SG155968A1 - Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling - Google Patents
Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profilingInfo
- Publication number
- SG155968A1 SG155968A1 SG200906376-9A SG2009063769A SG155968A1 SG 155968 A1 SG155968 A1 SG 155968A1 SG 2009063769 A SG2009063769 A SG 2009063769A SG 155968 A1 SG155968 A1 SG 155968A1
- Authority
- SG
- Singapore
- Prior art keywords
- prognosis
- diagnosis
- classification
- gene expression
- myeloid leukemia
- Prior art date
Links
- 208000031261 Acute myeloid leukaemia Diseases 0.000 title 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 238000011223 gene expression profiling Methods 0.000 title 1
- 238000004393 prognosis Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04075570 | 2004-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG155968A1 true SG155968A1 (en) | 2009-10-29 |
Family
ID=34878266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG200906376-9A SG155968A1 (en) | 2004-02-23 | 2005-02-23 | Classification, diagnosis and prognosis of acute myeloid leukemia by gene expression profiling |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8142994B2 (de) |
| EP (1) | EP1723257B1 (de) |
| JP (1) | JP4980878B2 (de) |
| CN (1) | CN101088089A (de) |
| AU (1) | AU2005214286A1 (de) |
| CA (1) | CA2558366A1 (de) |
| SG (1) | SG155968A1 (de) |
| WO (1) | WO2005080601A2 (de) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030114410A1 (en) | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| EP1603585A2 (de) | 2003-03-14 | 2005-12-14 | Bristol-Myers Squibb Company | Polynucleotid kodierend für eine neue humane g-proteingekoppelte rezeptor-variante von hm74, hgprbmy74 |
| WO2006048263A2 (en) * | 2004-11-04 | 2006-05-11 | Roche Diagnostics Gmbh | Gene expression profiling in acute promyelocytic leukemia |
| KR100565698B1 (ko) * | 2004-12-29 | 2006-03-28 | 디지탈 지노믹스(주) | 급성골수성백혈병(aml), b-세포형 급성임파구성백혈병(b-all), t 세포형 급성임파구성백혈병(t-all) 진단용 마커 |
| EP1848994A2 (de) * | 2005-02-16 | 2007-10-31 | Wyeth | Verfahren und produkte zur feststellung, prognose und selektion zur behandlung von leukämie |
| CN103820562B (zh) | 2005-08-01 | 2015-05-13 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| JP2009507918A (ja) | 2005-09-12 | 2009-02-26 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | Ｂｃｌ２関連癌の診断及び療法のための組成物及び方法 |
| KR100617467B1 (ko) * | 2005-09-27 | 2006-09-01 | 디지탈 지노믹스(주) | 급성 골수성 백혈병 환자의 항암제 치료 반응성 예측용마커 |
| ES2324435B1 (es) * | 2005-10-27 | 2010-05-31 | Fundacion Para El Estudio De La Hematologia Y Hemoterapia De Aragon (Fehha) | Procedimiento y dispositivo de analisis in vitro de mrna de genes implicados en neoplasias hematologicas. |
| US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| EP1969147B1 (de) | 2006-01-05 | 2014-07-30 | The Ohio State University Research Foundation | mikro-RNA-basierte verfahren zur Diagnose von Magenkrebs |
| EP2369011A1 (de) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Miko-RNA-Fingerabdrücke während humaner Megakaryozytopoiese |
| EP2041317A4 (de) | 2006-07-13 | 2009-10-14 | Univ Ohio State Res Found | Mikro-rna-basierte verfahren und zusammensetzungen zur diagnose und behandlung von erkrankungen in zusammenhang mit darmkrebs |
| EP2061907B1 (de) | 2006-09-19 | 2011-11-23 | The Ohio State University Research Foundation | Tcl1-expression in durch mir-29 und mir-181 regulierter chronischer lymphozyten-leukämie (cll) |
| US8252538B2 (en) | 2006-11-01 | 2012-08-28 | The Ohio State University | MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008094545A2 (en) | 2007-01-31 | 2008-08-07 | The Ohio State University Research Foundation | Mic orna-based methods and compositions for the treatment of acute myeloid leukemia |
| US20100311606A1 (en) * | 2007-05-07 | 2010-12-09 | Liewei Wang | Pharmacogenomic cell line panel and use thereof |
