SE8004934L - 5-(-pyridinyl)-2(lh)-pyridioner, anvendbara sasom kardiotoniska medel, samt framstellning derav - Google Patents
5-(-pyridinyl)-2(lh)-pyridioner, anvendbara sasom kardiotoniska medel, samt framstellning deravInfo
- Publication number
- SE8004934L SE8004934L SE8004934A SE8004934A SE8004934L SE 8004934 L SE8004934 L SE 8004934L SE 8004934 A SE8004934 A SE 8004934A SE 8004934 A SE8004934 A SE 8004934A SE 8004934 L SE8004934 L SE 8004934L
- Authority
- SE
- Sweden
- Prior art keywords
- pyridinyl
- pyridinone
- hydroxymethyl
- hydroxy
- pyridions
- Prior art date
Links
- 239000000496 cardiotonic agent Substances 0.000 title abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 230000000747 cardiac effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- GRKBYHVDMXGSHY-UHFFFAOYSA-N 3-(hydroxymethyl)-5-pyridin-4-yl-1h-pyridin-2-one Chemical compound N1C(=O)C(CO)=CC(C=2C=CN=CC=2)=C1 GRKBYHVDMXGSHY-UHFFFAOYSA-N 0.000 abstract 1
- AAPQMQONUZNMAM-UHFFFAOYSA-N 3-hydroxy-5-pyridin-4-yl-1h-pyridin-2-one Chemical compound N1C(=O)C(O)=CC(C=2C=CN=CC=2)=C1 AAPQMQONUZNMAM-UHFFFAOYSA-N 0.000 abstract 1
- JLEJXZDPNYUTIR-UHFFFAOYSA-N 5-pyridin-4-yl-1h-pyridin-2-one Chemical compound N1C(=O)C=CC(C=2C=CN=CC=2)=C1 JLEJXZDPNYUTIR-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/073,885 US4225601A (en) | 1979-09-10 | 1979-09-10 | 3-Hydroxy or hydroxymethyl-5-(4-pyridinyl)2(1H)-pyridinones, useful as cardiotonic agents and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8004934L true SE8004934L (sv) | 1981-03-11 |
Family
ID=22116385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8004934A SE8004934L (sv) | 1979-09-10 | 1980-07-03 | 5-(-pyridinyl)-2(lh)-pyridioner, anvendbara sasom kardiotoniska medel, samt framstellning derav |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4225601A (fr) |
| JP (1) | JPS5668670A (fr) |
| KR (1) | KR830003470A (fr) |
| AR (1) | AR223716A1 (fr) |
| AU (1) | AU6003080A (fr) |
| BE (1) | BE884329A (fr) |
| DE (1) | DE3027901A1 (fr) |
| DK (1) | DK314180A (fr) |
| ES (1) | ES493583A0 (fr) |
| FI (1) | FI802298A7 (fr) |
| FR (1) | FR2465722A1 (fr) |
| GB (1) | GB2058751A (fr) |
| IL (1) | IL60360A0 (fr) |
| IT (1) | IT1132192B (fr) |
| LU (1) | LU82650A1 (fr) |
| NL (1) | NL8004126A (fr) |
| NO (1) | NO802138L (fr) |
| NZ (1) | NZ194106A (fr) |
| PT (1) | PT71427A (fr) |
| SE (1) | SE8004934L (fr) |
| ZA (1) | ZA803679B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4361569A (en) * | 1981-08-26 | 1982-11-30 | Sterling Drug Inc. | 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof |
| US4432979A (en) * | 1981-10-26 | 1984-02-21 | William H. Rorer, Inc. | Pyridone compounds |
| US4463008A (en) * | 1982-11-10 | 1984-07-31 | Sterling Drug Inc. | 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof |
| US6068581A (en) * | 1998-04-29 | 2000-05-30 | Timm Medical Technologies, Inc. | Method and apparatus for testing and exercising pelvic muscles |
| CN102933079B (zh) * | 2010-03-04 | 2016-02-17 | 默沙东公司 | 儿茶酚-o-甲基转移酶抑制剂及其在治疗精神障碍中的用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
-
1979
- 1979-09-10 US US06/073,885 patent/US4225601A/en not_active Expired - Lifetime
-
1980
- 1980-06-19 IL IL60360A patent/IL60360A0/xx unknown
- 1980-06-20 ZA ZA00803679A patent/ZA803679B/xx unknown
- 1980-06-20 NZ NZ194106A patent/NZ194106A/xx unknown
- 1980-06-20 PT PT71427A patent/PT71427A/pt unknown
- 1980-06-24 GB GB8020570A patent/GB2058751A/en not_active Withdrawn
- 1980-07-02 AU AU60030/80A patent/AU6003080A/en not_active Abandoned
- 1980-07-03 SE SE8004934A patent/SE8004934L/xx not_active Application Discontinuation
- 1980-07-10 KR KR1019800002751A patent/KR830003470A/ko not_active Ceased
- 1980-07-14 IT IT23422/80A patent/IT1132192B/it active
- 1980-07-16 FR FR8015702A patent/FR2465722A1/fr not_active Withdrawn
- 1980-07-16 NO NO802138A patent/NO802138L/no unknown
- 1980-07-16 BE BE1/9898A patent/BE884329A/fr unknown
- 1980-07-17 NL NL8004126A patent/NL8004126A/nl not_active Application Discontinuation
- 1980-07-21 FI FI802298A patent/FI802298A7/fi not_active Application Discontinuation
- 1980-07-22 DK DK314180A patent/DK314180A/da unknown
- 1980-07-22 ES ES493583A patent/ES493583A0/es active Granted
- 1980-07-23 DE DE19803027901 patent/DE3027901A1/de not_active Withdrawn
- 1980-07-23 AR AR281876A patent/AR223716A1/es active
- 1980-07-23 LU LU82650A patent/LU82650A1/fr unknown
- 1980-08-20 JP JP11463280A patent/JPS5668670A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL8004126A (nl) | 1981-03-12 |
| FR2465722A1 (fr) | 1981-03-27 |
| US4225601A (en) | 1980-09-30 |
| IT1132192B (it) | 1986-06-25 |
| IL60360A0 (en) | 1980-09-16 |
| NZ194106A (en) | 1982-03-30 |
| ES8106514A1 (es) | 1981-07-01 |
| IT8023422A0 (it) | 1980-07-14 |
| DE3027901A1 (de) | 1981-03-26 |
| KR830003470A (ko) | 1983-06-20 |
| DK314180A (da) | 1981-03-11 |
| NO802138L (no) | 1981-03-11 |
| JPS5668670A (en) | 1981-06-09 |
| GB2058751A (en) | 1981-04-15 |
| AU6003080A (en) | 1981-03-19 |
| ZA803679B (en) | 1981-06-24 |
| AR223716A1 (es) | 1981-09-15 |
| PT71427A (en) | 1980-07-01 |
| BE884329A (fr) | 1981-01-16 |
| FI802298A7 (fi) | 1981-01-01 |
| ES493583A0 (es) | 1981-07-01 |
| LU82650A1 (fr) | 1981-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8004934-9 |