SA518392005B1 - تحديد خصائص التسلسل العميق للأورام - Google Patents

تحديد خصائص التسلسل العميق للأورام

Info

Publication number
SA518392005B1
SA518392005B1 SA518392005A SA518392005A SA518392005B1 SA 518392005 B1 SA518392005 B1 SA 518392005B1 SA 518392005 A SA518392005 A SA 518392005A SA 518392005 A SA518392005 A SA 518392005A SA 518392005 B1 SA518392005 B1 SA 518392005B1
Authority
SA
Saudi Arabia
Prior art keywords
tumors
deep sequencing
profiling
amplification cycles
sequencing profiling
Prior art date
Application number
SA518392005A
Other languages
English (en)
Inventor
نيلسون أليكساندر
بيرجس دانيال
ستاسي ستانيسلاو
روزنباوم هايدي
Original Assignee
.فينتانا ميديكال سيستمز، إنك
اف . هوفمان – لا روش ايه جى
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by .فينتانا ميديكال سيستمز، إنك, اف . هوفمان – لا روش ايه جى filed Critical .فينتانا ميديكال سيستمز، إنك
Publication of SA518392005B1 publication Critical patent/SA518392005B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/146—Concentration of target or template
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Prostheses (AREA)

Abstract

يتعلق الكشف الحالي في أحد جوانبه بخطوات إعداد متوالية موجهة targeted sequencing workflow، حيث تشتمل عينة مدخلة input sample على كمية كافية من مادة جينومية genomic material يتم توفيرها بحيث يتم استخدام عدد قليل جدًا من دورات التكبير amplification cycles، وقد لا يتم استخدام أي دورات تكبير، قبل إعداد المتوالية sequencing.
SA518392005A 2016-01-15 2018-07-11 تحديد خصائص التسلسل العميق للأورام SA518392005B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662279126P 2016-01-15 2016-01-15
US201662415952P 2016-11-01 2016-11-01

Publications (1)

Publication Number Publication Date
SA518392005B1 true SA518392005B1 (ar) 2022-02-08

Family

ID=57396824

Family Applications (1)

Application Number Title Priority Date Filing Date
SA518392005A SA518392005B1 (ar) 2016-01-15 2018-07-11 تحديد خصائص التسلسل العميق للأورام

Country Status (12)

Country Link
US (2) US11649492B2 (ar)
EP (1) EP3402896B1 (ar)
JP (2) JP7232643B2 (ar)
KR (1) KR102398465B1 (ar)
CN (1) CN108463559A (ar)
AU (1) AU2016386032B2 (ar)
CA (1) CA3011342C (ar)
IL (1) IL260304B2 (ar)
SA (1) SA518392005B1 (ar)
SG (1) SG11201805600VA (ar)
WO (1) WO2017123316A1 (ar)
ZA (1) ZA201804322B (ar)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2986436T3 (es) 2011-04-15 2024-11-11 Univ Johns Hopkins Sistema de secuenciación segura
ES2886507T5 (es) 2012-10-29 2024-11-15 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
SG11201805600VA (en) * 2016-01-15 2018-07-30 Ventana Med Syst Inc Deep sequencing profiling of tumors
CN111868260B (zh) 2017-08-07 2025-02-21 约翰斯霍普金斯大学 用于评估和治疗癌症的方法和材料
US20200004928A1 (en) 2018-06-29 2020-01-02 Roche Sequencing Solutions, Inc. Computing device with improved user interface for interpreting and visualizing data
CN109234356B (zh) * 2018-09-18 2021-10-08 南京迪康金诺生物技术有限公司 一种构建杂交捕获测序文库的方法及应用
CN113383089A (zh) * 2018-11-29 2021-09-10 文塔纳医疗系统公司 经由代表性DNA测序进行个性化ctDNA疾病监测
WO2020136133A1 (en) 2018-12-23 2020-07-02 F. Hoffmann-La Roche Ag Tumor classification based on predicted tumor mutational burden
WO2020249704A1 (en) 2019-06-13 2020-12-17 F. Hoffmann-La Roche Ag Systems and methods with improved user interface for interpreting and visualizing longitudinal data
EP4103748A4 (en) 2020-02-14 2024-03-13 The Johns Hopkins University METHOD AND MATERIALS FOR ASSESSING NUCLEIC ACIDS
JPWO2022244856A1 (ar) 2021-05-20 2022-11-24

