SE470477B - Salva innehållande fibronektin för behandling av sår - Google Patents
Salva innehållande fibronektin för behandling av sårInfo
- Publication number
- SE470477B SE470477B SE9202895A SE9202895A SE470477B SE 470477 B SE470477 B SE 470477B SE 9202895 A SE9202895 A SE 9202895A SE 9202895 A SE9202895 A SE 9202895A SE 470477 B SE470477 B SE 470477B
- Authority
- SE
- Sweden
- Prior art keywords
- weight
- ointment
- ointment according
- wound
- mixture
- Prior art date
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 34
- 108010067306 Fibronectins Proteins 0.000 title claims abstract description 14
- 102000016359 Fibronectins Human genes 0.000 title claims abstract description 14
- 206010052428 Wound Diseases 0.000 title claims description 18
- 208000027418 Wounds and injury Diseases 0.000 title claims description 18
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940082500 cetostearyl alcohol Drugs 0.000 claims abstract description 6
- 229920000136 polysorbate Polymers 0.000 claims abstract description 6
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229950008882 polysorbate Drugs 0.000 claims abstract description 5
- 241001465754 Metazoa Species 0.000 claims abstract description 4
- 241000894007 species Species 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 10
- 239000003871 white petrolatum Substances 0.000 claims description 9
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 4
- 229960000541 cetyl alcohol Drugs 0.000 claims description 4
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 4
- 229940012831 stearyl alcohol Drugs 0.000 claims description 4
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 3
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 claims description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 2
- 229930003316 Vitamin D Natural products 0.000 claims description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 claims description 2
- 229940075554 sorbate Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 235000019155 vitamin A Nutrition 0.000 claims description 2
- 239000011719 vitamin A Substances 0.000 claims description 2
- 235000019166 vitamin D Nutrition 0.000 claims description 2
- 239000011710 vitamin D Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 2
- 229940045997 vitamin a Drugs 0.000 claims description 2
- 229940046008 vitamin d Drugs 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 206010072170 Skin wound Diseases 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000009841 epithelial lesion Effects 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000035876 healing Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 229940067003 orabase Drugs 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 101001027553 Bos taurus Fibronectin Proteins 0.000 description 2
- 241000283086 Equidae Species 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229940003587 aquaphor Drugs 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
- 229920001219 Polysorbate 40 Polymers 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000000337 effect on mastitis Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- VEJWJJHJBSJZGF-UHFFFAOYSA-N formaldehyde;2-hydroxy-4-methylbenzenesulfonic acid Chemical compound O=C.CC1=CC=C(S(O)(=O)=O)C(O)=C1 VEJWJJHJBSJZGF-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9202895A SE470477B (sv) | 1992-10-05 | 1992-10-05 | Salva innehållande fibronektin för behandling av sår |
| ES93850180T ES2146223T3 (es) | 1992-10-05 | 1993-09-21 | Unguento que contiene fibronectina para el tratamiento de lesiones epiteliales. |
| AT93850180T ATE190500T1 (de) | 1992-10-05 | 1993-09-21 | Fibronektin enthaltende salbe zur behandlung von epithelialen verletzungen |
| EP93850180A EP0592380B1 (de) | 1992-10-05 | 1993-09-21 | Fibronektin enthaltende Salbe zur Behandlung von epithelialen Verletzungen |
| DE69328065T DE69328065T2 (de) | 1992-10-05 | 1993-09-21 | Fibronektin enthaltende Salbe zur Behandlung von epithelialen Verletzungen |
| AU48801/93A AU4880193A (en) | 1992-10-05 | 1993-10-01 | Ointment for treatment of epithelial lesions |
| CA002107598A CA2107598A1 (en) | 1992-10-05 | 1993-10-04 | Ointment for treatment of epithelial lesions |
| US08/131,149 US5733870A (en) | 1992-10-05 | 1993-10-04 | Ointment for treatment of epithelial lesions |
| JP24948193A JP3715659B2 (ja) | 1992-10-05 | 1993-10-05 | 上皮病巣の治療用軟膏 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9202895A SE470477B (sv) | 1992-10-05 | 1992-10-05 | Salva innehållande fibronektin för behandling av sår |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9202895D0 SE9202895D0 (sv) | 1992-10-05 |
