SE8801904L - PHOSPHORETIC HMG-COA REDUCTION INHIBITORS, NEW INTERMEDIATES AND METHOD - Google Patents

PHOSPHORETIC HMG-COA REDUCTION INHIBITORS, NEW INTERMEDIATES AND METHOD

Info

Publication number
SE8801904L
SE8801904L SE8801904A SE8801904A SE8801904L SE 8801904 L SE8801904 L SE 8801904L SE 8801904 A SE8801904 A SE 8801904A SE 8801904 A SE8801904 A SE 8801904A SE 8801904 L SE8801904 L SE 8801904L
Authority
SE
Sweden
Prior art keywords
compounds
phosphoretic
hmg
new intermediates
coa reduction
Prior art date
Application number
SE8801904A
Other languages
Swedish (sv)
Other versions
SE8801904D0 (en
SE501541C2 (en
Inventor
D S Karanewsky
M C Badia
S A Biller
E M Gordon
M J Sofia
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of SE8801904D0 publication Critical patent/SE8801904D0/en
Publication of SE8801904L publication Critical patent/SE8801904L/en
Publication of SE501541C2 publication Critical patent/SE501541C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/302—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/303—Cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3217—Esters of acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3241—Esters of arylalkanephosphinic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure <IMAGE> wherein R is OH, or salts thereof or lower alkoxy; R<x> is H or alkyl; X is -CH2-,-CH2-CH2-,-CH=CH-, -C IDENTICAL C-, -CH2CH2CH2- or -CH2O- (where O is linked to Z); Z is a hydrophobic anchor, such as <IMAGE> wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
SE8801904A 1987-05-22 1988-05-20 Phosphorus-containing HMG-CoA reductase inhibitors, novel intermediates and method SE501541C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5323887A 1987-05-22 1987-05-22
US10968187A 1987-10-19 1987-10-19

Publications (3)

Publication Number Publication Date
SE8801904D0 SE8801904D0 (en) 1988-05-20
SE8801904L true SE8801904L (en) 1988-11-23
SE501541C2 SE501541C2 (en) 1995-03-06

Family

ID=26731613

Family Applications (3)

Application Number Title Priority Date Filing Date
SE8801904A SE501541C2 (en) 1987-05-22 1988-05-20 Phosphorus-containing HMG-CoA reductase inhibitors, novel intermediates and method
SE9201587A SE9201587D0 (en) 1987-05-22 1992-05-14 PHOSPHORETIC HMG-COA REDUCTION INHIBITORS, NEW INTERMEDIATES AND METHOD
SE9201588A SE9201588A0 (en) 1987-05-22 1992-05-20 Phosphorus-containing HMG-CoA reductase inhibitors, novel intermediates and method

Family Applications After (2)

Application Number Title Priority Date Filing Date
SE9201587A SE9201587D0 (en) 1987-05-22 1992-05-14 PHOSPHORETIC HMG-COA REDUCTION INHIBITORS, NEW INTERMEDIATES AND METHOD
SE9201588A SE9201588A0 (en) 1987-05-22 1992-05-20 Phosphorus-containing HMG-CoA reductase inhibitors, novel intermediates and method

Country Status (24)

