SE447119B - Aktiverad bermassa baserad pa en polypackarid for anvendning vid kromatografi, samt forfarande for framstellning derav - Google Patents

Aktiverad bermassa baserad pa en polypackarid for anvendning vid kromatografi, samt forfarande for framstellning derav

Info

Publication number: SE447119B
Authority: SE; Sweden
Prior art keywords: sepharose; activated; cdi; carrier mass; cellulose
Prior art date: 1977-02-08

Application number

SE7801355A

Other languages

English (en)

Swedish (sv)

Other versions

SE7801355L (sv

Inventor

J S Ayers

G S Bethell

W S Hancock

M T W Hearn

Original Assignee

New Zealand Dev Finance

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-08

Filing date

1978-02-06

Publication date

1986-10-27

1978-02-06 Application filed by New Zealand Dev Finance filed Critical New Zealand Dev Finance

1978-08-09 Publication of SE7801355L publication Critical patent/SE7801355L/xx

1986-10-27 Publication of SE447119B publication Critical patent/SE447119B/sv

Links

238000000034 method Methods 0.000 title claims description 50
238000004587 chromatography analysis Methods 0.000 title claims 2
229920002678 cellulose Polymers 0.000 claims description 16
239000001913 cellulose Substances 0.000 claims description 16
239000004627 regenerated cellulose Substances 0.000 claims description 12
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims description 10
150000001875 compounds Chemical class 0.000 claims description 8
-1 1,2,3-benzotriazolyl group Chemical group 0.000 claims description 7
150000004676 glycans Chemical class 0.000 claims description 7
229920001282 polysaccharide Polymers 0.000 claims description 7
239000005017 polysaccharide Substances 0.000 claims description 7
229920000936 Agarose Polymers 0.000 claims description 6
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
230000008569 process Effects 0.000 claims description 6
239000003960 organic solvent Substances 0.000 claims description 5
239000003795 chemical substances by application Substances 0.000 claims description 4
125000002883 imidazolyl group Chemical group 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
229920002307 Dextran Polymers 0.000 claims description 2
229920002472 Starch Polymers 0.000 claims description 2
239000008107 starch Substances 0.000 claims description 2
235000019698 starch Nutrition 0.000 claims description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
238000000354 decomposition reaction Methods 0.000 claims 1
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
239000002904 solvent Substances 0.000 claims 1
PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical group C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 80
229920002684 Sepharose Polymers 0.000 description 41
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 24
238000005859 coupling reaction Methods 0.000 description 23
229910052757 nitrogen Inorganic materials 0.000 description 21
230000008878 coupling Effects 0.000 description 20
238000010168 coupling process Methods 0.000 description 20
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 14
102000004142 Trypsin Human genes 0.000 description 14
108090000631 Trypsin Proteins 0.000 description 14
239000012588 trypsin Substances 0.000 description 14
238000006243 chemical reaction Methods 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
230000004913 activation Effects 0.000 description 12
150000001412 amines Chemical class 0.000 description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
238000004448 titration Methods 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
239000000523 sample Substances 0.000 description 10
239000003446 ligand Substances 0.000 description 9
239000000463 material Substances 0.000 description 9
239000000047 product Substances 0.000 description 9
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 8
SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 8
239000003153 chemical reaction reagent Substances 0.000 description 8
235000010469 Glycine max Nutrition 0.000 description 7
244000068988 Glycine max Species 0.000 description 7
101710162629 Trypsin inhibitor Proteins 0.000 description 7
229940122618 Trypsin inhibitor Drugs 0.000 description 7
229960002684 aminocaproic acid Drugs 0.000 description 7
239000007822 coupling agent Substances 0.000 description 7
230000007062 hydrolysis Effects 0.000 description 7
238000006460 hydrolysis reaction Methods 0.000 description 7
238000000954 titration curve Methods 0.000 description 7
239000002753 trypsin inhibitor Substances 0.000 description 7
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
239000002253 acid Substances 0.000 description 6
YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 5
238000004458 analytical method Methods 0.000 description 5
HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 5
239000000969 carrier Substances 0.000 description 5
230000035484 reaction time Effects 0.000 description 5
239000000243 solution Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
239000004471 Glycine Substances 0.000 description 3
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
238000001042 affinity chromatography Methods 0.000 description 3
239000003513 alkali Substances 0.000 description 3
