SE506496C2 - Nya extrakt av Cucurbita sp., förfarande för deras framställning och deras användning i läkemedel och kosmetika - Google Patents

Nya extrakt av Cucurbita sp., förfarande för deras framställning och deras användning i läkemedel och kosmetika

Info

Publication number: SE506496C2
Authority: SE; Sweden
Prior art keywords: extraction; carbon dioxide; temperature; bar; extracts
Prior art date: 1992-12-09

Application number

SE9304080A

Other languages

English (en)

Swedish (sv)

Other versions

SE9304080L (sv

SE9304080D0 (sv

Inventor

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-09

Filing date

1993-12-08

Publication date

1997-12-22

1993-12-08 Application filed by Indena Spa filed Critical Indena Spa

1993-12-08 Publication of SE9304080D0 publication Critical patent/SE9304080D0/xx

1994-06-10 Publication of SE9304080L publication Critical patent/SE9304080L/xx

1997-12-22 Publication of SE506496C2 publication Critical patent/SE506496C2/sv

Links

239000000284 extract Substances 0.000 title claims abstract description 54
241000219122 Cucurbita Species 0.000 title claims abstract description 18
238000000034 method Methods 0.000 title claims abstract description 12
238000002360 preparation method Methods 0.000 title claims abstract description 8
239000002537 cosmetic Substances 0.000 title claims abstract description 6
239000003814 drug Substances 0.000 title description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 38
238000000605 extraction Methods 0.000 claims abstract description 29
229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 19
239000001569 carbon dioxide Substances 0.000 claims abstract description 18
230000008569 process Effects 0.000 claims abstract description 8
239000013543 active substance Substances 0.000 claims abstract description 6
208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 3
206010000496 acne Diseases 0.000 claims abstract description 3
239000003795 chemical substances by application Substances 0.000 claims abstract 2
230000000366 juvenile effect Effects 0.000 claims abstract 2
239000002904 solvent Substances 0.000 claims description 9
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 6
208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 6
-1 aliphatic alcohols Chemical class 0.000 claims description 5
239000000203 mixture Substances 0.000 claims description 5
125000001931 aliphatic group Chemical group 0.000 claims description 4
239000000126 substance Substances 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 3
229910052799 carbon Inorganic materials 0.000 claims description 3
238000000227 grinding Methods 0.000 claims description 3
239000008194 pharmaceutical composition Substances 0.000 claims description 3
238000009835 boiling Methods 0.000 claims description 2
239000002245 particle Substances 0.000 claims description 2
206010039792 Seborrhoea Diseases 0.000 claims 1
208000008742 seborrheic dermatitis Diseases 0.000 claims 1
210000002307 prostate Anatomy 0.000 abstract description 5
238000003801 milling Methods 0.000 abstract description 2
239000003960 organic solvent Substances 0.000 abstract description 2
240000001980 Cucurbita pepo Species 0.000 abstract 1
235000009852 Cucurbita pepo Nutrition 0.000 abstract 1
206010020880 Hypertrophy Diseases 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
230000000694 effects Effects 0.000 description 10
241000196324 Embryophyta Species 0.000 description 8
239000000463 material Substances 0.000 description 7
238000007127 saponification reaction Methods 0.000 description 7
229930182558 Sterol Natural products 0.000 description 6
150000003432 sterols Chemical class 0.000 description 6
235000003702 sterols Nutrition 0.000 description 6
230000009471 action Effects 0.000 description 5
235000014113 dietary fatty acids Nutrition 0.000 description 5
229930195729 fatty acid Natural products 0.000 description 5
239000000194 fatty acid Substances 0.000 description 5
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
239000002253 acid Substances 0.000 description 4
150000004665 fatty acids Chemical class 0.000 description 4
239000007903 gelatin capsule Substances 0.000 description 4
229910052740 iodine Inorganic materials 0.000 description 4
239000011630 iodine Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
238000001035 drying Methods 0.000 description 3
238000001030 gas--liquid chromatography Methods 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
230000001548 androgenic effect Effects 0.000 description 2
229960003473 androstanolone Drugs 0.000 description 2
230000008485 antagonism Effects 0.000 description 2
239000012298 atmosphere Substances 0.000 description 2
NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
230000007423 decrease Effects 0.000 description 2
206010013990 dysuria Diseases 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
150000008131 glucosides Chemical group 0.000 description 2
239000007788 liquid Substances 0.000 description 2
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
229960003604 testosterone Drugs 0.000 description 2
SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
235000002566 Capsicum Nutrition 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
238000001157 Fourier transform infrared spectrum Methods 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
239000006002 Pepper Substances 0.000 description 1
235000016761 Piper aduncum Nutrition 0.000 description 1
235000017804 Piper guineense Nutrition 0.000 description 1
244000203593 Piper nigrum Species 0.000 description 1
235000008184 Piper nigrum Nutrition 0.000 description 1
208000025844 Prostatic disease Diseases 0.000 description 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
206010046555 Urinary retention Diseases 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000003431 anti-prostaglandin Effects 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
229940076810 beta sitosterol Drugs 0.000 description 1
LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
239000002775 capsule Substances 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
238000004821 distillation Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
ZSRQDUNHUIEDHK-UHFFFAOYSA-N excelsioside Natural products COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C(=CC)C1CC(=O)Oc3ccc(CCO)cc3 ZSRQDUNHUIEDHK-UHFFFAOYSA-N 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
VTSMBFKSVVGHBS-UHFFFAOYSA-N formoside Natural products C1CC2(C)C(C(CCC=C(C)C)C)CCC2(C(O)=O)C(CCC2C3(C)C)=C1C2(C)CCC3OC(C1OC2C(C(O)C(O)C(CO)O2)O)OCC(O)C1OC(C1O)OCC(O)C1OC1OC(CO)C(O)C(O)C1O VTSMBFKSVVGHBS-UHFFFAOYSA-N 0.000 description 1
238000009472 formulation Methods 0.000 description 1
235000021588 free fatty acids Nutrition 0.000 description 1
239000007789 gas Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
230000000762 glandular Effects 0.000 description 1
229930182478 glucoside Natural products 0.000 description 1
229930182470 glycoside Natural products 0.000 description 1
150000002338 glycosides Chemical class 0.000 description 1
230000036541 health Effects 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
238000002329 infrared spectrum Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002366 lipolytic effect Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229940050176 methyl chloride Drugs 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000007119 pathological manifestation Effects 0.000 description 1
238000003825 pressing Methods 0.000 description 1
208000017497 prostate disease Diseases 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000011669 selenium Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
229950005143 sitosterol Drugs 0.000 description 1
208000017520 skin disease Diseases 0.000 description 1
239000000344 soap Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
125000002328 sterol group Chemical group 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
230000036318 urination frequency Effects 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0203—Solvent extraction of solids with a supercritical fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Botany (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Birds (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Medical Informatics (AREA)
Alternative & Traditional Medicine (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Medicines Containing Plant Substances (AREA)
Cosmetics (AREA)
Fats And Perfumes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE9304080A 1992-12-09 1993-12-08 Nya extrakt av Cucurbita sp., förfarande för deras framställning och deras användning i läkemedel och kosmetika SE506496C2 (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4241487A DE4241487C2 (de)	1992-12-09	1992-12-09	Neue Extrakte von Cucurbita sp., Verfahren zu deren Herstellung und deren Verwendung in Arzneimitteln und in der Kosmetik

