SE501217C2 - Cellproliferationsmatris och användning därav - Google Patents

Cellproliferationsmatris och användning därav

Info

Publication number: SE501217C2
Authority: SE; Sweden
Prior art keywords: cell proliferation; weight; sodium hyaluronate; average molecular; molecular weight
Prior art date: 1990-12-06

Application number

SE9003887A

Other languages

English (en)

Swedish (sv)

Other versions

SE9003887L (sv

Inventor

Kerstin Brismar

Bertil Aaberg

Original Assignee

Skandigen Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-06

Filing date

1990-12-06

Publication date

1994-12-12

1990-12-06 Application filed by Skandigen Ab filed Critical Skandigen Ab

1990-12-06 Priority to SE9003887A priority Critical patent/SE501217C2/sv

1991-12-05 Priority to JP4500592A priority patent/JPH06503319A/ja

1991-12-05 Priority to AU90409/91A priority patent/AU649092B2/en

1991-12-05 Priority to EP92900297A priority patent/EP0560845B1/de

1991-12-05 Priority to US08/066,165 priority patent/US5432167A/en

1991-12-05 Priority to DE69127459T priority patent/DE69127459T2/de

1991-12-05 Priority to CA002097181A priority patent/CA2097181A1/en

1991-12-05 Priority to KR1019930701656A priority patent/KR100206314B1/ko

1991-12-05 Priority to PCT/SE1991/000839 priority patent/WO1992010195A1/en

1991-12-05 Priority to AT92900297T priority patent/ATE157253T1/de

1992-06-07 Publication of SE9003887L publication Critical patent/SE9003887L/xx

1994-12-12 Publication of SE501217C2 publication Critical patent/SE501217C2/sv

Links

230000004663 cell proliferation Effects 0.000 title claims abstract description 28
239000011159 matrix material Substances 0.000 title claims abstract description 28
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 18
229920002674 hyaluronan Polymers 0.000 claims abstract description 18
229960003160 hyaluronic acid Drugs 0.000 claims abstract description 18
238000011282 treatment Methods 0.000 claims abstract description 17
150000003839 salts Chemical class 0.000 claims abstract description 13
241001465754 Metazoa Species 0.000 claims abstract description 9
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 9
208000010392 Bone Fractures Diseases 0.000 claims abstract description 8
230000001771 impaired effect Effects 0.000 claims abstract description 8
238000004519 manufacturing process Methods 0.000 claims abstract description 8
206010011985 Decubitus ulcer Diseases 0.000 claims abstract description 6
201000010099 disease Diseases 0.000 claims abstract description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
230000008321 arterial blood flow Effects 0.000 claims abstract description 4
208000025865 Ulcer Diseases 0.000 claims description 28
231100000397 ulcer Toxicity 0.000 claims description 28
229920002385 Sodium hyaluronate Polymers 0.000 claims description 22
229940010747 sodium hyaluronate Drugs 0.000 claims description 22
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 22
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 5
239000002953 phosphate buffered saline Substances 0.000 claims description 5
238000002360 preparation method Methods 0.000 abstract description 2
238000000034 method Methods 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 description 4
229940088710 antibiotic agent Drugs 0.000 description 4
239000008280 blood Substances 0.000 description 4
210000004369 blood Anatomy 0.000 description 4
208000015181 infectious disease Diseases 0.000 description 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
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208000033808 peripheral neuropathy Diseases 0.000 description 4
206010016717 Fistula Diseases 0.000 description 3
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210000002683 foot Anatomy 0.000 description 3
230000035876 healing Effects 0.000 description 3
206010002383 Angina Pectoris Diseases 0.000 description 2
206010017711 Gangrene Diseases 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
102000004877 Insulin Human genes 0.000 description 2
108090001061 Insulin Proteins 0.000 description 2
208000031481 Pathologic Constriction Diseases 0.000 description 2
208000035415 Reinfection Diseases 0.000 description 2
208000017442 Retinal disease Diseases 0.000 description 2
206010038923 Retinopathy Diseases 0.000 description 2
-1 Vitamineral Chemical compound 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
230000017531 blood circulation Effects 0.000 description 2
230000010261 cell growth Effects 0.000 description 2
230000004087 circulation Effects 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
229940125396 insulin Drugs 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
208000017169 kidney disease Diseases 0.000 description 2
244000005700 microbiome Species 0.000 description 2
