SE7612176L - SUBSTITUTED PHENYLAMIDINOCARBAMIDE ASSOCIATIONS - Google Patents
SUBSTITUTED PHENYLAMIDINOCARBAMIDE ASSOCIATIONSInfo
- Publication number
- SE7612176L SE7612176L SE7612176A SE7612176A SE7612176L SE 7612176 L SE7612176 L SE 7612176L SE 7612176 A SE7612176 A SE 7612176A SE 7612176 A SE7612176 A SE 7612176A SE 7612176 L SE7612176 L SE 7612176L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- hydrogen
- loweralkyl
- halogen atom
- cycloalkylloweralkyl
- Prior art date
Links
- -1 cycloalkylloweralkyl Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- QRJZGVVKGFIGLI-UHFFFAOYSA-N 2-phenylguanidine Chemical class NC(=N)NC1=CC=CC=C1 QRJZGVVKGFIGLI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1514198 Substituted phenyl guanidines WILLIAM H RORER Inc 30 May 1975 23574/75 Addition to 1451478 Heading C2C Novel compounds of Formula IA (wherein X<SP>1</SP>, Y<SP>1</SP> and Z<SP>1</SP> may be at any available position in the phenyl nucleus; X<SP>1</SP> is a hydrogen or halogen atom; Y<SP>1</SP> is a hydrogen or halogen atom, or is a lower alkyl haloloweralkyl, loweralkoxy or nitro group; either Z<SP>1</SP> is a haloloweralkyl, haloloweralkoxy or loweralkylsulphonyl group, or-with the proviso that X<SP>1</SP> and Y<SP>1</SP> are not both hydrogen-Z<SP>1</SP> is a halogen atom or a loweralkyl, loweralkoxy, nitro or cyano group; R is a loweralkyl group; R<SP>111</SP> is a hydrogen atom or a loweralkyl, intermediate alkyl, cycloalkyl, cycloalkylloweralkyl, aralkyl, loweralkenyl, cycloalkenyl, aryl, acyl or aroyl group; and either R<SP>1</SP> and R<SP>11</SP>, which may be the same or different, are each a hydrogen atom or a loweralkyl, intermediate alkyl, cycloalkyl, cycloalkylloweralkyl, aralkyl, loweralkenyl, cycloalkenyl, aryl, acyl or aroyl group, or R<SP>1</SP> and R<SP>11</SP> together are a loweralkylidenyl or heteroloweralkylidenyl group), and non-toxic acid addition salts thereof are prepared by standard methods. Pharmaceutical compositions in conventional forms having anti-hypertensive activity comprise an above novel compound and a carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29147472A | 1972-09-22 | 1972-09-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7612176L true SE7612176L (en) | 1976-11-02 |
| SE416953B SE416953B (en) | 1981-02-16 |
Family
ID=23120445
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7312880A SE416952B (en) | 1972-09-22 | 1973-09-21 | METHOD OF PREPARING SUBSTITUTED PHENYLAMIDINOCARBAMIDE COMPOUNDS |
| SE7612176A SE416953B (en) | 1972-09-22 | 1976-11-02 | ANALOGY PROCEDURE FOR PREPARING SUBSTITUTED PHENYLAMIDINOCARBAMIDE COMPOUNDS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7312880A SE416952B (en) | 1972-09-22 | 1973-09-21 | METHOD OF PREPARING SUBSTITUTED PHENYLAMIDINOCARBAMIDE COMPOUNDS |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS593471B2 (en) |
| AR (1) | AR200024A1 (en) |
| BE (1) | BE805138A (en) |
| CA (1) | CA1041908A (en) |
| CH (2) | CH614430A5 (en) |
| DE (1) | DE2345951C2 (en) |
| ES (1) | ES418987A1 (en) |
| FR (1) | FR2200002B1 (en) |
| GB (5) | GB1451480A (en) |
| IL (1) | IL43280A (en) |
| NL (1) | NL7313040A (en) |
| PH (1) | PH12016A (en) |
| SE (2) | SE416952B (en) |
| ZA (1) | ZA737475B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025652A (en) * | 1975-03-31 | 1977-05-24 | William H. Rorer, Inc. | Amidinoureas |
| US4220658A (en) * | 1972-09-22 | 1980-09-02 | William H. Rorer, Inc. | Treatment of hypertension with amidinoureas |
| US4488993A (en) * | 1972-09-22 | 1984-12-18 | William H. Rorer, Inc. | Amidinoureas |
| US4326074A (en) | 1972-09-22 | 1982-04-20 | William H. Rorer, Inc. | Amidinoureas |
| US4713382A (en) * | 1985-05-30 | 1987-12-15 | Syntex (U.S.A.) Inc. | N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents |
| ATE157351T1 (en) * | 1993-02-20 | 1997-09-15 | Hoechst Ag | SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION, AS INHIBITORS OF CELLULAR NA+/H+ EXCHANGE OR AS A DIAGNOSTIC, AND MEDICINE CONTAINING THEM |
| RU2156759C1 (en) * | 2000-01-24 | 2000-09-27 | Совместное предприятие Закрытое акционерное общество "Пронова" | Method of preparing n,n'-diphenylguanidine |
-
1973
