SE7704088L - WAY TO PREPARE DIPEPTI DERIVATIVES - Google Patents

WAY TO PREPARE DIPEPTI DERIVATIVES

Info

Publication number
SE7704088L
SE7704088L SE7704088A SE7704088A SE7704088L SE 7704088 L SE7704088 L SE 7704088L SE 7704088 A SE7704088 A SE 7704088A SE 7704088 A SE7704088 A SE 7704088A SE 7704088 L SE7704088 L SE 7704088L
Authority
SE
Sweden
Prior art keywords
activity
carboxylic acid
image
compounds
derivatives
Prior art date
Application number
SE7704088A
Other languages
Swedish (sv)
Other versions
SE427835B (en
Inventor
E Schwertner
L A N Flohe
S Herrling
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of SE7704088L publication Critical patent/SE7704088L/en
Publication of SE427835B publication Critical patent/SE427835B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compounds correspond to the formula: <IMAGE> in which the symbols R1 to R5 have the meanings given in Claim 1. The preparation is effected by forming the amide bond in accordance with one of four process variants, starting from amino compounds of the formulae: <IMAGE> and the carboxylic acid corresponding in each case to the remainder of the molecule. The reaction is also carried out using functional derivatives of the carboxylic acid or with the 1 and 3 positions of the imidazole group in the histidyl residue being temporarily protected. The compounds show a spectrum of activity which is similar to that of thyrotropin-releasing hormone, but with a longer duration of activity and a stronger stimulatory effect on the central nervous system; they can be used therapeutically as psychostimulants and as antidepressants.
SE7704088A 1976-04-09 1977-04-06 SET TO MAKE DIPEPTID DERIVATIVES WITH THERAPEUTIC EFFECT SE427835B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2615455A DE2615455C2 (en) 1976-04-09 1976-04-09 N-acyl-L-histidyl-L-proline (N-substituted) amides, processes for their preparation and pharmaceutical preparations containing these compounds

Publications (2)

Publication Number Publication Date
SE7704088L true SE7704088L (en) 1977-10-10
SE427835B SE427835B (en) 1983-05-09

Family

ID=5974903

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7704088A SE427835B (en) 1976-04-09 1977-04-06 SET TO MAKE DIPEPTID DERIVATIVES WITH THERAPEUTIC EFFECT

Country Status (17)

Country Link
JP (1) JPS52125166A (en)
AT (1) AT352921B (en)
AU (1) AU2322677A (en)
BE (1) BE853444A (en)
CA (1) CA1088520A (en)
CH (1) CH632737A5 (en)
DE (1) DE2615455C2 (en)
DK (1) DK148902C (en)
ES (1) ES457563A1 (en)
FR (1) FR2347338A1 (en)
GB (1) GB1564078A (en)
IE (1) IE44485B1 (en)
NL (1) NL7703789A (en)
PT (1) PT66283B (en)
SE (1) SE427835B (en)
YU (1) YU85977A (en)
ZA (1) ZA771097B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58849B1 (en) * 1984-12-18 1993-11-17 Gruenenthal Chemie Use of dipeptide derivatives for the manufacture of medicaments for the treatment of patients with amyotrophic lateral sclerosis
DE3502041A1 (en) 1985-01-23 1986-07-24 Grünenthal GmbH, 5190 Stolberg USE OF DIPEPTIDE DERIVATIVES FOR THE TREATMENT OF POSTTRAUMATIC NERVOUS DAMAGE
JPS63316724A (en) * 1987-06-19 1988-12-26 Nippon Shinyaku Co Ltd Anticonvulsant
US5151497A (en) * 1989-02-21 1992-09-29 Japan Tobacco Inc. Histidyl peptide derivatives
AU704838B2 (en) * 1994-09-12 1999-05-06 Trustees Of The University Of Pennsylvania, The Corticotropin release inhibiting factor and methods of using same
US6039956A (en) * 1994-09-12 2000-03-21 Pennsylvania, Trustees Of The University Of, The Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder

Also Published As

Publication number Publication date
PT66283B (en) 1978-08-09
PT66283A (en) 1977-04-01
FR2347338B1 (en) 1980-07-11
YU85977A (en) 1982-10-31
ES457563A1 (en) 1978-03-16
ATA113977A (en) 1979-03-15
ZA771097B (en) 1978-01-25
IE44485L (en) 1977-10-09
AU2322677A (en) 1978-09-21
CH632737A5 (en) 1982-10-29
JPS6110479B2 (en) 1986-03-29
DK148902B (en) 1985-11-11
SE427835B (en) 1983-05-09
DK148902C (en) 1986-06-09
GB1564078A (en) 1980-04-02
FR2347338A1 (en) 1977-11-04
JPS52125166A (en) 1977-10-20
DE2615455C2 (en) 1985-06-20
DK157077A (en) 1977-10-10
NL7703789A (en) 1977-10-11
AT352921B (en) 1979-10-10
BE853444A (en) 1977-08-01
DE2615455A1 (en) 1977-10-20
IE44485B1 (en) 1981-12-16
CA1088520A (en) 1980-10-28

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