SE1551460A1 - Method for manufacturing of spherical calcium phosphate particles - Google Patents

Method for manufacturing of spherical calcium phosphate particles Download PDF

Info

Publication number: SE1551460A1
Authority: SE; Sweden
Prior art keywords: particles; ions; particies; solution; cap
Prior art date: 2015-11-12

Application number

SE1551460A

Other languages

English (en)

Swedish (sv)

Inventor

Mellgren Torbjörn

Unosson Erik

Xia Wei

Original Assignee

Psilox Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-11-12

Filing date

2015-11-12

Publication date

2017-05-13

2015-11-12 Application filed by Psilox Ab filed Critical Psilox Ab

2015-11-12 Priority to SE1551460A priority Critical patent/SE1551460A1/en

2016-11-14 Priority to PCT/SE2016/051121 priority patent/WO2017082811A1/fr

2017-05-13 Publication of SE1551460A1 publication Critical patent/SE1551460A1/en

Links

238000000034 method Methods 0.000 title claims abstract description 30
239000002245 particle Substances 0.000 title abstract description 66
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title description 48
239000001506 calcium phosphate Substances 0.000 title description 44
235000011010 calcium phosphates Nutrition 0.000 title description 42
229910000389 calcium phosphate Inorganic materials 0.000 title description 11
238000004519 manufacturing process Methods 0.000 title description 4
150000002500 ions Chemical class 0.000 claims description 22
238000010438 heat treatment Methods 0.000 claims description 3
239000000872 buffer Substances 0.000 claims description 2
235000021170 buffet Nutrition 0.000 claims 1
239000011575 calcium Substances 0.000 abstract description 15
239000011777 magnesium Substances 0.000 abstract description 13
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract description 11
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract description 11
229910052749 magnesium Inorganic materials 0.000 abstract description 10
229910019142 PO4 Inorganic materials 0.000 abstract description 8
229910052791 calcium Inorganic materials 0.000 abstract description 8
239000010452 phosphate Substances 0.000 abstract description 8
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 7
239000000243 solution Substances 0.000 description 37
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 25
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
229910000402 monopotassium phosphate Inorganic materials 0.000 description 13
229910000397 disodium phosphate Inorganic materials 0.000 description 12
239000011780 sodium chloride Substances 0.000 description 12
229960001714 calcium phosphate Drugs 0.000 description 10
238000002474 experimental method Methods 0.000 description 8
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 7
229910001425 magnesium ion Inorganic materials 0.000 description 7
235000021317 phosphate Nutrition 0.000 description 7
239000011591 potassium Substances 0.000 description 7
238000001878 scanning electron micrograph Methods 0.000 description 7
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 6
230000015572 biosynthetic process Effects 0.000 description 6
229960005069 calcium Drugs 0.000 description 6
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 6
229910052588 hydroxylapatite Inorganic materials 0.000 description 6
239000000203 mixture Substances 0.000 description 6
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 6
150000002978 peroxides Chemical class 0.000 description 6
239000002953 phosphate buffered saline Substances 0.000 description 6
229910052700 potassium Inorganic materials 0.000 description 6
239000011734 sodium Substances 0.000 description 6
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
238000012377 drug delivery Methods 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
238000003756 stirring Methods 0.000 description 5
238000004061 bleaching Methods 0.000 description 4
239000007844 bleaching agent Substances 0.000 description 4
239000003795 chemical substances by application Substances 0.000 description 4
238000012216 screening Methods 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
239000012062 aqueous buffer Substances 0.000 description 3
210000000988 bone and bone Anatomy 0.000 description 3
229910001424 calcium ion Inorganic materials 0.000 description 3
229940112822 chewing gum Drugs 0.000 description 3
235000015218 chewing gum Nutrition 0.000 description 3
229910001414 potassium ion Inorganic materials 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
229910001415 sodium ion Inorganic materials 0.000 description 3
239000000126 substance Substances 0.000 description 3
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
239000000654 additive Substances 0.000 description 2
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 2
229940078916 carbamide peroxide Drugs 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium phosphate dihydrate Substances O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
235000019800 disodium phosphate Nutrition 0.000 description 2
238000009826 distribution Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
239000000945 filler Substances 0.000 description 2
229910000392 octacalcium phosphate Inorganic materials 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000008213 purified water Substances 0.000 description 2
238000004064 recycling Methods 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
239000012798 spherical particle Substances 0.000 description 2
229910001427 strontium ion Inorganic materials 0.000 description 2
YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 description 2
229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
235000019731 tricalcium phosphate Nutrition 0.000 description 2
229940078499 tricalcium phosphate Drugs 0.000 description 2
210000005239 tubule Anatomy 0.000 description 2
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 2
229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
206010070245 Foreign body Diseases 0.000 description 1
239000007836 KH2PO4 Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
XRCFXMGQEVUZFC-UHFFFAOYSA-N anisindione Chemical compound C1=CC(OC)=CC=C1C1C(=O)C2=CC=CC=C2C1=O XRCFXMGQEVUZFC-UHFFFAOYSA-N 0.000 description 1
229960002138 anisindione Drugs 0.000 description 1
230000010072 bone remodeling Effects 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000007975 buffered saline Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000001055 chewing effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
210000003298 dental enamel Anatomy 0.000 description 1
201000002170 dentin sensitivity Diseases 0.000 description 1
238000000586 desensitisation Methods 0.000 description 1
238000013461 design Methods 0.000 description 1
VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000012154 double-distilled water Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000000835 fiber Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000001476 gene delivery Methods 0.000 description 1
238000001027 hydrothermal synthesis Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003993 interaction Effects 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000012803 optimization experiment Methods 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000005245 sintering Methods 0.000 description 1
UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
229960002218 sodium chlorite Drugs 0.000 description 1
229960001922 sodium perborate Drugs 0.000 description 1
229940045872 sodium percarbonate Drugs 0.000 description 1
YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000036347 tooth sensitivity Effects 0.000 description 1
229910021642 ultra pure water Inorganic materials 0.000 description 1
239000012498 ultrapure water Substances 0.000 description 1
239000011800 void material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/025—Explicitly spheroidal or spherical shape
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
- A61K8/0279—Porous; Hollow
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

