SE7701668L - Forfarande for framstellning av cefalosporinantibiotika - Google Patents

Forfarande for framstellning av cefalosporinantibiotika

Info

Publication number: SE7701668L
Authority: SE; Sweden
Prior art keywords: procedure; preparation; primary; carbon atoms; alkyl group
Prior art date: 1976-02-16

Application number

SE7701668A

Other languages

Unknown language ( )

English (en)

Other versions

SE431986B (sv

Inventor

M Gregson

R B Sykes

Original Assignee

Glaxo Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-02-16

Filing date

1977-02-15

Publication date

1977-08-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27254745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE7701668(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1976-02-16 Priority claimed from GB6009/76A external-priority patent/GB1571683A/en

1977-02-15 Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd

1977-08-17 Publication of SE7701668L publication Critical patent/SE7701668L/sv

1984-03-12 Publication of SE431986B publication Critical patent/SE431986B/sv

Links

239000003242 anti bacterial agent Substances 0.000 title abstract 2
229940088710 antibiotic agent Drugs 0.000 title abstract 2
HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
230000003115 biocidal effect Effects 0.000 abstract 1
JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical class N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7701668A 1976-02-16 1977-02-15 Forfarande for framstellning av esterderivat av (6r,7r)-3-karbamoyloximetyl-7-/(z)-2-(fur-2-yl)-2-metoxiiminoacetamido/-cef-3-em-4-karbonsyra SE431986B (sv)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB6009/76A GB1571683A (en)	1976-02-16	1976-02-16	Ester derivatives of cefuroxime
GB2730176		1976-06-30
GB2730276		1976-06-30

Publications (2)

Publication Number	Publication Date
SE7701668L true SE7701668L (sv)	1977-08-17
SE431986B SE431986B (sv)	1984-03-12

Family

ID=27254745

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7701668A SE431986B (sv)	1976-02-16	1977-02-15	Forfarande for framstellning av esterderivat av (6r,7r)-3-karbamoyloximetyl-7-/(z)-2-(fur-2-yl)-2-metoxiiminoacetamido/-cef-3-em-4-karbonsyra

Country Status (16)

