SE8002600L - Forfarande for framstellning av beta-laktamasinhibitorer - Google Patents

Forfarande for framstellning av beta-laktamasinhibitorer

Info

Publication number: SE8002600L
Authority: SE; Sweden
Prior art keywords: beta; lower alkyl; preparation; lactama; inhibitors
Prior art date: 1979-04-06

Application number

SE8002600A

Other languages

English (en)

Swedish (sv)

Inventor

P Lombardi

G Franceschi

F Arcamone

Original Assignee

Erba Farmitalia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-04-06

Filing date

1980-04-03

Publication date

1980-10-07

1980-04-03 Application filed by Erba Farmitalia filed Critical Erba Farmitalia

1980-10-07 Publication of SE8002600L publication Critical patent/SE8002600L/xx

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
-1 acetoxymethyl Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
OEYMQQDJCUHKQS-UHFFFAOYSA-N (4-oxoazetidin-2-yl) acetate Chemical compound CC(=O)OC1CC(=O)N1 OEYMQQDJCUHKQS-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 abstract 1
229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
125000005633 phthalidyl group Chemical group 0.000 abstract 1
125000006000 trichloroethyl group Chemical group 0.000 abstract 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SE8002600A 1979-04-06 1980-04-03 Forfarande for framstellning av beta-laktamasinhibitorer SE8002600L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7912168		1979-04-06

Publications (1)

Publication Number	Publication Date
SE8002600L true SE8002600L (sv)	1980-10-07

Family

ID=10504396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8002600A SE8002600L (sv)	1979-04-06	1980-04-03	Forfarande for framstellning av beta-laktamasinhibitorer

Country Status (24)

Country	Link
US (1)	US4269771A (de)
JP (1)	JPS55139385A (de)
AT (1)	AT369371B (de)
AU (1)	AU536673B2 (de)
BE (1)	BE882621A (de)
CA (1)	CA1148143A (de)
CH (1)	CH645645A5 (de)
CS (1)	CS219273B2 (de)
DE (1)	DE3012975A1 (de)
DK (1)	DK144180A (de)
FI (1)	FI801080A7 (de)
FR (1)	FR2453162A1 (de)
GB (1)	GB2048857B (de)
GR (1)	GR66673B (de)
HU (1)	HU182118B (de)
IE (1)	IE49656B1 (de)
IL (1)	IL59760A (de)
IT (1)	IT1196407B (de)
LU (1)	LU82320A1 (de)
NL (1)	NL8001919A (de)
SE (1)	SE8002600L (de)
SU (1)	SU1152524A3 (de)
YU (1)	YU93880A (de)
ZA (1)	ZA802000B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4500457A (en) *	1977-05-09	1985-02-19	Ciba-Geigy Corporation	Process for preparing thia-aza compounds with a beta-lactam ring
AT365594B (de) *	1978-11-24	1982-01-25	Erba Farmitalia	Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
JPS5625110A (en) *	1978-12-18	1981-03-10	Bristol Myers Co	Antibacterial
US4347183A (en) *	1981-02-02	1982-08-31	Schering Corporation	Process for the synthesis of penems and carbapenems
US4508649A (en) *	1981-12-11	1985-04-02	Farmitalia Carlo Erba	Process for preparing optically active penems
NO831160L (no) *	1982-04-08	1983-10-10	Erba Farmitalia	Fremstilling av substituerte penem-derivater
GB8321677D0 (en) *	1983-08-11	1983-09-14	Erba Farmitalia	Preparation of penems
US6720445B2 (en) *	2000-12-21	2004-04-13	Beacon Laboratories, Inc.	Acetyloxymethyl esters and methods for using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3905965A (en) *	1969-10-17	1975-09-16	Roussel Uclaf	Process of total synthesis of cephalosporin derivatives and intermediates
US4053468A (en) *	1976-02-25	1977-10-11	Smithkline Corporation	Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
LU77306A1 (de)	1977-05-09	1979-01-18
AU3796278A (en) *	1977-07-13	1980-01-17	Glaxo Group Ltd	Penams and azetidinones
US4168314A (en) *	1977-11-17	1979-09-18	Merck & Co., Inc.	6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
US4155912A (en) *	1977-12-14	1979-05-22	Bristol-Myers Company	2-Methylpenem-3-carboxylic acid antibiotics
JPS54117459A (en) *	1978-01-20	1979-09-12	Glaxo Group Ltd	Novel lactam compound
GB2014574A (en) *	1978-02-16	1979-08-30	Glaxo Group Ltd	Lactam Compounds
JPS5559193A (en) *	1978-09-20	1980-05-02	Glaxo Group Ltd	Bblactam compound

