоффманн-Ля Рош Аг | Glutamine fructose-6-phosphate amidotransferase inhibitors |
| DE102004055633A1 (en) * | 2004-11-12 | 2006-05-18 | Schering Ag | New 5-substituted quinoline and isoquinoline derivatives are glucocorticoid receptor binders useful for treating inflammatory diseases e.g. alveolitis, Sjogren's syndrome, atopic dermatitis, acute lymphatic leukemia, rhinitis and emesis |
| DE602008006368D1 (en) * | 2007-03-15 | 2011-06-01 | Hoffmann La Roche | MALONAMIDES AS OREXIN ANTAGONISTS |
| CZ20106A3 (en) * | 2010-01-05 | 2011-08-10 | Zentiva, K. S | Process for preparing 6,7-dimethoxy-1-[2-(4-trifluoromethylphenyl)ethyl]-3-4-dihydroisoquinoline |
| EP2420237A1 (en) | 2010-08-11 | 2012-02-22 | Ville Takio | Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways |
| KR101645930B1 (en) | 2014-12-16 | 2016-08-05 | (주) 우수 | The towel dispenser |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3013906A1 (en) * | 1980-04-11 | 1981-10-15 | C.H. Boehringer Sohn, 6507 Ingelheim | SUBSTITUTED (ALPHA) -AMINOCARBONYL-L-BENZYL-3,4-DIHYDRO-ISOCHINOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF |
| DE3621413A1 (en) * | 1986-06-26 | 1988-01-07 | Boehringer Ingelheim Kg | USE OF CARBOCYCLIC AND HETEROCYCLICALLY FURNISHED DIHYDROPYRIDINE AS A CARDIOPROTECTIVE AGENT AND NEW HETEROCYCLIC AND CARBOCYCLICALLY FURNISHED DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND ITS ADDITIONAL PRODUCTS |
| IL86131A0 (en) * | 1987-04-24 | 1988-11-15 | Boehringer Ingelheim Kg | Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
| DE3827727A1 (en) * | 1988-08-16 | 1990-02-22 | Boehringer Ingelheim Kg | ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE OF SUCH CONNECTIONS FOR CARDIRO PROTECTION |
-
1990
- 1990-12-22 DE DE9017900U patent/DE9017900U1/en not_active Expired - Lifetime
- 1990-12-22 DE DE4041482A patent/DE4041482A1/en not_active Ceased
-
1991
- 1991-12-20 KR KR1019930701908A patent/KR100227953B1/en not_active Expired - Fee Related
- 1991-12-20 SG SG1996003170A patent/SG43064A1/en unknown
- 1991-12-20 HU HU9301820A patent/HU217819B/en not_active IP Right Cessation
- 1991-12-20 IL IL10045091A patent/IL100450A/en not_active IP Right Cessation
- 1991-12-20 IE IE448691A patent/IE914486A1/en not_active Application Discontinuation
- 1991-12-20 JP JP50207392A patent/JP3283877B2/en not_active Expired - Fee Related
- 1991-12-20 AT AT92901178T patent/ATE177948T1/en not_active IP Right Cessation
- 1991-12-20 CZ CZ952846A patent/CZ284695A3/en not_active IP Right Cessation
- 1991-12-20 IE IE19990430A patent/IE990430A1/en unknown
- 1991-12-20 DE DE59109115T patent/DE59109115D1/en not_active Expired - Fee Related
- 1991-12-20 WO PCT/EP1991/002470 patent/WO1992011010A1/en not_active Ceased
- 1991-12-20 ES ES92901178T patent/ES2129040T3/en not_active Expired - Lifetime
- 1991-12-20 EP EP92901178A patent/EP0563128B1/en not_active Expired - Lifetime
- 1991-12-20 RU RU93046319A patent/RU2115647C1/en not_active IP Right Cessation
- 1991-12-20 CZ CZ19931213A patent/CZ289533B6/en not_active IP Right Cessation
- 1991-12-20 EP EP96119881A patent/EP0781556A1/en not_active Withdrawn
- 1991-12-20 PL PL91299674A patent/PL172262B1/en unknown
- 1991-12-20 CA CA002098917A patent/CA2098917A1/en not_active Abandoned
- 1991-12-20 IE IE20001043A patent/IE20001043A1/en unknown
- 1991-12-20 PT PT99901A patent/PT99901B/en not_active IP Right Cessation
- 1991-12-20 RU RU94046320/14A patent/RU2149000C1/en not_active IP Right Cessation
- 1991-12-20 SK SK617-93A patent/SK281017B6/en unknown
- 1991-12-20 AU AU90802/91A patent/AU666107B2/en not_active Ceased
- 1991-12-20 DK DK92901178T patent/DK0563128T3/en active
- 1991-12-23 ZA ZA9110116A patent/ZA9110116B/en unknown
- 1991-12-23 SI SI9111975A patent/SI9111975B/en unknown
