SG148027A1 - Methods for identifying combinations of entities as therapeutics - Google Patents
Methods for identifying combinations of entities as therapeuticsInfo
- Publication number
- SG148027A1 SG148027A1 SG200502530-9A SG2005025309A SG148027A1 SG 148027 A1 SG148027 A1 SG 148027A1 SG 2005025309 A SG2005025309 A SG 2005025309A SG 148027 A1 SG148027 A1 SG 148027A1
- Authority
- SG
- Singapore
- Prior art keywords
- compounds
- whole cells
- combinations
- effect
- contacting
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 12
- 238000003556 assay Methods 0.000 abstract 2
- UIEATEWHFDRYRU-UHFFFAOYSA-N bepridil Chemical compound C1CCCN1C(COCC(C)C)CN(C=1C=CC=CC=1)CC1=CC=CC=C1 UIEATEWHFDRYRU-UHFFFAOYSA-N 0.000 abstract 2
- 229960003665 bepridil Drugs 0.000 abstract 2
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 abstract 2
- 229960002768 dipyridamole Drugs 0.000 abstract 2
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 abstract 2
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 abstract 2
- 229960001237 podophyllotoxin Drugs 0.000 abstract 2
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 abstract 2
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 229960003910 promethazine Drugs 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61183500A | 2000-07-07 | 2000-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG148027A1 true SG148027A1 (en) | 2008-12-31 |
Family
ID=24450586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200502530-9A SG148027A1 (en) | 2000-07-07 | 2001-07-05 | Methods for identifying combinations of entities as therapeutics |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20020019011A1 (de) |
| EP (2) | EP1170591B1 (de) |
| JP (1) | JP3790447B2 (de) |
| KR (1) | KR100470825B1 (de) |
| CN (1) | CN1452719A (de) |
| AR (1) | AR029581A1 (de) |
| AT (1) | ATE298424T1 (de) |
| AU (1) | AU2001271841A1 (de) |
| BR (1) | BR0102781A (de) |
| CA (1) | CA2352515C (de) |
| DE (1) | DE60111595T2 (de) |
| DK (1) | DK1170591T3 (de) |
| ES (1) | ES2243367T3 (de) |
| IL (1) | IL144049A (de) |
| MX (1) | MXPA01006914A (de) |
| NZ (2) | NZ524186A (de) |
| PT (1) | PT1170591E (de) |
| SG (1) | SG148027A1 (de) |
| TW (1) | TWI240074B (de) |
| WO (1) | WO2002004946A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1243327A1 (de) * | 2001-03-19 | 2002-09-25 | BioChip Technologies GmbH | Oberfläche mit einem Muster aus Zellen und Verfahren zu deren Herstellung |
| TW573125B (en) * | 2001-08-29 | 2004-01-21 | Combinatorx Inc | A screening system for identifying drug-drug interactions and methods of use thereof |
| WO2004080445A1 (en) * | 2003-03-12 | 2004-09-23 | Molecular Engines Laboratories Sa | Methods and compositions for the treatment of cancer |
| WO2004088272A2 (en) | 2003-03-26 | 2004-10-14 | Synergy Biosystems Ltd. | Methods to identify biologically active agents and synergistic combinations |
| CA2528508A1 (en) * | 2003-06-06 | 2004-12-16 | Combinatorx Incorporated | System and method for multidimensional evaluation of combinations of compositions |
| JP4632400B2 (ja) | 2003-12-16 | 2011-02-16 | キヤノン株式会社 | 細胞培養用基板、その製造方法、それを用いた細胞スクリーニング法 |
| WO2005059086A1 (en) * | 2003-12-16 | 2005-06-30 | Canon Kabushiki Kaisha | Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same |
| US20060040338A1 (en) * | 2004-08-18 | 2006-02-23 | Odyssey Thera, Inc. | Pharmacological profiling of drugs with cell-based assays |
| EP2089723A2 (de) * | 2006-11-13 | 2009-08-19 | University of Wyoming | Vorrichtung und verfahren zum messen der fluoreszenz grosser mehrzelliger organismen |
| WO2009151511A1 (en) * | 2008-04-29 | 2009-12-17 | Therasis, Inc. | Systems and methods for identifying combinations of compounds of therapeutic interest |
| CN104090094A (zh) * | 2013-05-28 | 2014-10-08 | 长兴化学工业股份有限公司 | 生物医学装置 |
| US11313772B2 (en) | 2015-11-13 | 2022-04-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fixatives and methods of use |
| WO2018049250A1 (en) * | 2016-09-08 | 2018-03-15 | Curematch, Inc. | Optimizing therapeutic options in personalized medicine |
| DE102020202529A1 (de) * | 2020-02-27 | 2021-09-02 | Robert Bosch Gesellschaft mit beschränkter Haftung | Verfahren zur Identifikation einer Wirkstoffkombination |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| CA2058252A1 (en) * | 1991-03-18 | 1992-09-19 | Linda R. Robertson | Synergistic product selection test for biocides |
