SE501288C2 - Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial - Google Patents

Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial

Info

Publication number: SE501288C2
Authority: SE; Sweden
Prior art keywords: ceramic; carried out; spongy; implant material; parts
Prior art date: 1993-11-30

Application number

SE9303977A

Other languages

English (en)

Swedish (sv)

Other versions

SE9303977L (sv

SE9303977D0 (sv

Inventor

Klaus Otten

Original Assignee

Corimed Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-30

Filing date

1993-11-30

Publication date

1995-01-09

1993-11-30 Application filed by Corimed Gmbh filed Critical Corimed Gmbh

1993-11-30 Priority to SE9303977A priority Critical patent/SE501288C2/sv

1993-11-30 Publication of SE9303977D0 publication Critical patent/SE9303977D0/xx

1994-11-14 Priority to ES94117912T priority patent/ES2179833T3/es

1994-11-14 Priority to EP94117912A priority patent/EP0657178B1/fr

1994-11-14 Priority to DE59410147T priority patent/DE59410147D1/de

1994-11-14 Priority to AT94117912T priority patent/ATE219950T1/de

1995-01-09 Publication of SE9303977L publication Critical patent/SE9303977L/xx

1995-01-09 Publication of SE501288C2 publication Critical patent/SE501288C2/sv

1996-06-05 Priority to US08/658,526 priority patent/US5667796A/en

Links

239000000463 material Substances 0.000 title claims abstract description 32
239000007943 implant Substances 0.000 title claims abstract description 25
238000004519 manufacturing process Methods 0.000 title claims abstract description 13
229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 10
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 10
239000000919 ceramic Substances 0.000 title claims description 28
238000000034 method Methods 0.000 claims abstract description 38
239000000470 constituent Substances 0.000 claims abstract description 14
241000283690 Bos taurus Species 0.000 claims abstract description 12
241001465754 Metazoa Species 0.000 claims abstract description 7
239000000126 substance Substances 0.000 claims abstract description 6
229910010293 ceramic material Inorganic materials 0.000 claims abstract description 4
239000000654 additive Substances 0.000 claims abstract description 3
238000011081 inoculation Methods 0.000 claims abstract 3
238000004113 cell culture Methods 0.000 claims abstract 2
238000011010 flushing procedure Methods 0.000 claims abstract 2
238000005245 sintering Methods 0.000 claims description 17
210000000988 bone and bone Anatomy 0.000 claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
238000002485 combustion reaction Methods 0.000 claims description 13
210000001503 joint Anatomy 0.000 claims description 7
230000008569 process Effects 0.000 claims description 5
239000007789 gas Substances 0.000 claims description 4
210000004394 hip joint Anatomy 0.000 claims description 4
229910052751 metal Inorganic materials 0.000 claims description 4
239000002184 metal Substances 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
239000002918 waste heat Substances 0.000 claims description 4
238000006243 chemical reaction Methods 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 3
239000000203 mixture Substances 0.000 claims description 3
210000002310 elbow joint Anatomy 0.000 claims description 2
210000000629 knee joint Anatomy 0.000 claims description 2
150000002739 metals Chemical class 0.000 claims description 2
210000000323 shoulder joint Anatomy 0.000 claims description 2
239000013543 active substance Substances 0.000 claims 3
238000005470 impregnation Methods 0.000 claims 2
239000012266 salt solution Substances 0.000 claims 2
241000894006 Bacteria Species 0.000 claims 1
239000003242 anti bacterial agent Substances 0.000 claims 1
229940088710 antibiotic agent Drugs 0.000 claims 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
239000008280 blood Substances 0.000 claims 1
210000004369 blood Anatomy 0.000 claims 1
210000000845 cartilage Anatomy 0.000 claims 1
230000006835 compression Effects 0.000 claims 1
238000007906 compression Methods 0.000 claims 1
238000002405 diagnostic procedure Methods 0.000 claims 1
239000012467 final product Substances 0.000 claims 1
238000000338 in vitro Methods 0.000 claims 1
208000015181 infectious disease Diseases 0.000 claims 1
239000010985 leather Substances 0.000 claims 1
239000001301 oxygen Substances 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
206010016825 Flushing Diseases 0.000 abstract 1
239000013078 crystal Substances 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000011148 porous material Substances 0.000 description 4
238000000197 pyrolysis Methods 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000011161 development Methods 0.000 description 3
239000011159 matrix material Substances 0.000 description 3
239000003595 mist Substances 0.000 description 3
230000001105 regulatory effect Effects 0.000 description 3
238000003860 storage Methods 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
230000003197 catalytic effect Effects 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000001035 drying Methods 0.000 description 2
235000014103 egg white Nutrition 0.000 description 2
210000000969 egg white Anatomy 0.000 description 2
230000007613 environmental effect Effects 0.000 description 2
238000003780 insertion Methods 0.000 description 2
230000037431 insertion Effects 0.000 description 2
210000002414 leg Anatomy 0.000 description 2
238000011084 recovery Methods 0.000 description 2
238000005507 spraying Methods 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
239000002351 wastewater Substances 0.000 description 2
QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
241000242757 Anthozoa Species 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
235000014653 Carica parviflora Nutrition 0.000 description 1
241000195493 Cryptophyta Species 0.000 description 1
102000002322 Egg Proteins Human genes 0.000 description 1
108010000912 Egg Proteins Proteins 0.000 description 1
208000002430 Multiple chemical sensitivity Diseases 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
239000000316 bone substitute Substances 0.000 description 1
235000013339 cereals Nutrition 0.000 description 1
230000008859 change Effects 0.000 description 1
238000004939 coking Methods 0.000 description 1
239000000567 combustion gas Substances 0.000 description 1
238000005056 compaction Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000006378 damage Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
238000005265 energy consumption Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000003344 environmental pollutant Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000010354 integration Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000005416 organic matter Substances 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
238000012856 packing Methods 0.000 description 1
231100000719 pollutant Toxicity 0.000 description 1
239000010970 precious metal Substances 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000004064 recycling Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000012859 sterile filling Methods 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
210000001585 trabecular meshwork Anatomy 0.000 description 1
230000009466 transformation Effects 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Transplantation (AREA)
Molecular Biology (AREA)
Botany (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Zoology (AREA)
Inorganic Chemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Materials For Medical Uses (AREA)
Compositions Of Oxide Ceramics (AREA)
Prostheses (AREA)

