SG11202111116VA - Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof - Google Patents

Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof

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Publication number
SG11202111116VA
SG11202111116VA SG11202111116VA SG11202111116VA SG11202111116VA SG 11202111116V A SG11202111116V A SG 11202111116VA SG 11202111116V A SG11202111116V A SG 11202111116VA SG 11202111116V A SG11202111116V A SG 11202111116VA SG 11202111116V A SG11202111116V A SG 11202111116VA
Authority
SG
Singapore
Prior art keywords
preparation
application
method therefor
composition
pharmaceutical composition
Prior art date
Application number
SG11202111116VA
Other languages
English (en)
Inventor
Yuling Liu
Hengfeng Liao
Yue Gao
Wujun Dong
Zhihua Liu
Bangyuan Wang
Yun Zhang
Yu Feng
Junzhuo Zhou
Lu Liu
Jun Ye
Yanfang Yang
Xuejun Xia
Original Assignee
Beijing Wehand Bio Pharmaceutical Co Ltd
Institute Of Materia Medica Chinese Academy Of Medical Science & Peking Union Medical College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Wehand Bio Pharmaceutical Co Ltd, Institute Of Materia Medica Chinese Academy Of Medical Science & Peking Union Medical College filed Critical Beijing Wehand Bio Pharmaceutical Co Ltd
Publication of SG11202111116VA publication Critical patent/SG11202111116VA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
SG11202111116VA 2019-04-09 2020-04-08 Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof SG11202111116VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910278955.6A CN111803632B (zh) 2019-04-09 2019-04-09 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途
PCT/CN2020/083837 WO2020207417A1 (fr) 2019-04-09 2020-04-08 Composition médicamenteuse auto-émulsifiante à base de polyphénol flavonoïde, son procédé de préparation, composition pharmaceutique associée et application associée

Publications (1)

Publication Number Publication Date
SG11202111116VA true SG11202111116VA (en) 2021-11-29

Family

ID=72750939

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202111116VA SG11202111116VA (en) 2019-04-09 2020-04-08 Flavonoid polyphenol drug self-emulsifying composition, preparation method therefor, pharmaceutical composition thereof and application thereof

Country Status (11)

Country Link
US (1) US11771660B2 (fr)
EP (1) EP3954380A4 (fr)
JP (1) JP7762566B2 (fr)
KR (1) KR102497718B1 (fr)
CN (2) CN111803632B (fr)
AU (1) AU2020256609B2 (fr)
CA (1) CA3132454C (fr)
MX (1) MX2021012268A (fr)
SG (1) SG11202111116VA (fr)
WO (1) WO2020207417A1 (fr)
ZA (1) ZA202108771B (fr)

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CN115252801B (zh) * 2021-04-29 2025-07-08 苏州裕泰医药科技有限公司 多西他赛-油酸甘油三酯前药及脂质制剂的制备
CN115252802B (zh) * 2021-04-29 2025-04-18 苏州裕泰医药科技有限公司 多西他赛-硬脂酸甘油三酯前药及其脂质制剂的制备
CN113350515B (zh) * 2021-05-31 2023-03-17 浙江中医药大学 一种漆黄素磷脂复合物及其制备方法和应用
CN113925862A (zh) * 2021-12-17 2022-01-14 北京五和博澳药业股份有限公司 一种预防和/或治疗炎症风暴的药物组合物及其制剂与应用
CN114712311B (zh) * 2022-04-15 2023-05-23 青岛科技大学 一种丝素蛋白肽自组装载药纳米粒的制备及其肾保护作用
CN117159464A (zh) * 2023-07-26 2023-12-05 中国科学院上海药物研究所 芍药苷微乳剂及其制备方法和应用
WO2025108530A1 (fr) * 2023-11-23 2025-05-30 Sarl Laboratoire Beker Formulation d'une solution de quercétine à inhaler pour la prise en charge des maladies respiratoires.
CN117815179A (zh) * 2023-12-08 2024-04-05 成都金瑞基业生物科技有限公司 一种和厚朴酚脂质体粉雾剂及其制备方法和应用
WO2026078718A1 (fr) * 2024-10-08 2026-04-16 Avt Natural Products Ltd. Composition flavonoïde et ses applicatoins

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CN107007569B (zh) * 2017-03-23 2019-08-30 徐州医科大学 一种载槲皮素和白藜芦醇的磁性脂质纳米粒及其制备方法

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CN114617968B (zh) 2023-10-03
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BR112021020359A2 (pt) 2021-12-07
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CA3132454A1 (fr) 2020-10-15
JP2022530752A (ja) 2022-07-01
CN111803632A (zh) 2020-10-23
CA3132454C (fr) 2023-11-07
JP7762566B2 (ja) 2025-10-30
AU2020256609B2 (en) 2023-09-28
EP3954380A4 (fr) 2023-01-11
ZA202108771B (en) 2022-09-28
CN111803632B (zh) 2022-04-29
CN114617968A (zh) 2022-06-14
US11771660B2 (en) 2023-10-03
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