Publications (3)

Publication Number	Publication Date
SE9304080D0 SE9304080D0 (sv)	1993-12-08
SE9304080L SE9304080L (sv)	1994-06-10
SE506496C2 true SE506496C2 (sv)	1997-12-22

Family

ID=6474800

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9304080A SE506496C2 (sv)	1992-12-09	1993-12-08	Nya extrakt av Cucurbita sp., förfarande för deras framställning och deras användning i läkemedel och kosmetika

Country Status (13)

Country	Link
US (1)	US5547673A (da)
JP (1)	JP2912537B2 (da)
KR (1)	KR100188572B1 (da)
AU (1)	AU674710B2 (da)
CA (1)	CA2111036C (da)
DE (1)	DE4241487C2 (da)
DK (1)	DK176155B1 (da)
FI (1)	FI104362B (da)
FR (1)	FR2698791B1 (da)
GB (1)	GB2273442B (da)
IT (1)	IT1265258B1 (da)
NO (1)	NO307866B1 (da)
SE (1)	SE506496C2 (da)

Families Citing this family (28)

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US6379714B1 (en)	1995-04-14	2002-04-30	Pharmaprint, Inc.	Pharmaceutical grade botanical drugs
DE69711025T2 (de) *	1997-05-15	2002-08-22	Societe Des Produits Nestle S.A., Vevey	Verfahren zur Herstellung und Extraktion von Aromas
US6111108A (en) *	1997-07-01	2000-08-29	Midwest Research Institute	Extraction of biologically active components from Camptotheca acuminata with supercritical fluids
ES2297934T3 (es)	1998-08-03	2008-05-01	Ronald E. Wheeler	Formula prostatica.
US6241987B1 (en) *	1998-08-20	2001-06-05	Amway Corporation	Dietary supplement containing saw palmetto, pumpkin seed, and nettle root
KR100546735B1 (ko) *	1998-09-23	2006-04-20	주식회사 엘지생활건강	피부미백제 조성물
FR2786778A1 (fr) *	1998-12-04	2000-06-09	Soldive	Extrait placentaire de fruit, procede de preparation et composition le contenant
US6117431A (en) *	1999-12-03	2000-09-12	Pharmline Inc.	Method for obtaining an extract from ginkgo biloba leaves
RU2197977C2 (ru) *	2001-04-17	2003-02-10	Дмитриенко Николай Васильевич	Масло семян тыквы, обладающее противовоспалительным, противоязвенным и гепатопротекторным действием, и способ его получения
FR2832418B1 (fr) *	2001-11-16	2005-06-24	Fabre Pierre Dermo Cosmetique	Procede de preparation d'une huile de courge hydrolysee, l'huile de courge hydrolysee susceptible d'etre obtenue par ce procede et son utilisation
JP2004002217A (ja) *	2002-05-31	2004-01-08	Noevir Co Ltd	皮膚外用剤
KR100511222B1 (ko) *	2002-06-05	2005-08-31	유앤아이화장품(주)	동아 추출물을 함유하는 여드름 피부용 화장료 조성물과그의 제조방법
KR100627618B1 (ko)	2004-08-23	2006-09-25	최성애	곡류 또는 씨앗을 이용한 기능성 물질 추출방법
MY146635A (en) *	2004-09-01	2012-09-14	Malaysian Palm Oil Board	Specialty palm oil products and other specialty vegetable oil products
FR2874503B1 (fr) *	2004-09-01	2006-11-24	Soc Ind Limousine Dapplication Biologique Silab	Procede d'obtention d'un principe actif raffermissant et a visee anti-vergetures, actif obtenu et les fonctionnalites
JP4630102B2 (ja) *	2005-03-30	2011-02-09	株式会社ナリス化粧品	ヒアルロン酸産生促進剤、及びこれを含有する化粧料
DE102005017407A1 (de)	2005-04-15	2006-10-19	Degussa Ag	Verfahren zur Behandlung von natürlichen Ausgangsmaterialien mit Hilfe verdichteter Gase
