SE9300657D0 - New compounds - Google Patents
New compoundsInfo
- Publication number
- SE9300657D0 SE9300657D0 SE9300657A SE9300657A SE9300657D0 SE 9300657 D0 SE9300657 D0 SE 9300657D0 SE 9300657 A SE9300657 A SE 9300657A SE 9300657 A SE9300657 A SE 9300657A SE 9300657 D0 SE9300657 D0 SE 9300657D0
- Authority
- SE
- Sweden
- Prior art keywords
- pct
- alkyl
- date
- fluoroalkyl
- cyano
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 108010072768 3-hydroxyanthranilate 3,4-dioxygenase Proteins 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 102100029016 3-hydroxyanthranilate 3,4-dioxygenase Human genes 0.000 abstract 1
- WJXSWCUQABXPFS-UHFFFAOYSA-N 3-hydroxyanthranilic acid Chemical class NC1=C(O)C=CC=C1C(O)=O WJXSWCUQABXPFS-UHFFFAOYSA-N 0.000 abstract 1
- 101710138657 Neurotoxin Proteins 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000002581 neurotoxin Substances 0.000 abstract 1
- 231100000618 neurotoxin Toxicity 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- GJAWHXHKYYXBSV-UHFFFAOYSA-N quinolinic acid Chemical compound OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/68—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C229/70—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9300657A SE9300657D0 (sv) | 1993-02-26 | 1993-02-26 | New compounds |
| IS4133A IS4133A (is) | 1993-02-26 | 1994-02-21 | Aðferð við framleiðslu á nýjum afleiðum af 3-hýdroxýantraniliksýru og milliefni við framleiðslu þeirra |
| PL94310398A PL310398A1 (en) | 1993-02-26 | 1994-02-22 | Novel compounds |
| US08/433,339 US5661183A (en) | 1993-02-22 | 1994-02-22 | 3-hydroxy anthanilic acid derivatives |
| CA002156079A CA2156079C (en) | 1993-02-26 | 1994-02-22 | Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutial compositions and the use thereof |
| HU9502491A HUT72992A (en) | 1993-02-26 | 1994-02-22 | New derivatives of 3-hydroxyantranilic acid, process to prepare them and pharmaceutical compns. contg. them |
| JP6518900A JPH08507294A (ja) | 1993-02-26 | 1994-02-22 | 新規化合物 |
| AU61599/94A AU6159994A (en) | 1993-02-26 | 1994-02-22 | New compounds |
| CN94191796A CN1121344A (zh) | 1993-02-26 | 1994-02-22 | 新化合物 |
| SK969-95A SK96995A3 (en) | 1993-02-26 | 1994-02-22 | 3-hydroxyanthranile acid derivatives, methods and intermediates products for their production, pharmaceutical compositions and their use |
| CZ952139A CZ213995A3 (en) | 1993-02-26 | 1994-02-22 | Novel derivatives of 3-hydroxyanthranilic acid, processes and intermediates of their preparation, novel pharmaceutical preparations and their use |
| AT94908556T ATE191908T1 (de) | 1993-02-26 | 1994-02-24 | Neue verbindungen |
| PCT/SE1994/000152 WO1994019315A1 (en) | 1993-02-26 | 1994-02-24 | New compounds |
| EP94908556A EP0686144B1 (de) | 1993-02-26 | 1994-02-24 | Neue verbindungen |
| DE69424039T DE69424039D1 (de) | 1993-02-26 | 1994-02-24 | Neue verbindungen |
| NO953332A NO953332L (no) | 1993-02-26 | 1995-08-24 | Nye forbindelser |
| FI954016A FI954016A0 (fi) | 1993-02-26 | 1995-08-25 | Uudet yhdisteet |
| US08/770,488 US5688945A (en) | 1993-02-26 | 1996-12-20 | Compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9300657A SE9300657D0 (sv) | 1993-02-26 | 1993-02-26 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE9300657D0 true SE9300657D0 (sv) | 1993-02-26 |
Family
ID=20389053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9300657A SE9300657D0 (sv) | 1993-02-22 | 1993-02-26 | New compounds |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5661183A (de) |
| EP (1) | EP0686144B1 (de) |