238000013059 nephrectomy Methods 0.000 description 2
238000010606 normalization Methods 0.000 description 2
230000000306 recurrent effect Effects 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
208000000044 Amnesia Diseases 0.000 description 1
208000031091 Amnestic disease Diseases 0.000 description 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
108010074051 C-Reactive Protein Proteins 0.000 description 1
102100032752 C-reactive protein Human genes 0.000 description 1
208000002177 Cataract Diseases 0.000 description 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
108010036949 Cyclosporine Proteins 0.000 description 1
241000450599 DNA viruses Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
229930182566 Gentamicin Natural products 0.000 description 1
229920002683 Glycosaminoglycan Polymers 0.000 description 1
241000700721 Hepatitis B virus Species 0.000 description 1
RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 description 1
241000725303 Human immunodeficiency virus Species 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
206010022562 Intermittent claudication Diseases 0.000 description 1
208000008839 Kidney Neoplasms Diseases 0.000 description 1
206010054805 Macroangiopathy Diseases 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
206010031149 Osteitis Diseases 0.000 description 1
206010031252 Osteomyelitis Diseases 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
206010038389 Renal cancer Diseases 0.000 description 1
206010062237 Renal impairment Diseases 0.000 description 1
206010039203 Road traffic accident Diseases 0.000 description 1
206010040943 Skin Ulcer Diseases 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
241000194048 Streptococcus equi Species 0.000 description 1
208000032109 Transient ischaemic attack Diseases 0.000 description 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000010306 acid treatment Methods 0.000 description 1
230000001919 adrenal effect Effects 0.000 description 1
210000004100 adrenal gland Anatomy 0.000 description 1
230000006986 amnesia Effects 0.000 description 1
238000002266 amputation Methods 0.000 description 1
210000003447 amputation stump Anatomy 0.000 description 1
LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
229940042710 azathioprine 10 mg Drugs 0.000 description 1
208000018339 bone inflammation disease Diseases 0.000 description 1
239000002775 capsule Substances 0.000 description 1
210000000845 cartilage Anatomy 0.000 description 1
MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 1
208000024980 claudication Diseases 0.000 description 1
229960003326 cloxacillin Drugs 0.000 description 1
LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 description 1
210000001520 comb Anatomy 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
238000011109 contamination Methods 0.000 description 1
229940109239 creatinine Drugs 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
229960002768 dipyridamole Drugs 0.000 description 1
241001493065 dsRNA viruses Species 0.000 description 1
230000000797 effect on infection Effects 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000003527 fibrinolytic agent Substances 0.000 description 1
230000003480 fibrinolytic effect Effects 0.000 description 1
229940063190 flagyl Drugs 0.000 description 1
230000012010 growth Effects 0.000 description 1
210000001255 hallux Anatomy 0.000 description 1
229940014041 hyaluronate Drugs 0.000 description 1
238000009434 installation Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
201000010982 kidney cancer Diseases 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
210000001872 metatarsal bone Anatomy 0.000 description 1
FPTPAIQTXYFGJC-UHFFFAOYSA-N metronidazole hydrochloride Chemical group Cl.CC1=NC=C([N+]([O-])=O)N1CCO FPTPAIQTXYFGJC-UHFFFAOYSA-N 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
210000000963 osteoblast Anatomy 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000011505 plaster Substances 0.000 description 1
231100000857 poor renal function Toxicity 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
201000001474 proteinuria Diseases 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000007787 solid Substances 0.000 description 1
208000037804 stenosis Diseases 0.000 description 1
230000036262 stenosis Effects 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
201000010875 transient cerebral ischemia Diseases 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
238000007631 vascular surgery Methods 0.000 description 1
230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
Materials Engineering (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Mattresses And Other Support Structures For Chairs And Beds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

