SE444732B - Testanordning for pavisande av bilirubin i serum, forfarande for framstellning av testanordningen samt forfarande for pavisande av bilirubin i serum - Google Patents

Testanordning for pavisande av bilirubin i serum, forfarande for framstellning av testanordningen samt forfarande for pavisande av bilirubin i serum

Info

Publication number: SE444732B
Authority: SE; Sweden
Prior art keywords: test device; bilirubin; salt; serum; sample
Prior art date: 1978-09-22

Application number

SE7905701A

Other languages

English (en)

Swedish (sv)

Other versions

SE7905701L (sv

Inventor

R Bauer

Original Assignee

Miles Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-09-22

Filing date

1979-06-28

Publication date

1986-04-28

1979-06-28 Application filed by Miles Lab filed Critical Miles Lab

1980-03-23 Publication of SE7905701L publication Critical patent/SE7905701L/xx

1986-04-28 Publication of SE444732B publication Critical patent/SE444732B/sv

Links

238000012360 testing method Methods 0.000 title claims description 57
BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 title claims description 46
210000002966 serum Anatomy 0.000 title claims description 16
238000000034 method Methods 0.000 title claims description 6
238000005470 impregnation Methods 0.000 claims description 15
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 13
239000012954 diazonium Substances 0.000 claims description 12
150000001989 diazonium salts Chemical class 0.000 claims description 12
239000000203 mixture Substances 0.000 claims description 11
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 claims description 8
229960002819 diprophylline Drugs 0.000 claims description 6
KSCFJBIXMNOVSH-UHFFFAOYSA-N dyphylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CC(O)CO)C=N2 KSCFJBIXMNOVSH-UHFFFAOYSA-N 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 6
-1 2,1-dichlorobenzene diazonium-1,5-naphthalene disulfonate Chemical group 0.000 claims description 5
238000011161 development Methods 0.000 claims description 4
235000010288 sodium nitrite Nutrition 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 3
150000005171 halobenzenes Chemical group 0.000 claims description 2
KGNUXSSLTONYAW-UHFFFAOYSA-N 1,6-dichlorocyclohexa-2,4-dien-1-amine Chemical compound NC1(Cl)C=CC=CC1Cl KGNUXSSLTONYAW-UHFFFAOYSA-N 0.000 claims 2
VMKYTTSJFPJNOS-UHFFFAOYSA-N 2-ethylsulfanylethyl 2-methylprop-2-enoate Chemical compound CCSCCOC(=O)C(C)=C VMKYTTSJFPJNOS-UHFFFAOYSA-N 0.000 claims 2
ICMFHHGKLRTCBM-UHFFFAOYSA-N 4-nitrobenzenediazonium Chemical group [O-][N+](=O)C1=CC=C([N+]#N)C=C1 ICMFHHGKLRTCBM-UHFFFAOYSA-N 0.000 claims 1
RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 6
239000011159 matrix material Substances 0.000 description 6
239000000126 substance Substances 0.000 description 6
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 4
239000000123 paper Substances 0.000 description 4
LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 3
229960001948 caffeine Drugs 0.000 description 3
VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 3
238000011065 in-situ storage Methods 0.000 description 3
238000005259 measurement Methods 0.000 description 3
239000004033 plastic Substances 0.000 description 3
229920003023 plastic Polymers 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 description 2
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
125000003545 alkoxy group Chemical group 0.000 description 2
150000001555 benzenes Chemical class 0.000 description 2
238000005859 coupling reaction Methods 0.000 description 2
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 2
XTEGVFVZDVNBPF-UHFFFAOYSA-N naphthalene-1,5-disulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-N 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
ZPQOPVIELGIULI-UHFFFAOYSA-N 1,3-dichlorobenzene Chemical compound ClC1=CC=CC(Cl)=C1 ZPQOPVIELGIULI-UHFFFAOYSA-N 0.000 description 1
RUFPHBVGCFYCNW-UHFFFAOYSA-N 1-naphthylamine Chemical compound C1=CC=C2C(N)=CC=CC2=C1 RUFPHBVGCFYCNW-UHFFFAOYSA-N 0.000 description 1
KQCMTOWTPBNWDB-UHFFFAOYSA-N 2,4-dichloroaniline Chemical compound NC1=CC=C(Cl)C=C1Cl KQCMTOWTPBNWDB-UHFFFAOYSA-N 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
241000978776 Senegalia senegal Species 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
239000006096 absorbing agent Substances 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
150000001448 anilines Chemical class 0.000 description 1
125000001769 aryl amino group Chemical group 0.000 description 1
TWFGZXYQDMQOJI-UHFFFAOYSA-L benzenediazonium naphthalene-1,5-disulfonate Chemical compound N#[N+]C1=CC=CC=C1.N#[N+]C1=CC=CC=C1.C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1S([O-])(=O)=O TWFGZXYQDMQOJI-UHFFFAOYSA-L 0.000 description 1
HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical class C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 description 1
239000003809 bile pigment Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
125000000664 diazo group Chemical group [N-]=[N+]=[*] 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
125000006575 electron-withdrawing group Chemical group 0.000 description 1
239000003365 glass fiber Substances 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
239000000463 material Substances 0.000 description 1
230000003340 mental effect Effects 0.000 description 1
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
125000002560 nitrile group Chemical group 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
239000004745 nonwoven fabric Substances 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
238000007639 printing Methods 0.000 description 1
230000006920 protein precipitation Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011160 research Methods 0.000 description 1
239000010979 ruby Substances 0.000 description 1
229910001750 ruby Inorganic materials 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229960004249 sodium acetate Drugs 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229960003885 sodium benzoate Drugs 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000002594 sorbent Substances 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000758 substrate Substances 0.000 description 1
150000003459 sulfonic acid esters Chemical class 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
238000004804 winding Methods 0.000 description 1
239000002023 wood Substances 0.000 description 1
239000002759 woven fabric Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/728—Bilirubin; including biliverdin
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/903—Diazo reactions
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/146666—Bile pigment