Country	Link
US (1)	US4267320A (sv)
JP (1)	JPS52100494A (sv)
AT (1)	AT358727B (sv)
AU (1)	AU514236B2 (sv)
CA (1)	CA1094545A (sv)
CH (2)	CH628901A5 (sv)
CY (1)	CY1181A (sv)
DE (1)	DE2706413C2 (sv)
DK (1)	DK149062C (sv)
FR (1)	FR2340950A1 (sv)
HK (1)	HK17185A (sv)
IL (1)	IL51450A (sv)
KE (1)	KE3260A (sv)
NL (2)	NL185209C (sv)
SE (1)	SE431986B (sv)
YU (1)	YU40977B (sv)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1093549A (en) *	1976-02-16	1981-01-13	Michael Gregson	Cephalosporin antibiotics
GB1598568A (en) *	1977-04-19	1981-09-23	Glaxo Lab Ltd	Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
GB1602736A (en) *	1977-08-12	1981-11-18	Glaxo Operations Ltd	A-acetoxyethyl esters of 3-carbamoyloxymethyl-7-(2-(fur-2-yl)-2-methoxyiminoacetamido)ceph-3-em-4-carboxylic acids
YU44680B (en) *	1982-07-30	1990-12-31	Glaxo Lab Ltd	Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320521D0 (en) *	1983-07-29	1983-09-01	Glaxo Group Ltd	Chemical process
JPS60190783A (ja) *	1983-12-21	1985-09-28	Sumitomo Seiyaku Kk	セフエム系化合物
GB8400024D0 (en) *	1984-01-03	1984-02-08	Glaxo Group Ltd	Cephalosporin antibiotics
GB8524001D0 (en) *	1985-09-30	1985-11-06	Glaxo Group Ltd	Pharmaceutical composition
GB8810393D0 (en) *	1988-05-03	1988-06-08	Glaxo Group Ltd	Chemical process
GB8810394D0 (en) *	1988-05-03	1988-06-08	Glaxo Group Ltd	Chemical process
JPH0586375U (ja) *	1991-07-11	1993-11-22	田中食品機械株式会社	ゴルフ練習用マット
JPH0541572U (ja) *	1991-11-15	1993-06-08	コナミ株式会社	遊戯機器用起伏形成装置
IT1277426B1 (it) *	1995-08-03	1997-11-10	Acs Dobfar Spa	Forma cristallina biodisponibile del cefuroxima axetil
CN1111537C (zh) *	1997-05-15	2003-06-18	第一制糖株式会社	高纯晶形头孢呋辛1－乙酰氧乙酯的制备方法
IN186539B (sv) *	1997-09-29	2001-09-29	Ranbaxy Lab Ltd
DE19907521A1 (de) *	1998-02-20	1999-11-04	Fako Ilaclari A S	Lösliches kristallines Cefuroxim axetil
US6384213B1 (en)	1998-10-23	2002-05-07	Ranbaxy Laboratories Limited	Process for preparing a pure, pharmacopoeial grade amorphous form of cefuroxime axetil
PT1165051E (pt)	1999-03-19	2003-11-28	Ranbaxy Lab Ltd	Processo para a preparacao de uma forma de dosagem oral biodisponivel de cefuroxima axetil
IN190831B (sv)	1999-03-19	2003-08-23	Ranbaxy Lab Ltd
CA2280925A1 (en)	1999-07-29	2001-01-29	Bernard Charles Sherman	Stabilized cefuroxime axetil
IN190849B (sv)	2000-07-17	2003-08-23	Ranbaxy Lab Ltd
AT411996B (de) *	2000-09-11	2004-08-26	Sandoz Ag	Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes
EP1409492B1 (en) *	2001-07-25	2008-10-15	Lupin Limited	An improved method for preparation of cefuroxime axetil
ITMI20011763A1 (it) *	2001-08-10	2003-02-10	Antibioticos Spa	Processo di preparazione di cefuroxime axelite ad elevata purezza
ES2201932B2 (es) *	2001-11-23	2005-03-16	Glaxo Group Limited	Composicion farmaceutica.
KR100552567B1 (ko) *	2003-08-23	2006-02-15	한국유나이티드제약 주식회사	수분 흡수에 안정하고 빠르게 붕해되는 세푸록심 악세틸을포함하는 정제의 조성물 및 제조 방법
CN1295234C (zh) *	2004-11-15	2007-01-17	中山大学	一种头孢呋辛酯非对映异构体的分离方法
DE102005019458A1 (de)	2005-04-25	2006-10-26	Grünenthal GmbH	Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
DE102006019619A1 (de) *	2006-04-25	2007-10-31	Grünenthal GmbH	Kristalline Modifikation von Cefuroximaxetil
WO2013038323A1 (en)	2011-09-13	2013-03-21	Unimark Remedies Ltd.	Taste masked pharmaceutical compositions of cefuroxime axetil
CN111732599A (zh) *	2020-07-08	2020-10-02	江苏正大清江制药有限公司	一种合成头孢呋辛酯二聚体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1310642A (en)	1970-11-09	1973-03-21	Pfizer	Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins
US3870713A (en) *	1970-12-07	1975-03-11	Pfizer	Phosphono substituted alkylcephalosporins
CA996929A (en) *	1971-04-05	1976-09-14	Kohzi Nakano	Acyloxyalkyl ester derivatives of penicillin
US3974153A (en) *	1971-05-14	1976-08-10	Glaxo Laboratories Limited	7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
BE794844A (fr) *	1972-02-24	1973-08-01	Pfizer	Alpha-carboxy-2-thienylmethylpenicilline et alpha-carboxy-2-thienylmethylcephalosporine,leurs esters et leurs sels
PL98296B1 (pl)	1973-02-07	1978-04-29	Politechnika Gdanskapo	Sposob otrzymywania estrow acetoksymetylowych cefalosporyn
US3962227A (en) *	1973-02-23	1976-06-08	Eli Lilly And Company	3-halo cephalosporins
AR207148A1 (es) *	1974-05-02	1976-09-15	Rhone Poulenc Ind	Procedimiento para la preparacion de un nuevo derivado de la cefalosporina

1977
- 1977-02-11 CA CA271,637A patent/CA1094545A/en not_active Expired
- 1977-02-15 SE SE7701668A patent/SE431986B/sv not_active IP Right Cessation
- 1977-02-15 CH CH187477A patent/CH628901A5/de not_active IP Right Cessation
- 1977-02-15 DE DE2706413A patent/DE2706413C2/de not_active Expired
- 1977-02-15 NL NLAANVRAGE7701568,A patent/NL185209C/xx not_active IP Right Cessation
- 1977-02-15 JP JP1602077A patent/JPS52100494A/ja active Granted
- 1977-02-15 YU YU411/77A patent/YU40977B/xx unknown
- 1977-02-15 AT AT100677A patent/AT358727B/de active Protection Beyond IP Right Term
- 1977-02-15 CY CY1181A patent/CY1181A/xx unknown
- 1977-02-15 AU AU22288/77A patent/AU514236B2/en not_active Expired
- 1977-02-15 DK DK63877A patent/DK149062C/da not_active IP Right Cessation
- 1977-02-15 IL IL51450A patent/IL51450A/xx unknown
- 1977-02-16 FR FR7704339A patent/FR2340950A1/fr active Granted
1979
- 1979-07-27 US US06/061,260 patent/US4267320A/en not_active Expired - Lifetime
1982
- 1982-03-05 CH CH137382A patent/CH634328A5/de not_active IP Right Cessation
1983
- 1983-02-05 KE KE3260A patent/KE3260A/xx unknown
1985
- 1985-03-14 HK HK171/85A patent/HK17185A/xx unknown
1993
- 1993-06-14 NL NL930073C patent/NL930073I2/nl unknown