| US5885782A (en) * | 1994-09-13 | 1999-03-23 | Nce Pharmaceuticals, Inc. | Synthetic antibiotics |
| US5985356A (en) * | 1994-10-18 | 1999-11-16 | The Regents Of The University Of California | Combinatorial synthesis of novel materials |
| US5756304A (en) * | 1995-07-14 | 1998-05-26 | Molecular Solutions | Screening of microorganisms for bioremediation |
| US5989835A (en) * | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
| US6030942A (en) * | 1996-08-30 | 2000-02-29 | The Trustees Of The University Of Pennsylvania | Peptides peptide analogs peptidomimetics and other small molecules useful for inhibiting the activity of ribonucleotide reductase |
| US5985214A (en) * | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
| ATE322477T1 (de) * | 1997-05-16 | 2006-04-15 | Woman & Infants Hospital | 3-epi-vitamin d2 verbindungen und ihre anwendungen |
| US5992226A (en) * | 1998-05-08 | 1999-11-30 | The United States Of America As Represented By The Secretary Of The Navy | Apparatus and method for measuring intermolecular interactions by atomic force microscopy |
| US6219674B1 (en) * | 1999-11-24 | 2001-04-17 | Classen Immunotherapies, Inc. | System for creating and managing proprietary product data |
| US7266458B2 (en) * | 2000-03-06 | 2007-09-04 | Bioseek, Inc. | BioMAP analysis |
-
2001
- 2001-03-22 US US09/815,429 patent/US20020019011A1/en not_active Abandoned
- 2001-03-22 US US09/815,417 patent/US20020019010A1/en not_active Abandoned
- 2001-06-28 IL IL144049A patent/IL144049A/en not_active IP Right Cessation
- 2001-07-01 NZ NZ524186A patent/NZ524186A/en unknown
- 2001-07-05 EP EP01115703A patent/EP1170591B1/de not_active Expired - Lifetime
- 2001-07-05 PT PT01115703T patent/PT1170591E/pt unknown
- 2001-07-05 CN CN01815353A patent/CN1452719A/zh active Pending
- 2001-07-05 DK DK01115703T patent/DK1170591T3/da active
- 2001-07-05 ES ES01115703T patent/ES2243367T3/es not_active Expired - Lifetime
- 2001-07-05 DE DE60111595T patent/DE60111595T2/de not_active Expired - Fee Related
- 2001-07-05 AT AT01115703T patent/ATE298424T1/de not_active IP Right Cessation
- 2001-07-05 KR KR10-2001-7011539A patent/KR100470825B1/ko not_active Expired - Fee Related
- 2001-07-05 AU AU2001271841A patent/AU2001271841A1/en not_active Abandoned
- 2001-07-05 EP EP05013343A patent/EP1586900A3/de not_active Withdrawn
- 2001-07-05 WO PCT/US2001/021292 patent/WO2002004946A2/en not_active Ceased
- 2001-07-05 SG SG200502530-9A patent/SG148027A1/en unknown
- 2001-07-06 MX MXPA01006914A patent/MXPA01006914A/es active IP Right Grant
- 2001-07-06 CA CA002352515A patent/CA2352515C/en not_active Expired - Lifetime
- 2001-07-06 NZ NZ512821A patent/NZ512821A/en unknown
- 2001-07-06 AR ARP010103237A patent/AR029581A1/es not_active Application Discontinuation
- 2001-07-09 JP JP2001208607A patent/JP3790447B2/ja not_active Expired - Fee Related
- 2001-07-09 BR BR0102781-6A patent/BR0102781A/pt not_active IP Right Cessation
- 2001-09-21 TW TW090116629A patent/TWI240074B/zh active
-
2006
- 2006-04-18 US US11/379,179 patent/US20060177877A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002004946A3 (en) | 2003-01-23 |
| CA2352515A1 (en) | 2002-01-07 |
| EP1170591B1 (de) | 2005-06-22 |
| DE60111595T2 (de) | 2006-05-18 |
| AU2001271841A1 (en) | 2002-01-21 |
| DE60111595D1 (de) | 2005-07-28 |
| EP1586900A3 (de) | 2005-12-14 |
| IL144049A (en) | 2006-12-10 |
| MXPA01006914A (es) | 2004-10-15 |
| US20020019011A1 (en) | 2002-02-14 |
| TWI240074B (en) | 2005-09-21 |
| CN1452719A (zh) | 2003-10-29 |
| JP2002328124A (ja) | 2002-11-15 |
| BR0102781A (pt) | 2002-03-12 |
| IL144049A0 (en) | 2002-04-21 |
| PT1170591E (pt) | 2005-11-30 |
| JP3790447B2 (ja) | 2006-06-28 |
| EP1170591A2 (de) | 2002-01-09 |
| EP1586900A2 (de) | 2005-10-19 |
| NZ524186A (en) | 2004-10-29 |
| US20060177877A1 (en) | 2006-08-10 |
| DK1170591T3 (da) | 2005-10-10 |
| NZ512821A (en) | 2003-05-30 |
| WO2002004946A2 (en) | 2002-01-17 |
| AR029581A1 (es) | 2003-07-02 |
| CA2352515C (en) | 2007-06-19 |
| ES2243367T3 (es) | 2005-12-01 |
| ATE298424T1 (de) | 2005-07-15 |
| EP1170591A3 (de) | 2002-09-18 |
| KR20020065340A (ko) | 2002-08-13 |
| US20020019010A1 (en) | 2002-02-14 |
| KR100470825B1 (ko) | 2005-03-08 |
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