1979
- 1979-11-13 US US06/093,603 patent/US4269771A/en not_active Expired - Lifetime
1980
- 1980-04-01 AU AU57015/80A patent/AU536673B2/en not_active Ceased
- 1980-04-01 GB GB8010920A patent/GB2048857B/en not_active Expired
- 1980-04-01 NL NL8001919A patent/NL8001919A/nl not_active Application Discontinuation
- 1980-04-01 IT IT21099/80A patent/IT1196407B/it active
- 1980-04-01 LU LU82320A patent/LU82320A1/fr unknown
- 1980-04-01 AT AT0177480A patent/AT369371B/de not_active IP Right Cessation
- 1980-04-02 JP JP4403280A patent/JPS55139385A/ja active Pending
- 1980-04-02 CH CH261580A patent/CH645645A5/de not_active IP Right Cessation
- 1980-04-02 CS CS802289A patent/CS219273B2/cs unknown
- 1980-04-02 IE IE668/80A patent/IE49656B1/en unknown
- 1980-04-02 GR GR61611A patent/GR66673B/el unknown
- 1980-04-02 DE DE19803012975 patent/DE3012975A1/de not_active Withdrawn
- 1980-04-02 DK DK144180A patent/DK144180A/da not_active Application Discontinuation
- 1980-04-02 CA CA000349137A patent/CA1148143A/en not_active Expired
- 1980-04-03 FI FI801080A patent/FI801080A7/fi not_active Application Discontinuation
- 1980-04-03 SE SE8002600A patent/SE8002600L/xx not_active Application Discontinuation
- 1980-04-03 ZA ZA00802000A patent/ZA802000B/xx unknown
- 1980-04-03 IL IL59760A patent/IL59760A/xx unknown
- 1980-04-03 BE BE0/200106A patent/BE882621A/fr not_active IP Right Cessation
- 1980-04-03 HU HU80810A patent/HU182118B/hu unknown
- 1980-04-04 SU SU802903400A patent/SU1152524A3/ru active
- 1980-04-04 FR FR8007730A patent/FR2453162A1/fr active Pending
- 1980-04-04 YU YU00938/80A patent/YU93880A/xx unknown

Also Published As

Publication number	Publication date
YU93880A (en)	1983-02-28
AU5701580A (en)	1980-10-09
IE49656B1 (en)	1985-11-13
US4269771A (en)	1981-05-26
IT8021099A0 (it)	1980-04-01
CA1148143A (en)	1983-06-14
GR66673B (de)	1981-04-08
CS219273B2 (en)	1983-03-25
GB2048857B (en)	1983-05-25
GB2048857A (en)	1980-12-17
LU82320A1 (fr)	1980-07-02
CH645645A5 (de)	1984-10-15
BE882621A (fr)	1980-10-03
FR2453162A1 (fr)	1980-10-31
NL8001919A (nl)	1980-10-08
IE800668L (en)	1980-10-06
ZA802000B (en)	1981-04-29
ATA177480A (de)	1982-05-15
IL59760A0 (en)	1980-06-30
DK144180A (da)	1980-10-07
HU182118B (en)	1983-12-28
FI801080A7 (fi)	1981-01-01
DE3012975A1 (de)	1980-10-23
SU1152524A3 (en)	1985-04-23
IL59760A (en)	1983-07-31
IT1196407B (it)	1988-11-16
JPS55139385A (en)	1980-10-31
AT369371B (de)	1982-12-27
AU536673B2 (en)	1984-05-17

Legal Events

Date	Code	Title	Description
1995-02-28	NAV	Patent application has lapsed	Ref document number: 8002600-8

Publication	Publication Date	Title
SE7909667L (sv)	1980-05-25	7-oxo-4-tia-1-aza-bicyklo(3,2,0)-heptanderivat och forfarande for framstellning derav
IE800668L (en)	1980-10-06	2-substituted penems and penams
JPS55145687A (en)	1980-11-13	Pyridoindoles and their manufacture
ES445348A1 (es)	1977-10-16	Un procedimiento para preparar compuestos de 3-aciloximetil-cefem.
NO155621C (no)	1987-04-29	Fremgangsmaate for fremstilling av benzotiazin-karboksamider.
IE781325L (en)	1979-01-05	Azetidinones.
BR7907605A (pt)	1980-08-05	Pramidas de acido fenoxi-fenoxi-propionico processo para sua producao agentes herbicidas e aplicacao dos ditos compostos
HUT49453A (en)	1989-10-30	Herbicides containing as active substance derivatives of n-phenil-tetrahydroftalimid and process for production of the active substance
GB1420896A (en)	1976-01-14	Production of 2,5-disubstituted benzamides
DE3577435D1 (de)	1990-06-07	Pyrrolizidinverbindungen, methode zu deren herstellung und anwendung.
BG50501A3 (bg)	1992-08-14	Метод за получаване на 1,5-бензтиазепинови производни
GB1364088A (en)	1974-08-21	3-substituted-thio-methyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
ATE2745T1 (de)	1983-03-15	Verfahren zur herstellung von 5-(2,2,-
JPS54115365A (en)	1979-09-07	Preparation of optically active beta-lactam
ES457510A1 (es)	1978-03-16	Procedimiento para preparar un acido 7-(acetamido alfa,alfa disustituido)-3-sustituido-3-cefem-4-carboxilico.