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000159A (en) 1974-06-28 1976-12-28 Phillips Petroleum Company Preparation of n,n-disubstituted thioamides
US5176995A (en) 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
WO2009061840A1 (en) * 2007-11-05 2009-05-14 Complete Genomics, Inc. Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
US8592150B2 (en) * 2007-12-05 2013-11-26 Complete Genomics, Inc. Methods and compositions for long fragment read sequencing
EP2227563B1 (en) 2007-12-05 2012-06-06 Complete Genomics, Inc. Efficient base determination in sequencing reactions
EP2245198A1 (en) * 2008-02-04 2010-11-03 Massachusetts Institute of Technology Selection of nucleic acids by solution hybridization to oligonucleotide baits
JP5757572B2 (ja) 2009-07-03 2015-07-29 国立大学法人 東京大学 癌細胞の存否を判定する方法および癌患者の予後を判定する方法
DK2539450T3 (da) * 2010-02-25 2016-05-30 Advanced Liquid Logic Inc Fremgangsmåde til fremstilling af nukleinsyrebiblioteker
EP2606154B1 (en) * 2010-08-20 2019-09-25 Integenx Inc. Integrated analysis system
KR102759126B1 (ko) * 2010-12-30 2025-01-24 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
GB2497510A (en) 2011-11-10 2013-06-19 Harry Cuppens Methods for determining mononucleotide sequence repeats
US10138519B2 (en) 2012-12-28 2018-11-27 Quest Diagnostics Investments Incorporated Universal sanger sequencing from next-gen sequencing amplicons
EP2971122B1 (en) * 2013-03-15 2020-08-26 Memorial Sloan Kettering Cancer Center Biomarkers for response to rapamycin analogs
US20140278461A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center System and method for integrating a medical sequencing apparatus and laboratory system into a medical facility
KR20160062763A (ko) 2013-10-18 2016-06-02 세븐 브릿지스 지노믹스 인크. 유전자 샘플을 유전자형 결정하기 위한 방법 및 시스템
US10415083B2 (en) * 2013-10-28 2019-09-17 The Translational Genomics Research Institute Long insert-based whole genome sequencing
SG11201805600VA (en) * 2016-01-15 2018-07-30 Ventana Med Syst Inc Deep sequencing profiling of tumors

Also Published As

Publication number Publication date
IL260304A (en) 2018-08-30
US11649492B2 (en) 2023-05-16
EP3402896B1 (en) 2021-03-31
JP2019503182A (ja) 2019-02-07
EP3402896A1 (en) 2018-11-21
US20230250476A1 (en) 2023-08-10
AU2016386032B2 (en) 2021-08-12
KR102398465B1 (ko) 2022-05-13
WO2017123316A1 (en) 2017-07-20
KR20180098412A (ko) 2018-09-03
CA3011342A1 (en) 2017-07-20
AU2016386032A1 (en) 2018-07-12
BR112018014349A2 (pt) 2019-02-12
JP7232643B2 (ja) 2023-03-03
ZA201804322B (en) 2022-10-26
CA3011342C (en) 2023-03-14
US20180320229A1 (en) 2018-11-08
IL260304B2 (en) 2025-04-01
CN108463559A (zh) 2018-08-28
SG11201805600VA (en) 2018-07-30
JP7379418B2 (ja) 2023-11-14
JP2021176302A (ja) 2021-11-11
IL260304B1 (en) 2024-12-01

Similar Documents

Publication Publication Date Title
SA518392005B1 (ar) تحديد خصائص التسلسل العميق للأورام
EA202091540A1 (ru) Антитела к lilrb2
CY1124215T1 (el) Μκ2 αναστολεις και χρησεις αυτων
SA519401522B1 (ar) Lag-3 أجـسـام مـضـادة لـ وتـركـيـبـات
EA201791029A1 (ru) Антитела против интерлейкина-33 и их применение
BR112019012342A2 (pt) anticorpos il-11
AR101845A1 (es) Anticuerpos anti-her2 e inmunoconjugados
BR112019012343A2 (pt) anticorpos il-11ra
MA40579A (fr) Anticorps anti-cll-1 et immunoconjugués
IL258378A (en) 18f-tagged inhibitors of prostate specific membrane antigen (psma) and their use as imaging agents for prostate cancer
MX374788B (es) Anticuerpos anti-tim3 y metodos de uso.
MX386587B (es) ANTICUERPOS ANTI-CD79b Y MÉTODOS DE USO.
BR112017008666A2 (pt) anticorpos anti-fgfr2/3 e métodos de uso dos mesmos
EA201691765A1 (ru) Молекулы антител против lag-3 и их применения
BR112017006664A2 (pt) terapias de combinação
TR201810635T4 (tr) Anti-jagged1 antikorları ve kullanım yöntemleri.
EP3433383A4 (en) PROCESS FOR QUANTITATIVE AMPLIFICATION
CN106659716A8 (zh) 阿吡莫德组合物及其使用方法
EP3430140A4 (en) IMPROVED REINFORCEMENT AND SEQUENCING PROCEDURES
MX2018016057A (es) Composiciones y metodos para tratar enfermedades cardiovasculares.
MX2016013877A (es) Composiciones y metodos para mejorar y/o predecir la amplificacion de adn.
EP3515559A4 (en) COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND TREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS
MX390053B (es) Metodos de evaluacion genomica en ganado.
MX377774B (es) Formulaciones de proteinas.
BR112017009265A2 (pt) apilimode para uso no tratamento do câncer colorretal