SG10201803473WA - Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide - Google Patents

Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide

Info

Publication number
SG10201803473WA
SG10201803473WA SG10201803473WA SG10201803473WA SG10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA SG 10201803473W A SG10201803473W A SG 10201803473WA
Authority
SG
Singapore
Prior art keywords
methods
binding polypeptide
immunosuppressive therapy
alpha beta
tcr
Prior art date
Application number
SG10201803473WA
Inventor
Gregor Blank
Rupert Handgretinger
Karin Schilbach
Gina Lacorcia
Daniel Snell
Andreas Menrad
Original Assignee
Genzyme Corp
Univ Eberhard Karls Tuebingen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp, Univ Eberhard Karls Tuebingen filed Critical Genzyme Corp
Publication of SG10201803473WA publication Critical patent/SG10201803473WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METHODS FOR ENHANCING IMMUNOSUPPRESSIVE THERAPY BY MULTIPLE ADMINISTRATION OF ALPHA BETA TCR-BINDING POLYPEPTIDE 5 The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (αβ -TCR). In particular, this disclosure relates to improved methods of use of a humanized anti-αβ -TCR antibody, which is derived from the murine monoclonal antibody BMA031, in immunosuppressive therapy. Novel 10 methods using humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-αβTCR antibod ies and/or fragments thereof) are also provided. Novel methods using repetitive administration of humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-αβTCR antibod ies and/or fragments thereof) to reduce  T cells in the subject relative to γδ T cells in the subject are provided. 15 [No Figure]
SG10201803473WA 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide SG10201803473WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361897809P 2013-10-30 2013-10-30

Publications (1)

Publication Number Publication Date
SG10201803473WA true SG10201803473WA (en) 2018-06-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201603193PA SG11201603193PA (en) 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide
SG10201803473WA SG10201803473WA (en) 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201603193PA SG11201603193PA (en) 2013-10-30 2014-10-30 Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide

Country Status (8)

Country Link
US (2) US11142575B2 (en)
EP (1) EP3063174B1 (en)
CN (1) CN106795220A (en)
AU (2) AU2014342182B2 (en)
CA (1) CA2928756A1 (en)
MX (1) MX384246B (en)
SG (2) SG11201603193PA (en)
WO (1) WO2015066379A2 (en)

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UY34317A (en) 2011-09-12 2013-02-28 Genzyme Corp T cell antireceptor antibody (alpha) / ß
CN106795220A (en) * 2013-10-30 2017-05-31 建新公司 By the method for strengthening immunosuppressive therapy of the multiple administration of α β TCR Binding peptides
WO2016059220A1 (en) 2014-10-16 2016-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Tcr-activating agents for use in the treatment of t-all
WO2017049159A1 (en) * 2015-09-16 2017-03-23 Ledebur Jr Harry C T-CELL RECEPTOR (TCR) TARGETING THERAPIES FOR IMMUNE-MEDIATED ADVERSE DRUG REACTIONS (ADRs) AND OTHER CONDITIONS
CN108070644B (en) * 2016-11-08 2021-06-29 国家卫生计生委科学技术研究所 Diagnosis system for gestational hypertension
TW201829463A (en) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 anti-HLA-G antibody and use thereof
US20200157172A1 (en) * 2017-07-07 2020-05-21 HANMl PHARM. CO., LTD. Novel therapeutic enzyme fusion protein and use thereof
CN109777778B (en) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 A Genetically Modified γδT Cell
DE102017127984B4 (en) * 2017-11-27 2019-12-05 Immatics US, Inc. Method for the propagation and activation of γδ T cells
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
EP3765517A1 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
AR114789A1 (en) 2018-04-18 2020-10-14 Hoffmann La Roche ANTI-HLA-G ANTIBODIES AND THE USE OF THEM
WO2020010250A2 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
AU2020226893B2 (en) 2019-02-21 2025-02-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
JP7579795B2 (en) 2019-02-21 2024-11-08 マレンゴ・セラピューティクス，インコーポレーテッド Antibody molecules that bind to NKp30 and uses thereof
JP7575401B2 (en) * 2019-04-03 2024-10-29 ジェンザイム・コーポレーション Anti-alpha beta TCR binding polypeptides with reduced fragmentation - Patents.com
CN115003698A (en) * 2019-11-14 2022-09-02 马伦戈治疗公司 Anti-TCR antibody molecules and their uses
WO2021138474A2 (en) * 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
WO2022129120A1 (en) 2020-12-17 2022-06-23 F. Hoffmann-La Roche Ag Anti-hla-g antibodies and use thereof
KR20240004937A (en) 2021-05-05 2024-01-11 이매틱스 바이오테크놀로지스 게엠베하 BMA031 antigen-binding polypeptide
WO2023025668A1 (en) 2021-08-25 2023-03-02 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Methods for the generation of stem cell memory t cells for adoptive t cell therapy
CN118108842B (en) * 2023-06-09 2026-06-05 浙江大学 Humanized anti-CD24 antibody and its application

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CA2018248A1 (en) * 1989-06-07 1990-12-07 Clyde W. Shearman Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
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JP2007512846A (en) 2003-12-04 2007-05-24 ゼンコー・インコーポレイテッド Method for producing mutant protein having increased host string content and composition thereof
JP5238936B2 (en) 2005-03-25 2013-07-17 ジーアイティーアール，インク． GITR binding molecules and uses thereof
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GEP20125693B (en) 2007-01-09 2012-11-26 Biogen Idec Inc Sp35 antibodies and usage thereof
CA2735193A1 (en) 2008-08-26 2010-03-11 Macrogenics, Inc. T-cell receptor antibodies and methods of use thereof
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US9018006B2 (en) * 2010-07-23 2015-04-28 The University Of Toledo Stable Tregs and related materials and methods
UY34317A (en) * 2011-09-12 2013-02-28 Genzyme Corp T cell antireceptor antibody (alpha) / ß
CN106795220A (en) * 2013-10-30 2017-05-31 建新公司 By the method for strengthening immunosuppressive therapy of the multiple administration of α β TCR Binding peptides

Also Published As

Publication number Publication date
US20160244523A1 (en) 2016-08-25
AU2014342182A1 (en) 2016-05-19
AU2014342182B2 (en) 2020-05-14
WO2015066379A3 (en) 2015-07-09
CN106795220A (en) 2017-05-31
EP3063174A2 (en) 2016-09-07
MX2016005687A (en) 2017-03-30
US20220098299A1 (en) 2022-03-31
CA2928756A1 (en) 2015-05-07
EP3063174B1 (en) 2020-12-09
US11142575B2 (en) 2021-10-12
SG11201603193PA (en) 2016-05-30
WO2015066379A2 (en) 2015-05-07
AU2020217395A1 (en) 2020-09-03
MX384246B (en) 2025-03-14

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