SE7905940L - NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- SE7905940L SE7905940L SE7905940A SE7905940A SE7905940L SE 7905940 L SE7905940 L SE 7905940L SE 7905940 A SE7905940 A SE 7905940A SE 7905940 A SE7905940 A SE 7905940A SE 7905940 L SE7905940 L SE 7905940L
- Authority
- SE
- Sweden
- Prior art keywords
- carbon atoms
- radical
- general formula
- image
- radical containing
- Prior art date
Links
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 alkyl radical Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- QSLPNSWXUQHVLP-UHFFFAOYSA-N $l^{1}-sulfanylmethane Chemical compound [S]C QSLPNSWXUQHVLP-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
Daunorubicin derivatives of the general formula: <IMAGE> (wherein R1 represents a group of the general formula: <IMAGE> in which (i) X1 and X2 both represent oxygen atoms or both represent sulphur atoms and the symbols R3 each represent a straight- or branched-chain alkyl radical containing 1 to 4 carbon atoms, a phenyl radical or a phenyl radical substituted in the para-position by a methyl, methoxy or methylthio radical, or together form an alkylene radical containing 2 to 4 carbon atoms, or (ii) one of X1 and X2 represents an oxygen atom and the other represents a sulphur atom and the symbols R3 together form an alkylene radical containing 2 to 4 carbon atoms; and R2 represents a group of the general formula: <IMAGE> wherein R4 represents a hydrogen atom, a straight- or branched-chain alkyl radical containing 1 to 4 carbon atoms, or a phenyl or benzyl radical), are new therapeutically useful compounds possessing antitumoral properties and can be incorporated into pharmaceutical compositions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7820306A FR2430425A1 (en) | 1978-07-07 | 1978-07-07 | NOVEL DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7905940L true SE7905940L (en) | 1980-01-08 |
Family
ID=9210459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7905940A SE7905940L (en) | 1978-07-07 | 1979-07-06 | NEW DERIVATIVES OF DAUNORUBICIN, PREPARATION OF THESE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5511593A (en) |
| BE (1) | BE877555A (en) |
| CA (1) | CA1118414A (en) |
| CH (1) | CH641190A5 (en) |
| DE (1) | DE2927452A1 (en) |
| FR (1) | FR2430425A1 (en) |
| GB (1) | GB2032420B (en) |
| IT (1) | IT1122046B (en) |
| NL (1) | NL7905098A (en) |
| SE (1) | SE7905940L (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296105A (en) * | 1978-08-03 | 1981-10-20 | Institut International De Pathologie Cellulaire Et Moleculaire | Derivatives of doxorubicine, their preparation and use |
| US5124317A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.P.A. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
| US5977082A (en) * | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
| JP2549726Y2 (en) * | 1991-04-16 | 1997-09-30 | 良忠 越原 | Construction lift |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL170737C (en) * | 1975-11-12 | 1982-12-16 | Rhone Poulenc Ind | PROCESS FOR PREPARING ESTERS OF ADRIAMYCIN AGAINST TUMORS, AND PREPARING MEDICINES WITH ANTI-TUMOR ACTIVITY. |
-
1978
- 1978-07-07 FR FR7820306A patent/FR2430425A1/en active Granted
-
1979
- 1979-06-29 NL NL7905098A patent/NL7905098A/en not_active Application Discontinuation
- 1979-07-04 GB GB7923301A patent/GB2032420B/en not_active Expired
- 1979-07-05 JP JP8449379A patent/JPS5511593A/en active Pending
- 1979-07-06 SE SE7905940A patent/SE7905940L/en not_active Application Discontinuation
- 1979-07-06 BE BE0/196193A patent/BE877555A/en not_active IP Right Cessation
- 1979-07-06 CA CA000331335A patent/CA1118414A/en not_active Expired
- 1979-07-06 DE DE19792927452 patent/DE2927452A1/en not_active Withdrawn
- 1979-07-06 CH CH635679A patent/CH641190A5/en not_active IP Right Cessation
- 1979-07-06 IT IT24158/79A patent/IT1122046B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| FR2430425A1 (en) | 1980-02-01 |
| GB2032420A (en) | 1980-05-08 |
| GB2032420B (en) | 1982-08-11 |
| DE2927452A1 (en) | 1980-01-17 |
| CA1118414A (en) | 1982-02-16 |
| BE877555A (en) | 1980-01-07 |
| FR2430425B1 (en) | 1980-11-07 |
| IT1122046B (en) | 1986-04-23 |
| NL7905098A (en) | 1980-01-09 |
| CH641190A5 (en) | 1984-02-15 |
| IT7924158A0 (en) | 1979-07-06 |
| JPS5511593A (en) | 1980-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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