SA522440295B1 - مركب وسيط مفيد لتخليق مثبط ناقل مرتبط بصوديوم-جلوكوز وطريقة لتحضير مثبط ناقل مرتبط بصوديوم-جلوكوز باستخدامه - Google Patents

مركب وسيط مفيد لتخليق مثبط ناقل مرتبط بصوديوم-جلوكوز وطريقة لتحضير مثبط ناقل مرتبط بصوديوم-جلوكوز باستخدامه

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Publication number
SA522440295B1
SA522440295B1 SA522440295A SA522440295A SA522440295B1 SA 522440295 B1 SA522440295 B1 SA 522440295B1 SA 522440295 A SA522440295 A SA 522440295A SA 522440295 A SA522440295 A SA 522440295A SA 522440295 B1 SA522440295 B1 SA 522440295B1
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Saudi Arabia
Prior art keywords
sglt inhibitor
compound
synthesis
chemical formula
preparing
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SA522440295A
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English (en)
Inventor
هي كون يون،
يون جونج يون،
Original Assignee
ديونج فارماسوتيكالز كو.، ليمتد.
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Application filed by ديونج فارماسوتيكالز كو.، ليمتد. filed Critical ديونج فارماسوتيكالز كو.، ليمتد.
Publication of SA522440295B1 publication Critical patent/SA522440295B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

يتعلق الاختراع الحالي بتوفير مركب وسيط intermediate مفيد لتخليق مثبط ناقل مرتبط بصوديوم-جلوكوز sodium-glucose linked transporter (SGLT) وطريقة لتحضير مثبط ناقل مرتبط بصوديوم-جلوكوز باستخدامه. وفقًا للاختراع الحالي، من خلال تطوير مركب له الصيغة الكيميائية 5 مناظر لمركب وسيط جديد، يمكن حل صعوبة التنقية بالعمليات الحالية، ويمكن مطابقة متطلبات الجودة للمواد ذات الصلة مع خطوة تنقية واحدة فقط، ويمكن أن يتم حل مشكلة مراقبة الجودة في كل خطوة عن طريق تنفيذ عدة خطوات في الموقع in situ. تتيح طريقة تخليق مركب له الصيغة الكيميائية 1 بواسطة استخدام مركب له الصيغة الكيميائية 5، وفقًا للاختراع الحالي، التنقية في خطوة تصنيع مركب له الصيغة الكيميائية 5، وبالتالي حل مشكلات عمليات التخليق الحالية، والتي كان من الصعب فيها التحكم في متطلبات الجودة للمواد ذات الصلة خطوة بخطوة نتيجة عملية مستمرة، وتقليل مقدار المواد ذات الصلة في المنتج النهائي. بالإضافة إلى ذلك، مع زيادة عدد خطوات التنقية، يمكن تبسيط العملية لأنه لا يتم بالضرورة إجراء التنقية مرتين أو أكثر في خطوة واحدة كما في الفن السابق، وبالتالي زيادة إنتا
SA522440295A 2020-02-27 2022-08-24 مركب وسيط مفيد لتخليق مثبط ناقل مرتبط بصوديوم-جلوكوز وطريقة لتحضير مثبط ناقل مرتبط بصوديوم-جلوكوز باستخدامه SA522440295B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20200024525 2020-02-27
PCT/KR2021/002507 WO2021172955A1 (ko) 2020-02-27 2021-02-26 Sglt 저해제의 합성에 유용한 중간체 및 이를 이용한 sglt 저해제의 제조 방법

Publications (1)

Publication Number Publication Date
SA522440295B1 true SA522440295B1 (ar) 2025-04-10

Family

ID=77490302

Family Applications (1)

Application Number Title Priority Date Filing Date
SA522440295A SA522440295B1 (ar) 2020-02-27 2022-08-24 مركب وسيط مفيد لتخليق مثبط ناقل مرتبط بصوديوم-جلوكوز وطريقة لتحضير مثبط ناقل مرتبط بصوديوم-جلوكوز باستخدامه

Country Status (16)