SE9303977A 1993-11-30 1993-11-30 Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial SE501288C2 (sv)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
SE9303977A SE501288C2 (sv)	1993-11-30	1993-11-30	Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial
ES94117912T ES2179833T3 (es)	1993-11-30	1994-11-14	Procedimiento de preparacion de material ceramico para implante en particular material ceramico para implante que contiene hidroxiapatita.
EP94117912A EP0657178B1 (fr)	1993-11-30	1994-11-14	Procédé de préparation de matériau céramique pour implant en particulier matériau céramique pour implant contenant de l'hydroxyapatite
DE59410147T DE59410147D1 (de)	1993-11-30	1994-11-14	Verfahren zur Herstellung von Implantatkeramikmaterial, insbesonders von Hydroxylapatit aufweisenden Implantatkeramikmaterial
AT94117912T ATE219950T1 (de)	1993-11-30	1994-11-14	Verfahren zur herstellung von implantatkeramikmaterial, insbesonders von hydroxylapatit aufweisenden implantatkeramikmaterial
US08/658,526 US5667796A (en)	1993-11-30	1996-06-05	Method for producing ceramic implant materials, preferably ceramic implant materials including hydroxyl apatite

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9303977A SE501288C2 (sv)	1993-11-30	1993-11-30	Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial

Publications (3)

Publication Number	Publication Date
SE9303977D0 SE9303977D0 (sv)	1993-11-30
SE9303977L SE9303977L (sv)	1995-01-09
SE501288C2 true SE501288C2 (sv)	1995-01-09

Family

ID=20391943

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9303977A SE501288C2 (sv)	1993-11-30	1993-11-30	Förfarande för framställning av keramiskt implantatmaterial, företrädesvis hydroxylapatit uppvisande keramiskt implantatmaterial

Country Status (6)

