SA519401954B1 - تركيبة صيدلانية للوقاية من أو معالجة سرطان تشتمل على صورة متعددة الشكل البلوري من تترا أرسينيك هيكسوكسويد - Google Patents
تركيبة صيدلانية للوقاية من أو معالجة سرطان تشتمل على صورة متعددة الشكل البلوري من تترا أرسينيك هيكسوكسويدInfo
- Publication number
- SA519401954B1 SA519401954B1 SA519401954A SA519401954A SA519401954B1 SA 519401954 B1 SA519401954 B1 SA 519401954B1 SA 519401954 A SA519401954 A SA 519401954A SA 519401954 A SA519401954 A SA 519401954A SA 519401954 B1 SA519401954 B1 SA 519401954B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- prevention
- treatment
- cancer
- pharmaceutical composition
- hexoxide
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 230000009702 cancer cell proliferation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- UYVQXFOBKTWZCW-UHFFFAOYSA-N tetraarsenic Chemical compound [As]12[As]3[As]1[As]32 UYVQXFOBKTWZCW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/285—Arsenic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/36—Arsenic; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G28/00—Compounds of arsenic
- C01G28/005—Oxides; Hydroxides; Oxyacids
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/60—Compounds characterised by their crystallite size
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/70—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data
- C01P2002/72—Crystal-structural characteristics defined by measured X-ray, neutron or electron diffraction data by d-values or two theta-values, e.g. as X-ray diagram
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/80—Compositional purity
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
يتعلق الاختراع الحالي بتركيبة صيدلانية للوقاية من أو معالجة السرطان cancer وطريقة لإنتاجها، وتشتمل التركيبة على هيكسوكسيد تتراسينيك tetraarsenic hexoxide وحيث يكون به محتوى الصورة متعددة الأشكال المتبلرة أ (As4O6-a ) هو 99٪ أو أكثر. وتعرض تركيبة الاختراع الحالي تأثير تثبيط تكاثر خلية السرطان cancer cell وبالتالي يمكن أن تكون مفيدة في شكل عقار مضاد للسرطان anticancer drug. شكل10
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160167222A KR101844050B1 (ko) | 2016-12-09 | 2016-12-09 | 육산화사비소의 결정다형을 포함하는 암 예방 또는 치료용 약학 조성물 |
| PCT/KR2017/014082 WO2018105972A1 (ko) | 2016-12-09 | 2017-12-04 | 육산화사비소의 결정다형을 포함하는 암 예방 또는 치료용 약학 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA519401954B1 true SA519401954B1 (ar) | 2024-01-29 |
Family
ID=62187734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA519401954A SA519401954B1 (ar) | 2016-12-09 | 2019-06-09 | تركيبة صيدلانية للوقاية من أو معالجة سرطان تشتمل على صورة متعددة الشكل البلوري من تترا أرسينيك هيكسوكسويد |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US11191779B2 (ar) |
| EP (1) | EP3552611A4 (ar) |
| JP (1) | JP6824409B2 (ar) |
| KR (1) | KR101844050B1 (ar) |
| CN (2) | CN108606979A (ar) |
| AU (1) | AU2017371040B2 (ar) |
| BR (1) | BR112019010999A2 (ar) |
| CA (1) | CA3044514C (ar) |
| CL (1) | CL2019001565A1 (ar) |
| IL (1) | IL267132B (ar) |
| MX (1) | MX392459B (ar) |
| MY (1) | MY197417A (ar) |
| PH (1) | PH12019501292A1 (ar) |
| SA (1) | SA519401954B1 (ar) |
| WO (1) | WO2018105972A1 (ar) |
| ZA (1) | ZA201903059B (ar) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
| AU2019262579B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Salts of an FGFR inhibitor |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3157361A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Fgfr阻害剤の誘導体 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR102240693B1 (ko) * | 2020-05-18 | 2021-04-15 | 주식회사 케마스 | 육산화사비소를 포함하는 코로나바이러스 감염증의 예방 또는 치료용 약학조성물 |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| US11939331B2 (en) | 2021-06-09 | 2024-03-26 | Incyte Corporation | Tricyclic heterocycles as FGFR inhibitors |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2025165158A1 (ko) * | 2024-01-29 | 2025-08-07 | 배일주 | 육산화사비소(As4O6)를 포함하는 방광암 예방 또는 치료용 약학 조성물 |