| ES2537349T3 (es) | 2007-06-08 | 2015-06-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar un subtipo de carcinoma hepatocelular |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| CN101809169B (zh) | 2007-07-31 | 2013-07-17 | 俄亥俄州立大学研究基金会 | 通过靶向dnmt3a和dnmt3b恢复甲基化的方法 |
| ES2700141T3 (es) | 2007-08-02 | 2019-02-14 | Gilead Biologics Inc | Anticuerpos inhibidores LOXL2 y usos de los mismos |
| EP2653561B1 (de) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultrakonservierte Bereiche zur Codierung von ncRNA |
| EP3028708A1 (de) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Verfahren und zusammensetzungen zur induzierung von epha7-deregulierung und erk-phosphorlylierung bei humaner akuter leukämie |
| EP2036988A1 (de) * | 2007-09-12 | 2009-03-18 | Siemens Healthcare Diagnostics GmbH | Verfahren zur Vorhersage des Ansprechens eines Tumors auf einen chemotherapeutischen Wirkstoff bei einer Patientin, die unter einer rekurrenten gynäkologischen Krebserkrankung leidet oder Gefahr läuft, eine solche zu entwickeln |
| CA2703707A1 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| EP2307028B1 (de) | 2008-06-11 | 2013-10-02 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Verwendung der mir-26-familie als prädiktiver marker für hepatozelluläres karzinom und des ansprechens auf die therapie |
| EP2352849A1 (de) * | 2008-11-13 | 2011-08-10 | Erasmus University Medical Center Rotterdam | Effizienter nachweis von doppelmutanten des cebpa-gens bei akuter myeloischer leukämie |
| WO2010080769A2 (en) | 2009-01-06 | 2010-07-15 | Arresto Biosciences, Inc. | Chemotherapeutic methods and compositions |
| WO2010110346A1 (ja) * | 2009-03-24 | 2010-09-30 | 独立行政法人理化学研究所 | 白血病幹細胞マーカー |
| EP2433232A1 (de) * | 2009-05-20 | 2012-03-28 | Koninklijke Philips Electronics N.V. | Auf molekularen signatureinheiten basierende biomarker |
| SG178845A1 (en) | 2009-08-21 | 2012-04-27 | Gilead Biologics Inc | Catalytic domains from lysyl oxidase and loxl2 |
| AU2010321555B2 (en) | 2009-11-23 | 2015-10-15 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| BR112012019693A2 (pt) | 2010-02-04 | 2017-06-20 | Gilead Biologics Inc | anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles. |
| EP2458014A1 (de) * | 2010-09-07 | 2012-05-30 | Rijksuniversiteit Groningen | Prognosemarker für akute myeloische Leukämie (AML) |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| CN103313706A (zh) | 2010-11-15 | 2013-09-18 | 俄亥俄州立大学研究基金会 | 控制释放粘膜粘合系统 |
| WO2012078931A2 (en) * | 2010-12-08 | 2012-06-14 | Ravi Bhatia | Gene signatures for prediction of therapy-related myelodysplasia and methods for identification of patients at risk for development of the same |
| EP2655658B1 (de) | 2010-12-22 | 2016-11-09 | Universite Francois Rabelais de Tours | Verfahren zur diagnose hämatologischer erkrankungen |
| WO2012112958A2 (en) * | 2011-02-19 | 2012-08-23 | The Broad Institute, Inc | High-throughput assays to probe leukemia within the stromal niche |
| US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
| WO2012131564A1 (en) * | 2011-03-27 | 2012-10-04 | Oncostem Diagnostics Pvt. Ltd. | Markers for identifying tumor cells, methods and kit thereof |
| US20150018225A1 (en) * | 2011-05-13 | 2015-01-15 | University Of Miyazaki | Cell adhesion inhibitor, cell proliferation inhibitor, and method and kit for examining cancer |
| WO2012170710A1 (en) * | 2011-06-08 | 2012-12-13 | Altheadx Incorporated | Disease classification modules |
| WO2013033734A1 (en) | 2011-09-02 | 2013-03-07 | The Trustees Of Columbia University In The City Of New York | Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand |
| EP2766500A4 (de) | 2011-10-14 | 2015-10-14 | Univ Ohio State | Verfahren und materialien in verbindung mit eierstockkrebs |
| AU2012352265B2 (en) | 2011-12-13 | 2017-02-16 | Ohio State Innovation Foundation | Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis |
| US8859202B2 (en) | 2012-01-20 | 2014-10-14 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| US9659087B2 (en) * | 2012-11-19 | 2017-05-23 | Amplero, Inc. | Unsupervised prioritization and visualization of clusters |