Also Published As

Publication number	Publication date
YU41177A (en)	1982-06-30
US4267320A (en)	1981-05-12
NL185209C (nl)	1990-02-16
NL7701568A (nl)	1977-08-18
DE2706413C2 (de)	1986-08-28
IL51450A0 (en)	1977-04-29
NL930073I1 (nl)	1993-09-16
DK149062C (da)	1986-06-16
CY1181A (en)	1983-10-07
CH634328A5 (de)	1983-01-31
SE431986B (sv)	1984-03-12
DK63877A (da)	1977-08-17
ATA100677A (de)	1980-02-15
AU514236B2 (en)	1981-01-29
AU2228877A (en)	1978-08-24
NL185209B (nl)	1989-09-18
JPS633868B2 (sv)	1988-01-26
JPS52100494A (en)	1977-08-23
YU40977B (en)	1986-10-31
AT358727B (de)	1980-09-25
CH628901A5 (de)	1982-03-31
FR2340950B1 (sv)	1980-02-01
HK17185A (en)	1985-03-22
IL51450A (en)	1980-11-30
CA1094545A (en)	1981-01-27
DE2706413A1 (de)	1977-08-18
NL930073I2 (nl)	1993-11-01
FR2340950A1 (fr)	1977-09-09
DK149062B (da)	1986-01-06
KE3260A (en)	1983-03-25

Legal Events

Date	Code	Title	Description
1994-03-28	SPCF	Application for supplementary protection certificate filed	Free format text: 7701668
1994-07-11	SPCG	Supplementary protection certificate granted	Free format text: 7701668, EXPIRES: 20020215
1995-01-31	NAL	Patent in force	Ref document number: 7701668-1 Format of ref document f/p: F
1997-05-12	NUG	Patent has lapsed	Ref document number: 7701668-1 Format of ref document f/p: F

Publication	Publication Date	Title
SE8401134D0 (sv)	1984-03-01	Forfarande for framstellning av dihydro-cyklosporin d
DE3060585D1 (en)	1982-08-12	Derivatives of cyclohexylbiphenyl, process for their preparation, dielectrics containing them, and electron optical indicating elements
DE3262698D1 (en)	1985-04-25	Antifibrinolytically active compounds
PH16017A (en)	1983-05-30	8-phenyl-purines and pharmaceutical compositions containing same
SE7602122L (sv)	1976-09-06	Nya piperazinyliminorifamyciner och sett att framstella desamma
AU533417B2 (en)	1983-11-24	Mixtures of stilbene optical brighteners
ES8705891A1 (es)	1987-05-16	Un procedimiento para preparar antibioticos de cefalosporina.
IE782502L (en)	1979-06-20	Cephalosporins
ES8204416A1 (es)	1982-05-01	Un procedimiento para la produccion de un derivado de benza-mida
ES445348A1 (es)	1977-10-16	Un procedimiento para preparar compuestos de 3-aciloximetil-cefem.
ES455918A1 (es)	1978-01-01	Procedimiento para preparar derivados de cefalosporina.
AU536912B2 (en)	1984-05-31	Benzothiazole derivatives
SE7602123L (sv)	1976-09-06	Nya substituerade piperazinyliminorifamyciner och sett att framstella desamma
IE43208L (en)	1976-06-21	Xanthine derivatives
IE41767L (en)	1975-05-28	Dihydroergopeptine derivatives
ES442057A1 (es)	1977-07-01	Procedimiento para la obtencion de penicilinas.
SE7506674L (sv)	1975-12-15	Forfarande for framstellning av arylalkansyror innehallande dihydrofuran- eller dihydropyranringar
IE791781L (en)	1980-03-21	4, 5-methano-bufadienolide rhamnosides
ES471267A1 (es)	1979-10-01	Procedimiento para la preparacion de alquilo inferior 2-tri-(inferior) alquilsililacetileno-n-carbetoxiglicinatos y ami-no acidos derivados de ellos
GB2019843A (en)	1979-11-07	N-Alkenylmoranoline derivatives
SE7505272L (sv)	1975-11-10	Nya, kvevehaltiga, polycykliska foreningar jemte sett for deras framstellning.
GB2017103A (en)	1979-10-03	Cephalosporin analogues
GB2017689A (en)	1979-10-10	Substituted N- Iminomethylpiperidines
GB2001531A (en)	1979-02-07	Organic compounds
ES441244A1 (es)	1977-04-01	Metodo de preparar compuestos esteres basicos.