| KR20250118232A (ko) | 2024-01-29 | 2025-08-05 | 배일주 | 육산화사비소(As4O6)를 포함하는 방광암 예방 또는 치료용 약학 조성물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6875451B2 (en) | 1997-10-15 | 2005-04-05 | Polarx Biopharmaceuticals Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| TR200002243T2 (tr) * | 1997-11-10 | 2000-12-21 | Memorial Sloan-Kettering Cancer Center | Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı. |
| US7261906B2 (en) | 1998-05-08 | 2007-08-28 | Ill-Ju Bae | Anti-cancer therapy agent of arsenic hexoxide (As4O6) of a natural chemical substance and its pharmaceutical composition |
| KR100272835B1 (ko) | 1998-05-08 | 2000-11-15 | 배일주 | 천연 화학물질 육산화사비소의 신규한 항종양 치료제로서의 용도 및 그 약학적 조성물 |
| DE19821508C2 (de) | 1998-05-13 | 2002-08-29 | Trelleborg Automotive Tech Ct | Zweikammer-Motorlager |
| EP1248869A2 (en) * | 2000-01-07 | 2002-10-16 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| KR20020095835A (ko) | 2001-06-16 | 2002-12-28 | 배일주 | 아폽토시스 유도제 |
| TWI296527B (en) * | 2003-04-23 | 2008-05-11 | Inst Of Nuclear Energy Res Rocaec | Radioactive aesenic-containing compounds and their uses in the treatment of tumors |
| US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
| KR101572529B1 (ko) | 2008-11-14 | 2015-11-27 | 배일주 | 암 치료를 위한 육산화사비소의 병용요법 |
| CN117899029A (zh) | 2015-02-01 | 2024-04-19 | 希洛斯医药品股份有限公司 | 用于在患者中口服施用的含有砷的高表面积冻干组合物 |
| KR101755556B1 (ko) | 2016-11-18 | 2017-07-07 | 주식회사 케마스 | 육산화사비소의 결정다형을 포함하는 뇌암 예방 또는 치료용 약학 조성물 및 이의 제조방법 |
| KR101834366B1 (ko) | 2016-11-21 | 2018-03-05 | 주식회사 케마스 | 육산화사비소의 결정다형을 포함하는 유방암 예방 또는 치료용 약학 조성물 및 이의 제조방법 |
| KR101844049B1 (ko) | 2016-12-05 | 2018-03-30 | 주식회사 케마스 | 육산화사비소의 결정다형을 포함하는 간암 예방 또는 치료용 약학 조성물 |
-
2016
- 2016-12-09 KR KR1020160167222A patent/KR101844050B1/ko active Active
-
2017
- 2017-03-06 CN CN201710127742.4A patent/CN108606979A/zh active Pending
- 2017-03-06 CN CN202310686518.4A patent/CN116672363A/zh active Pending
- 2017-12-04 MY MYPI2019003009A patent/MY197417A/en unknown
- 2017-12-04 BR BR112019010999A patent/BR112019010999A2/pt not_active IP Right Cessation
- 2017-12-04 JP JP2019529224A patent/JP6824409B2/ja not_active Expired - Fee Related
- 2017-12-04 WO PCT/KR2017/014082 patent/WO2018105972A1/ko not_active Ceased
- 2017-12-04 EP EP17878772.7A patent/EP3552611A4/en not_active Withdrawn
- 2017-12-04 AU AU2017371040A patent/AU2017371040B2/en not_active Ceased
- 2017-12-04 US US16/467,593 patent/US11191779B2/en not_active Expired - Fee Related
- 2017-12-04 CA CA3044514A patent/CA3044514C/en active Active
- 2017-12-04 MX MX2019006622A patent/MX392459B/es unknown
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2019
- 2019-05-16 ZA ZA2019/03059A patent/ZA201903059B/en unknown
- 2019-06-06 IL IL267132A patent/IL267132B/en unknown
- 2019-06-07 CL CL2019001565A patent/CL2019001565A1/es unknown
- 2019-06-07 PH PH12019501292A patent/PH12019501292A1/en unknown
- 2019-06-09 SA SA519401954A patent/SA519401954B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20200000846A1 (en) | 2020-01-02 |
| JP6824409B2 (ja) | 2021-02-03 |
| MX2019006622A (es) | 2019-08-01 |
| IL267132A (en) | 2019-10-31 |
| MY197417A (en) | 2023-06-16 |
| CN108606979A (zh) | 2018-10-02 |
| WO2018105972A1 (ko) | 2018-06-14 |
| PH12019501292A1 (en) | 2019-12-02 |
| CA3044514C (en) | 2021-06-15 |
| CL2019001565A1 (es) | 2020-02-21 |
| EP3552611A1 (en) | 2019-10-16 |
| ZA201903059B (en) | 2020-09-30 |
| CA3044514A1 (en) | 2018-06-14 |
| JP2020504088A (ja) | 2020-02-06 |
| MX392459B (es) | 2025-03-24 |
| CN116672363A (zh) | 2023-09-01 |
| AU2017371040A1 (en) | 2019-06-20 |
| US11191779B2 (en) | 2021-12-07 |
| BR112019010999A2 (pt) | 2019-10-15 |
| EP3552611A4 (en) | 2020-06-24 |
| AU2017371040B2 (en) | 2020-05-07 |
| IL267132B (en) | 2022-05-01 |
| KR101844050B1 (ko) | 2018-05-14 |
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