SE9003887A 1990-12-06 1990-12-06 Cellproliferationsmatris och användning därav SE501217C2 (sv)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
SE9003887A SE501217C2 (sv)	1990-12-06	1990-12-06	Cellproliferationsmatris och användning därav
JP4500592A JPH06503319A (ja)	1990-12-06	1991-12-05	細胞増殖マトリックス及びその用法
AU90409/91A AU649092B2 (en)	1990-12-06	1991-12-05	Cell proliferation matrix and use thereof
EP92900297A EP0560845B1 (de)	1990-12-06	1991-12-05	Zellprofilerationsmatritze und ihre verwendung
US08/066,165 US5432167A (en)	1990-12-06	1991-12-05	Cell proliferation matrix and use thereof
DE69127459T DE69127459T2 (de)	1990-12-06	1991-12-05	Zellprofilerationsmatritze und ihre verwendung
CA002097181A CA2097181A1 (en)	1990-12-06	1991-12-05	Cell proliferation matrix and use thereof
KR1019930701656A KR100206314B1 (ko)	1990-12-06	1991-12-05	세포증식 매트릭스
PCT/SE1991/000839 WO1992010195A1 (en)	1990-12-06	1991-12-05	Cell proliferation matrix and use thereof
AT92900297T ATE157253T1 (de)	1990-12-06	1991-12-05	Zellprofilerationsmatritze und ihre verwendung

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9003887A SE501217C2 (sv)	1990-12-06	1990-12-06	Cellproliferationsmatris och användning därav

Publications (2)

Publication Number	Publication Date
SE9003887L SE9003887L (sv)	1992-06-07
SE501217C2 true SE501217C2 (sv)	1994-12-12

Family

ID=20381109

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9003887A SE501217C2 (sv)	1990-12-06	1990-12-06	Cellproliferationsmatris och användning därav

Country Status (10)

Country	Link
US (1)	US5432167A (de)
EP (1)	EP0560845B1 (de)
JP (1)	JPH06503319A (de)
KR (1)	KR100206314B1 (de)
AT (1)	ATE157253T1 (de)
AU (1)	AU649092B2 (de)
CA (1)	CA2097181A1 (de)
DE (1)	DE69127459T2 (de)
SE (1)	SE501217C2 (de)
WO (1)	WO1992010195A1 (de)

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RU2721303C1 (ru) *	2019-12-03	2020-05-18	Самсунг Электроникс Ко., Лтд.	Оптически-управляемый переключатель миллиметрового диапазона со встроенным источником света, основанный на линии передачи с полупроводниковой подложкой
US12527109B2 (en)	2019-12-03	2026-01-13	Samsung Electronics Co., Ltd.	Optical control switch and electronic device comprising same

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1990
- 1990-12-06 SE SE9003887A patent/SE501217C2/sv unknown
1991
- 1991-12-05 KR KR1019930701656A patent/KR100206314B1/ko not_active Expired - Fee Related
- 1991-12-05 AU AU90409/91A patent/AU649092B2/en not_active Ceased
- 1991-12-05 WO PCT/SE1991/000839 patent/WO1992010195A1/en not_active Ceased
- 1991-12-05 JP JP4500592A patent/JPH06503319A/ja not_active Withdrawn
- 1991-12-05 CA CA002097181A patent/CA2097181A1/en not_active Abandoned
- 1991-12-05 US US08/066,165 patent/US5432167A/en not_active Expired - Fee Related
- 1991-12-05 DE DE69127459T patent/DE69127459T2/de not_active Expired - Fee Related
- 1991-12-05 EP EP92900297A patent/EP0560845B1/de not_active Expired - Lifetime
- 1991-12-05 AT AT92900297T patent/ATE157253T1/de not_active IP Right Cessation

