SE503482C2 - Användning av 17-ketosteroider, eventuellt åtföljande eller i kombination med ett immunomoduleringsmedel eller ett antiviralt medel, för framställning av ett läkemedel för användning vid profylax och terapi av en retroviral infektion - Google Patents

Användning av 17-ketosteroider, eventuellt åtföljande eller i kombination med ett immunomoduleringsmedel eller ett antiviralt medel, för framställning av ett läkemedel för användning vid profylax och terapi av en retroviral infektion

Info

Publication number: SE503482C2
Authority: SE; Sweden
Prior art keywords: compound; hiv; infection; prophylaxis; therapy
Prior art date: 1987-04-16

Application number

SE8801406A

Other languages

English (en)

Swedish (sv)

Other versions

SE8801406L (sv

SE8801406D0 (sv

Inventor

Patrick Thomas Prendergast

Original Assignee

Colthurst Ltd

Patrick Thomas Prendergast

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-04-15

Publication date

1996-06-24

1988-04-15 Application filed by Colthurst Ltd, Patrick Thomas Prendergast filed Critical Colthurst Ltd

1988-04-15 Publication of SE8801406D0 publication Critical patent/SE8801406D0/xx

1988-10-17 Publication of SE8801406L publication Critical patent/SE8801406L/xx

1996-06-24 Publication of SE503482C2 publication Critical patent/SE503482C2/sv

Links

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- A61K36/258—Panax (ginseng)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Natural Medicines & Medicinal Plants (AREA)
Molecular Biology (AREA)
Mycology (AREA)
Microbiology (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Alternative & Traditional Medicine (AREA)
Biotechnology (AREA)
Botany (AREA)
Medical Informatics (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SE8801406A 1987-04-16 1988-04-15 Användning av 17-ketosteroider, eventuellt åtföljande eller i kombination med ett immunomoduleringsmedel eller ett antiviralt medel, för framställning av ett läkemedel för användning vid profylax och terapi av en retroviral infektion SE503482C2 (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IE99787		1987-04-16
IE228987		1987-08-27

Publications (3)

Publication Number	Publication Date
SE8801406D0 SE8801406D0 (sv)	1988-04-15
SE8801406L SE8801406L (sv)	1988-10-17
SE503482C2 true SE503482C2 (sv)	1996-06-24

Family

ID=26319024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8801406A SE503482C2 (sv)	1987-04-16	1988-04-15	Användning av 17-ketosteroider, eventuellt åtföljande eller i kombination med ett immunomoduleringsmedel eller ett antiviralt medel, för framställning av ett läkemedel för användning vid profylax och terapi av en retroviral infektion

Country Status (23)

