SE424861B - Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest - Google Patents

Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest

Info

Publication number
SE424861B
SE424861B SE7706520A SE7706520A SE424861B SE 424861 B SE424861 B SE 424861B SE 7706520 A SE7706520 A SE 7706520A SE 7706520 A SE7706520 A SE 7706520A SE 424861 B SE424861 B SE 424861B
Authority
SE
Sweden
Prior art keywords
pyrroline
pyrrol
pyrrolidine
rest
procedure
Prior art date
Application number
SE7706520A
Other languages
English (en)
Swedish (sv)
Other versions
SE7706520L (sv
Inventor
T J Ward
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB23331/76A external-priority patent/GB1530675A/en
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of SE7706520L publication Critical patent/SE7706520L/xx
Publication of SE424861B publication Critical patent/SE424861B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
SE7706520A 1976-06-05 1977-06-03 Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest SE424861B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB23331/76A GB1530675A (en) 1976-06-05 1976-06-05 Guanidine derivatives
GB305677 1977-01-26

Publications (2)

Publication Number Publication Date
SE7706520L SE7706520L (sv) 1978-01-20
SE424861B true SE424861B (sv) 1982-08-16

Family

ID=26237989

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7706520A SE424861B (sv) 1976-06-05 1977-06-03 Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest

Country Status (15)

Country Link
US (1) US4140793A (de)
JP (1) JPS52151161A (de)
AU (1) AU509883B2 (de)
CA (1) CA1070691A (de)
CH (1) CH641159A5 (de)
CY (1) CY1130A (de)
DE (1) DE2724989A1 (de)
DK (1) DK248177A (de)
FR (1) FR2353530A1 (de)
HK (1) HK57981A (de)
IE (1) IE45198B1 (de)
KE (1) KE3170A (de)
MY (1) MY8200180A (de)
NL (1) NL7706173A (de)
SE (1) SE424861B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1580559A (en) * 1977-11-24 1980-12-03 Wyeth John & Brother Ltd Amide cerivatives
GB1588096A (en) * 1978-05-20 1981-04-15 Wyeth & Bros Ltd John Pyrrole derivatives
US4332822A (en) * 1980-02-05 1982-06-01 John Wyeth & Brother Limited Guanidine derivatives
FR2490026A1 (fr) * 1980-09-09 1982-03-12 Thomson Csf Antenne reseau non dispersive et son application a la realisation d'une antenne a balayage electronique
US4563475A (en) * 1984-01-13 1986-01-07 William H. Rorer, Inc. Guanidine derivatives for treating gastrointestinal motility dysfunction
JPH01106831U (de) * 1988-01-08 1989-07-19
RU2006144075A (ru) 2004-06-16 2008-07-27 Вайет (Us) ДИФЕНИЛИМИДАЗОПИРИМИДИН И -ИМИДАЗОЛАМИНЫ КАК ИНГИБИТОРЫ β-СЕКРЕТАЗЫ
BRPI0512213A (pt) * 2004-06-16 2008-02-19 Wyeth Corp método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto
CA2593515A1 (en) * 2005-01-14 2006-07-20 Wyeth Amino-imidazolones for the inhibition of beta-secretase
CN101111489A (zh) * 2005-02-01 2008-01-23 惠氏公司 作为β-分泌酶的抑制剂的氨基-吡啶
BRPI0606902A2 (pt) * 2005-02-14 2009-07-28 Wyeth Corp composto; método para o tratamento de uma doença ou distúrbio associado a atividade excessiva de bace em um paciente que dele necessite; método para modular a atividade de bace; composição farmacêutica
TW200738683A (en) * 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
AU2006266167A1 (en) * 2005-06-30 2007-01-11 Wyeth Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
TW200730523A (en) * 2005-07-29 2007-08-16 Wyeth Corp Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
JP2009509957A (ja) * 2005-09-26 2009-03-12 ワイス β−セクレターゼ阻害剤としてのアミノ−５−［４−（ジフルオロメトキシ）フェニル］−５−フェニルイミダゾロン化合物
AU2006333049A1 (en) * 2005-12-19 2007-07-12 Wyeth 2-amino-5-piperidinylimidazolone compounds and use thereof for beta-secretase modulation
WO2007100536A1 (en) * 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
WO2008036196A2 (en) * 2006-09-21 2008-03-27 Wyeth Indolylalkylpyridin-2-amines for the inhibition of beta-secretase
CL2008000784A1 (es) * 2007-03-20 2008-05-30 Wyeth Corp Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co
CL2008000791A1 (es) 2007-03-23 2008-05-30 Wyeth Corp Compuestos derivados de 2-amino-5-(4-difluorometoxi-fenil)-5-fenil-imidazolidin-4-ona; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de una enfermedad asociada con la actividad bace excesiva, tales como enferm