Country Link
US (3) US12497390B2 (ar)
EP (1) EP4112612B1 (ar)
JP (1) JP7442663B2 (ar)
KR (1) KR102572714B1 (ar)
CN (1) CN115087649B (ar)
AU (1) AU2021225706B2 (ar)
BR (1) BR112022014762A2 (ar)
CA (1) CA3169604C (ar)
CL (1) CL2022002326A1 (ar)
CO (1) CO2022011686A2 (ar)
EC (1) ECSP22067279A (ar)
ES (1) ES3056001T3 (ar)
MX (1) MX2022010220A (ar)
PE (1) PE20221498A1 (ar)
SA (1) SA522440295B1 (ar)
WO (1) WO2021172955A1 (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102837948B1 (ko) * 2024-11-13 2025-07-25 대웅바이오(주) 분배 투입법을 도입한 연속반응 공정을 이용한 이나보글리플로진 합성방법
KR102853437B1 (ko) * 2024-11-13 2025-09-04 대웅바이오(주) 연속반응 공정을 이용한 이나보글리플로진 합성방법
KR102837941B1 (ko) * 2024-11-13 2025-07-25 대웅바이오(주) Inline quenching 공정을 도입한 연속반응 공정을 이용한 이나보글리플로진 합성방법

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US5530124A (en) * 1994-06-30 1996-06-25 The Dupont Merck Pharmaceutical Company Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors
CN103910702A (zh) * 2008-08-22 2014-07-09 泰拉科斯有限公司 制备sglt2抑制剂的方法
US9006187B2 (en) * 2010-09-10 2015-04-14 Green Cross Corporation Thiophene derivative as SGLT2 inhibitor and pharmaceutical composition comprising same
ES2719656T3 (es) * 2011-06-01 2019-07-11 Green Cross Corp Derivados de difenilmetano novedosos como inhibidores del SGLT2
US9340521B2 (en) * 2013-03-18 2016-05-17 Green Cross Corporation Method for dual inhibition of SGLT1 and SGLT2 using diphenylmethane derivatives
US10174010B2 (en) * 2014-03-19 2019-01-08 Hangzhou Pushai Pharmaceutical Technology Co., Ltd. Canagliflozin monohydrate and its crystalline forms, preparation methods and uses thereof
WO2016098016A1 (en) * 2014-12-17 2016-06-23 Dr. Reddy’S Laboratories Limited Process for the preparation of sglt2 inhibitors
CA3026756C (en) * 2016-06-17 2021-03-02 Daewoong Pharmaceutical Co., Ltd. Method for producing diphenylmethane derivative
CN108530408A (zh) * 2018-04-13 2018-09-14 海门慧聚药业有限公司 制备达格列净的方法
WO2020036382A1 (ko) * 2018-08-13 2020-02-20 주식회사 대웅제약 Sglt 저해제의 합성에 유용한 중간체의 제조

Also Published As

Publication number Publication date
ES3056001T3 (en) 2026-02-17
PE20221498A1 (es) 2022-09-29
WO2021172955A1 (ko) 2021-09-02
ECSP22067279A (es) 2022-09-30
CA3169604C (en) 2025-03-11
EP4112612B1 (en) 2025-10-22
AU2021225706A1 (en) 2022-09-01
AU2021225706B2 (en) 2024-06-13
US12497390B2 (en) 2025-12-16
CO2022011686A2 (es) 2022-08-30
BR112022014762A2 (pt) 2022-10-11
US20260078109A1 (en) 2026-03-19
CA3169604A1 (en) 2021-09-02
JP7442663B2 (ja) 2024-03-04
US20260085065A1 (en) 2026-03-26
KR20210109476A (ko) 2021-09-06
EP4112612A1 (en) 2023-01-04
CL2022002326A1 (es) 2023-02-10
MX2022010220A (es) 2022-10-10
CN115087649B (zh) 2024-07-05
JP2023514754A (ja) 2023-04-07
US20230096670A1 (en) 2023-03-30
CN115087649A (zh) 2022-09-20
EP4112612A4 (en) 2024-04-03
KR102572714B1 (ko) 2023-08-31

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