- 1973-09-10 PH PH15001A patent/PH12016A/en unknown
- 1973-09-12 DE DE2345951A patent/DE2345951C2/en not_active Expired
- 1973-09-13 CA CA181,015A patent/CA1041908A/en not_active Expired
- 1973-09-17 CH CH1605977A patent/CH614430A5/en not_active IP Right Cessation
- 1973-09-17 CH CH1330773A patent/CH605703A5/xx not_active IP Right Cessation
- 1973-09-20 AR AR250179A patent/AR200024A1/en active
- 1973-09-21 NL NL7313040A patent/NL7313040A/xx not_active Application Discontinuation
- 1973-09-21 IL IL43280A patent/IL43280A/en unknown
- 1973-09-21 ZA ZA737475A patent/ZA737475B/en unknown
- 1973-09-21 JP JP48107418A patent/JPS593471B2/en not_active Expired
- 1973-09-21 BE BE135886A patent/BE805138A/en not_active IP Right Cessation
- 1973-09-21 FR FR7333963A patent/FR2200002B1/fr not_active Expired
- 1973-09-21 SE SE7312880A patent/SE416952B/en unknown
- 1973-09-21 ES ES418987A patent/ES418987A1/en not_active Expired
- 1973-09-24 GB GB2499276A patent/GB1451480A/en not_active Expired
- 1973-09-24 GB GB3221175A patent/GB1451478A/en not_active Expired
- 1973-09-24 GB GB4465473A patent/GB1451477A/en not_active Expired
- 1973-09-24 GB GB2491476A patent/GB1451479A/en not_active Expired
-
1975
- 1975-05-30 GB GB23574/75A patent/GB1514198A/en not_active Expired
-
1976
- 1976-11-02 SE SE7612176A patent/SE416953B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB1451478A (en) | 1976-10-06 |
| GB1451479A (en) | 1976-10-06 |
| GB1514198A (en) | 1978-06-14 |
| GB1451480A (en) | 1976-10-06 |
| IL43280A (en) | 1977-06-30 |
| FR2200002B1 (en) | 1977-07-15 |
| GB1451477A (en) | 1976-10-06 |
| DE2345951A1 (en) | 1974-04-04 |
| ES418987A1 (en) | 1976-07-01 |
| CA1041908A (en) | 1978-11-07 |
| JPS4985046A (en) | 1974-08-15 |
| JPS593471B2 (en) | 1984-01-24 |
| SE416953B (en) | 1981-02-16 |
| BE805138A (en) | 1974-01-16 |
| IL43280A0 (en) | 1973-11-28 |
| CH605703A5 (en) | 1978-10-13 |
| ZA737475B (en) | 1974-10-30 |
| CH614430A5 (en) | 1979-11-30 |
| AR200024A1 (en) | 1974-10-15 |
| NL7313040A (en) | 1974-03-26 |
| DE2345951C2 (en) | 1986-10-23 |
| FR2200002A1 (en) | 1974-04-19 |
| SE416952B (en) | 1981-02-16 |
| PH12016A (en) | 1978-10-06 |
| AU6047973A (en) | 1975-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE7614201L (en) | WAY TO PREPARE PHOTOS | |
| GB1324293A (en) | Derivatives of urea or thiourea and biologically active composition containing them | |
| DK623586D0 (en) | PIPERIDE INGREDIENTS OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS | |
| GB1351501A (en) | Adenosine derivatives and the production thereof | |
| GB1287659A (en) | Pyrimidinylpyrazole derivatives | |
| GB1435573A (en) | Indoloquinolizines | |
| GB1514198A (en) | Substituted phenylguanidine compounds processes for their preparation and pharmaceutical compositions containing the same | |
| GB1271466A (en) | Thiocarbamic acid derivatives | |
| SE7600969L (en) | NEW OXIMETERS AND PROCEDURES FOR THEIR MANUFACTURE | |
| GB1407856A (en) | Anti-inflammatory thiazole compositions and methods for using same | |
| GB1462521A (en) | Triazole derivatives | |
| GB1156781A (en) | New Heterocyclic Compounds | |
| GB1353508A (en) | Aminoisoquinolines | |
| GB1342760A (en) | Substituted phthalazines | |
| ES381036A1 (en) | Analgesic drugs based on N- (aroilalkil) n '- (alfanols) piperacinas and their derivatives, and procedure for their obtaination. (Machine-translation by Google Translate, not legally binding) | |
| GB1231959A (en) | ||
| GB1305725A (en) | ||
| GB1299566A (en) | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones | |
| GB1197691A (en) | Substituted Thienoimidazoles | |
| GB962944A (en) | N,n-disubstituted piperazine derivatives | |
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1324579A (en) | N-substituted 3-aminoalkoxy-6-hydrazinopyridazines having antihypertensive activity and their preparation | |
| GB1280288A (en) | Pyrimidopyrimidines | |
| ES347819A1 (en) | 5-nitro-2-thiazolyl-oxamides | |
| GB1514907A (en) | Process for the preparation of substituted phenylguanidines and substituted phenylguanidines when thus prepared |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7612176-3 Effective date: 19891002 Format of ref document f/p: F |