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)

SE7905701A 1978-09-22 1979-06-28 Testanordning for pavisande av bilirubin i serum, forfarande for framstellning av testanordningen samt forfarande for pavisande av bilirubin i serum SE444732B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/944,718 US4190419A (en)	1978-09-22	1978-09-22	Device for detecting serum bilirubin

Publications (2)

Publication Number	Publication Date
SE7905701L SE7905701L (sv)	1980-03-23
SE444732B true SE444732B (sv)	1986-04-28

Family

ID=25481942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7905701A SE444732B (sv)	1978-09-22	1979-06-28	Testanordning for pavisande av bilirubin i serum, forfarande for framstellning av testanordningen samt forfarande for pavisande av bilirubin i serum

Country Status (11)

Country	Link
US (1)	US4190419A (2)
JP (1)	JPS5544992A (2)
AU (1)	AU526798B2 (2)
CA (1)	CA1110528A (2)
DE (1)	DE2925524C2 (2)
FR (1)	FR2436994A1 (2)
GB (1)	GB2030291B (2)
IL (1)	IL57547A (2)
IT (1)	IT1117780B (2)
NL (1)	NL7905350A (2)
SE (1)	SE444732B (2)

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US8293098B2 (en) *	2006-10-24	2012-10-23	Siemens Industry, Inc.	Infiltration/inflow control for membrane bioreactor
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CN102112213B (zh)	2008-07-24	2016-08-03	伊沃夸水处理技术有限责任公司	用于膜过滤模块的框架系统
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CN102869432B (zh)	2010-04-30	2016-02-03	伊沃夸水处理技术有限责任公司	流体流分配装置
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JP2014528354A (ja)	2011-09-30	2014-10-27	エヴォクアウォーターテクノロジーズエルエルシーＥｖｏｑｕａＷａｔｅｒＴｅｃｈｎｏｌｏｇｉｅｓｌｌｃ	隔離バルブ
CN103958024B (zh)	2011-09-30	2016-07-06	伊沃夸水处理技术有限责任公司	改进的歧管排列
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DE2240471C3 (de) *	1972-08-17	1975-04-03	Boehringer Mannheim Gmbh, 6800 Mannheim	Testpapier zum Nachweis von Bilirubin in Körperflüssigkeiten
FI55166C (fi) *	1974-11-26	1979-06-11	Pentti Valanti	Foerfarande foer rening av emulsioner och foerorenade vatten speciellt av oljehaltiga vatten med tillhjaelp av elektrolys samt anordning foer foerverkligande av foerfarandet
US4078892A (en) *	1975-06-30	1978-03-14	Becton, Dickinson And Company	Novel means and method for diagnostic quantitation of serum or plasma bilirubin
US4038031A (en) *	1975-10-02	1977-07-26	Miles Laboratories, Inc.	Test composition, device and method for detecting bilirubin

1978
- 1978-09-22 US US05/944,718 patent/US4190419A/en not_active Expired - Lifetime
1979
- 1979-06-05 CA CA329,127A patent/CA1110528A/en not_active Expired
- 1979-06-12 IL IL57547A patent/IL57547A/xx unknown
- 1979-06-25 DE DE2925524A patent/DE2925524C2/de not_active Expired
- 1979-06-28 SE SE7905701A patent/SE444732B/sv not_active IP Right Cessation
- 1979-07-09 NL NL7905350A patent/NL7905350A/nl not_active Application Discontinuation
- 1979-07-12 GB GB7924259A patent/GB2030291B/en not_active Expired
- 1979-07-20 IT IT49823/79A patent/IT1117780B/it active
- 1979-08-07 FR FR7920200A patent/FR2436994A1/fr active Granted
- 1979-08-10 AU AU49813/79A patent/AU526798B2/en not_active Ceased
- 1979-09-12 JP JP11624579A patent/JPS5544992A/ja active Granted

Also Published As

Publication number	Publication date
JPS5544992A (en)	1980-03-29
IL57547A (en)	1982-02-28
IT7949823A0 (it)	1979-07-20
NL7905350A (nl)	1980-03-25
AU526798B2 (en)	1983-02-03
DE2925524A1 (de)	1980-04-10
US4190419A (en)	1980-02-26
SE7905701L (sv)	1980-03-23
GB2030291A (en)	1980-04-02
DE2925524C2 (de)	1982-05-13
GB2030291B (en)	1983-02-16
JPS6250782B2 (2)	1987-10-27
IT1117780B (it)	1986-02-24
FR2436994A1 (fr)	1980-04-18
FR2436994B1 (2)	1985-02-08
CA1110528A (en)	1981-10-13
AU4981379A (en)	1980-03-27
IL57547A0 (en)	1979-10-31

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