SE0300103D0 - Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof - Google Patents

Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Info

Publication number
SE0300103D0
SE0300103D0 SE0300103A SE0300103A SE0300103D0 SE 0300103 D0 SE0300103 D0 SE 0300103D0 SE 0300103 A SE0300103 A SE 0300103A SE 0300103 A SE0300103 A SE 0300103A SE 0300103 D0 SE0300103 D0 SE 0300103D0
Authority
SE
Sweden
Prior art keywords
sup
preparations
piperidine derivatives
diarylmethylidene piperidine
diarylmethylidene
Prior art date
Application number
SE0300103A
Other languages
English (en)
Swedish (sv)
Inventor
William Brown
Andrew Griffin
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0300103A priority Critical patent/SE0300103D0/xx
Publication of SE0300103D0 publication Critical patent/SE0300103D0/xx
Priority to EP04701634A priority patent/EP1587791A1/en
Priority to US10/541,656 priority patent/US20060116399A1/en
Priority to KR1020057013175A priority patent/KR20050096138A/ko
Priority to BR0406594-8A priority patent/BRPI0406594A/pt
Priority to MXPA05007483A priority patent/MXPA05007483A/es
Priority to AU2004203969A priority patent/AU2004203969B2/en
Priority to CNB2004800021233A priority patent/CN100430379C/zh
Priority to NZ540759A priority patent/NZ540759A/en
Priority to PL378335A priority patent/PL378335A1/pl
Priority to TW093100809A priority patent/TW200427449A/zh
Priority to PCT/GB2004/000116 priority patent/WO2004063157A1/en
Priority to CA002510400A priority patent/CA2510400A1/en
Priority to UAA200506381A priority patent/UA80310C2/uk
Priority to RU2005121490/04A priority patent/RU2326865C2/ru
Priority to JP2006500208A priority patent/JP2006515356A/ja
Priority to ARP040100104A priority patent/AR042886A1/es
Priority to IL169360A priority patent/IL169360A0/en
Priority to ZA200505189A priority patent/ZA200505189B/en
Priority to IS7961A priority patent/IS7961A/is
Priority to NO20053805A priority patent/NO20053805L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE0300103A 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof SE0300103D0 (sv)

Priority Applications (21)

Application Number Priority Date Filing Date Title
SE0300103A SE0300103D0 (sv) 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
JP2006500208A JP2006515356A (ja) 2003-01-16 2004-01-13 ジアリールメチリデンピペリジン誘導体、その製造方法及びその使用
NZ540759A NZ540759A (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
TW093100809A TW200427449A (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
KR1020057013175A KR20050096138A (ko) 2003-01-16 2004-01-13 디아릴메틸리덴 피페리딘 유도체, 그의 제조방법 및 용도
BR0406594-8A BRPI0406594A (pt) 2003-01-16 2004-01-13 Composto, uso do mesmo, composição farmacêutica, métodos para a terapia de dor e de distúrbios gastrointestinais funcionais em um animal de sangue quente, e, processo para preparar um composto, processo para preparar um composto.
MXPA05007483A MXPA05007483A (es) 2003-01-16 2004-01-13 Derivados de diarilmetilidina piperidina, preparacion y uso de los mismos.
AU2004203969A AU2004203969B2 (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
CNB2004800021233A CN100430379C (zh) 2003-01-16 2004-01-13 二芳基亚甲基哌啶衍生物、其制备及其用途
EP04701634A EP1587791A1 (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
PL378335A PL378335A1 (pl) 2003-01-16 2004-01-13 Pochodne diarylometylidenopiperydyny, ich preparaty i ich zastosowanie
US10/541,656 US20060116399A1 (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
PCT/GB2004/000116 WO2004063157A1 (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
CA002510400A CA2510400A1 (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
UAA200506381A UA80310C2 (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
RU2005121490/04A RU2326865C2 (ru) 2003-01-16 2004-01-13 Производные диарилметилиденпиперидина, способ их получения (варианты) и применение
ARP040100104A AR042886A1 (es) 2003-01-16 2004-01-15 Derivados de diarilmetilen piperidina, su preparacion y uso de los mismos tanto en composiciones farmaceuticas como en la fabricacion de medicamentos.
IL169360A IL169360A0 (en) 2003-01-16 2005-06-23 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
ZA200505189A ZA200505189B (en) 2003-01-16 2005-06-27 Diarylmethylidene piperidine derivatives, preperations thereof and uses thereof
IS7961A IS7961A (is) 2003-01-16 2005-07-27 Díarýlmetýlídenpíperidínafleiður, lyfjablöndur þeirra og notkun þeirra
NO20053805A NO20053805L (no) 2003-01-16 2005-08-12 Diarylmetylindenpiperidinderivater, framgangsmate for fremstilling derav, og anvendelse derav

