SE8006413L - NEW CEPHALOSPORINES - Google Patents

NEW CEPHALOSPORINES

Info

Publication number
SE8006413L
SE8006413L SE8006413A SE8006413A SE8006413L SE 8006413 L SE8006413 L SE 8006413L SE 8006413 A SE8006413 A SE 8006413A SE 8006413 A SE8006413 A SE 8006413A SE 8006413 L SE8006413 L SE 8006413L
Authority
SE
Sweden
Prior art keywords
formula
cephalosporines
new
new cephalosporines
mercaptotetrazole
Prior art date
Application number
SE8006413A
Other languages
Swedish (sv)
Other versions
SE452621B (en
Inventor
D A Berges
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/704,142 external-priority patent/US4118491A/en
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of SE8006413L publication Critical patent/SE8006413L/en
Publication of SE452621B publication Critical patent/SE452621B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The cephalosporin derivatives of the formula I in which the symbols have the meanings stated in Claim 1 are antibiotics. They are prepared from the 7-acylaminocephalosporanic acid of the formula II by replacement of the acetoxy group by the appropriately substituted 5-mercaptotetrazole.

Claims (1)

1. PATENTKRAV I. Fdrening,hdrinetecknod or formeln: NH2 Picture or vdte eller en skyddonde estergrupp.1. A patent or formula: NH2 Picture or vdte or a protecting ester group.
SE8006413A 1975-10-30 1976-09-28 7-AMINO CEPHALOSPORINE DERIVATIVES FOR USE AS INTERMEDIATE PRODUCTS FOR THE PREPARATION OF SIMILAR 7-SUBSTITUTED CEPHALOSPORINE DERIVATIVES SE452621B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62716475A 1975-10-30 1975-10-30
US66583776A 1976-03-11 1976-03-11
US05/704,142 US4118491A (en) 1976-03-11 1976-07-12 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them

Publications (2)

Publication Number Publication Date
SE8006413L true SE8006413L (en) 1980-09-12
SE452621B SE452621B (en) 1987-12-07

Family

ID=27417417

Family Applications (3)

Application Number Title Priority Date Filing Date
SE8006413A SE452621B (en) 1975-10-30 1976-09-28 7-AMINO CEPHALOSPORINE DERIVATIVES FOR USE AS INTERMEDIATE PRODUCTS FOR THE PREPARATION OF SIMILAR 7-SUBSTITUTED CEPHALOSPORINE DERIVATIVES
SE7610722A SE435291B (en) 1975-10-30 1976-09-28 PROCEDURE FOR PREPARING 7-ACYLAMINO-3 (1- (2-SULFAMINOETHYL) -TETRAZOL-5-YLTIOMETHYL) -3-CEFEM-4-CARBONIC ACID
SE8006414A SE437025B (en) 1975-10-30 1980-09-12 1- (2-SULFAMINOETHYL) -TETRAZOL-5-THIOL USED FOR THE PREPARATION OF CEPHALOSPORINE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE7610722A SE435291B (en) 1975-10-30 1976-09-28 PROCEDURE FOR PREPARING 7-ACYLAMINO-3 (1- (2-SULFAMINOETHYL) -TETRAZOL-5-YLTIOMETHYL) -3-CEFEM-4-CARBONIC ACID
SE8006414A SE437025B (en) 1975-10-30 1980-09-12 1- (2-SULFAMINOETHYL) -TETRAZOL-5-THIOL USED FOR THE PREPARATION OF CEPHALOSPORINE COMPOUNDS WITH ANTIBACTERIAL ACTIVITY

Country Status (17)

Country Link
JP (1) JPS6053026B2 (en)
AT (1) AT353957B (en)
AU (1) AU505141B2 (en)
CA (1) CA1071188A (en)
CH (1) CH627757A5 (en)
DE (1) DE2649545A1 (en)
DK (1) DK463176A (en)
ES (1) ES452769A1 (en)
FI (1) FI60868C (en)
FR (3) FR2361896A1 (en)
GB (3) GB1570095A (en)
GR (1) GR61667B (en)
IE (1) IE44393B1 (en)
IL (3) IL50546A (en)
LU (1) LU76092A1 (en)
NL (1) NL7612010A (en)
SE (3) SE452621B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117123A (en) * 1977-06-09 1978-09-26 Smithkline Corporation 7-Acylamino-3-[1-(2-sulfamidoethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids
AT383811B (en) * 1983-09-22 1987-08-25 Biochemie Gmbh Process for the preparation of monoalkali metal salts of 7-amino-3-cephem-4-carboxylic acid derivatives
US4717531A (en) * 1983-09-23 1988-01-05 Westinghouse Electric Corp. Fuel transfer system upender using translation drive

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207752A1 (en) * 1973-03-30 1976-10-29 Fujisawa Pharmaceutical Co PROCEDURE FOR OBTAINING 7-AMINO-SUBSTITUTED-3-THIOMETHYL SUBSTITUTED-3-CEFEM-4-CARBOXYL ACIDS
NL7414119A (en) * 1973-10-31 1975-05-02 Fujisawa Pharmaceutical Co PROCESS FOR PREPARING 1H-TETRAZOL-5-THIOL DERIVATIVES AND 1-SUBSTITUATED 1H-TETRAZOL-5-THIOLS.
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
US4066762A (en) * 1976-07-12 1978-01-03 Smithkline Corporation Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid

Also Published As

Publication number Publication date
FI60868B (en) 1981-12-31
AT353957B (en) 1979-12-10
FR2351982A1 (en) 1977-12-16
CA1071188A (en) 1980-02-05
GB1570093A (en) 1980-06-25
JPS5257191A (en) 1977-05-11
ES452769A1 (en) 1978-01-16
FR2337720B1 (en) 1981-07-10
FR2361896B1 (en) 1979-02-23
IE44393B1 (en) 1981-11-18
AU1870276A (en) 1978-04-20
DE2649545A1 (en) 1977-05-12
FR2351982B1 (en) 1981-07-03
SE7610722L (en) 1977-05-01
DK463176A (en) 1977-05-01
FR2361896A1 (en) 1978-03-17
JPS6053026B2 (en) 1985-11-22
IE44393L (en) 1977-09-11
CH627757A5 (en) 1982-01-29
FI60868C (en) 1982-04-13
SE8006414L (en) 1980-09-12
IL56757A0 (en) 1979-05-31
IL56758A0 (en) 1979-05-31
NL7612010A (en) 1977-05-03
LU76092A1 (en) 1977-05-17
AU505141B2 (en) 1979-11-08
GB1570094A (en) 1980-06-25
GB1570095A (en) 1980-06-25
FI763044A7 (en) 1977-05-01
GR61667B (en) 1978-12-05
SE437025B (en) 1985-02-04
SE452621B (en) 1987-12-07
FR2337720A1 (en) 1977-08-05
IL50546A0 (en) 1976-11-30
ATA807276A (en) 1979-05-15
SE435291B (en) 1984-09-17
IL50546A (en) 1980-07-31

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