SE7704609L - NEW IMMUNOLOGICAL ASSISTANCE ASSOCIATIONS AND WAYS TO PRODUCE THE SAME - Google Patents

NEW IMMUNOLOGICAL ASSISTANCE ASSOCIATIONS AND WAYS TO PRODUCE THE SAME

Info

Publication number
SE7704609L
SE7704609L SE7704609A SE7704609A SE7704609L SE 7704609 L SE7704609 L SE 7704609L SE 7704609 A SE7704609 A SE 7704609A SE 7704609 A SE7704609 A SE 7704609A SE 7704609 L SE7704609 L SE 7704609L
Authority
SE
Sweden
Prior art keywords
associations
assistance
ways
produce
same
Prior art date
Application number
SE7704609A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE445924B (en
Inventor
G H Jones
J G Moffatt
Jr J J Nestor
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/680,618 external-priority patent/US4082736A/en
Priority claimed from US05/680,260 external-priority patent/US4082735A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of SE7704609L publication Critical patent/SE7704609L/en
Publication of SE445924B publication Critical patent/SE445924B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The novel compounds of the formula: <IMAGE> are prepared by catalytic hydrogenolysis of a compound of the formula <IMAGE> As a result, the benzyl ether, benzyl thioether, benzylidene acetal and benzyl ester groups are removed. In the formulae, R, R<1>, R<2>, R<6>, R', R'', X, X<1>, Y and n have the meanings given in Patent Claim 1. The compounds of the formula I are immunological adjuvants. They are easily degraded by the human metabolism, delay the release of the antigen and stimulate the immune reaction.
SE7704609A 1976-04-26 1977-04-21 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW IMMUNOLOGICAL AID SOCIETIES SE445924B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/680,618 US4082736A (en) 1976-04-26 1976-04-26 Novel immunological adjuvant compounds and methods of preparation thereof
US05/680,260 US4082735A (en) 1976-04-26 1976-04-26 Novel immunological adjuvant compounds and methods of preparation thereof
US77720477A 1977-03-14 1977-03-14

Publications (2)

Publication Number Publication Date
SE7704609L true SE7704609L (en) 1977-10-27
SE445924B SE445924B (en) 1986-07-28

Family

ID=27418368

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7704609A SE445924B (en) 1976-04-26 1977-04-21 ANALOGY PROCEDURE FOR THE PREPARATION OF NEW IMMUNOLOGICAL AID SOCIETIES

Country Status (8)

Country Link
JP (2) JPS52131526A (en)
CH (1) CH636887A5 (en)
DE (1) DE2718010A1 (en)
ES (1) ES458197A1 (en)
FR (1) FR2349600A1 (en)
GB (1) GB1571133A (en)
NL (1) NL7704555A (en)
SE (1) SE445924B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862107D1 (en) * 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
FR2442241A2 (en) * 1978-03-20 1980-06-20 Anvar NOVEL ESTER COMPOUNDS OF MURAMYL-PEPTIDE, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, IN PARTICULAR IN THE FORM OF LIPOSOMES
FR2420545A1 (en) * 1978-03-20 1979-10-19 Anvar NEW ESTERS OF N-ACETYL-MURAMYL-AMINOACYL-GLUTAMIC ACID OR SUBSTITUTION DERIVATIVES THEREOF WITH ANTI-INFECTIOUS PROPERTIES AND / OR IMMUNOLOGICAL ADJUVANTS
US4335111A (en) * 1978-12-22 1982-06-15 Agence National De Valorisation De La Recherche (Anvar) Compounds associating peptidyl of aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
US4256735A (en) * 1979-01-29 1981-03-17 Merck & Co., Inc. Immunologically active dipeptidyl saccharides and methods of preparation
FR2449697A1 (en) * 1979-02-20 1980-09-19 Anvar NOVEL MURAMYL-PEPTIDES SUBSTITUTED ON PEPTIDE NITROGEN AND MEDICAMENTS CONTAINING THEM
CA1185237A (en) * 1979-02-28 1985-04-09 Yuichi Yamamura 6-deoxyglucosamine-peptide derivatives, their production and use
FR2482957A2 (en) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Prepn. of immunostimulant di:peptide(s) - by a solid phase synthesis from glutamic acid and alanine
US4406889A (en) * 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4368190A (en) * 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
JPS6042398A (en) * 1983-08-18 1985-03-06 Toshiyuki Hamaoka Muramyldipeptide active ester derivative
US4777160A (en) * 1986-09-18 1988-10-11 Bristol-Myers BU-2867T peptide antibiotics
US10927147B2 (en) 2015-12-10 2021-02-23 Bharat Biotech International Limited Muramyl peptide derivative compound, synthesis and uses thereof
US12134664B2 (en) 2015-12-10 2024-11-05 Bharat Biotech International Ltd. Muramyl peptide derivatives
CN108883080B (en) * 2015-12-15 2021-12-21 巴拉特生物技术国际有限公司 Muramyl peptide derivative compounds, their synthesis and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH613709A5 (en) * 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives

Also Published As

Publication number Publication date
DE2718010A1 (en) 1977-11-10
FR2349600B1 (en) 1981-01-02
JPS638119B2 (en) 1988-02-19
NL7704555A (en) 1977-10-28
SE445924B (en) 1986-07-28
ES458197A1 (en) 1978-08-16
JPH02138290A (en) 1990-05-28
FR2349600A1 (en) 1977-11-25
DE2718010C2 (en) 1990-11-08
JPH0371440B2 (en) 1991-11-13
JPS52131526A (en) 1977-11-04
CH636887A5 (en) 1983-06-30
GB1571133A (en) 1980-07-09

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