SE8103106L - Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindiner - Google Patents
Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindinerInfo
- Publication number
- SE8103106L SE8103106L SE8103106A SE8103106A SE8103106L SE 8103106 L SE8103106 L SE 8103106L SE 8103106 A SE8103106 A SE 8103106A SE 8103106 A SE8103106 A SE 8103106A SE 8103106 L SE8103106 L SE 8103106L
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- pyrindines
- octahydro
- aryl
- procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Claims (1)
1. Patentkrav FOrfarande for :Crams-tanning av en cis-forening med den allmNn- na formeln: dar Ri ocn R2 bar de ovan angivna betydelsei7na, omsattes med era reduktionsmedel; vdrefter eventuellt, nNr 02 betecknar C1-03-alkoxi, den erhAllna foreningen avetras till bildLing av en fOrening med formeln I, dal, R2 betecknar hydroxf_. (I) dar IO. betecknar 01-C8-alkyl elder bensyl; och dar R2 betecknar vate, hydroxi eller 01-03-alkoxi; sant ogiftiga, farmaceutiskt godtagbara syraadditionssalter ddrav, kOnnetecknat av att en forening ned den allmanna formeln:
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73795876A | 1976-11-02 | 1976-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8103106L true SE8103106L (sv) | 1981-05-18 |
Family
ID=24965981
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7712218A SE7712218L (sv) | 1976-11-02 | 1977-10-28 | Forfarande for framstellning av 4a-aryloktahydro-1h-2-pyrindiner |
| SE8103106A SE8103106L (sv) | 1976-11-02 | 1981-05-18 | Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindiner |
| SE8103107A SE8103107L (sv) | 1976-11-02 | 1981-05-18 | Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindiner |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7712218A SE7712218L (sv) | 1976-11-02 | 1977-10-28 | Forfarande for framstellning av 4a-aryloktahydro-1h-2-pyrindiner |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8103107A SE8103107L (sv) | 1976-11-02 | 1981-05-18 | Forfarande for framstellning av 4a-aryl-oktahydro-1h-2-pyrindiner |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5356669A (sv) |
| AR (1) | AR223454A1 (sv) |
| AT (1) | ATA782177A (sv) |
| AU (1) | AU513679B2 (sv) |
| BE (1) | BE860314A (sv) |
| CA (1) | CA1100136A (sv) |
| CS (1) | CS211380B2 (sv) |
| DD (1) | DD133795A5 (sv) |
| DE (1) | DE2748466A1 (sv) |
| DK (1) | DK485277A (sv) |
| ES (3) | ES463784A1 (sv) |
| FR (1) | FR2369267A1 (sv) |
| GB (1) | GB1590155A (sv) |
| GR (1) | GR70053B (sv) |
| HU (1) | HU176231B (sv) |
| IE (1) | IE45901B1 (sv) |
| IL (1) | IL53236A0 (sv) |
| NL (1) | NL7712053A (sv) |
| NZ (1) | NZ185539A (sv) |
| PH (1) | PH12590A (sv) |
| PL (3) | PL108466B1 (sv) |
| PT (1) | PT67194B (sv) |
| RO (3) | RO77935A (sv) |
| SE (3) | SE7712218L (sv) |
| SU (3) | SU812174A3 (sv) |
| ZA (1) | ZA776497B (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ189230A (en) * | 1977-12-27 | 1981-05-15 | Lilly Co Eli | Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines |
| US4277608A (en) * | 1979-06-21 | 1981-07-07 | Eli Lilly And Company | Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines |
| US4236009A (en) * | 1979-06-21 | 1980-11-25 | Eli Lilly And Company | Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines |
| ZA9510829B (en) * | 1994-12-23 | 1996-07-03 | Smithkline Beecham Corp | 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds |
| CA2812526A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| BR112013019211A2 (pt) | 2011-02-02 | 2021-07-06 | Vertex Pharma | amidas de piperidina espirocíclicas de pirrolopirazina como moduladores de canais de íon |
| CN103443105A (zh) | 2011-02-18 | 2013-12-11 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的苯并二氢吡喃-螺环哌啶酰胺 |
| US8828996B2 (en) | 2011-03-14 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
-
1977
- 1977-10-26 PT PT67194A patent/PT67194B/pt unknown
- 1977-10-27 IL IL53236A patent/IL53236A0/xx unknown
- 1977-10-27 NZ NZ185539A patent/NZ185539A/xx unknown
- 1977-10-27 GB GB44729/77A patent/GB1590155A/en not_active Expired
- 1977-10-27 CA CA289,687A patent/CA1100136A/en not_active Expired
- 1977-10-28 BE BE1008483A patent/BE860314A/xx unknown
- 1977-10-28 DE DE19772748466 patent/DE2748466A1/de not_active Withdrawn
- 1977-10-28 PH PH20380A patent/PH12590A/en unknown
- 1977-10-28 SE SE7712218A patent/SE7712218L/sv unknown
- 1977-10-28 IE IE2206/77A patent/IE45901B1/en unknown
- 1977-10-28 FR FR7732776A patent/FR2369267A1/fr active Granted
- 1977-10-29 GR GR54664A patent/GR70053B/el unknown
- 1977-10-31 AR AR269797A patent/AR223454A1/es active
- 1977-11-01 ZA ZA00776497A patent/ZA776497B/xx unknown
- 1977-11-01 HU HU77EI768A patent/HU176231B/hu unknown
- 1977-11-01 AU AU30235/77A patent/AU513679B2/en not_active Expired
- 1977-11-01 NL NL7712053A patent/NL7712053A/xx not_active Application Discontinuation
- 1977-11-01 DK DK485277A patent/DK485277A/da unknown
- 1977-11-02 SU SU772539649A patent/SU812174A3/ru active
- 1977-11-02 AT AT0782177A patent/ATA782177A/de not_active Application Discontinuation
- 1977-11-02 RO RO7799435A patent/RO77935A/ro unknown
- 1977-11-02 JP JP13211177A patent/JPS5356669A/ja active Pending
- 1977-11-02 RO RO7799434A patent/RO78300A/ro unknown
- 1977-11-02 PL PL1977212226A patent/PL108466B1/pl unknown
- 1977-11-02 PL PL1977212225A patent/PL108610B1/pl unknown
- 1977-11-02 PL PL1977201885A patent/PL109690B1/pl unknown
- 1977-11-02 CS CS777150A patent/CS211380B2/cs unknown
- 1977-11-02 RO RO7792007A patent/RO72900A/ro unknown
- 1977-11-02 DD DD7700201831A patent/DD133795A5/xx unknown
- 1977-11-02 ES ES463784A patent/ES463784A1/es not_active Expired
- 1977-11-02 ES ES463783A patent/ES463783A1/es not_active Expired
-
1978
- 1978-08-01 ES ES472276A patent/ES472276A1/es not_active Expired
- 1978-10-03 SU SU782669355A patent/SU913941A3/ru active
- 1978-10-03 SU SU782669395A patent/SU845777A3/ru active
-
1981
- 1981-05-18 SE SE8103106A patent/SE8103106L/sv unknown
- 1981-05-18 SE SE8103107A patent/SE8103107L/sv unknown
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