- 1991-12-23 NZ NZ241140A patent/NZ241140A/en unknown
- 1991-12-23 TW TW080110028A patent/TW283145B/zh active
- 1991-12-23 YU YU197591A patent/YU48063B/en unknown
- 1991-12-23 MX MX9102765A patent/MX9102765A/en not_active IP Right Cessation
-
1993
- 1993-06-14 FI FI932709A patent/FI105026B/en active
- 1993-06-21 NO NO932279A patent/NO179515C/en unknown
-
1994
- 1994-10-21 HR HRP-1975/91A patent/HRP940721B1/en not_active IP Right Cessation
-
1995
- 1995-06-01 US US08/458,069 patent/US6034094A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,889 patent/US5686462A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,357 patent/US5665729A/en not_active Expired - Fee Related
-
1996
- 1996-05-27 CZ CZ19961523A patent/CZ289685B6/en not_active IP Right Cessation
-
1997
- 1997-05-13 BR BR1100520-3A patent/BR1100520A/en active IP Right Grant
- 1997-06-13 ID IDP972024A patent/ID16001A/en unknown
-
1999
- 1999-05-27 GR GR990401430T patent/GR3030341T3/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU93035829A (en) | Aminoquinolone derivatives substituted by an aryl or heteroaromatic group and anti-HIV drugs | |
| TR200101884T2 (en) | 4-mercaptopyrolidine derivatives as farnesyl transferase inhibitors. | |
| RU93005057A (en) | PHARMACEUTICAL COMPOUNDS, THYENOBENZODIAZEPINE DERIVATIVES, METHOD FOR THEIR PRODUCTION, PHARMOCOMPOSITION AND THEIR USE | |
| ATE43840T1 (en) | HETEROCYCLIC NITROGEN COMPOUNDS, THEIR PRODUCTION AND REMEDIES THEY CONTAIN. | |
| IT1195277B (en) | PIPERIDIL DERIVATIVES OF MACROCYCLIC TRIAZIN COMPOUNDS, HAVING STABILIZING ACTIVITY FOR POLYMERS AND PROCESSES FOR THEIR PREPARATION | |
| ATE140920T1 (en) | INDOLOCARBAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | |
| ATA520781A (en) | METHOD FOR PRODUCING NEW 2-OXACETIDINE DERIVATIVES | |
| ES2045420T3 (en) | CYCLIC AMIDES. | |
| PT90269A (en) | METHOD FOR THE PREPARATION OF HETERO-ALIFATIC CARBOXAMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| KR890011596A (en) | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for treating insomnia | |
| AR248011A1 (en) | Methods for the treatment and prophylaxis of pneumocystis cariniipneumonia and other diseases and compounds and formulations for use in said methods | |
| EP0353526A3 (en) | Agent against fish parasites containing triazinedione derivatives | |
| EP0645382A4 (en) | COUMARIN DERIVATIVE AND ITS USE. | |
| DE3686979D1 (en) | CEPHEM CONNECTIONS AND METHOD FOR THEIR PRODUCTION. | |
| ATE149507T1 (en) | SOLUBLE, NON-TOXIC DERIVATIVES OF BASIC POLYEN MACROLIDS, THEIR PREPARATION AND USE | |
| PT1015449E (en) | (HETERO) ARIL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FACTOR XA INHIBITORS | |
| DK0709383T3 (en) | Diosmethine derivatives, processes for their preparation, and pharmaceutical agents containing them | |
| DE3774273D1 (en) | CHINAZOLINE DERIVATIVE, METHOD FOR THE PRODUCTION THEREOF AND MEANS FOR TREATING CEREBRAL DISFUNCTION AS AN ACTIVE INGREDIENT. | |
| FR2395998A1 (en) | NEW THIAZOLIDINE DERIVATIVES AND THEIR APPLICATION IN THE TREATMENT OF HYPERTENSION | |
| DE69019404D1 (en) | Penciclovir derivatives used to treat hepatitis B infections. | |
| DE3675778D1 (en) | (2-AMINO-4-ARYL-THIAZOL-5-YL) AETHANOL, AND THEIR DERIVATIVES WITH DIURETIC ACTIVITY AND METHOD FOR THE PRODUCTION THEREOF. | |
| KR880001596A (en) | Dihydropyridine Compound-containing Brain Dysfunction | |
| ES2074992T3 (en) | FUNGICIDE DERIVATIVES OF AZOLYL. | |
| FI902901A0 (en) | DIBENZOLE / 1,5 / DIOXOCIN-5-ONE DERIVATIVES, DERAS ANVAENDNING I LAEKEMEDEL OCH FOERFARANDE FOER DERAS FRAMSTAELLNING. | |
| FI872980A0 (en) | ISOKINOLINFOERENINGAR, VILKA HAR EN KVAEVESUBSTITUENT I 4-POSITIONEN OCH VILKA HAR KARDIOTONA FOSFODIESTERASFRAKTION III-INHIBERADE EGENSKAPER OCH / ELLER NJURVASODILATORISKA EGENSKAPER. |