| SE9202895L SE9202895L (sv) | 1994-04-06 |
| SE470477B true SE470477B (sv) | 1994-05-24 |
Family
ID=20387373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9202895A SE470477B (sv) | 1992-10-05 | 1992-10-05 | Salva innehållande fibronektin för behandling av sår |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5733870A (de) |
| EP (1) | EP0592380B1 (de) |
| JP (1) | JP3715659B2 (de) |
| AT (1) | ATE190500T1 (de) |
| AU (1) | AU4880193A (de) |
| CA (1) | CA2107598A1 (de) |
| DE (1) | DE69328065T2 (de) |
| ES (1) | ES2146223T3 (de) |
| SE (1) | SE470477B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
| US7112320B1 (en) | 1995-06-07 | 2006-09-26 | Andre Beaulieu | Solid wound healing formulations containing fibronectin |
| GB9705340D0 (en) * | 1997-03-14 | 1997-04-30 | Nycomed Imaging As | Compositions |
| FR2777461B1 (fr) * | 1998-04-16 | 2003-04-25 | Ceetal Sa Lab | Agent de soin du trayon et procede de preparation |
| US6917095B1 (en) | 2000-05-30 | 2005-07-12 | Altera Corporation | Integrated radio frequency circuits |
| JP4313033B2 (ja) * | 2002-12-27 | 2009-08-12 | 株式会社日本点眼薬研究所 | 眼科用治療組成物 |
| US20050014730A1 (en) * | 2003-04-02 | 2005-01-20 | Carlson Robert M. | Anti-fungal formulation of triterpene and essential oil |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017615A (en) * | 1970-10-29 | 1977-04-12 | Syntex Corporation | Propylene carbonate ointment vehicle |
| JPS5976007A (ja) * | 1982-10-22 | 1984-04-28 | Shiseido Co Ltd | 化粧料 |
| DE3426903A1 (de) * | 1984-07-20 | 1986-01-23 | Biotest Pharma GmbH, 6000 Frankfurt | Eine immunglobulinpraeparation in kombination mit einer anderen pharmakologisch wirksamen praeparation zur verwendung bei der behandlung von krankheiten |
| JPS61103836A (ja) * | 1984-10-24 | 1986-05-22 | Green Cross Corp:The | フイブロネクチン製剤 |
| JPS62123112A (ja) * | 1985-11-22 | 1987-06-04 | Sunstar Inc | 軟膏基剤 |
| FI854634A0 (fi) * | 1985-11-22 | 1985-11-22 | Labsystems Oy | Foerfarande foer bestaemning av proteolytisk aktivitet. |
| US4837019A (en) * | 1986-08-11 | 1989-06-06 | Charles Of The Ritz Group Ltd. | Skin treatment composition and method for treating burned skin |
| US4929442A (en) * | 1986-09-26 | 1990-05-29 | Exovir, Inc. | Compositions suitable for human topical application including a growth factor and/or related materials |
| US5036056A (en) * | 1987-07-08 | 1991-07-30 | Martin Kludas | Methods for treating damaged corneal, uterine, or cartilage tissue |
| US5246708A (en) * | 1987-10-28 | 1993-09-21 | Pro-Neuron, Inc. | Methods for promoting wound healing with deoxyribonucleosides |
| US5053388A (en) * | 1987-11-09 | 1991-10-01 | Chiron Ophthalmics, Inc. | Wound healing composition and method |
| US5055298A (en) * | 1987-12-01 | 1991-10-08 | Chemisches Laboratorium Dr. Kurt Richter Gmbh | Cosmetic composition comprising an extracellular connective tissue matrix |
| US4939135A (en) * | 1988-10-03 | 1990-07-03 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation |
| US5196185A (en) * | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
| JP3088744B2 (ja) * | 1990-05-28 | 2000-09-18 | 日本ケミカルリサーチ株式会社 | フィブロネクチン組成物 |
-
1992
- 1992-10-05 SE SE9202895A patent/SE470477B/sv not_active IP Right Cessation
-
1993
- 1993-09-21 ES ES93850180T patent/ES2146223T3/es not_active Expired - Lifetime
- 1993-09-21 AT AT93850180T patent/ATE190500T1/de not_active IP Right Cessation
- 1993-09-21 EP EP93850180A patent/EP0592380B1/de not_active Expired - Lifetime
- 1993-09-21 DE DE69328065T patent/DE69328065T2/de not_active Expired - Lifetime
- 1993-10-01 AU AU48801/93A patent/AU4880193A/en not_active Abandoned
- 1993-10-04 CA CA002107598A patent/CA2107598A1/en not_active Abandoned
- 1993-10-04 US US08/131,149 patent/US5733870A/en not_active Expired - Fee Related
- 1993-10-05 JP JP24948193A patent/JP3715659B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP3715659B2 (ja) | 2005-11-09 |
| SE9202895D0 (sv) | 1992-10-05 |
| CA2107598A1 (en) | 1994-04-06 |
| EP0592380A1 (de) | 1994-04-13 |
| ES2146223T3 (es) | 2000-08-01 |
| SE9202895L (sv) | 1994-04-06 |
| US5733870A (en) | 1998-03-31 |
| DE69328065T2 (de) | 2000-11-02 |
| JPH06199684A (ja) | 1994-07-19 |
| EP0592380B1 (de) | 2000-03-15 |
| AU4880193A (en) | 1994-04-21 |
| DE69328065D1 (de) | 2000-04-20 |
| ATE190500T1 (de) | 2000-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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| NUG | Patent has lapsed |