ES2345396T3 (es) *	2006-02-10	2010-09-22	Carotech Sdn. Bhd	Proceso para la produccion de fracciones altamente enriquecidas de compuestos naturales de aceite de palma con fluidos supercriticos y proximos al estado critico.
GB0712972D0 (en) *	2007-07-04	2007-08-15	Glaxosmithkline Consumer Healt	Formulation
MY162712A (en) *	2008-12-04	2017-07-14	Univ Putra Malaysia	A supercritical fluid extraction process of kenaf seeds
DE102010031263A1 (de)	2009-07-10	2011-03-03	Hohenester, Hermann, Dr.	Zubereitung enthaltend Zucchini und/oder Ingwer und/oder Papaya und/oder Ananas zur Behandlung von Körperteilen bzw. zur kosmetischen Pflege und insbesondere zur Mundpflege
JP5809470B2 (ja) *	2011-07-25	2015-11-11	株式会社ファンケル	玄米由来の植物性ステロール配糖体の製造方法
AU2012302146A1 (en) *	2011-09-02	2014-04-03	Burt's Farm, LLC	Personal care compositions comprising squash or pumpkin extract
FR2992859B1 (fr) *	2012-07-09	2014-10-03	Fabre Pierre Dermo Cosmetique	Utilisation de coceth sulfate de zinc comme agent antibacterien vis a vis de propionibacterium acnes
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1992
- 1992-12-09 DE DE4241487A patent/DE4241487C2/de not_active Expired - Fee Related
1993
- 1993-12-06 IT IT93MI002571A patent/IT1265258B1/it active IP Right Grant
- 1993-12-08 SE SE9304080A patent/SE506496C2/sv not_active IP Right Cessation
- 1993-12-08 AU AU52297/93A patent/AU674710B2/en not_active Ceased
- 1993-12-08 US US08/162,764 patent/US5547673A/en not_active Expired - Lifetime
- 1993-12-08 NO NO934472A patent/NO307866B1/no not_active IP Right Cessation
- 1993-12-08 JP JP5340211A patent/JP2912537B2/ja not_active Expired - Fee Related
- 1993-12-08 CA CA002111036A patent/CA2111036C/en not_active Expired - Fee Related
- 1993-12-08 FI FI935499A patent/FI104362B/fi not_active IP Right Cessation
- 1993-12-08 GB GB9325172A patent/GB2273442B/en not_active Expired - Fee Related
- 1993-12-09 DK DK199301377A patent/DK176155B1/da not_active IP Right Cessation
- 1993-12-09 FR FR9314808A patent/FR2698791B1/fr not_active Expired - Fee Related
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Publication number	Publication date
ITMI932571A1 (it)	1995-06-06
JPH06234648A (ja)	1994-08-23
DK137793D0 (da)	1993-12-09
GB9325172D0 (en)	1994-02-09
FR2698791A1 (fr)	1994-06-10
FI104362B (fi)	2000-01-14
DK137793A (da)	1994-06-10
US5547673A (en)	1996-08-20
FI935499L (fi)	1994-06-10
NO934472L (no)	1994-06-10
NO307866B1 (no)	2000-06-13
DE4241487A1 (de)	1994-06-16
DE4241487C2 (de)	1996-07-25
CA2111036C (en)	2000-08-01
KR940013528A (ko)	1994-07-15
DK176155B1 (da)	2006-10-23
ITMI932571A0 (it)	1993-12-06
AU5229793A (en)	1994-06-23
KR100188572B1 (ko)	1999-06-01
FR2698791B1 (fr)	1995-09-15
SE9304080L (sv)	1994-06-10
GB2273442B (en)	1996-07-03
AU674710B2 (en)	1997-01-09
SE9304080D0 (sv)	1993-12-08
NO934472D0 (no)	1993-12-08
JP2912537B2 (ja)	1999-06-28
IT1265258B1 (it)	1996-10-31
GB2273442A (en)	1994-06-22
FI935499A0 (fi)	1993-12-08
CA2111036A1 (en)	1994-06-10