| JP (1) | JPH08507294A (de) |
| CN (1) | CN1121344A (de) |
| AT (1) | ATE191908T1 (de) |
| AU (1) | AU6159994A (de) |
| CZ (1) | CZ213995A3 (de) |
| DE (1) | DE69424039D1 (de) |
| FI (1) | FI954016A0 (de) |
| HU (1) | HUT72992A (de) |
| IS (1) | IS4133A (de) |
| NO (1) | NO953332L (de) |
| PL (1) | PL310398A1 (de) |
| SE (1) | SE9300657D0 (de) |
| SK (1) | SK96995A3 (de) |
| WO (1) | WO1994019315A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100897642B1 (ko) | 2002-12-20 | 2009-05-14 | 글락소 그룹 리미티드 | 신경 장애 치료용 벤즈아제핀 유도체 |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| US8603945B2 (en) * | 2008-07-23 | 2013-12-10 | The Regents Of The University Of California | Methods and compositions for providing salicyclic acid-independent pathogen resistance in plants |
| EP2344470B1 (de) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexylderivate als modulatoren von metabotropen glutamatrezeptoren |
| JP5690277B2 (ja) | 2008-11-28 | 2015-03-25 | ジャンセン ファーマシューティカルズ， インコーポレイテッド． | 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体 |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| US9271967B2 (en) | 2010-11-08 | 2016-03-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| MX386697B (es) | 2014-01-21 | 2025-03-19 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso |
| ME03518B (de) | 2014-01-21 | 2020-04-20 | Janssen Pharmaceutica Nv | Kombinationen mit positiven allosterischen modulatoren von metabotropem glutamatergen rezeptor vom subtyp 2 und deren verwendung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0621083B2 (ja) * | 1986-12-22 | 1994-03-23 | 株式会社三光開発科学研究所 | ジ（アリ−ルオキシ）アルカンの製造方法 |
-
1993
- 1993-02-26 SE SE9300657A patent/SE9300657D0/xx unknown
-
1994
- 1994-02-21 IS IS4133A patent/IS4133A/is unknown
- 1994-02-22 CZ CZ952139A patent/CZ213995A3/cs unknown
- 1994-02-22 HU HU9502491A patent/HUT72992A/hu unknown
- 1994-02-22 US US08/433,339 patent/US5661183A/en not_active Expired - Lifetime
- 1994-02-22 AU AU61599/94A patent/AU6159994A/en not_active Abandoned
- 1994-02-22 SK SK969-95A patent/SK96995A3/sk unknown
- 1994-02-22 PL PL94310398A patent/PL310398A1/xx unknown
- 1994-02-22 CN CN94191796A patent/CN1121344A/zh active Pending
- 1994-02-22 JP JP6518900A patent/JPH08507294A/ja active Pending
- 1994-02-24 WO PCT/SE1994/000152 patent/WO1994019315A1/en not_active Ceased
- 1994-02-24 DE DE69424039T patent/DE69424039D1/de not_active Expired - Lifetime
- 1994-02-24 AT AT94908556T patent/ATE191908T1/de not_active IP Right Cessation
- 1994-02-24 EP EP94908556A patent/EP0686144B1/de not_active Expired - Lifetime
-
1995
- 1995-08-24 NO NO953332A patent/NO953332L/no unknown
- 1995-08-25 FI FI954016A patent/FI954016A0/fi unknown
-
1996
- 1996-12-20 US US08/770,488 patent/US5688945A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI954016A7 (fi) | 1995-08-25 |
| DE69424039D1 (de) | 2000-05-25 |
| IS4133A (is) | 1994-08-27 |
| CN1121344A (zh) | 1996-04-24 |
| EP0686144A1 (de) | 1995-12-13 |
| SK96995A3 (en) | 1996-06-05 |
| NO953332D0 (no) | 1995-08-24 |
| ATE191908T1 (de) | 2000-05-15 |
| JPH08507294A (ja) | 1996-08-06 |
| US5688945A (en) | 1997-11-18 |
| HU9502491D0 (en) | 1995-10-30 |
| WO1994019315A1 (en) | 1994-09-01 |
| AU6159994A (en) | 1994-09-14 |
| EP0686144B1 (de) | 2000-04-19 |
| PL310398A1 (en) | 1995-12-11 |
| CZ213995A3 (en) | 1996-04-17 |
| FI954016A0 (fi) | 1995-08-25 |
| US5661183A (en) | 1997-08-26 |
| HUT72992A (en) | 1996-06-28 |
| NO953332L (no) | 1995-08-24 |
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