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3189601A (en) * 1964-01-10 1965-06-15 Ciba Geigy Corp N, n-alkylene-imino-lower alkanoamidine compounds

Also Published As

Publication number Publication date
JPS52151161A (en) 1977-12-15
CH641159A5 (de) 1984-02-15
FR2353530B1 (de) 1981-07-17
NL7706173A (nl) 1977-12-07
DK248177A (da) 1977-12-06
JPS613332B2 (de) 1986-01-31
CY1130A (en) 1982-02-19
HK57981A (en) 1981-12-04
AU2535677A (en) 1978-11-23
IE45198L (en) 1977-12-05
FR2353530A1 (fr) 1977-12-30
US4140793A (en) 1979-02-20
CA1070691A (en) 1980-01-29
AU509883B2 (en) 1980-05-29
DE2724989A1 (de) 1977-12-15
KE3170A (en) 1981-12-18
MY8200180A (en) 1982-12-31
SE7706520L (sv) 1978-01-20
IE45198B1 (en) 1982-07-14

Similar Documents

Publication Publication Date Title
SE424861B (sv) Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest
RO76589A (ro) Procedeu pentru prepararea alchilaminelor heterociclice
NO780464L (no) Fremgangsmaate til fremstilling av pyrrolidin-derivater
DK365176A (da) Fremgangsmade til fremstilling af pyrrolidinderivater
SE429655B (sv) Forfarande for framstellning av 4'-deoxidauromycin hydroklorid
NO780463L (no) Fremgangsmaate til fremstilling av pyrrolidin-derivater
SE441360B (sv) Forfarande for framstellning av fosfonsyraderivat
SE417315B (sv) Forfarande for framstellning av n-(merkaptoacyl)-histidiner
SE412908B (sv) Forfarande for framstellning av terapeutiskt aktiva 2-metoxibensamider innehallande en pyrrolidin- eller en piperidinrest
SE7604373L (sv) Forfarande for framstellning av ett farmaceutiskt preparat innehallande biologiskt aktiva amider
NZ184832A (en) Optically active n-substituted pyrrolidines
NO146598C (no) Analogifremgangsmaate for fremstilling av det terapeutisk aktive n-(1`-allyl-2`-pyrrolidylmetyl)-2,3-dimetoksy-5-sulfamoylbenzamider og derivater derav
NO149471C (no) Analogifremgangsmaate for fremstilling av farmasoeytisk aktive tetracyklononanderivater
GB1539811A (en) Insecticidally active 3-n-phenyl-carbamoyl-4-hydroxy-1,2-(benzo)pyrone-derivatives
SE417091B (sv) Forfarande att framstella farmakologiskt aktiva derivat av 2-karboxialkyl-4,4dimetyl-pyrrolidin-5-on
GB1547798A (en) N-(3-2-hydroxypropopyl)-4-methyl-2-oxo-2h-1-benzopyran-7-yl)- carboxamide derivatives
DK3376A (da) Fremgangsmade til fremstilling af psykotropt og antimikrobielt virksomme polysubstituerede 10-piperazinodibenzo(b,f)tiepinderivater
SE421792B (sv) Forfarande for framstellning av n-(2-pyridyl)-4-hydroxi-2-metyl-2h-1,2-benso-tiazin-3-karboxamid-1,1-dioxid
SE427353B (sv) Forfarande for framstellniong av terapeutiskt aktiva derivat av ditiepino-(1,4) (2,3-c)-pyrrol
SE431751B (sv) Forfarande for framstellning av n-propargyl-piperonylamin hydroklorid
AU504263B2 (en) N- (benzenesulphonyl) thiocaramates and herbicidal anidotes
NO145274C (no) Fremgangsmaate for fremstilling av et 1-benzoyl-2-(2`,6`-diklorfenylamino)-2-imidazolin og av deres salter
NO143500C (no) Analogifremgangsmaate ved fremstilling av antiviralt aktive n-(substituerte benzyl)-alkandiaminer
NO145135C (no) Analogifremgangsmaate ved fremstilling av den terapeutisk aktive forbindelse 3-cyan-n-(n,n-diemtylaminopropyl)-iminodibenzyl
NO145436C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive aminer.

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7706520-9

Effective date: 19890725

Format of ref document f/p: F