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2012-07-31	NUG	Patent has lapsed

Publication	Publication Date	Title
SE506496C2 (sv)	1997-12-22	Nya extrakt av Cucurbita sp., förfarande för deras framställning och deras användning i läkemedel och kosmetika
Syamasundar et al.	1985	Antihepatotoxic principles of Phyllanthus niruri herbs
US9872879B2 (en)	2018-01-23	Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds
JP2003509506A (ja)	2003-03-11	アボガドのフラン脂質化合物およびポリヒドロキシル化された脂肪族アルコールを抽出する方法、該化合物に基く組成物および治療、美容並びに食品における該化合物の使用
EP1906983A2 (en)	2008-04-09	Cynara scolymus extracts, the use thereof ans formulations containing them
JP2004537578A (ja)	2004-12-16	アーティチョーク葉抽出物
EA030607B1 (ru)	2018-08-31	Способ получения экстракта из растений семейства норичниковых рода пикрориза и его применение для профилактики и лечения заболеваний, вызванных днк-вирусами
EP1014927A1 (fr)	2000-07-05	Utilisation des shogaols et des gingerols pour la preparation de compositions deodorantes
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NO328444B1 (no)	2010-02-22	Hyperforinderivat, anvendelse derav og farmasoytisk sammensetning inneholdende det
KR102905015B1 (ko)	2025-12-29	중대가리풀 유래의 추출물을 포함하는 항염, 자가면역 질환 및 비알코올성 지방간 질환 예방 및 치료용 조성물
AU2002247935B2 (en)	2009-04-23	A simple process for obtaining beta-aescin from indian horse chestnut (aesculus indica)
JP2003500346A (ja)	2003-01-07	皮膚美白剤
JP4105498B2 (ja)	2008-06-25	アトピー性疾患の症状の予防・緩和に有効な組成物
JP4459503B2 (ja)	2010-04-28	エラスターゼ阻害剤及び該剤を含有する化粧品、飲食品又は医薬品
JP2003221343A (ja)	2003-08-05	冬中夏草の超臨界抽出物
JPH0398562A (ja)	1991-04-24	飲料組成物
JP2002173437A (ja)	2002-06-21	体液中の脂質量を調節するために枇杷核エキスを含有する医薬組成物
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JPH0474334B2 (da)	1992-11-26
JPH1160479A (ja)	1999-03-02	痩身剤
JPH0892118A (ja)	1996-04-09	狼毒に含まれる抗癌および抗ウィルス性成分の採取法および使用法
INVITÉ	2016	Abdelgadir A. ABDELGADIR