230000008901 benefit Effects 0.000 description 3
239000000872 buffer Substances 0.000 description 3
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
150000005676 cyclic carbonates Chemical group 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
229910000029 sodium carbonate Inorganic materials 0.000 description 3
238000005406 washing Methods 0.000 description 3
RNHDAKUGFHSZEV-UHFFFAOYSA-N 1,4-dioxane;hydrate Chemical compound O.C1COCCO1 RNHDAKUGFHSZEV-UHFFFAOYSA-N 0.000 description 2
BMVXCPBXGZKUPN-UHFFFAOYSA-N 1-hexanamine Chemical compound CCCCCCN BMVXCPBXGZKUPN-UHFFFAOYSA-N 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
239000012190 activator Substances 0.000 description 2
230000027455 binding Effects 0.000 description 2
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
238000000921 elemental analysis Methods 0.000 description 2
YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 2
NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
238000003127 radioimmunoassay Methods 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
WPANETAWYGDRLL-UHFFFAOYSA-N 4-aminobenzenecarboximidamide Chemical compound NC(=N)C1=CC=C(N)C=C1 WPANETAWYGDRLL-UHFFFAOYSA-N 0.000 description 1
YAVZGKYMGKLGFB-UHFFFAOYSA-N 4-aminobenzenecarboximidamide;hydron;chloride Chemical compound Cl.NC(=N)C1=CC=C(N)C=C1 YAVZGKYMGKLGFB-UHFFFAOYSA-N 0.000 description 1
IUZXQGCIJLIGLS-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4-one;hydron;chloride Chemical compound Cl.C1C(=O)N(CCN(C)C)C2=CC=CC=C2SC1C1=CC=CC=C1 IUZXQGCIJLIGLS-UHFFFAOYSA-N 0.000 description 1
GGZZISOUXJHYOY-UHFFFAOYSA-N 8-amino-4-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C(N)=CC=CC2=C1O GGZZISOUXJHYOY-UHFFFAOYSA-N 0.000 description 1
241001143500 Aceraceae Species 0.000 description 1
101000898299 Acinetobacter lwoffii Catechol 1,2-dioxygenase 1 Proteins 0.000 description 1
241000428352 Amma Species 0.000 description 1
238000012935 Averaging Methods 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical group NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 1
108010008488 Glycylglycine Proteins 0.000 description 1
101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 1
101000800133 Homo sapiens Thyroglobulin Proteins 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
241000935974 Paralichthys dentatus Species 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
101000993800 Sus scrofa Insulin Proteins 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
239000003929 acidic solution Substances 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000007825 activation reagent Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
125000002015 acyclic group Chemical group 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
125000003368 amide group Chemical group 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
235000015278 beef Nutrition 0.000 description 1
QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
239000012964 benzotriazole Substances 0.000 description 1
GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
230000008859 change Effects 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000013068 control sample Substances 0.000 description 1
229940109239 creatinine Drugs 0.000 description 1
238000003795 desorption Methods 0.000 description 1
150000004985 diamines Chemical class 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
239000006167 equilibration buffer Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
229940043257 glycylglycine Drugs 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
102000047688 human TG Human genes 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000012160 loading buffer Substances 0.000 description 1
238000011068 loading method Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
230000000269 nucleophilic effect Effects 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
238000012545 processing Methods 0.000 description 1
238000010926 purge Methods 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000012958 reprocessing Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
230000003335 steric effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
238000000870 ultraviolet spectroscopy Methods 0.000 description 1
239000011534 wash buffer Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
- C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0036—Galactans; Derivatives thereof
- C08B37/0039—Agar; Agarose, i.e. D-galactose, 3,6-anhydro-D-galactose, methylated, sulfated, e.g. from the red algae Gelidium and Gracilaria; Agaropectin; Derivatives thereof, e.g. Sepharose, i.e. crosslinked agarose
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/548—Carbohydrates, e.g. dextran
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Materials Engineering (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Cell Biology (AREA)
Analytical Chemistry (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7801355A 1977-02-08 1978-02-06 Aktiverad bermassa baserad pa en polypackarid for anvendning vid kromatografi, samt forfarande for framstellning derav SE447119B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NZ18328377		1977-02-08

Publications (2)

Publication Number	Publication Date
SE7801355L SE7801355L (sv)	1978-08-09
SE447119B true SE447119B (sv)	1986-10-27

