SE334357B - - Google Patents
Info
- Publication number
- SE334357B SE334357B SE1167966A SE1167966A SE334357B SE 334357 B SE334357 B SE 334357B SE 1167966 A SE1167966 A SE 1167966A SE 1167966 A SE1167966 A SE 1167966A SE 334357 B SE334357 B SE 334357B
- Authority
- SE
- Sweden
- Prior art keywords
- acid
- trihaloacetoxy
- pregnane series
- lower alkanoyloxy
- solvolysed
- Prior art date
Links
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Chemical class OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 150000003128 pregnanes Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical class COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- -1 alkanoyloxy ester Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- JUINSXZKUKVTMD-UHFFFAOYSA-N hydrogen azide Chemical class N=[N+]=[N-] JUINSXZKUKVTMD-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 159000000001 potassium salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
11b -Hydroxy-17a -lower alkanoyloxy esters of the pregnane series are obtained by treating an 11b -trihaloacetoxy-17a -lower alkanoyloxy ester of the pregnane series in a lower alkanol with a salt of an acid having a pKa falling within the range of about 2.3 and about 7.3 whereby the 11b -trihaloacetoxy grouping is selectively solvolysed to a free hydroxy group. Suitable salts are the sodium or potassium salts of hydrazoic acid, formic acid or trifluoroacetic acid. Pharmaceutical compositions having anti-inflammatory activity and containing the above compounds are administered topically.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48381065A | 1965-08-30 | 1965-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE334357B true SE334357B (en) | 1971-04-26 |
Family
ID=23921623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE1167966A SE334357B (en) | 1965-08-30 | 1966-08-30 |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE686189A (en) |
| CH (1) | CH481085A (en) |
| DE (1) | DE1593519B2 (en) |
| DK (1) | DK117350B (en) |
| ES (1) | ES330696A1 (en) |
| GB (1) | GB1097164A (en) |
| SE (1) | SE334357B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH622811A5 (en) * | 1974-03-27 | 1981-04-30 | Plurichemie Anstalt | |
| IL66432A0 (en) * | 1981-08-04 | 1982-12-31 | Plurichemie Anstalt | Process for the preparation of steroidal esters |
-
1966
- 1966-08-26 CH CH1244266A patent/CH481085A/en not_active IP Right Cessation
- 1966-08-27 DE DE19661593519 patent/DE1593519B2/en active Pending
- 1966-08-29 DK DK441866A patent/DK117350B/en unknown
- 1966-08-29 ES ES0330696A patent/ES330696A1/en not_active Expired
- 1966-08-30 BE BE686189D patent/BE686189A/xx unknown
- 1966-08-30 GB GB3866066A patent/GB1097164A/en not_active Expired
- 1966-08-30 SE SE1167966A patent/SE334357B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1097164A (en) | 1967-12-29 |
| DK117350B (en) | 1970-04-20 |
| ES330696A1 (en) | 1967-06-16 |
| DE1593519A1 (en) | 1970-09-03 |
| CH481085A (en) | 1969-11-15 |
| DE1593519B2 (en) | 1975-08-14 |
| BE686189A (en) | 1967-02-28 |
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