SE7708141L - 5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a) pyrrol-1-karbonsyraderivat och sett att framstella desamma - Google Patents

5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a) pyrrol-1-karbonsyraderivat och sett att framstella desamma

Info

Publication number: SE7708141L
Authority: SE; Sweden
Prior art keywords: pyrrolo; dihydro; alkyl; aroyl; pyrrol
Prior art date: 1976-07-14

Application number

SE7708141A

Other languages

English (en)

Other versions

SE434643B (sv

Inventor

J M Michowski

A F Kluge

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-14

Filing date

1977-07-13

Publication date

1978-01-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE7708141(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1977-02-23 Priority claimed from US05/771,286 external-priority patent/US4089969A/en

1977-07-13 Application filed by Syntex Inc filed Critical Syntex Inc

1978-01-15 Publication of SE7708141L publication Critical patent/SE7708141L/sv

1984-08-06 Publication of SE434643B publication Critical patent/SE434643B/sv

Links

125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003527 fibrinolytic agent Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
229940035363 muscle relaxants Drugs 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
FDDQRDMHICUGQC-UHFFFAOYSA-M pyrrole-1-carboxylate Chemical compound [O-]C(=O)N1C=CC=C1 FDDQRDMHICUGQC-UHFFFAOYSA-M 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

SE7708141A 1976-07-14 1977-07-13 Analogiforfarande for framstellning av 5-aroyl-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-1-karbonsyraderivat SE434643B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70490976A	1976-07-14	1976-07-14
US05/771,286 US4089969A (en)	1976-07-14	1977-02-23	5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number	Publication Date
SE7708141L true SE7708141L (sv)	1978-01-15
SE434643B SE434643B (sv)	1984-08-06

Family

ID=27107410

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7708141A SE434643B (sv)	1976-07-14	1977-07-13	Analogiforfarande for framstellning av 5-aroyl-1,2-dihydro-3h-pyrrolo(1,2-a)-pyrrol-1-karbonsyraderivat

Country Status (27)

Country	Link
JP (1)	JPS539788A (sv)
AR (1)	AR224997A1 (sv)
CA (1)	CA1102809A (sv)
CH (3)	CH641458A5 (sv)
CS (1)	CS204954B2 (sv)
DE (2)	DE2760330C2 (sv)
DK (1)	DK151886C (sv)
ES (2)	ES460706A1 (sv)
FI (1)	FI63406C (sv)
FR (2)	FR2358406A1 (sv)
GB (1)	GB1554075A (sv)
GR (1)	GR61111B (sv)
HK (1)	HK15981A (sv)
HU (1)	HU174224B (sv)
IE (1)	IE45253B1 (sv)
IL (2)	IL52493A (sv)
IT (1)	IT1117313B (sv)
MX (1)	MX163202B (sv)
MY (1)	MY8100357A (sv)
NL (2)	NL186318C (sv)
NO (1)	NO147564C (sv)
NZ (1)	NZ184610A (sv)
PL (4)	PL124444B1 (sv)
PT (1)	PT66780B (sv)
SE (1)	SE434643B (sv)
SU (1)	SU695558A3 (sv)
YU (1)	YU40816B (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4140698A (en) *	1977-07-25	1979-02-20	Syntex (Usa) Inc.	1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
JPS55124633A (en) *	1979-03-19	1980-09-25	Sohachi Takeuchi	Manufacturing method of tubular vessel
US4344943A (en) *	1980-06-09	1982-08-17	Syntex (U.S.A.) Inc.	6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) *	1980-11-21	1982-10-12	Syntex (U.S.A.) Inc.	Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) *	1982-06-10	1985-04-16	Merck & Co., Inc.	5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) *	1982-06-10	1984-01-20	メルク　エンド　カムパニー　インコーポレーテツド	抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
US4874871A (en) *	1987-03-25	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JPH0739418B2 (ja) *	1987-09-10	1995-05-01	久光製薬株式会社	新規な３−アロイル−６，７−ジヒドロ−５Ｈ−ピロロ〔１，２−ｃ〕イミダゾール−７−カルボン酸誘導体
JP2649168B2 (ja) *	1988-02-25	1997-09-03	久光製薬株式会社	新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
IT1250691B (it) *	1991-07-22	1995-04-21	Giancarlo Santus	Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
EP0612521B1 (en) *	1991-11-11	1999-06-30	Hisamitsu Pharmaceutical Co., Inc.	Fomentation containing ketorolac
DE4300697C1 (de) *	1993-01-13	1994-05-19	Roemmers Sa	Keterolac-Derivat mit wesentlich geringerer gastrointestinaler Reizung und Ulzeration
US5622948A (en) *	1994-12-01	1997-04-22	Syntex (U.S.A.) Inc.	Pyrrole pyridazine and pyridazinone anti-inflammatory agents
JP2008210666A (ja) *	2007-02-27	2008-09-11	Okamura Corp	商品陳列棚における照明装置
CA3202461A1 (en) *	2020-12-16	2022-06-23	Robert T. Streeper	Dicarboxylic acid esters for inducing an analgesic effect