Country	Link
US (1)	US4956355A (fr)
JP (1)	JP2577771B2 (fr)
KR (1)	KR960014988B1 (fr)
AT (1)	AT401470B (fr)
AU (1)	AU608824B2 (fr)
BE (1)	BE1004315A5 (fr)
CA (1)	CA1325594C (fr)
CH (1)	CH675358A5 (fr)
DE (1)	DE3812595C2 (fr)
DK (1)	DK175582B1 (fr)
FI (1)	FI881773A7 (fr)
FR (1)	FR2615394B1 (fr)
GB (1)	GB2204237B (fr)
GR (1)	GR1002240B (fr)
IL (1)	IL86089A (fr)
IT (1)	IT1227073B (fr)
LU (1)	LU87202A1 (fr)
NL (1)	NL194728C (fr)
NZ (1)	NZ224272A (fr)
OA (1)	OA08729A (fr)
PH (1)	PH25907A (fr)
PT (1)	PT87259B (fr)
SE (1)	SE503482C2 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0222385B1 (fr) *	1985-11-13	1993-02-03	Research Development Corporation of Japan	Hormones sexuelles pour le traitement des maladies de l'immunodéficience
US5356900A (en) *	1986-10-07	1994-10-18	Bernard Bihari	Method of treating chronic herpes virus infections using an opiate receptor antagonist
US6638894B1 (en) *	1987-01-09	2003-10-28	Lucent Technologies Inc.	Devices and systems based on novel superconducting material
US5204113A (en) *	1987-04-09	1993-04-20	Fisons Plc	Pharmaceutical compositions containing pentamidine
JP2770970B2 (ja) *	1987-04-09	1998-07-02	フアイソンズ・ピーエルシー	ペンタミジンを含有する医薬組成物
US5407684A (en) *	1988-12-30	1995-04-18	Virginia Commonwealth University	Use of DHEA as a medicinal
US5077284A (en) *	1988-12-30	1991-12-31	Loria Roger M	Use of dehydroepiandrosterone to improve immune response
US5824313A (en) *	1989-09-25	1998-10-20	University Of Utah Research Foundation	Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
US5837269A (en) *	1989-09-25	1998-11-17	University Of Utah Research Foundation	Vaccine compositions and method for enhancing an immune response
US5518725A (en) *	1989-09-25	1996-05-21	University Of Utah Research Foundation	Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
US5562910A (en) *	1989-09-25	1996-10-08	University Of Utah Research Foundation	Vaccine compositions and method for enhancing an immune response
US5753237A (en) *	1989-09-25	1998-05-19	University Of Utah Research Foundation	Method for augmenting immunological responses
DE69033541D1 (de) *	1989-09-25	2000-06-15	Univ Utah Res Found	Verwendung von steroidhormonen in zubereitungen zur induzierung von t-zell-lymphokin-erzeugung
US5162361A (en) *	1990-04-10	1992-11-10	The United States Of America As Represented By The Secretary, Department Of Health And Human Services	Method of treating diseases associated with elevated levels of interleukin 1
US5292730A (en) *	1990-08-29	1994-03-08	Humanetics Corporation	Modulation of immune system with Δ5-androstenes
IE63418B1 (en) *	1990-09-10	1995-04-19	Elan Corp Plc	Progression risk of HIV by assay of dehydroepiandrosterone in body fluid
US5206008A (en) *	1991-04-15	1993-04-27	Virginia Commonwealth University	Enhancement of immune response
JPH05317041A (ja) *	1991-06-05	1993-12-03	Nippon Oil Co Ltd	動物細胞増殖促進剤及び無血清培地
US5230897A (en) *	1991-10-31	1993-07-27	G. D. Searle & Co.	Transdermal pentamidine
JPH07504198A (ja) *	1992-02-24	1995-05-11	イーストカロライナユニバーシティ	デヒドロエピアンドロステロンおよびその類縁体を用いる処置によって発癌を抑制する方法
CA2134228A1 (fr) *	1992-05-01	1993-11-11	Raymond A. Daynes	Compositions et methodes servant a la regulation de la production d'il-6 in vivo
US5346997A (en) *	1992-08-26	1994-09-13	Murphy James G	Agents for complexing sodium under biological conditions
FR2696934B1 (fr) *	1992-10-20	1995-06-02	Conservatoire Nal Arts Metiers	Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir.
EP0680327B1 (fr) *	1993-01-19	2004-09-15	Endorecherche Inc.	Procedes therapeutiques et systemes d'apport de deshydroepiandrosterone
US5776923A (en) *	1993-01-19	1998-07-07	Endorecherche, Inc.	Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
US5439899A (en) *	1993-03-10	1995-08-08	Purdue Research Foundation	Cosalane and related compounds having activity against aids and aids-related infections
US5407927A (en) *	1993-04-16	1995-04-18	The Regents Of The University Of California	Treatment of mild depression and restoration of IGF-I levels in aging by dehydroepiandrosterone
US5466465A (en) *	1993-12-30	1995-11-14	Harrogate Holdings, Limited	Transdermal drug delivery system
JPH10503921A (ja) *	1994-04-05	1998-04-14	パーデュリサーチファウンデーション	診断並びに治療におけるターゲットとしてのｎａｄｈオキシダーゼ
US20020032160A1 (en) *	1995-02-24	2002-03-14	Nyce Jonathan W.	Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels
US7893044B2 (en) *	1995-02-24	2011-02-22	Epigenesis Pharmaceutical, Inc.	Composition and method for altering levels of or sensitivity to adenosine with analogs of dehydroepiandrosterone
US5660835A (en) *	1995-02-24	1997-08-26	East Carolina University	Method of treating adenosine depletion
US5922335A (en) *	1995-05-15	1999-07-13	Avon Products, Inc.	Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
US6162450A (en) *	1995-05-15	2000-12-19	Avon Products, Inc.	Uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same
US5736537A (en) *	1995-09-12	1998-04-07	Estee Lauder, Inc.	Dehydroep:androsterone sailcylate useful against skin atrophy
BR9608158A (pt) *	1996-05-14	1999-02-09	Avon Prod Inc	Ascorbil-fosforil-colesterol
GB9612990D0 (en) *	1996-06-20	1996-08-21	Stanford Rock Ltd	Compositions and methods for the treatment of chronic infections
