SG11202108398YA - Anti-claudin 18 antibodies and methods of use thereof - Google Patents
Anti-claudin 18 antibodies and methods of use thereofInfo
- Publication number
- SG11202108398YA SG11202108398YA SG11202108398YA SG11202108398YA SG11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA
- Authority
- SG
- Singapore
- Prior art keywords
- claudin
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/828—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/852—Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962800359P | 2019-02-01 | 2019-02-01 | |
| US201962891925P | 2019-08-26 | 2019-08-26 | |
| PCT/US2020/016459 WO2020160560A2 (en) | 2019-02-01 | 2020-02-03 | Anti-claudin 18 antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202108398YA true SG11202108398YA (en) | 2021-08-30 |
Family
ID=71842386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202108398YA SG11202108398YA (en) | 2019-02-01 | 2020-02-03 | Anti-claudin 18 antibodies and methods of use thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11407828B2 (en) |
| EP (1) | EP3917564A4 (en) |
| JP (1) | JP7840511B2 (en) |
| KR (1) | KR20210134321A (en) |
| CN (1) | CN113645996B (en) |
| AU (1) | AU2020217012B2 (en) |
| CA (1) | CA3128502A1 (en) |
| SG (1) | SG11202108398YA (en) |
| WO (1) | WO2020160560A2 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11643455B2 (en) | 2018-04-13 | 2023-05-09 | Albert Einstein College Of Medicine | High-affinity Mycobacterium tuberculosis capsule-specific human monoclonal antibody |
| EP3902839A4 (en) * | 2018-12-28 | 2022-12-14 | Nanjing GenScript Biotech Co., Ltd. | Claudin18.2 binding moieties and uses thereof |
| SG11202108398YA (en) * | 2019-02-01 | 2021-08-30 | Novarock Biotherapeutics Ltd | Anti-claudin 18 antibodies and methods of use thereof |
| AU2021354827A1 (en) * | 2020-09-30 | 2023-06-01 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising antibody-drug conjugate, and use of pharmaceutical composition |
| EP4252782A4 (en) * | 2020-11-30 | 2025-12-10 | Cspc Megalith Biopharmaceutical Co Ltd | ANTI-CLDN18.2 ANTIBODIES, DRUG CONJUGATE AND METHOD OF MANUFACTURING THERE AND USES THEREOF |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| WO2022132868A1 (en) * | 2020-12-15 | 2022-06-23 | Albert Einstein College Of Medicine | High-affinity mycobacterium tuberculosis capsule-specific human monoclonal antibodies |
| JP2024502907A (en) * | 2020-12-22 | 2024-01-23 | ベルティス インコーポレイテッド | Pancreatic ductal adenocarcinoma subtype determination method and subtype determination kit |
| CN116635085A (en) | 2020-12-23 | 2023-08-22 | 斯迪安生物技术公司 | Tumor-specific claudin 18.2 antibody-drug conjugate |
| KR20230166096A (en) * | 2021-04-02 | 2023-12-06 | 오리셀 테라퓨틱스 컴퍼니 리미티드 | CLDN18.2 antigen binding protein and its applications |
| CN116761826B (en) * | 2021-05-31 | 2026-04-14 | 上海以岭药业有限公司 | Monoclonal antibodies against CLDN18.2 and Fc engineered versions thereof |
| CA3236417A1 (en) | 2021-11-05 | 2023-05-11 | American Diagnostics & Therapy, Llc (Adxrx) | Monoclonal antibodies against carcinoembryonic antigens, and their uses |
| WO2023078386A1 (en) * | 2021-11-05 | 2023-05-11 | 正大天晴药业集团股份有限公司 | Anti-cldn18.2 antibody and use thereof |
| AU2023278315A1 (en) * | 2022-05-31 | 2024-12-12 | CSPC Megalith Biopharmaceutical Co., Ltd. | Pharmaceutical composition of recombinant anti-human cldn18.2 monoclonal antibody-mmae conjugate |
| CN117777288A (en) * | 2022-09-29 | 2024-03-29 | 南京博望医药科技有限公司 | Anti-claudin 18.2 antibody |
| KR20240101987A (en) * | 2022-12-23 | 2024-07-03 | 주식회사 와이바이오로직스 | Monoclonal antibody specifically binding to claudin-18.2 and uses thereof |