1977
- 1977-05-17 JP JP5697777A patent/JPS539788A/ja active Granted
- 1977-07-07 DK DK307577A patent/DK151886C/da active
- 1977-07-07 AR AR268356A patent/AR224997A1/es active
- 1977-07-07 GR GR53907A patent/GR61111B/el unknown
- 1977-07-08 IL IL52493A patent/IL52493A/xx unknown
- 1977-07-08 PT PT66780A patent/PT66780B/pt unknown
- 1977-07-08 CH CH850077A patent/CH641458A5/de not_active IP Right Cessation
- 1977-07-08 NL NLAANVRAGE7707651,A patent/NL186318C/xx not_active IP Right Cessation
- 1977-07-08 IE IE1423/77A patent/IE45253B1/en not_active IP Right Cessation
- 1977-07-11 GB GB28919/77A patent/GB1554075A/en not_active Expired
- 1977-07-11 YU YU1721/77A patent/YU40816B/xx unknown
- 1977-07-11 FR FR7721356A patent/FR2358406A1/fr active Granted
- 1977-07-11 FI FI772153A patent/FI63406C/fi not_active IP Right Cessation
- 1977-07-11 NZ NZ184610A patent/NZ184610A/xx unknown
- 1977-07-12 CA CA282,599A patent/CA1102809A/en not_active Expired
- 1977-07-12 CS CS774646A patent/CS204954B2/cs unknown
- 1977-07-13 ES ES460706A patent/ES460706A1/es not_active Expired
- 1977-07-13 DE DE2760330A patent/DE2760330C2/de not_active Expired
- 1977-07-13 PL PL1977227290A patent/PL124444B1/pl unknown
- 1977-07-13 SU SU772501050A patent/SU695558A3/ru active
- 1977-07-13 DE DE19772731678 patent/DE2731678A1/de active Granted
- 1977-07-13 SE SE7708141A patent/SE434643B/sv not_active IP Right Cessation
- 1977-07-13 IT IT68630/77A patent/IT1117313B/it active Protection Beyond IP Right Term
- 1977-07-13 PL PL1977199603A patent/PL109390B1/pl unknown
- 1977-07-13 PL PL1977227291A patent/PL124445B1/pl unknown
- 1977-07-13 PL PL1977227289A patent/PL124711B1/pl unknown
- 1977-07-13 NO NO772494A patent/NO147564C/no unknown
- 1977-07-14 HU HU77SI1582A patent/HU174224B/hu unknown
- 1977-12-20 FR FR7738508A patent/FR2375234A1/fr active Granted
1978
- 1978-05-24 ES ES470214A patent/ES470214A1/es not_active Expired
1979
- 1979-11-22 IL IL58779A patent/IL58779A0/xx unknown
1981
- 1981-04-23 HK HK159/81A patent/HK15981A/en unknown
- 1981-12-30 MY MY357/81A patent/MY8100357A/xx unknown
1984
- 1984-02-22 CH CH86584A patent/CH646972A5/de not_active IP Right Cessation
- 1984-02-22 CH CH86684A patent/CH646973A5/de not_active IP Right Cessation
1991
- 1991-07-05 MX MX9100104A patent/MX163202B/es unknown
1993
- 1993-03-23 NL NL930021C patent/NL930021I2/nl unknown

