SE454842B - Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne - Google Patents

Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne

Info

Publication number: SE454842B
Authority: SE; Sweden
Prior art keywords: molecular weight; composition; dye; high molecular; aqueous solution
Prior art date: 1984-11-01

Application number

SE8405464A

Other languages

English (en)

Swedish (sv)

Other versions

SE8405464D0 (sv

SE8405464L (sv

Inventor

T Melson

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-01

Filing date

1984-11-01

Publication date

1988-06-06

1984-11-01 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1984-11-01 Priority to SE8405464A priority Critical patent/SE454842B/sv

1984-11-01 Publication of SE8405464D0 publication Critical patent/SE8405464D0/xx

1985-10-18 Priority to CA000493264A priority patent/CA1256030A/en

1985-10-23 Priority to EP85905444A priority patent/EP0202257B1/de

1985-10-23 Priority to US06/878,832 priority patent/US4764360A/en

1985-10-23 Priority to JP60504964A priority patent/JPS62500720A/ja

1985-10-23 Priority to DE8585905444T priority patent/DE3567374D1/de

1985-10-23 Priority to AU50164/85A priority patent/AU5016485A/en

1985-10-23 Priority to PCT/SE1985/000410 priority patent/WO1986002548A1/en

1985-10-30 Priority to ES548369A priority patent/ES8800605A1/es

1985-10-30 Priority to MX45085A priority patent/MX450A/es

1986-05-02 Publication of SE8405464L publication Critical patent/SE8405464L/xx

1988-06-06 Publication of SE454842B publication Critical patent/SE454842B/sv

Links

239000000203 mixture Substances 0.000 title claims description 22
239000007864 aqueous solution Substances 0.000 title claims description 5
229920006158 high molecular weight polymer Polymers 0.000 title claims description 4
239000000126 substance Substances 0.000 title description 8
229920002307 Dextran Polymers 0.000 claims description 15
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 11
229920002674 hyaluronan Polymers 0.000 claims description 11
229960003160 hyaluronic acid Drugs 0.000 claims description 11
229920000642 polymer Polymers 0.000 claims description 9
229920000609 methyl cellulose Polymers 0.000 claims description 6
239000001923 methylcellulose Substances 0.000 claims description 6
229920002678 cellulose Polymers 0.000 claims description 2
239000001913 cellulose Substances 0.000 claims description 2
239000000975 dye Substances 0.000 description 30
239000000243 solution Substances 0.000 description 20
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 8
210000004027 cell Anatomy 0.000 description 6
238000000034 method Methods 0.000 description 6
238000006467 substitution reaction Methods 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
241000283973 Oryctolagus cuniculus Species 0.000 description 5
235000010981 methylcellulose Nutrition 0.000 description 5
239000000047 product Substances 0.000 description 5
229920002385 Sodium hyaluronate Polymers 0.000 description 4
238000009792 diffusion process Methods 0.000 description 4
229940089982 healon Drugs 0.000 description 4
229940010747 sodium hyaluronate Drugs 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
SJEYSFABYSGQBG-UHFFFAOYSA-M Patent blue Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 SJEYSFABYSGQBG-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
210000002159 anterior chamber Anatomy 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
210000004087 cornea Anatomy 0.000 description 2
238000004043 dyeing Methods 0.000 description 2
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
239000000985 reactive dye Substances 0.000 description 2
RTLULCVBFCRQKI-UHFFFAOYSA-N 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfoanilino]-9,10-dioxoanthracene-2-sulfonic acid Chemical compound C1=2C(=O)C3=CC=CC=C3C(=O)C=2C(N)=C(S(O)(=O)=O)C=C1NC(C=1)=CC=C(S(O)(=O)=O)C=1NC1=NC(Cl)=NC(Cl)=N1 RTLULCVBFCRQKI-UHFFFAOYSA-N 0.000 description 1
RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
RTNUTCOTGVKVBR-UHFFFAOYSA-N 4-chlorotriazine Chemical group ClC1=CC=NN=N1 RTNUTCOTGVKVBR-UHFFFAOYSA-N 0.000 description 1
101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
102000008100 Human Serum Albumin Human genes 0.000 description 1
108091006905 Human Serum Albumin Proteins 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
210000001742 aqueous humor Anatomy 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
-1 carboxy, hydroxy, propyl Chemical class 0.000 description 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
YKCWQPZFAFZLBI-UHFFFAOYSA-N cibacron blue Chemical compound C1=2C(=O)C3=CC=CC=C3C(=O)C=2C(N)=C(S(O)(=O)=O)C=C1NC(C=C1S(O)(=O)=O)=CC=C1NC(N=1)=NC(Cl)=NC=1NC1=CC=CC=C1S(O)(=O)=O YKCWQPZFAFZLBI-UHFFFAOYSA-N 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
239000012634 fragment Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229960000907 methylthioninium chloride Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000005191 phase separation Methods 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940016052 sodium hyaluronate 10 mg/ml Drugs 0.000 description 1
238000010186 staining Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Ophthalmology & Optometry (AREA)
Surgery (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)

