SG11201508017QA - Modulation of structured polypeptide specificity - Google Patents

Modulation of structured polypeptide specificity

Info

Publication number
SG11201508017QA
SG11201508017QA SG11201508017QA SG11201508017QA SG11201508017QA SG 11201508017Q A SG11201508017Q A SG 11201508017QA SG 11201508017Q A SG11201508017Q A SG 11201508017QA SG 11201508017Q A SG11201508017Q A SG 11201508017QA SG 11201508017Q A SG11201508017Q A SG 11201508017QA
Authority
SG
Singapore
Prior art keywords
modulation
polypeptide specificity
structured polypeptide
structured
specificity
Prior art date
Application number
SG11201508017QA
Inventor
Daniel Paul Teufel
Catherine Stace
Edward Walker
John Tite
Original Assignee
Bicycle Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bicycle Therapeutics Ltd filed Critical Bicycle Therapeutics Ltd
Publication of SG11201508017QA publication Critical patent/SG11201508017QA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6445Kallikreins (3.4.21.34; 3.4.21.35)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201508017QA 2013-04-11 2014-04-11 Modulation of structured polypeptide specificity SG11201508017QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201306623A GB201306623D0 (en) 2013-04-11 2013-04-11 Modulation of structured polypeptide specificity
PCT/EP2014/057440 WO2014167122A1 (en) 2013-04-11 2014-04-11 Modulation of structured polypeptide specificity

Publications (1)

Publication Number Publication Date
SG11201508017QA true SG11201508017QA (en) 2015-10-29

Family

ID=48537122

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201805806RA SG10201805806RA (en) 2013-04-11 2014-04-11 Modulation of Structured Polypeptide Specificity
SG11201508017QA SG11201508017QA (en) 2013-04-11 2014-04-11 Modulation of structured polypeptide specificity

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201805806RA SG10201805806RA (en) 2013-04-11 2014-04-11 Modulation of Structured Polypeptide Specificity

Country Status (16)

Country Link
US (3) US10118947B2 (en)
EP (1) EP2983722B1 (en)
JP (2) JP6588890B2 (en)
CN (1) CN105307686B (en)
AU (1) AU2014253036B2 (en)
CA (1) CA2908406C (en)
DK (1) DK2983722T3 (en)
ES (1) ES2715406T3 (en)
GB (1) GB201306623D0 (en)
NZ (1) NZ713439A (en)
PL (1) PL2983722T3 (en)
PT (1) PT2983722T (en)
RU (1) RU2674070C2 (en)
SG (2) SG10201805806RA (en)
TR (1) TR201903649T4 (en)
WO (1) WO2014167122A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2764140T3 (en) * 2011-10-07 2018-04-30 Bicyclerd Limited Modulation of structured polypeptide specificity
GB201306623D0 (en) 2013-04-11 2013-05-29 Bicycle Therapeutics Ltd Modulation of structured polypeptide specificity
ES2715379T3 (en) * 2013-10-28 2019-06-04 Bicyclerd Ltd Novel Polypeptides
CN107148425B (en) 2014-10-29 2021-08-03 拜斯科阿迪有限公司 Bicyclic peptide ligands specific for MT1-MMP
EP3444264A4 (en) * 2016-04-14 2020-03-18 TAO Health Life Pharma Co., Ltd. PEPTIDE FOR AMYLOSPHEROID BINDING INHIBITION (ASPD), AND ASSESSMENT AND SCREENING METHOD
GB201607827D0 (en) 2016-05-04 2016-06-15 Bicycle Therapeutics Ltd Bicyclic peptide-toxin conjugates specific for MT1-MMP
WO2018115203A1 (en) 2016-12-23 2018-06-28 Bicyclerd Limited Peptide derivatives having novel linkage structures
EP3645549A1 (en) * 2017-06-26 2020-05-06 BicycleRD Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP7670481B2 (en) 2017-08-04 2025-04-30 バイスクルテクス・リミテッド Bicyclic peptide ligands specific for CD137 - Patent application
TWI825046B (en) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Bicyclic peptide ligands specific for epha2
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
CN111902429A (en) 2018-02-23 2020-11-06 拜斯科技术开发有限公司 Multimeric bicyclic peptide ligands
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate comprising the peptide ligand and a pharmaceutical composition comprising the drug conjugate
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
WO2020120984A1 (en) * 2018-12-13 2020-06-18 Bicycletx Limited Bicyclic peptide ligands specific for mt1-mmp
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
WO2020128527A1 (en) 2018-12-21 2020-06-25 Bicyclerd Limited Bicyclic peptide ligands specific for pd-l1
US12492224B2 (en) 2018-12-21 2025-12-09 Bicycletx Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
TWI860386B (en) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 Heterotandem bicyclic peptide complex
SMT202500247T1 (en) 2019-10-03 2025-09-12 Bicycletx Ltd Heterotandem bicyclic peptide complexes
WO2021198534A1 (en) 2020-04-04 2021-10-07 Oxurion NV Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
CN115768456A (en) * 2020-04-06 2023-03-07 拜斯科技术开发有限公司 TSLP-specific bicyclic peptide ligands
AU2021322934A1 (en) 2020-08-03 2023-03-30 Bicycletx Limited Peptide-based linkers
KR102486996B1 (en) * 2020-09-04 2023-01-10 서울대학교병원 Peptide and composition for improving wrinkle and treating metabolic desease containing the same
WO2023144030A1 (en) 2022-01-31 2023-08-03 Oxurion NV Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en) 2022-02-04 2023-08-10 Oxurion NV Biomarker for plasma kallikrein inhibitor therapy response
WO2024151615A1 (en) * 2023-01-10 2024-07-18 The University Of North Carolina At Chapel Hill Mrna display libraries and methods of use

