SE8501965L - Forfarande och mellanprodukter for framstellning av at-125 - Google Patents

Forfarande och mellanprodukter for framstellning av at-125

Info

Publication number: SE8501965L
Authority: SE; Sweden
Prior art keywords: analogues; amino; intermediates; procedures; manufacturing
Prior art date: 1978-05-15

Application number

SE8501965A

Other languages

English (en)

Other versions

SE8501965D0 (sv

Inventor

R C Kelly

W Wierenga

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-05-15

Filing date

1985-04-23

Publication date

1985-04-23

1985-04-23 Application filed by Upjohn Co filed Critical Upjohn Co

1985-04-23 Publication of SE8501965D0 publication Critical patent/SE8501965D0/sv

1985-04-23 Publication of SE8501965L publication Critical patent/SE8501965L/sv

Links

239000000543 intermediate Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000005110 aryl thio group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000005544 phthalimido group Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
NTHMUJMQOXQYBR-OKKQSCSOSA-N tricholomic acid Chemical class OC(=O)[C@@H](N)[C@@H]1CC(=O)NO1 NTHMUJMQOXQYBR-OKKQSCSOSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

SE8501965A 1978-05-15 1985-04-23 Forfarande och mellanprodukter for framstellning av at-125 SE8501965L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US90596378A	1978-05-15	1978-05-15

Publications (2)

Publication Number	Publication Date
SE8501965D0 SE8501965D0 (sv)	1985-04-23
SE8501965L true SE8501965L (sv)	1985-04-23

Family

ID=25421749

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SE7904163A SE448376B (sv)	1978-05-15	1979-05-11	Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav
SE8501965A SE8501965L (sv)	1978-05-15	1985-04-23	Forfarande och mellanprodukter for framstellning av at-125

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SE7904163A SE448376B (sv)	1978-05-15	1979-05-11	Forfarande for framstellning av (alfas,55)-alfa-amino-3-kloro-2-isoxazolin-5-ettiksyra (at-125) och analoger derav

Country Status (10)

Country	Link
JP (1)	JPS54148781A (sv)
AU (1)	AU526380B2 (sv)
BE (1)	BE876261A (sv)
CH (1)	CH646961A5 (sv)
DE (1)	DE2918878A1 (sv)
FR (1)	FR2426049A1 (sv)
GB (1)	GB2023135B (sv)
IT (1)	IT1116816B (sv)
NL (1)	NL7903771A (sv)
SE (2)	SE448376B (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4643807A (en) *	1985-12-13	1987-02-17	The Dow Chemical Company	Process for electrochemically forming an aromatic compound containing one or more alpha-acyloxylated aliphatic substitutent(s)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3856807A (en) *	1972-03-13	1974-12-24	Upjohn Co	L-({60 s,5s)-{60 -amino-3-chloro-2-isoxazoline-5-acetic acid
US3878047A (en) *	1973-02-02	1975-04-15	Upjohn Co	Process for production of AT-125
US3944562A (en) *	1974-04-17	1976-03-16	The Upjohn Company	αS, 4S, 5R α-Amino-3-chloro-4-hydroxy-2-isoxazoline-5-acetic acid

1979
- 1979-05-03 AU AU46723/79A patent/AU526380B2/en not_active Ceased
- 1979-05-10 DE DE19792918878 patent/DE2918878A1/de not_active Ceased
- 1979-05-11 SE SE7904163A patent/SE448376B/sv not_active IP Right Cessation
- 1979-05-14 IT IT48040/79A patent/IT1116816B/it active
- 1979-05-14 NL NL7903771A patent/NL7903771A/xx not_active Application Discontinuation
- 1979-05-14 FR FR7912246A patent/FR2426049A1/fr active Granted
- 1979-05-15 GB GB7916822A patent/GB2023135B/en not_active Expired
- 1979-05-15 CH CH452779A patent/CH646961A5/de not_active IP Right Cessation
- 1979-05-15 BE BE0/195169A patent/BE876261A/xx unknown
- 1979-05-15 JP JP5960179A patent/JPS54148781A/ja active Pending
1985
- 1985-04-23 SE SE8501965A patent/SE8501965L/sv not_active Application Discontinuation

Also Published As

Publication number	Publication date
GB2023135A (en)	1979-12-28
DE2918878A1 (de)	1979-11-22
GB2023135B (en)	1982-08-25
SE8501965D0 (sv)	1985-04-23
JPS54148781A (en)	1979-11-21
IT1116816B (it)	1986-02-10
FR2426049A1 (fr)	1979-12-14
FR2426049B1 (sv)	1983-06-17
AU526380B2 (en)	1983-01-06
NL7903771A (nl)	1979-11-19
AU4672379A (en)	1979-11-22
SE448376B (sv)	1987-02-16
SE7904163L (sv)	1979-11-16
CH646961A5 (de)	1984-12-28
BE876261A (fr)	1979-11-16
IT7949040A0 (it)	1979-05-14

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Legal Events

Date

Code

Title

Description

1995-02-28

NAV

Patent application has lapsed

Ref document number: 8501965-1

Effective date: 19900414