SE0300104D0 - Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof - Google Patents

Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Info

Publication number
SE0300104D0
SE0300104D0 SE0300104A SE0300104A SE0300104D0 SE 0300104 D0 SE0300104 D0 SE 0300104D0 SE 0300104 A SE0300104 A SE 0300104A SE 0300104 A SE0300104 A SE 0300104A SE 0300104 D0 SE0300104 D0 SE 0300104D0
Authority
SE
Sweden
Prior art keywords
sup
preparations
piperidine derivatives
diarylmethylidene piperidine
diarylmethylidene
Prior art date
Application number
SE0300104A
Other languages
English (en)
Swedish (sv)
Inventor
William Brown
Andrew Griffin
Christopher Walpole
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0300104A priority Critical patent/SE0300104D0/xx
Publication of SE0300104D0 publication Critical patent/SE0300104D0/xx
Priority to US10/541,664 priority patent/US20060148850A1/en
Priority to JP2006500189A priority patent/JP2006515352A/ja
Priority to DE602004002933T priority patent/DE602004002933T2/de
Priority to ES04701628T priority patent/ES2274415T3/es
Priority to EP04701628A priority patent/EP1590346B1/de
Priority to PCT/GB2004/000061 priority patent/WO2004063193A1/en
Priority to AT04701628T priority patent/ATE343571T1/de
Priority to TW093100792A priority patent/TW200500356A/zh
Priority to ARP040100103A priority patent/AR042885A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE0300104A 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof SE0300104D0 (sv)

Priority Applications (10)

Application Number Priority Date Filing Date Title
SE0300104A SE0300104D0 (sv) 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
US10/541,664 US20060148850A1 (en) 2003-01-16 2004-01-13 4-{'3-(Sulfonylamino) phenyl!'1-(cyclymethyl) piperidin-4-ylidene! methyl}benazmide derivativess as delta opioid receptor ligands for the treatment of pain, anxiety and functional gastrointestinal disorder
JP2006500189A JP2006515352A (ja) 2003-01-16 2004-01-13 疼痛、不安及び機能的胃腸管障害の治療のためのデルタオピオイド受容体リガンドとしての４−｛［３−（スルホニルアミノ）フェニル］［１−（シクロメチル）ピペリジン−４−イリデン］メチル｝ベンズアミド誘導体
DE602004002933T DE602004002933T2 (de) 2003-01-16 2004-01-13 4-ä'3-(SULFONYLAMINO)PHENYLÜ'1-(CYCLYMETHYL)PIPERIDIN-4-YLIDENEÜMETHYLüBENZAMIDEDERIVATE ALS DELTA-OPIOID-REZEPTORLIGANDEN ZUR BEHANDLUNG VON SCHMERZEN,ANGSTZUSTÄNDEN UND FUNKTIONELLEN GASTROINTESTINALEN ERKRANKUNGEN
ES04701628T ES2274415T3 (es) 2003-01-16 2004-01-13 Derivados de 4-(3'-(sulfonilamino)fenil)-1'-(ciclimetil)piperidin-4-iliden)metil)benzamida como ligandos de receptores de opioides para el tratamiento de dolor, ansiedad y trastorno gastrointestinal funcional.
EP04701628A EP1590346B1 (de) 2003-01-16 2004-01-13 4-{'3-(sulfonylamino)phenyl]'1-(cyclymethyl)piperidin-4-ylidene]methyl}benzamidederivate als delta-opioid-rezeptorliganden zur behandlung von schmerzen,angstzuständen und funktionellen gastrointestinalen erkrankungen
PCT/GB2004/000061 WO2004063193A1 (en) 2003-01-16 2004-01-13 4-{`3-(sulfonylamino) phenyl! `1-(cyclymethyl) piperidin-4-ylidene! methyl} benazmide derivatives as delta opioid receptor ligands for the treatment of pain, anxiety and functional gastrointestinal disorder
AT04701628T ATE343571T1 (de) 2003-01-16 2004-01-13 4-ä'3-(sulfonylamino)phenyl)'1- (cyclymethyl)piperidin-4- ylidene)methylübenzamidederivate als delta-opioid-rezeptorliganden zur behandlung von schmerzen, angstzuständen und funktionellen gastrointestinalen erkrankungen
TW093100792A TW200500356A (en) 2003-01-16 2004-01-13 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
ARP040100103A AR042885A1 (es) 2003-01-16 2004-01-15 Derivados de diarilmetiliden piperidina, preparaciones y usos de los mismos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0300104A SE0300104D0 (sv) 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Publications (1)

Publication Number Publication Date
SE0300104D0 true SE0300104D0 (sv) 2003-01-16

Family

ID=20290139

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0300104A SE0300104D0 (sv) 2003-01-16 2003-01-16 Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof

Country Status (10)

Country Link
US (1) US20060148850A1 (de)
EP (1) EP1590346B1 (de)
JP (1) JP2006515352A (de)
AR (1) AR042885A1 (de)
AT (1) ATE343571T1 (de)
DE (1) DE602004002933T2 (de)
ES (1) ES2274415T3 (de)
SE (1) SE0300104D0 (de)
TW (1) TW200500356A (de)
WO (1) WO2004063193A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005136524A (ru) * 2003-05-16 2006-06-27 Астразенека Аб (Se) Производные диарилметилиденпиперидина, способы их получения и их применение
NZ546834A (en) 2003-10-01 2010-03-26 Adolor Corp Spirocyclic heterocyclic derivatives and methods of their use
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
IT1396951B1 (it) 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2898339A (en) * 1957-07-29 1959-08-04 Wm S Merrell Co N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5140029A (en) * 1989-01-09 1992-08-18 Janssen Pharmaceutica N.V. 2-aminopyrimidinone derivatives
US4939137A (en) * 1989-06-28 1990-07-03 Ortho Pharmaceutical Corporation Ring-fused thienopyrimidinedione derivatives
US5683998A (en) * 1991-04-23 1997-11-04 Toray Industries, Inc. Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5574159A (en) * 1992-02-03 1996-11-12 Delta Pharmaceuticals, Inc. Opioid compounds and methods for making therefor
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
IL151550A0 (en) * 2000-03-03 2003-04-10 Ortho Mcneil Pharm Inc 3-(diarylmethylene)-8-azabicyclo [3.2.1] octane derivatives
US6556387B1 (en) * 2000-03-31 2003-04-29 Seagate Technology Llc Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly
SE0001207D0 (sv) * 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
SE0101766D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101765D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
EP1590346A1 (de) 2005-11-02
EP1590346B1 (de) 2006-10-25
AR042885A1 (es) 2005-07-06
DE602004002933T2 (de) 2007-09-06
DE602004002933D1 (de) 2006-12-07
ES2274415T3 (es) 2007-05-16
US20060148850A1 (en) 2006-07-06
ATE343571T1 (de) 2006-11-15
JP2006515352A (ja) 2006-05-25
TW200500356A (en) 2005-01-01
WO2004063193A1 (en) 2004-07-29

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