SE7714976L - ANTI-INFLAMMATORY STEROIDS - Google Patents

ANTI-INFLAMMATORY STEROIDS

Info

Publication number
SE7714976L
SE7714976L SE7714976A SE7714976A SE7714976L SE 7714976 L SE7714976 L SE 7714976L SE 7714976 A SE7714976 A SE 7714976A SE 7714976 A SE7714976 A SE 7714976A SE 7714976 L SE7714976 L SE 7714976L
Authority
SE
Sweden
Prior art keywords
formula
inflammatory steroids
novel compounds
esterifying
systemically
Prior art date
Application number
SE7714976A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE430607B (en
Inventor
A Meli
Col M Da
G Palladino
P Castelli
Original Assignee
Lark Spa
Menarini Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lark Spa, Menarini Sas filed Critical Lark Spa
Publication of SE7714976L publication Critical patent/SE7714976L/en
Publication of SE430607B publication Critical patent/SE430607B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

The novel compounds of the formula I, in which the substituents have the meaning indicated in Patent Claim 1, are prepared by esterifying a compound of the formula II with salicylic acid or acetylsalicylic acid. The novel compounds of the formula I exhibit a high level of antiinflammatory activity when administered topically and/or systemically. <IMAGE>
SE7714976A 1976-12-31 1977-12-30 ANALOGY PROCEDURE FOR PREPARING NEW 21-SALIEYL ACID ESTERS AND 21-ACETYLSALYYL ACID ESTERS FROM PREGNOMY SERIES SE430607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB54510/76A GB1593978A (en) 1976-12-31 1976-12-31 Anti-inflammatory steroids

Publications (2)

Publication Number Publication Date
SE7714976L true SE7714976L (en) 1978-07-02
SE430607B SE430607B (en) 1983-11-28

Family

ID=10471258

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7714976A SE430607B (en) 1976-12-31 1977-12-30 ANALOGY PROCEDURE FOR PREPARING NEW 21-SALIEYL ACID ESTERS AND 21-ACETYLSALYYL ACID ESTERS FROM PREGNOMY SERIES

Country Status (10)

Country Link
JP (1) JPS53144561A (en)
BE (1) BE862507A (en)
CH (1) CH633301A5 (en)
DK (1) DK155673C (en)
FI (1) FI63422C (en)
FR (1) FR2376160A1 (en)
GB (1) GB1593978A (en)
NL (1) NL7714482A (en)
NO (1) NO148491C (en)
SE (1) SE430607B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids

Also Published As

Publication number Publication date
GB1593978A (en) 1981-07-22
JPS53144561A (en) 1978-12-15
NL7714482A (en) 1978-07-04
DK155673B (en) 1989-05-01
FR2376160B1 (en) 1980-11-14
BE862507A (en) 1978-04-14
CH633301A5 (en) 1982-11-30
NO774525L (en) 1978-07-03
FI63422B (en) 1983-02-28
DK155673C (en) 1989-09-04
FI773929A7 (en) 1978-07-01
JPS6220197B2 (en) 1987-05-06
DK581677A (en) 1978-07-01
FI63422C (en) 1983-06-10
FR2376160A1 (en) 1978-07-28
SE430607B (en) 1983-11-28
NO148491C (en) 1983-10-19
NO148491B (en) 1983-07-11

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