| EP4653017A1 (en) | 2023-01-18 | 2025-11-26 | Tyligand Bioscience (Shanghai) Limited | Antibody-drug conjugate and use thereof |
| WO2024211459A1 (en) * | 2023-04-04 | 2024-10-10 | Zai Lab (Shanghai) Co., Ltd | Use of anti-claudin antibody for cancer treatment based on certain biomarkers |
| CN118530349B (en) * | 2024-06-03 | 2025-04-11 | 华中农业大学 | A monoclonal antibody that can neutralize different serotypes of porcine rotavirus |
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| CN111867630B (en) | 2018-06-17 | 2023-10-13 | 上海健信生物医药科技有限公司 | Antibodies, bispecific antibodies, ADCs and CARs targeting CLDN18.2 and their applications |
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| JP7458399B2 (en) | 2018-12-07 | 2024-03-29 | ゼットリップ ホールディング リミテッド | Anti-claudin antibodies and their use |
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| CN113166246B (en) | 2018-12-28 | 2024-10-18 | 四川科伦博泰生物医药股份有限公司 | An antibody and its use |
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| SG11202108398YA (en) * | 2019-02-01 | 2021-08-30 | Novarock Biotherapeutics Ltd | Anti-claudin 18 antibodies and methods of use thereof |
| JP2022527173A (en) | 2019-03-29 | 2022-05-31 | フェインズ セラピューティクス，インコーポレーテッド | Humanized anti-claudin 18.2 chimeric antigen receptor and its use |
| CA3134411A1 (en) | 2019-04-01 | 2020-10-08 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-claudin 18.2 antibody and application thereof |
| CN119613553A (en) | 2019-04-19 | 2025-03-14 | 康诺亚生物医药科技（成都）有限公司 | Tumor therapeutic agents and their applications |
| CN117264059A (en) | 2019-05-16 | 2023-12-22 | 启愈生物技术(上海)有限公司 | Anti-CLDN antibodies and pharmaceutical compositions and detection methods thereof |
| CN114127109B (en) | 2019-05-30 | 2022-06-21 | 山东博安生物技术股份有限公司 | Antibody or chimeric antigen receptor targeting Claudin18.2 |
| CN116063504A (en) | 2019-07-12 | 2023-05-05 | 明济生物制药（北京）有限公司 | CLDN18.2 antibody and use thereof |
| MX2022000652A (en) | 2019-07-17 | 2022-06-02 | Univ California | ANTIBODIES AGAINST CLAUDIN 18 AND CANCER TREATMENT METHODS. |
| WO2021032157A1 (en) * | 2019-08-20 | 2021-02-25 | Mabspace Biosciences (Suzhou) Co., Limited | Novel anti-cldn18.2 antibodies |
-
2020
- 2020-02-03 SG SG11202108398YA patent/SG11202108398YA/en unknown
- 2020-02-03 KR KR1020217027503A patent/KR20210134321A/en active Pending
- 2020-02-03 CN CN202080025850.0A patent/CN113645996B/en active Active
- 2020-02-03 US US17/427,909 patent/US11407828B2/en active Active
- 2020-02-03 CA CA3128502A patent/CA3128502A1/en active Pending
- 2020-02-03 AU AU2020217012A patent/AU2020217012B2/en active Active
- 2020-02-03 JP JP2021544859A patent/JP7840511B2/en active Active
- 2020-02-03 WO PCT/US2020/016459 patent/WO2020160560A2/en not_active Ceased
- 2020-02-03 EP EP20748335.5A patent/EP3917564A4/en active Pending
-
2022
- 2022-06-22 US US17/846,709 patent/US20230067757A1/en active Pending
- 2022-07-13 US US17/864,335 patent/US20230272063A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020217012B2 (en) | 2026-04-30 |
| AU2020217012A1 (en) | 2021-08-19 |
| JP2022519118A (en) | 2022-03-18 |
| CN113645996B (en) | 2024-04-02 |
| EP3917564A2 (en) | 2021-12-08 |
| US20230272063A1 (en) | 2023-08-31 |
| US11407828B2 (en) | 2022-08-09 |
| US20230067757A1 (en) | 2023-03-02 |
| CA3128502A1 (en) | 2020-08-06 |
| WO2020160560A2 (en) | 2020-08-06 |
| EP3917564A4 (en) | 2022-12-21 |
| KR20210134321A (en) | 2021-11-09 |
| JP7840511B2 (en) | 2026-04-06 |
| CN113645996A (en) | 2021-11-12 |
| WO2020160560A3 (en) | 2020-09-17 |
| US20220041712A1 (en) | 2022-02-10 |
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