SE1551460A 2015-11-12 2015-11-12 Method for manufacturing of spherical calcium phosphate particles SE1551460A1 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
SE1551460A SE1551460A1 (en)	2015-11-12	2015-11-12	Method for manufacturing of spherical calcium phosphate particles
PCT/SE2016/051121 WO2017082811A1 (fr)	2015-11-12	2016-11-14	Procédé de fabrication de particules sphériques constituées de phosphate et de calcium

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE1551460A SE1551460A1 (en)	2015-11-12	2015-11-12	Method for manufacturing of spherical calcium phosphate particles

Publications (1)

Publication Number	Publication Date
SE1551460A1 true SE1551460A1 (en)	2017-05-13

Family

ID=57485847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE1551460A SE1551460A1 (en)	2015-11-12	2015-11-12	Method for manufacturing of spherical calcium phosphate particles

Country Status (2)

Country	Link
SE (1)	SE1551460A1 (fr)
WO (1)	WO2017082811A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2021086252A1 (fr) *	2019-10-30	2021-05-06	Psilox Ab	Compositions de particules de phosphate de magnésium et de calcium amorphe stabilisées
CN114395521B (zh) *	2022-02-18	2024-06-04	南充市中心医院	一种空心磁性磷酸钙细胞微载体及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005087661A1 (fr) *	2004-03-16	2005-09-22	Abburi Visweswara Rao	Procede cyclique permettant de produire en continu du phosphate de bicalcium
CN102639159B (zh)	2009-08-04	2015-04-01	皮斯洛克斯有限公司	离子取代的磷酸钙颗粒
EP2976111B1 (fr)	2013-03-22	2018-11-14	Psilox AB	Particules creuses de phosphate de calcium

2015
- 2015-11-12 SE SE1551460A patent/SE1551460A1/en not_active Application Discontinuation
2016
- 2016-11-14 WO PCT/SE2016/051121 patent/WO2017082811A1/fr not_active Ceased

Also Published As

Publication number	Publication date
WO2017082811A1 (fr)	2017-05-18

Legal Events

Date	Code	Title	Description
2019-06-04	NAV	Patent application has lapsed

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