| CA2937387A1 (en) * | 2014-01-27 | 2015-07-30 | Medimmune, Llc | Dipeptidyl peptidase-4 (dpp4/cd26) as a peripheral biomarker of il-13 activation in asthmatic lung |
| WO2015119570A1 (en) * | 2014-02-07 | 2015-08-13 | Agency For Science, Technology And Research | Prl-3 as a biomarker for the prognosis of cancer and a target for therapy |
| GB201408100D0 (en) * | 2014-05-07 | 2014-06-18 | Sec Dep For Health The | Detection method |
| WO2016201365A2 (en) * | 2015-06-12 | 2016-12-15 | Visani Giuseppe | Methods for treating cancers |
| WO2017015227A1 (en) | 2015-07-17 | 2017-01-26 | The Trustees Of Columbia University In The City Of New York | Methods of treating cd166-expressing cancer |
| WO2017048121A1 (en) | 2015-09-15 | 2017-03-23 | Erasmus University Medical Center Rotterdam | Il17 related assays |
| CN105255896B (zh) * | 2015-11-21 | 2019-01-11 | 长沙绿天生物技术有限公司 | 一种水稻基因启动子、表达盒、表达载体及其应用 |
| CA3013646A1 (en) | 2016-02-06 | 2017-08-10 | University Health Network | Method for identifying high-risk aml patients |
| EP3411517B1 (de) * | 2016-02-06 | 2021-11-17 | University Health Network | Verfahren zur identifizierung von aml-hochrisikopatienten |
| CN105837679B (zh) * | 2016-04-29 | 2019-04-23 | 中国人民解放军第四军医大学 | 多肽及其用于制备治疗缺血性脑卒中药物的应用 |
| EP3548004A4 (de) * | 2016-11-30 | 2020-08-12 | Partha S. Ray | Diagnose, prognose und behandlung von akuter myeloischer leukämie |
| CN109402252A (zh) * | 2017-08-11 | 2019-03-01 | 上海交通大学医学院附属瑞金医院 | 急性髓系白血病风险评估基因标志物及其应用 |
| CA3073055A1 (en) | 2017-09-04 | 2019-03-07 | Agenus Inc. | T cell receptors that bind to mixed lineage leukemia (mll)-specific phosphopeptides and methods of use thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109754398A (zh) * | 2019-01-14 | 2019-05-14 | 武汉兰丁医学高科技有限公司 | 一种基于计算机的骨髓白细胞自动标记方法及系统 |
| CN111394463B (zh) * | 2020-04-22 | 2021-03-30 | 中国人民解放军联勤保障部队第九六0医院 | 一种与甲状腺癌相关的分子及其应用 |
| CN112760379A (zh) * | 2021-01-26 | 2021-05-07 | 暨南大学 | Tox3在制备预测aml预后试剂盒中的应用 |
| CN112904005B (zh) * | 2021-01-26 | 2023-10-27 | 李欣 | 用于鼻咽癌早期筛查的血浆外泌体蛋白标志物及其应用 |
| CN112980952B (zh) * | 2021-02-05 | 2022-11-29 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 用于预测异柠檬酸脱氢酶1基因野生型胶质瘤预后与抗pd1治疗疗效的标志物及其应用 |
| CN116392572B (zh) * | 2023-03-10 | 2026-03-24 | 武汉大学中南医院 | 整合素蛋白itga5作为标志物在制备治疗高白细胞性急性髓系白血病药物中的应用 |
| CN118465265A (zh) * | 2024-04-08 | 2024-08-09 | 北京大学人民医院 | 与急性髓系白血病造血干细胞移植术后临床结局相关的生物标志物及其应用 |
| CN120277548B (zh) * | 2025-06-11 | 2025-09-02 | 之江实验室 | 一种基于原型对比学习的急性髓系白血病亚型分型方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6647341B1 (en) * | 1999-04-09 | 2003-11-11 | Whitehead Institute For Biomedical Research | Methods for classifying samples and ascertaining previously unknown classes |
| WO2003102235A2 (en) * | 2002-05-31 | 2003-12-11 | Cancer Research Technology Limited | Specific genetic markets for cytogenetically defined acute myeloid leukaemia |
-
2005
- 2005-02-23 EP EP05710909.2A patent/EP1723257B1/de not_active Expired - Lifetime
- 2005-02-23 SG SG200906376-9A patent/SG155968A1/en unknown
- 2005-02-23 AU AU2005214286A patent/AU2005214286A1/en not_active Abandoned
- 2005-02-23 JP JP2007500702A patent/JP4980878B2/ja not_active Expired - Fee Related
- 2005-02-23 WO PCT/NL2005/000134 patent/WO2005080601A2/en not_active Ceased
- 2005-02-23 CA CA002558366A patent/CA2558366A1/en not_active Abandoned
- 2005-02-23 US US10/590,385 patent/US8142994B2/en not_active Expired - Fee Related
- 2005-02-23 CN CNA2005800127957A patent/CN101088089A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1723257B1 (de) | 2019-01-09 |
| US8142994B2 (en) | 2012-03-27 |
| CA2558366A1 (en) | 2005-09-01 |
| US20080305965A1 (en) | 2008-12-11 |
| EP1723257A2 (de) | 2006-11-22 |
| AU2005214286A1 (en) | 2005-09-01 |
| JP4980878B2 (ja) | 2012-07-18 |
| WO2005080601A3 (en) | 2007-05-10 |
| CN101088089A (zh) | 2007-12-12 |
| JP2007527238A (ja) | 2007-09-27 |
| WO2005080601A2 (en) | 2005-09-01 |
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