Also Published As

Publication number	Publication date
NL930021I2 (nl)	1997-03-03
SE434643B (sv)	1984-08-06
SU695558A3 (ru)	1979-10-30
NL186318C (nl)	1990-11-01
IT1117313B (it)	1986-02-17
CA1102809A (en)	1981-06-09
FR2358406B1 (sv)	1981-04-17
FR2375234A1 (fr)	1978-07-21
GB1554075A (en)	1979-10-17
FI63406B (fi)	1983-02-28
NZ184610A (en)	1979-03-28
NO147564B (no)	1983-01-24
NL930021I1 (nl)	1993-05-03
AU2697577A (en)	1979-01-18
FI772153A7 (sv)	1978-01-15
IE45253L (en)	1978-01-14
DE2731678C2 (sv)	1989-06-08
FR2358406A1 (fr)	1978-02-10
PL199603A1 (pl)	1978-04-24
FR2375234B1 (sv)	1980-11-07
MX163202B (es)	1992-02-20
MY8100357A (en)	1981-12-31
NO772494L (no)	1978-01-17
DK307577A (da)	1978-01-15
JPS6254109B2 (sv)	1987-11-13
ES460706A1 (es)	1978-12-01
NL186318B (nl)	1990-06-01
YU172177A (en)	1983-09-30
PT66780A (fr)	1977-08-01
PL124711B1 (en)	1983-02-28
NL7707651A (nl)	1978-01-17
HK15981A (en)	1981-05-01
DE2760330C2 (sv)	1989-06-15
CS204954B2 (en)	1981-04-30
IL58779A0 (en)	1980-02-29
PL124444B1 (en)	1983-01-31
AU513384B2 (en)	1980-11-27
DK151886C (da)	1988-06-06
YU40816B (en)	1986-06-30
NO147564C (no)	1983-05-18
DK151886B (da)	1988-01-11
DE2731678A1 (de)	1978-03-16
CH646972A5 (en)	1984-12-28
CH641458A5 (en)	1984-02-29
IL52493A (en)	1982-02-28
HU174224B (hu)	1979-11-28
ES470214A1 (es)	1979-09-16
CH646973A5 (en)	1984-12-28
PT66780B (fr)	1978-12-18
PL109390B1 (en)	1980-05-31
IE45253B1 (en)	1982-07-14
FI63406C (fi)	1983-06-10
IL52493A0 (en)	1977-10-31
GR61111B (en)	1978-09-12
PL124445B1 (en)	1983-01-31
AR224997A1 (es)	1982-02-15
JPS539788A (en)	1978-01-28

Legal Events

Date	Code	Title	Description
1994-06-06	SPCF	Application for supplementary protection certificate filed	Free format text: 7708141
1995-01-31	NAL	Patent in force	Ref document number: 7708141-2 Format of ref document f/p: F
1996-02-19	SPCG	Supplementary protection certificate granted	Free format text: 9490084, 900629, EXPIRES: 20020713
1997-10-06	NUG	Patent has lapsed	Ref document number: 7708141-2 Format of ref document f/p: F

Publication	Publication Date	Title
SE7708141L (sv)	1978-01-15	5-aroyl-1,2-dihydro-3h-pyrrolo (1,2-a) pyrrol-1-karbonsyraderivat och sett att framstella desamma
ES475677A1 (es)	1979-04-16	Procedimiento para la preparacion de nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamido-1,1-dioxidos.
ES8203845A1 (es)	1982-04-01	Procedimiento para preparar derivados de piridoxina
SE8301635D0 (sv)	1983-03-24	Sett att framstella cyklopropankarbonsyror med cis-struktur
ES465225A1 (es)	1978-09-16	Procedimiento para la preparacion de n-cicloalcohilmetil-2- fenilamino-imidazolinas-(2).
SE7811455L (sv)	1979-07-02	2-imino-imidazolidin-derivat
GB2018750A (en)	1979-10-24	Methyltetrahalobenzylacrylates and methacrylates, and polymers and plastics compositions based thereon
ATE29721T1 (de)	1987-10-15	5-(4-vinyl- oder 4-ethynylbenzoyl)-1,2-dihydro-3h-pyrrolo-(1,2-a -pyrrol-1-carbosaeure und deren derivate.
SE7705988L (sv)	1977-12-24	Sett att omvandla alletrolon
IE45302L (en)	1978-01-14	PYRROLO [1,2-a] PYRROLE DERIVATIVES
AU539870B2 (en)	1984-10-18	2-phenylamino-imidazolines-(2)
SE7701834L (sv)	1977-08-28	4-hydroxi-2-kinolinon-3-karboxylsyraestrar
AU519287B2 (en)	1981-11-19	Imidazo(1,2-alpha) imidazole derivatives
SE8002545L (sv)	1980-10-08	Arylsubstituerade furaner och sett for framstellning derav
ES474918A1 (es)	1979-10-16	Procedimiento para la preparacion de esteres 3-fenoxi-a-vi- nilbencilicos de acido vinilciclopropancarboxilico
AU535927B2 (en)	1984-04-12	2-phenylamino-imidazolines
IL72681A (en)	1988-02-29	4-alkyl-5-haloimidazole-1-carboxylic acid esters and amides,their preparation and their use as nitrification inhibitors
SE7811478L (sv)	1980-05-08	Substituerade tiofener
AU538931B2 (en)	1984-09-06	(n-thenyl-2-methyl) amino-2-imidazoline
GR79010B (sv)	1984-10-02
IE780559L (en)	1978-10-06	Furoyl- and thenoyl-aryloxyalkyl carboxylic acid
DK452984D0 (da)	1984-09-21	Fremgangsmaade til fremstilling af quinolin-4-oner
SE8003476L (sv)	1980-11-10	Isokinolinderivat
SE7908939L (sv)	1980-06-13	Tricykliska kvevehaltiga foreningar
JPS53111030A (en)	1978-09-28	Novel phenylacetic acid derivatives