SE8405464A 1984-11-01 1984-11-01 Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne SE454842B (sv)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
SE8405464A SE454842B (sv)	1984-11-01	1984-11-01	Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne
CA000493264A CA1256030A (en)	1984-11-01	1985-10-18	Composition for ophthalmological use
PCT/SE1985/000410 WO1986002548A1 (en)	1984-11-01	1985-10-23	Composition for ophthalmological use
JP60504964A JPS62500720A (ja)	1984-11-01	1985-10-23	眼科用組成物
US06/878,832 US4764360A (en)	1984-11-01	1985-10-23	Composition for ophthalmological use
EP85905444A EP0202257B1 (de)	1984-11-01	1985-10-23	Zusammensetzung für ophthalmologische verwendung
DE8585905444T DE3567374D1 (en)	1984-11-01	1985-10-23	Composition for ophthalmological use
AU50164/85A AU5016485A (en)	1984-11-01	1985-10-23	Composition for ophthalmological use
ES548369A ES8800605A1 (es)	1984-11-01	1985-10-30	Procedimiento para preparar una composicion coloeada de utilidad en cirugia ocular.
MX45085A MX450A (es)	1984-11-01	1985-10-30	Composicion fijadora y procedimiento para su preparacion.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8405464A SE454842B (sv)	1984-11-01	1984-11-01	Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne

Publications (3)

Publication Number	Publication Date
SE8405464D0 SE8405464D0 (sv)	1984-11-01
SE8405464L SE8405464L (sv)	1986-05-02
SE454842B true SE454842B (sv)	1988-06-06

Family

ID=20357565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8405464A SE454842B (sv)	1984-11-01	1984-11-01	Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne

Country Status (10)