US5885977A (en) *	1997-01-15	1999-03-23	Humanetics Corporation	Use of Δ5 androstenes in the treatment of HIV wasting syndrome
US5902593A (en) *	1997-10-01	1999-05-11	Kent; Frances B.	Topically applied personal lubricant containing benzalkonium chloride as the active ingredient
US20030083231A1 (en) *	1998-11-24	2003-05-01	Ahlem Clarence N.	Blood cell deficiency treatment method
IL142941A0 (en) *	1998-11-24	2002-04-21	Holis Eden Pharmaceuticals Inc	Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of malaria and the treatment of african and american trypanosomiasis
IL142942A0 (en) *	1998-11-24	2002-04-21	Holis Eden Pharmaceuticals Inc	Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of hepatitis c virus and other toga viruses
US6667299B1 (en)	2000-03-16	2003-12-23	Hollis-Eden Pharmaceuticals, Inc.	Pharmaceutical compositions and treatment methods
US20060079492A1 (en) *	1999-10-25	2006-04-13	Ahlem Clarence N	Compositions and treatment methods
US20070129282A1 (en) *	1998-11-24	2007-06-07	Ahlem Clarence N	Pharmaceutical treatments and compositions
AU1923500A (en) *	1998-11-27	2000-06-19	Hollis-Eden Pharmaceuticals, Inc.	Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in treatment of toxoplasmosis and in the treatment of cryptosporidiosis
ATE259825T1 (de) *	1999-03-23	2004-03-15	Hollis Eden Pharmaceuticals	Hemihydrat von 16.alpha.-bromoepiandrosterone
EP1422234A3 (fr) *	1999-03-23	2010-12-08	Harbor BioSciences, Inc.	Steroides avec activité d'immunomodulation, surtout le hemihydrat du 16.alpha.-bromoepiandrosterone
FR2792201B1 (fr) *	1999-04-15	2001-11-02	Donatien Mavoungou	Procede du renforcement immunitaire et du developpement d'un transporteur lipidique pour une therapie genique anti-vih et anti-bacterienne
US20050245502A1 (en) *	1999-08-23	2005-11-03	Phoenix Biosciences	Treatments for viral infections
US7479498B2 (en) *	1999-08-23	2009-01-20	Phoenix Biosciences, Inc.	Treatments for viral infections
DE60045751D1 (de)	1999-09-30	2011-04-28	Harbor Biosciences Inc	Therapeutische Behandlung androgenrezeptorbedingter Leiden
WO2002085296A2 (fr) *	2001-04-24	2002-10-31	Epigenesis Pharmaceuticals, Inc.	Composition, et formulations de traitement de maladies respiratoires et pulmonaires a l'aide de steroides non-glucocorticoides et/ou d'ubiquinone et d'un agent broncho-dilatateur
AU2003269889B2 (en) *	2002-06-17	2007-04-19	Epigenesis Pharmaceuticals, Llc	Dihydrate dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
US20090285900A1 (en) *	2003-07-31	2009-11-19	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026884A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050113318A1 (en) *	2003-07-31	2005-05-26	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) *	2003-07-31	2009-12-03	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090263381A1 (en) *	2003-07-31	2009-10-22	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) *	2003-07-31	2005-05-12	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026879A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050026880A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease
US20050026848A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050026890A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050026881A1 (en) *	2003-07-31	2005-02-03	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) *	2003-07-31	2005-02-17	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090285899A1 (en) *	2003-07-31	2009-11-19	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease
US20050043282A1 (en) *	2003-07-31	2005-02-24	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) *	2003-07-31	2009-12-24	Robinson Cynthia B	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4005200A (en) *	1975-07-17	1977-01-25	Kanebo, Ltd.	Method for improving the maturity of the parturient canal and the sensitivity to oxytocin
SE439586B (sv) *	1975-09-05	1985-06-24	Kanebo Ltd	Sett att framstella ett stabilt farmaceutiskt torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat
US4496556A (en) *	1982-08-16	1985-01-29	Norman Orentreich	Topical applications for preventing dry skin
US4518595A (en) *	1983-07-19	1985-05-21	The Jackson Laboratory	Method for treating diabetes using DHEA compounds
CA1314870C (fr) *	1983-08-02	1993-03-23	Arthur G. Schwartz	Steroides utilises comme agents contre le cancer, l'obesite, l'hyperglycemie, l'auto-immunite et l'hypercholesterolemie
US4507289A (en) *	1983-12-28	1985-03-26	Progenics, Inc.	Treatment of diabetes and other symptoms of hypercorticoidism using a synergistic combination of etiocholanolones and estrogen
US4602008A (en) *	1984-12-14	1986-07-22	Progenics, Inc.	Alkylated etiocholanolones and use as an anti-diabetic, anti-obesity and erythropoietic agent
US4724232A (en) *	1985-03-16	1988-02-09	Burroughs Wellcome Co.	Treatment of human viral infections
US4628052A (en) *	1985-05-28	1986-12-09	Peat Raymond F	Pharmaceutical compositions containing dehydroepiandrosterone and other anesthetic steroids in the treatment of arthritis and other joint disabilities
NL8502571A (nl) *	1985-09-20	1987-04-16	Akzo Nv	Steroiden met immunomodulerende eigenschappen.
EP0222385B1 (fr) *	1985-11-13	1993-02-03	Research Development Corporation of Japan	Hormones sexuelles pour le traitement des maladies de l'immunodéficience