Country	Link
US (1)	US5667796A (fr)
EP (1)	EP0657178B1 (fr)
AT (1)	ATE219950T1 (fr)
DE (1)	DE59410147D1 (fr)
ES (1)	ES2179833T3 (fr)
SE (1)	SE501288C2 (fr)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
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DE19543110C2 (de) *	1995-11-18	1998-05-28	Guy Florian Draenert	Steriles Knochenmaterial nativen Ursprungs für die Transplantation und Verfahren zur Hitzesterilisierung des Knochenmaterials
US6013591A (en)	1997-01-16	2000-01-11	Massachusetts Institute Of Technology	Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US6240616B1 (en)	1997-04-15	2001-06-05	Advanced Cardiovascular Systems, Inc.	Method of manufacturing a medicated porous metal prosthesis
US8172897B2 (en)	1997-04-15	2012-05-08	Advanced Cardiovascular Systems, Inc.	Polymer and metal composite implantable medical devices
US10028851B2 (en)	1997-04-15	2018-07-24	Advanced Cardiovascular Systems, Inc.	Coatings for controlling erosion of a substrate of an implantable medical device
US6776792B1 (en)	1997-04-24	2004-08-17	Advanced Cardiovascular Systems Inc.	Coated endovascular stent
DE19926083A1 (de) *	1999-06-08	2000-12-14	Universitaetsklinikum Freiburg	Biologisches Gelenkkonstrukt
US6783793B1 (en)	2000-10-26	2004-08-31	Advanced Cardiovascular Systems, Inc.	Selective coating of medical devices
US6565659B1 (en)	2001-06-28	2003-05-20	Advanced Cardiovascular Systems, Inc.	Stent mounting assembly and a method of using the same to coat a stent
US7989018B2 (en)	2001-09-17	2011-08-02	Advanced Cardiovascular Systems, Inc.	Fluid treatment of a polymeric coating on an implantable medical device
US7285304B1 (en)	2003-06-25	2007-10-23	Advanced Cardiovascular Systems, Inc.	Fluid treatment of a polymeric coating on an implantable medical device
US6863683B2 (en)	2001-09-19	2005-03-08	Abbott Laboratoris Vascular Entities Limited	Cold-molding process for loading a stent onto a stent delivery system
US7758881B2 (en)	2004-06-30	2010-07-20	Advanced Cardiovascular Systems, Inc.	Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
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DE102004016883A1 (de) *	2004-04-06	2005-10-27	Coripharm Medizinprodukte Gmbh & Co. Kg.	Verfahren zur Herstellung eines Knochen-Implantat-materials mit verbesserter mechanischer Beanspruchbarkeit auf der Basis von Formkörpern aus porösem Implantatmaterial sowie nach dem Verfahren hergestelltes Implantatmaterial
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US8568469B1 (en)	2004-06-28	2013-10-29	Advanced Cardiovascular Systems, Inc.	Stent locking element and a method of securing a stent on a delivery system
US8241554B1 (en)	2004-06-29	2012-08-14	Advanced Cardiovascular Systems, Inc.	Method of forming a stent pattern on a tube
US8778256B1 (en)	2004-09-30	2014-07-15	Advanced Cardiovascular Systems, Inc.	Deformation of a polymer tube in the fabrication of a medical article
US7971333B2 (en)	2006-05-30	2011-07-05	Advanced Cardiovascular Systems, Inc.	Manufacturing process for polymetric stents
US8747878B2 (en)	2006-04-28	2014-06-10	Advanced Cardiovascular Systems, Inc.	Method of fabricating an implantable medical device by controlling crystalline structure
US8747879B2 (en)	2006-04-28	2014-06-10	Advanced Cardiovascular Systems, Inc.	Method of fabricating an implantable medical device to reduce chance of late inflammatory response
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- 1994-11-14 EP EP94117912A patent/EP0657178B1/fr not_active Expired - Lifetime
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SE9303977L (sv)	1995-01-09
EP0657178A2 (fr)	1995-06-14
EP0657178B1 (fr)	2002-07-03
ATE219950T1 (de)	2002-07-15
ES2179833T3 (es)	2003-02-01
EP0657178A3 (fr)	2000-02-02
DE59410147D1 (de)	2002-08-08
SE9303977D0 (sv)	1993-11-30
US5667796A (en)	1997-09-16

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