Country Link
JP (1) JPH01139589A (en)
KR (1) KR880013959A (en)
CN (1) CN1030761A (en)
AU (2) AU610174B2 (en)
BE (1) BE1002251A3 (en)
CH (3) CH678625A5 (en)
DE (1) DE3817298C2 (en)
DK (1) DK277388A (en)
ES (1) ES2009919A6 (en)
FI (1) FI87927C (en)
FR (1) FR2615516B1 (en)
GB (1) GB2205838B (en)
GR (1) GR880100332A (en)
HU (1) HU201085B (en)
IE (1) IE63715B1 (en)
IL (1) IL86463A (en)
IT (1) IT1217684B (en)
NL (1) NL8801331A (en)
NO (1) NO882219L (en)
NZ (1) NZ224734A (en)
PH (2) PH25581A (en)
PL (1) PL157761B1 (en)
PT (1) PT87540B (en)
SE (3) SE501541C2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2009918A6 (en) * 1987-05-22 1989-10-16 Squibb & Sons Inc PROCEDURE FOR PREPARING HMG-COA-REDUCTASE INHIBITORS CONTAINING PHOSPHORUS.
JPH03184961A (en) * 1989-10-10 1991-08-12 Glaxo Group Ltd Compound
US5124453A (en) * 1990-03-02 1992-06-23 E. R. Squibb & Sons, Inc. Process for preparing certain 5,6,7,8-tetrahydroindolizinyl (ethyl or ethynyl)-hydroxy or methoxy-phosphinyl-3-hydroxy-butanoates and derivatives thereof
US5025000A (en) * 1990-03-02 1991-06-18 E. R. Squibb & Sons, Inc. Phosphorus-containing HMG-CoA reductase inhibitor compounds
CA2042526A1 (en) * 1990-06-11 1991-12-12 Adeoye Y. Olukotun Method for preventing a second heart attack employing an hmg coa reductase inhibitor
CA2043525A1 (en) * 1990-06-24 1991-12-25 Donald S. Karanewsky Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
DE4023308A1 (en) * 1990-07-21 1992-01-23 Bayer Ag SUBSTITUTED PYRIDO OXAZINE
DE4025818A1 (en) * 1990-08-16 1992-02-20 Bayer Ag PHENYL SULPHONAMIDE SUBSTITUTED PYRIDINALKEN AND -AMINOOXYALKANCARBONE ACID DERIVATIVES
NZ241574A (en) * 1991-02-22 1993-08-26 Ishihara Sangyo Kaisha Substituted phenyl derivatives of hydrazone and pesticidal compositions
US5202327A (en) * 1991-07-10 1993-04-13 E. R. Squibb & Sons, Inc. Phosphorus-containing hmg-coa reductase inhibitors
US5256692A (en) * 1992-01-07 1993-10-26 E. R. Squibb & Sons, Inc. Sulfur-containing HMG-COA reductase inhibitors
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
WO2003076409A1 (en) * 2002-03-14 2003-09-18 Syngenta Participations Ag Derivatives of 1-phenyl-3-phenylpyrazole as herbicides
JP4407237B2 (en) * 2002-12-24 2010-02-03 三菱化学株式会社 Non-aqueous electrolyte and non-aqueous electrolyte secondary battery using the same
JP4485169B2 (en) 2003-05-16 2010-06-16 花王株式会社 Intestinal mineral absorption capacity improver
CN1760363B (en) * 2004-10-14 2010-04-28 蒋继宏 Coded sequence of reductase enzyme protein of eucommia 3-hydroxy-3-coenzyme of methyl glutaryl A
TW200736225A (en) * 2006-01-16 2007-10-01 Sankyo Agro Co Ltd A (3-sulfur substituted phenyl) pyrazole derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR339233A (en) * 1903-12-23 1905-01-26 Cyanidgesellschaft Mit Beschra New process for obtaining explosives
DE803645C (en) * 1949-10-11 1951-04-05 Dynamit Act Ges Vormals Alfred Firedamp proof detonator in connection with electric igniters
DE918196C (en) * 1952-12-23 1954-09-20 J G W Berckholtz Fa Mass for producing colored smoke
US3274035A (en) * 1964-06-15 1966-09-20 Lohr A Burkardt Metallic composition for production of hygroscopic smoke
US3862866A (en) * 1971-08-02 1975-01-28 Specialty Products Dev Corp Gas generator composition and method
DE2841815C2 (en) * 1978-09-26 1985-02-21 Buck Chemisch-Technische Werke GmbH & Co, 7347 Bad Überkingen Method for producing a floor filling
US4438700A (en) * 1982-07-19 1984-03-27 The United States Of America As Represented By The Secretary Of The Army White smoke spotting composition for training ammunition
FR2596393B1 (en) * 1986-04-01 1988-06-03 Sanofi Sa HYDROXY-3 DIHYDROXYOXOPHOSPHORIO-4 BUTANOIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
ES2009918A6 (en) * 1987-05-22 1989-10-16 Squibb & Sons Inc PROCEDURE FOR PREPARING HMG-COA-REDUCTASE INHIBITORS CONTAINING PHOSPHORUS.

Also Published As

Publication number Publication date
NO882219D0 (en) 1988-05-20
HU201085B (en) 1990-09-28
AU1650288A (en) 1988-11-24
JPH01139589A (en) 1989-06-01
SE9201588D0 (en) 1992-05-20
CH675582A5 (en) 1990-10-15
AU610174B2 (en) 1991-05-16
GR880100332A (en) 1989-02-23
NL8801331A (en) 1988-12-16
IL86463A0 (en) 1988-11-15
FR2615516A1 (en) 1988-11-25
GB2205838A (en) 1988-12-21
SE8801904D0 (en) 1988-05-20
ES2009919A6 (en) 1989-10-16
HUT47123A (en) 1989-01-30
DE3817298C2 (en) 1997-02-13
KR880013959A (en) 1988-12-22
NO882219L (en) 1988-11-23
DK277388A (en) 1988-11-23
PT87540A (en) 1989-05-31
FI882385L (en) 1988-11-23
IE63715B1 (en) 1995-06-14
FI87927B (en) 1992-11-30
AU7126691A (en) 1991-05-02
IT8820681A0 (en) 1988-05-20
DE3817298A1 (en) 1988-12-01
SE9201588A0 (en) 1992-05-20
IL86463A (en) 1994-10-07
BE1002251A3 (en) 1990-11-06
CH678625A5 (en) 1991-10-15
FI87927C (en) 1993-03-10
PH26578A (en) 1992-08-19
PL157761B1 (en) 1992-06-30
FI882385A0 (en) 1988-05-20
DK277388D0 (en) 1988-05-20
GB8811931D0 (en) 1988-06-22
IT1217684B (en) 1990-03-30
CH678626A5 (en) 1991-10-15
SE9201587D0 (en) 1992-05-20
NZ224734A (en) 1991-04-26
GB2205838B (en) 1991-12-11
IE881544L (en) 1988-11-22
SE9201587A0 (en) 1992-05-14
PT87540B (en) 1992-09-30
CN1030761A (en) 1989-02-01
PH25581A (en) 1991-08-08
AU643501B2 (en) 1993-11-18
FR2615516B1 (en) 1991-04-12
SE501541C2 (en) 1995-03-06

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