1988
- 1988-04-11 NL NL8800926A patent/NL194728C/nl not_active IP Right Cessation
- 1988-04-14 PH PH36798A patent/PH25907A/en unknown
- 1988-04-14 GB GB8808864A patent/GB2204237B/en not_active Expired - Fee Related
- 1988-04-15 IL IL86089A patent/IL86089A/xx not_active IP Right Cessation
- 1988-04-15 IT IT8847858A patent/IT1227073B/it active
- 1988-04-15 US US07/182,480 patent/US4956355A/en not_active Expired - Lifetime
- 1988-04-15 OA OA59333A patent/OA08729A/xx unknown
- 1988-04-15 CA CA000564245A patent/CA1325594C/fr not_active Expired - Fee Related
- 1988-04-15 SE SE8801406A patent/SE503482C2/sv not_active IP Right Cessation
- 1988-04-15 NZ NZ224272A patent/NZ224272A/xx unknown
- 1988-04-15 FI FI881773A patent/FI881773A7/fi not_active IP Right Cessation
- 1988-04-15 KR KR1019880004283A patent/KR960014988B1/ko not_active Expired - Fee Related
- 1988-04-15 LU LU87202A patent/LU87202A1/fr unknown
- 1988-04-15 GR GR880100248A patent/GR1002240B/el not_active IP Right Cessation
- 1988-04-15 BE BE8800428A patent/BE1004315A5/fr not_active IP Right Cessation
- 1988-04-15 DK DK198802081A patent/DK175582B1/da not_active IP Right Cessation
- 1988-04-15 FR FR8805043A patent/FR2615394B1/fr not_active Expired - Fee Related
- 1988-04-15 CH CH1393/88A patent/CH675358A5/fr not_active IP Right Cessation
- 1988-04-15 DE DE3812595A patent/DE3812595C2/de not_active Expired - Fee Related
- 1988-04-15 PT PT87259A patent/PT87259B/pt not_active IP Right Cessation
- 1988-04-15 JP JP63093293A patent/JP2577771B2/ja not_active Expired - Fee Related
- 1988-04-15 AU AU14678/88A patent/AU608824B2/en not_active Ceased
- 1988-04-15 AT AT0098488A patent/AT401470B/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2577771B2 (ja)	1997-02-05
GB2204237B (en)	1991-02-06
IL86089A (en)	1992-11-15
CA1325594C (fr)	1993-12-28
IT8847858A0 (it)	1988-04-15
AU1467888A (en)	1988-10-20
KR960014988B1 (ko)	1996-10-23
CH675358A5 (fr)	1990-09-28
NL8800926A (nl)	1988-11-16
NL194728C (nl)	2003-01-07
FR2615394A1 (fr)	1988-11-25
FI881773A7 (fi)	1988-10-17
DK208188D0 (da)	1988-04-15
DE3812595C2 (de)	1997-07-03
BE1004315A5 (fr)	1992-11-03
LU87202A1 (fr)	1988-11-17
ATA98488A (de)	1996-02-15
JPS6425722A (en)	1989-01-27
DK175582B1 (da)	2004-12-13
SE8801406L (sv)	1988-10-17
SE8801406D0 (sv)	1988-04-15
AT401470B (de)	1996-09-25
PH25907A (en)	1991-12-19
FR2615394B1 (fr)	1994-09-23
NL194728B (nl)	2002-09-02
PT87259B (pt)	1992-08-31
AU608824B2 (en)	1991-04-18
IL86089A0 (en)	1988-09-30
FI881773A0 (fi)	1988-04-15
OA08729A (en)	1989-03-31
GB2204237A (en)	1988-11-09
IT1227073B (it)	1991-03-14
KR880012233A (ko)	1988-11-26
US4956355A (en)	1990-09-11
NZ224272A (en)	1991-09-25
PT87259A (pt)	1988-05-01
DE3812595A1 (de)	1988-10-27
GR880100248A (el)	1989-01-31
DK208188A (da)	1988-10-17
GR1002240B (en)	1996-04-22
GB8808864D0 (en)	1988-05-18