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ES2176484T3 (en) 1995-08-18 2002-12-01 Morphosys Ag PROTEIN BANKS / (POLI) PEPTIDES.
US20030166003A1 (en) 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2005122379A2 (en) 2004-05-27 2005-12-22 The Regents Of The University Of California Alpha-4 beta-1 integrin ligands for imaging and therapy
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
PL2374472T3 (en) * 2006-03-16 2018-11-30 Dyax Corp. Compositions and methods for treating ophthalmic disorders
ES2560868T3 (en) * 2006-12-22 2016-02-23 Phadia Ab Novel prostate calicrein allergen
EP2653545A1 (en) 2008-02-05 2013-10-23 Bicycle Therapeutics Limited Methods and compositions
GB0913775D0 (en) 2009-08-06 2009-09-16 Medical Res Council Multispecific peptides
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
EP2649095B1 (en) * 2010-12-10 2021-10-06 Aleksander S. Popel Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases
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PL2764140T3 (en) * 2011-10-07 2018-04-30 Bicyclerd Limited Modulation of structured polypeptide specificity
US20140274759A1 (en) 2013-03-15 2014-09-18 Bicycle Therapeutics Limited Modification of polypeptides
GB201306623D0 (en) 2013-04-11 2013-05-29 Bicycle Therapeutics Ltd Modulation of structured polypeptide specificity
ES2715379T3 (en) * 2013-10-28 2019-06-04 Bicyclerd Ltd Novel Polypeptides

Also Published As

Publication number Publication date
US20160046673A1 (en) 2016-02-18
CA2908406C (en) 2021-07-20
JP6588890B2 (en) 2019-10-09
US11753444B2 (en) 2023-09-12
US10118947B2 (en) 2018-11-06
DK2983722T3 (en) 2019-04-01
JP2020019778A (en) 2020-02-06
JP2016519683A (en) 2016-07-07
JP6785932B2 (en) 2020-11-18
NZ713439A (en) 2021-06-25
CN105307686B (en) 2019-05-28
US20180362585A1 (en) 2018-12-20
SG10201805806RA (en) 2018-08-30
AU2014253036A1 (en) 2015-10-22
AU2014253036B2 (en) 2019-01-31
ES2715406T3 (en) 2019-06-04
PT2983722T (en) 2019-03-25
HK1221172A1 (en) 2017-05-26
CN105307686A (en) 2016-02-03
RU2015147869A (en) 2017-05-16
US20210079043A1 (en) 2021-03-18
GB201306623D0 (en) 2013-05-29
US10870679B2 (en) 2020-12-22
PL2983722T3 (en) 2019-08-30
EP2983722B1 (en) 2018-12-12
TR201903649T4 (en) 2019-04-22
WO2014167122A1 (en) 2014-10-16
CA2908406A1 (en) 2014-10-16
EP2983722A1 (en) 2016-02-17
RU2674070C2 (en) 2018-12-04
BR112015025699A2 (en) 2017-10-10

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