Family

ID=19918024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7801355A SE447119B (sv)	1977-02-08	1978-02-06	Aktiverad bermassa baserad pa en polypackarid for anvendning vid kromatografi, samt forfarande for framstellning derav

Country Status (7)

Country	Link
US (1)	US4224439A (fr)
AU (1)	AU515785B2 (fr)
CA (1)	CA1106841A (fr)
DE (1)	DE2805056A1 (fr)
FR (1)	FR2379552A1 (fr)
GB (1)	GB1598763A (fr)
SE (1)	SE447119B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990007376A1 (fr) *	1988-12-30	1990-07-12	Exploaterings Ab T.B.F.	Adsorbant pour ions metalliques, proteines et autres substances inorganiques et organiques

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US4330440A (en) *	1977-02-08	1982-05-18	Development Finance Corporation Of New Zealand	Activated matrix and method of activation
FR2459479B1 (fr) *	1979-06-21	1983-07-08	Inst Nat Sante Rech Med	Procede de separation d'une substance proteinique a partir d'une solution la contenant par filtration d'affinite et application dudit procede aux dosages enzymatiques
DE3016618C2 (de) *	1980-04-30	1982-06-09	Gerhard 3560 Biedenkopf Scharf	Testmittel unter Verwendung von polymer gebundenen, bezüglich des Systems Peroxydase-Wasserstoffperoxyd oxydierbaren Chromogenen
US4374061A (en) *	1981-07-27	1983-02-15	Center For Blood Research, Inc.	Means and methods for purifying Clq, Clr and Cls
US5059654A (en) *	1983-02-14	1991-10-22	Cuno Inc.	Affinity matrices of modified polysaccharide supports
US4760135A (en) *	1984-09-06	1988-07-26	University Of Kentucky Research Foundation	Phloretin and phlorizin derivative containing compounds
US5229268A (en) *	1986-07-14	1993-07-20	Abbott Laboratories	Method for diagnostic immunoassay by solid phase separation
EP0401248A4 (en) *	1988-02-11	1992-04-15	Cuno, Incorporated	Affinity matrices of modified polysaccharide supports
US5011861A (en) *	1988-06-28	1991-04-30	Millipore Corporation	Membranes for solid phase protein sequencing
DE3836599A1 (de) *	1988-10-27	1990-05-03	Wolff Walsrode Ag	Neue polysaccharide, verfahren zu ihrer herstellung und ihre verwendung
DE4114588A1 (de) *	1991-05-04	1992-11-05	Wolff Walsrode Ag	Verfahren zur herstellung von kohlensaeurederivaten von polysacchariden
US5968839A (en) *	1996-05-13	1999-10-19	Metrika, Inc.	Method and device producing a predetermined distribution of detectable change in assays
US5958704A (en) *	1997-03-12	1999-09-28	Ddx, Inc.	Sensing system for specific substance and molecule detection
ES2661168T3 (es)	2003-07-12	2018-03-27	Accelerate Diagnostics, Inc.	Biodetección sensible y rápida
US20120077206A1 (en)	2003-07-12	2012-03-29	Accelr8 Technology Corporation	Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US10254204B2 (en)	2011-03-07	2019-04-09	Accelerate Diagnostics, Inc.	Membrane-assisted purification
US9434937B2 (en)	2011-03-07	2016-09-06	Accelerate Diagnostics, Inc.	Rapid cell purification systems
US9677109B2 (en)	2013-03-15	2017-06-13	Accelerate Diagnostics, Inc.	Rapid determination of microbial growth and antimicrobial susceptibility
US10253355B2 (en)	2015-03-30	2019-04-09	Accelerate Diagnostics, Inc.	Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10023895B2 (en)	2015-03-30	2018-07-17	Accelerate Diagnostics, Inc.	Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing

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NL278607A (fr)	1961-05-25	1900-01-01
US3271387A (en) *	1962-10-10	1966-09-06	Union Starch & Refining Co Inc	High viscosity starch derivatives
US3346563A (en)	1964-08-07	1967-10-10	Staley Mfg Co A E	Preparation of quaternary ammonium starch ethers
US3376287A (en) *	1965-06-28	1968-04-02	Nat Starch Chem Corp	Novel inhibited granular starch products prepared by the reaction of starch with phosgene
US3342806A (en)	1965-07-23	1967-09-19	Nat Starch Chem Corp	Novel acetoacetylated starch derivatives
US3388120A (en)	1966-11-25	1968-06-11	Staley Mfg Co A E	Acylated cyanoalkylated starch materials
GB1190000A (en)	1966-12-29	1970-04-29	Cooperative Verkoop En Product	Amino Derivatives of Starch
GB1289549A (fr)	1969-12-18	1972-09-20
US3793065A (en) *	1972-03-10	1974-02-19	Owens Corning Fiberglass Corp	Size coated glass fibers
US3833555A (en) *	1972-10-11	1974-09-03	Owens Illinois Inc	Polysaccharide cyclic carbamate containing compounds
US4020268A (en) *	1972-11-13	1977-04-26	Xerox Corporation	Agarose containing affinity matrix materials
US3880832A (en) *	1974-03-21	1975-04-29	Nat Starch Chem Corp	Starch ether derivatives and preparation thereof

1978
- 1978-02-02 US US05/874,628 patent/US4224439A/en not_active Expired - Lifetime
- 1978-02-06 GB GB4746/78A patent/GB1598763A/en not_active Expired
- 1978-02-06 SE SE7801355A patent/SE447119B/sv not_active IP Right Cessation
- 1978-02-07 DE DE19782805056 patent/DE2805056A1/de active Granted
- 1978-02-07 CA CA296,411A patent/CA1106841A/fr not_active Expired
- 1978-02-07 AU AU33057/78A patent/AU515785B2/en not_active Expired
- 1978-02-07 FR FR7803388A patent/FR2379552A1/fr active Granted

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990007376A1 (fr) *	1988-12-30	1990-07-12	Exploaterings Ab T.B.F.	Adsorbant pour ions metalliques, proteines et autres substances inorganiques et organiques

Also Published As

Publication number	Publication date
DE2805056A1 (de)	1978-10-19
GB1598763A (en)	1981-09-23
FR2379552A1 (fr)	1978-09-01
AU515785B2 (en)	1981-04-30
US4224439A (en)	1980-09-23
FR2379552B1 (fr)	1983-07-18
AU3305778A (en)	1979-08-16
SE7801355L (sv)	1978-08-09
CA1106841A (fr)	1981-08-11

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Publication	Publication Date	Title
SE447119B (sv)	1986-10-27	Aktiverad bermassa baserad pa en polypackarid for anvendning vid kromatografi, samt forfarande for framstellning derav
US4330440A (en)	1982-05-18	Activated matrix and method of activation
Inman	1975	Thymus-independent antigens: the preparation of covalent, hapten-ficoll conjugates
US5092992A (en)	1992-03-03	Polyethyleneimine matrixes for affinity chromatography
Trochimczuk et al.	2000	Synthesis and chelating properties of resins with methylthiourea, guanylthiourea and dithiocarbamate groups
JPS6259124B2 (fr)	1987-12-09
US4837348A (en)	1989-06-06	Bonded phase chromatographic supports
US5085779A (en)	1992-02-04	Polyethyleneimine matrixes for affinity chromatography
EP0625524B1 (fr)	1999-08-18	Polysaccharides liés à un support poreux, procédé de préparation et leur application
CARLSSON et al.	1998	10 Affinity Chromatography
FI74713B (fi)	1987-11-30	Foerfarande foer modifiering av staerkelse med organosilaner i en vattenhaltig mellanprodukt.
JPS615099A (ja)	1986-01-10	蛋白質等の分離用チオエ−テル吸着剤およびその製造方法
Machleidt et al.	1977	[29] New supports in solid-phase sequencing
JPH0651721B2 (ja)	1994-07-06	イオン変性セルロ−ス材料、その製造法、及びその使用
US4886755A (en)	1989-12-12	Preparation of polymeric thiol gels for covalent bonding of biologically active ligands
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Alagon et al.	1980	Activation of polysaccharides with 2-iminothiolane and its uses
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JP3613585B2 (ja)	2005-01-26	リガンドまたはリガンドが結合している化合物の固定化方法
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KR950004134B1 (ko)	1995-04-27	어피니티 크로마토그라피용 폴리에틸렌이민 매트릭스
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SE447119B - Aktiverad bermassa baserad pa en polypackarid for anvendning vid kromatografi, samt forfarande for framstellning derav - Google Patents

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Applications Claiming Priority (1)

Publications (2)

Family

ID=19918024

Family Applications (1)

Country Status (7)

Cited By (1)

Families Citing this family (20)

Family Cites Families (12)

Cited By (1)

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