Legal Events

Date	Code	Title	Description
2006-12-19	NUG	Patent has lapsed

Publication	Publication Date	Title
US4956355A (en)	1990-09-11	Agents for the arrest and therapy of retroviral infections
CA2223513C (fr)	2009-03-24	Derives d'acide betulinique et leurs utilisations
CA2322868C (fr)	2009-02-03	Derives acyles de betuline et de dihydrobetuline, leur preparation, et leur utilisation
US20210388320A1 (en)	2021-12-16	Differentiation-induced cell population from which undifferentiated cells have been removed, use of same, and method for producing same
HK85789A (en)	1989-11-03	Antiviral nucleosides
Huang et al.	2000	Effects of extracellular human immunodeficiency virus type 1 vpr protein in primary rat cortical cell cultures
CA1339854C (fr)	1998-05-05	Systeme de traitement des infections virales
Roberts et al.	1995	N-acetylcysteine enhances antibody-dependent cellular cytotoxicity in neutrophils and mononuclear cells from healthy adults and human immunodeficiency virus-infected patients
US4704357A (en)	1987-11-03	Immortalized T-lymphocyte cell line for testing HTLV-III inactivation
EP0415902B1 (fr)	1993-03-17	Analogues d'acides gras thio ou oxy substitués pour le traitement des infections retrovirales
EP1675866A1 (fr)	2006-07-05	Nouveaux derives de triterpenes, leur preparation et leur utilisation
Satoh et al.	1990	Absence of natural killer (NK) cell activity against oligodendrocytes in multiple sclerosis
Blakeslee Jr et al.	1985	Human T-Cell Leukemia Virus I Induction by 5-lodo-2′-deoxyuridine and N-Methyl-N′-nitro-N-nitrosoguanidine: Inhibition by Retinoids, l-Ascorbic Acid, and dl-α-Tocopherol
Kristiansen et al.	1991	Effect of Selected Neuroleptic Agents and Stereo‐Isomeric Analogues on Virus and Eukaryotic Cells
DE3724951A1 (de)	1989-02-09	Arzneimittel, enthaltend modifizierte desoxyribonukleinsaeure und dessen verwendung
Muhammad et al.	2004	Inhibition of Epstein-Barr virus by the triterpenoid betulin diphosphate and uvaol
US20070258970A1 (en)	2007-11-08	Methods for Inhibiting Hiv and Other Viral Infections by Modulating Ceramide Metabolism
WO1994004139A1 (fr)	1994-03-03	Traitement d'infections virales chez l'homme
AU735990B2 (en)	2001-07-26	Amino sugars and glycoproteins