Country	Link
US (1)	US4764360A (de)
EP (1)	EP0202257B1 (de)
JP (1)	JPS62500720A (de)
AU (1)	AU5016485A (de)
CA (1)	CA1256030A (de)
DE (1)	DE3567374D1 (de)
ES (1)	ES8800605A1 (de)
MX (1)	MX450A (de)
SE (1)	SE454842B (de)
WO (1)	WO1986002548A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5008102A (en) *	1986-02-26	1991-04-16	York Kenneth K	Biocompatible intraocular light-screening compositions and methods of intraocular light screening
JPH0739508B2 (ja) *	1986-11-11	1995-05-01	株式会社林原生物化学研究所	プルラン・ポリエチレングリコ−ル会合物とその製造方法並びに用途
EP0307525A1 (de) *	1987-09-18	1989-03-22	Kenneth K. York	Bioverträgliche intraokulare Lichtschützende Mischung
US5323775A (en) *	1991-09-13	1994-06-28	Allergan, Inc.	Diagnostic method for determining precorneal retention time of ophthalmic formulations
EP1132065A1 (de) *	2000-03-07	2001-09-12	Gerrit Reinold Jacob Melles	Farbige visko-elastische Zusammensetzung
AU2002366209A1 (en) *	2001-11-20	2003-06-10	Visco Dye Aps	Visco dye
DE10255601C5 (de)	2002-10-14	2017-10-19	Fluoron Gmbh	Verwendung eines Triphenylmethanfarbstoffs zur Herstellung eines Färbemittels bei der Netzhaut- und Glaskörperchirurgie
US8802651B2 (en) *	2004-06-30	2014-08-12	Abbott Medical Optics Inc.	Hyaluronic acid in the enhancement of lens regeneration
US20080038316A1 (en) *	2004-10-01	2008-02-14	Wong Vernon G	Conveniently implantable sustained release drug compositions
US20070031482A1 (en) *	2005-08-02	2007-02-08	Ceramoptec Industries, Ind.	PDT treatment method for cellulites and cosmetic use
DE102008064065B9 (de)	2008-12-19	2011-01-05	Fluoron Gmbh	Farbstofflösung
DE102009037514A1 (de)	2009-08-17	2011-03-10	Dirk-Henning Dr. Menz	Wasserlösliche Polysaccharidether und ihre Verwendung
EP2392355A1 (de) *	2010-06-03	2011-12-07	Medical Technology Transfer Holding B.V.	Farbzusammensetzung
EP2371395A1 (de) *	2010-04-01	2011-10-05	Medical Technology Transfer Holding B.V.	Farbzusammensetzung
WO2011122947A1 (en)	2010-04-01	2011-10-06	Medical Technology Transfer Holding B.V.	Staining composition
GB2493568B (en)	2011-08-09	2018-08-29	Zeiss Carl Meditec Ag	Opthalmologic composition comprising an aqueous solution of at least one viscoelastic polysaccharide
IN2014CN03706A (de) *	2011-11-16	2015-10-09	3M Innovative Properties Co
ITVR20120051A1 (it) *	2012-03-20	2013-09-21	Bbs Srl	Composizione colorata per uso in metodi chirurgici oftalmici
GB2501943B (en) *	2012-05-10	2020-09-23	Zeiss Carl Meditec Ag	Ophthalmic viscoelastic device
ITFI20130074A1 (it) *	2013-04-03	2014-10-04	Ambrosone Orazio	Soluzione acquosa di contrasto per rendere visibile mediante metodica fotografica il canale di schlemm e le vie di deflusso dell¿umore acqueo e metodo diagnostico che utilizza detta soluzione.
DE102014103512A1 (de) *	2014-03-14	2015-09-17	Carl Zeiss Meditec Ag	Injektor zur Injektion eines Operations-Hilfsfluids in ein Auge sowie Verfahren zum Erzeugen eines Operations-Hilfsfluids
CN105903088A (zh) *	2015-12-14	2016-08-31	上海其胜生物制剂有限公司	一种具有选择性前囊染色功能的眼科粘弹剂的制备方法
IT202300025521A1 (it)	2023-11-30	2025-05-30	Fidia Farm Spa	Composizioni farmaceutiche oftalmiche e relativo uso

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1340517A (en) *	1969-12-01	1973-12-12	Burton Parsons Chemicals Inc	Ophthalmic solution
SU1091056A1 (ru) *	1982-08-31	1984-05-07	Московский научно-исследовательский институт микрохирургии глаза	Способ окраски гиалуроновой кислоты в ткан х глаза

1984
- 1984-11-01 SE SE8405464A patent/SE454842B/sv not_active IP Right Cessation
1985
- 1985-10-18 CA CA000493264A patent/CA1256030A/en not_active Expired
- 1985-10-23 JP JP60504964A patent/JPS62500720A/ja active Granted
- 1985-10-23 US US06/878,832 patent/US4764360A/en not_active Expired - Lifetime
- 1985-10-23 EP EP85905444A patent/EP0202257B1/de not_active Expired
- 1985-10-23 AU AU50164/85A patent/AU5016485A/en not_active Abandoned
- 1985-10-23 WO PCT/SE1985/000410 patent/WO1986002548A1/en not_active Ceased
- 1985-10-23 DE DE8585905444T patent/DE3567374D1/de not_active Expired
- 1985-10-30 ES ES548369A patent/ES8800605A1/es not_active Expired
- 1985-10-30 MX MX45085A patent/MX450A/es unknown

Also Published As

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MX450A (es)	1993-12-01
SE8405464D0 (sv)	1984-11-01
EP0202257B1 (de)	1989-01-11
CA1256030A (en)	1989-06-20
ES8800605A1 (es)	1987-11-16
AU5016485A (en)	1986-05-15
DE3567374D1 (en)	1989-02-16
WO1986002548A1 (en)	1986-05-09
JPS62500720A (ja)	1987-03-26
ES548369A0 (es)	1987-11-16
EP0202257A1 (de)	1986-11-26
US4764360A (en)	1988-08-16
JPH0588206B2 (de)	1993-12-21
SE8405464L (sv)	1986-05-02

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