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0300103A SE0300103D0 (sv) 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Publications (1)

Publication Number Publication Date
SE0300103D0 true SE0300103D0 (sv) 2003-01-16

Family

ID=20290138

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0300103A SE0300103D0 (sv) 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Country Status (21)

Country Link
US (1) US20060116399A1 (pt)
EP (1) EP1587791A1 (pt)
JP (1) JP2006515356A (pt)
KR (1) KR20050096138A (pt)
CN (1) CN100430379C (pt)
AR (1) AR042886A1 (pt)
AU (1) AU2004203969B2 (pt)
BR (1) BRPI0406594A (pt)
CA (1) CA2510400A1 (pt)
IL (1) IL169360A0 (pt)
IS (1) IS7961A (pt)
MX (1) MXPA05007483A (pt)
NO (1) NO20053805L (pt)
NZ (1) NZ540759A (pt)
PL (1) PL378335A1 (pt)
RU (1) RU2326865C2 (pt)
SE (1) SE0300103D0 (pt)
TW (1) TW200427449A (pt)
UA (1) UA80310C2 (pt)
WO (1) WO2004063157A1 (pt)
ZA (1) ZA200505189B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0203301D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
BRPI0410347A (pt) * 2003-05-16 2006-05-30 Astrazeneca Ab composto, uso de um composto, composição farmacêutica, métodos para as terapias da dor e de distúrbios gostrointestinais funcionais em animal de sangue quente, e, processo para preparação de um composto
CN101921279A (zh) 2003-10-01 2010-12-22 阿得罗公司 螺环杂环衍生物及其应用方法
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP3233825B1 (en) * 2014-12-19 2020-04-29 Pharmnovo AB Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US4939137A (en) * 1989-06-28 1990-07-03 Ortho Pharmaceutical Corporation Ring-fused thienopyrimidinedione derivatives
US5683998A (en) * 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
ZA979781B (en) * 1996-11-14 1998-06-08 Akzo Nobel Nv Piperidine derivatives.
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
EP1263758A2 (en) * 2000-03-03 2002-12-11 Ortho-McNeil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
US6556387B1 (en) * 2000-03-31 2003-04-29 Seagate Technology Llc Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101765D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101766D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
US7589103B2 (en) * 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators

Also Published As

Publication number Publication date
AR042886A1 (es) 2005-07-06
RU2005121490A (ru) 2006-02-10
US20060116399A1 (en) 2006-06-01
PL378335A1 (pl) 2006-03-20
AU2004203969B2 (en) 2007-09-06
IS7961A (is) 2005-07-27
MXPA05007483A (es) 2005-12-05
RU2326865C2 (ru) 2008-06-20
KR20050096138A (ko) 2005-10-05
ZA200505189B (en) 2006-04-26
TW200427449A (en) 2004-12-16
NO20053805D0 (no) 2005-08-12
JP2006515356A (ja) 2006-05-25
UA80310C2 (en) 2007-09-10
NZ540759A (en) 2008-03-28
EP1587791A1 (en) 2005-10-26
CN100430379C (zh) 2008-11-05
BRPI0406594A (pt) 2005-12-20
AU2004203969A1 (en) 2004-07-29
NO20053805L (no) 2005-10-17
IL169360A0 (en) 2007-07-04
CA2510400A1 (en) 2004-07-29
WO2004063157A1 (en) 2004-07-29
CN1735596A (zh) 2006-02-15

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