SE7908285L - Forbettringar vid eller med avseende pa framstellning av halvsyntetiska penicillinantibiotika - Google Patents

Forbettringar vid eller med avseende pa framstellning av halvsyntetiska penicillinantibiotika

Info

Publication number: SE7908285L
Authority: SE; Sweden
Prior art keywords: tri; 6alkyl; apa; acyl chloride; preparation
Prior art date: 1978-10-06

Application number

SE7908285A

Other languages

English (en)

Swedish (sv)

Inventor

M Croci

G Maruzzelli

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-10-06

Filing date

1979-10-05

Publication date

1980-05-22

1979-10-05 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1980-05-22 Publication of SE7908285L publication Critical patent/SE7908285L/xx

Links

238000002360 preparation method Methods 0.000 title abstract 3
229930182555 Penicillin Natural products 0.000 title abstract 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title abstract 2
239000003242 anti bacterial agent Substances 0.000 title abstract 2
229940088710 antibiotic agent Drugs 0.000 title abstract 2
229940049954 penicillin Drugs 0.000 title abstract 2
NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 5
NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 5
150000001263 acyl chlorides Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
230000003115 biocidal effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
IYMSIPPWHNIMGE-UHFFFAOYSA-N silylurea Chemical compound NC(=O)N[SiH3] IYMSIPPWHNIMGE-UHFFFAOYSA-N 0.000 abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
229960003022 amoxicillin Drugs 0.000 abstract 1
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 abstract 1
229960000723 ampicillin Drugs 0.000 abstract 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910000039 hydrogen halide Inorganic materials 0.000 abstract 1
239000012433 hydrogen halide Substances 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 abstract 1
238000006884 silylation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/10—Modification of an amino radical directly attached in position 6
- C07D499/12—Acylation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)

SE7908285A 1978-10-06 1979-10-05 Forbettringar vid eller med avseende pa framstellning av halvsyntetiska penicillinantibiotika SE7908285L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7839599		1978-10-06

Publications (1)

Publication Number	Publication Date
SE7908285L true SE7908285L (sv)	1980-05-22

Family

ID=10500170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7908285A SE7908285L (sv)	1978-10-06	1979-10-05	Forbettringar vid eller med avseende pa framstellning av halvsyntetiska penicillinantibiotika

Country Status (16)

Country	Link
US (1)	US4272438A (de)
JP (1)	JPS5551090A (de)
KR (1)	KR830001290A (de)
AT (1)	AT364848B (de)
AU (1)	AU526766B2 (de)
BE (1)	BE879221A (de)
CH (1)	CH646435A5 (de)
DE (1)	DE2940489A1 (de)
DK (1)	DK417979A (de)
ES (1)	ES484763A1 (de)
FR (1)	FR2438049A1 (de)
IT (1)	IT1162681B (de)
NL (1)	NL7907414A (de)
SE (1)	SE7908285L (de)
YU (1)	YU242379A (de)
ZA (1)	ZA795330B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5073844A (en) *	1991-01-11	1991-12-17	The Annlouise Partnership	Lighted baggage piece
CN102702227A (zh) *	2012-06-12	2012-10-03	河北华日药业有限公司	一种氟氯西林钠的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4182709A (en) *	1976-01-15	1980-01-08	Glaxo Group Limited	Manufacture of semi-synthetic penicillin antibiotics
US4181656A (en) *	1976-01-15	1980-01-01	Glaxo Group Limited	Manufacture of semi-synthetic penicillin antibiotics

1979
- 1979-09-28 US US06/079,939 patent/US4272438A/en not_active Expired - Lifetime
- 1979-10-04 KR KR1019790003421A patent/KR830001290A/ko not_active Ceased
- 1979-10-04 YU YU02423/79A patent/YU242379A/xx unknown
- 1979-10-05 NL NL7907414A patent/NL7907414A/nl not_active Application Discontinuation
- 1979-10-05 AT AT0653079A patent/AT364848B/de not_active IP Right Cessation
- 1979-10-05 ZA ZA00795330A patent/ZA795330B/xx unknown
- 1979-10-05 BE BE197487A patent/BE879221A/fr unknown
- 1979-10-05 ES ES484763A patent/ES484763A1/es not_active Expired
- 1979-10-05 JP JP12807179A patent/JPS5551090A/ja active Pending
- 1979-10-05 CH CH900379A patent/CH646435A5/de not_active IP Right Cessation
- 1979-10-05 AU AU51508/79A patent/AU526766B2/en not_active Ceased
- 1979-10-05 SE SE7908285A patent/SE7908285L/xx not_active Application Discontinuation
- 1979-10-05 FR FR7924825A patent/FR2438049A1/fr active Granted
- 1979-10-05 DE DE19792940489 patent/DE2940489A1/de not_active Withdrawn
- 1979-10-05 DK DK417979A patent/DK417979A/da not_active Application Discontinuation
- 1979-10-05 IT IT50468/79A patent/IT1162681B/it active

Also Published As

Publication number	Publication date
JPS5551090A (en)	1980-04-14
YU242379A (en)	1982-10-31
DE2940489A1 (de)	1980-04-24
FR2438049B1 (de)	1982-10-22
FR2438049A1 (fr)	1980-04-30
IT1162681B (it)	1987-04-01
US4272438A (en)	1981-06-09
AU526766B2 (en)	1983-01-27
ATA653079A (de)	1981-04-15
AU5150879A (en)	1980-04-17
ES484763A1 (es)	1980-06-16
IT7950468A0 (it)	1979-10-05
ZA795330B (en)	1980-11-26
AT364848B (de)	1981-11-25
KR830001290A (ko)	1983-04-30
NL7907414A (nl)	1980-04-09
BE879221A (fr)	1980-04-08
CH646435A5 (de)	1984-11-30
DK417979A (da)	1980-04-07

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Legal Events

Date

Code

Title

Description

1995-02-28

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