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RU2721303C1 (ru) *	2019-12-03	2020-05-18	Самсунг Электроникс Ко., Лтд.	Оптически-управляемый переключатель миллиметрового диапазона со встроенным источником света, основанный на линии передачи с полупроводниковой подложкой
US12527109B2 (en)	2019-12-03	2026-01-13	Samsung Electronics Co., Ltd.	Optical control switch and electronic device comprising same

Also Published As

Publication number	Publication date
DE69127459T2 (de)	1998-01-02
SE9003887L (sv)	1992-06-07
EP0560845A1 (de)	1993-09-22
DE69127459D1 (de)	1997-10-02
CA2097181A1 (en)	1992-06-07
ATE157253T1 (de)	1997-09-15
KR100206314B1 (ko)	1999-07-01
EP0560845B1 (de)	1997-08-27
JPH06503319A (ja)	1994-04-14
AU9040991A (en)	1992-07-08
US5432167A (en)	1995-07-11
AU649092B2 (en)	1994-05-12
WO1992010195A1 (en)	1992-06-25
KR930702995A (ko)	1993-11-29

Publication	Publication Date	Title
Sherman et al.	1995	Maggot therapy for treating pressure ulcers in spinal cord injury patients
SE501217C2 (sv)	1994-12-12	Cellproliferationsmatris och användning därav
US5929050A (en)	1999-07-27	Chondroitin sulfate composition and method for wound treatment
CA1254510A (en)	1989-05-23	Fibronectin preparations
CA2312558C (en)	2005-04-12	Collagen containing tissue adhesive
DE69634430T2 (de)	2006-01-05	Formulierung fur die wundheilung mit menschlichem plasma fibronektin
Baddour et al.	1984	Recurrent cellulitis after coronary bypass surgery: association with superficial fungal infection in saphenous venectomy limbs
EP1317261B1 (de)	2006-04-05	Arzneimittel enthaltend hydroxyapatite zur behandlung von knochengewebserkrankungen
CN108452293A (zh)	2018-08-28	一种妇科用凝胶及其制备方法
Schwartzman	1951	Hyaluronidase: A review of its therapeutic use in pediatrics
Ofiaeli	1991	Complications of methods of fracture treatment used by traditional healers: a report of three cases necessitating amputation at Ihiala, Nigeria
US4708873A (en)	1987-11-24	Method of chemically debriding uncerated necrotic tissue
Eldad, A., Stark, M., Anais, D., Golan, J. & Ben-Hur	1977	Amniotic membranes as a biological dressing
KELLY et al.	1990	Results of treatment of tibial and femoral osteomyelitis in adults
EP1282429B1 (de)	2008-08-20	Pharmazeutische gel-zusammensetzung
ANDERSON et al.	1970	Irrigation-suction technic in the treatment of acute hematogenous osteomyelitis, chronic osteomyelitis, and acute and chronic joint infections
JPS58103324A (ja)	1983-06-20	インタ−フエロン組成物及びヘルペス感染症の治療における該組成物の使用
Zimmerman et al.	1980	Clindamycin unresponsive anaerobic osteomyelitis treated with oral metronidazole
RU2128975C1 (ru)	1999-04-20	Глазные капли "баларпан"
Gupta	1986	Efficacy of miconazole in experimental keratomycosis
RU2018309C1 (ru)	1994-08-30	Средство для лечения ложных суставов длинных трубчатых костей
Monami et al.	2002	Use of an oxidized regenerated cellulose and collagen composite for healing of chronic diabetic foot ulcers
RU2123854C1 (ru)	1998-12-27	Средство для лечения инфекционных заболеваний дыхательных путей
Buchman et al.	1947	Precautionary administration of penicillin in surgical procedures on bones and joints
Shearer et al.	1974	Osteomyelitis

SE501217C2 - Cellproliferationsmatris och användning därav - Google Patents

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