SG160212A1 - Process for the preparation of n-substituted 2-cyanopyrrolidines - Google Patents

Process for the preparation of n-substituted 2-cyanopyrrolidines

Info

Publication number
SG160212A1
SG160212A1 SG200716949-3A SG2007169493A SG160212A1 SG 160212 A1 SG160212 A1 SG 160212A1 SG 2007169493 A SG2007169493 A SG 2007169493A SG 160212 A1 SG160212 A1 SG 160212A1
Authority
SG
Singapore
Prior art keywords
reacting
preparation
resultant compound
substituted
halogen
Prior art date
Application number
SG200716949-3A
Other languages
English (en)
Inventor
Frank Schafer
Gottfried Sedelmeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33301223&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG160212(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0308854A external-priority patent/GB0308854D0/en
Priority claimed from GB0311836A external-priority patent/GB0311836D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG160212A1 publication Critical patent/SG160212A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG200716949-3A 2003-04-16 2004-04-15 Process for the preparation of n-substituted 2-cyanopyrrolidines SG160212A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308854A GB0308854D0 (en) 2003-04-16 2003-04-16 Organic compounds
GB0311836A GB0311836D0 (en) 2003-05-22 2003-05-22 Process for the manufacture of organic compounds

Publications (1)

Publication Number Publication Date
SG160212A1 true SG160212A1 (en) 2010-04-29

Family

ID=33301223

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200716949-3A SG160212A1 (en) 2003-04-16 2004-04-15 Process for the preparation of n-substituted 2-cyanopyrrolidines

Country Status (30)

Country Link
US (1) US7375238B2 (fr)
EP (1) EP1620396B1 (fr)
JP (1) JP4672647B2 (fr)
KR (1) KR101192538B1 (fr)
AR (1) AR044019A1 (fr)
AU (2) AU2004230245B2 (fr)
BR (1) BRPI0409471B8 (fr)
CA (1) CA2520128C (fr)
CL (1) CL2004000804A1 (fr)
CO (1) CO5700735A2 (fr)
CY (1) CY1116008T1 (fr)
DK (1) DK1620396T3 (fr)
EC (1) ECSP056093A (fr)
ES (1) ES2531084T3 (fr)
HR (1) HRP20150163T1 (fr)
IL (1) IL170887A (fr)
IS (1) IS2979B (fr)
MA (1) MA27765A1 (fr)
MX (1) MXPA05011073A (fr)
MY (1) MY139476A (fr)
NO (1) NO333251B1 (fr)
NZ (1) NZ542899A (fr)
PE (2) PE20081293A1 (fr)
PL (1) PL1620396T3 (fr)
PT (1) PT1620396E (fr)
RU (1) RU2369598C2 (fr)
SG (1) SG160212A1 (fr)
SI (1) SI1620396T1 (fr)
TW (1) TWI359135B (fr)
WO (1) WO2004092127A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR044019A1 (es) 2003-04-16 2005-08-24 Novartis Ag Proceso para la preparacion de 2-cianopirrolidinas n-sustituidas
JP5122144B2 (ja) 2004-01-20 2013-01-16 ノバルティス アーゲー 直接圧縮製剤および方法
GT200600008A (es) 2005-01-18 2006-08-09 Formulacion de compresion directa y proceso
MX2007011453A (es) 2005-04-22 2008-02-12 Alantos Pharmaceuticals Holding Inc Inhibidores de la dipeptidil peptidasa-iv.
EP1912938A2 (fr) * 2005-08-04 2008-04-23 Novartis AG Sels de vildagliptin
JP5165584B2 (ja) * 2006-11-29 2013-03-21 田辺三菱製薬株式会社 Ｎ−（ｎ’−置換グリシル）−２−シアノピロリジン誘導体の製法
AR064833A1 (es) * 2007-01-10 2009-04-29 Medichem Sa Un procedimiento para la preparacion de vildagliptin
CZ2008512A3 (cs) 2008-08-26 2010-03-10 Zentiva, A. S Zpusob prípravy vysoce cistého vildagliptinu
EA034049B1 (ru) * 2009-07-31 2019-12-23 КРКА, д.д., НОВО МЕСТО Гранулят, включающий вилдаглиптин, способ его получения и фармацевтическая композиция
HUP0900638A2 (en) * 2009-10-07 2011-05-30 Egyt Gyogyszervegyeszeti Gyar Adducts of inorganic salts basea on vildaelitpin applicable for preparation of pharmaceutical compositions
IT1400714B1 (it) 2010-07-06 2013-06-28 Chemelectiva S R L Processo ed intermedi per la preparazione di un principio attivo.
HU231050B1 (hu) 2010-08-19 2020-02-28 Egis Gyógyszergyár Nyrt. Eljárás gyógyszerhatóanyag előállítására
ITMI20112224A1 (it) 2011-12-06 2013-06-07 Chemelectiva S R L Nuovo processo ed intermedi per la sintesi di vildagliptin
WO2013179300A2 (fr) 2012-05-04 2013-12-05 Megafine Pharma (P) Ltd. Procédé de préparation de vildagliptine et de son intermédiaire
CN103922986B (zh) * 2013-01-16 2017-02-15 上海彩迩文生化科技有限公司 维大列汀及其类似物、中间体及其制备方法和应用
WO2015145467A1 (fr) * 2014-03-28 2015-10-01 Laurus Labs Private Limited Procédé amélioré de préparation de vildagliptine
WO2021234430A1 (fr) 2020-05-17 2021-11-25 Lotus International Pte. Ltd. Forme galénique à libération modifiée comprenant de la vildagliptine et son procédé de fabrication
WO2022003405A1 (fr) 2020-07-03 2022-01-06 Savoi Guilherme Procédé monotope permettant d'obtenir un composé intermédiaire pyrrolidine-2-carbonitrile et procédé télescopique à l'échelle industrielle permettant de préparer du (2s)-1-[n-(3-hydroxyadamantan-1-yl)glycyl]-2-pyrrolidinecarbonitrile (vildagliptine) l'utilisant

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510369A (en) * 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
CO5150173A1 (es) * 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6380398B2 (en) 2000-01-04 2002-04-30 Novo Nordisk A/S Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
WO2001055105A1 (fr) * 2000-01-24 2001-08-02 Novo Nordisk A/S 2-cyanopyroles et -pyrrolines a substitution n inhibant l'enzyme dpp-iv
TW583185B (en) * 2000-06-13 2004-04-11 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
JP2002265439A (ja) * 2001-03-08 2002-09-18 Mitsubishi Pharma Corp シアノピロリジン誘導体およびその医薬用途
AR044019A1 (es) 2003-04-16 2005-08-24 Novartis Ag Proceso para la preparacion de 2-cianopirrolidinas n-sustituidas

Also Published As

Publication number Publication date
MY139476A (en) 2009-10-30
RU2005135331A (ru) 2006-06-27
SI1620396T1 (sl) 2015-03-31
KR20060003878A (ko) 2006-01-11
IS8122A (is) 2005-11-10
JP2006523645A (ja) 2006-10-19
US7375238B2 (en) 2008-05-20
NO20055226L (no) 2005-11-07
TWI359135B (en) 2012-03-01
HK1087695A1 (en) 2006-10-20
NO333251B1 (no) 2013-04-22
CL2004000804A1 (es) 2005-02-11
PE20081293A1 (es) 2008-11-04
AR044019A1 (es) 2005-08-24
PT1620396E (pt) 2015-03-05
KR101192538B1 (ko) 2012-10-17
JP4672647B2 (ja) 2011-04-20
PE20050021A1 (es) 2005-03-15
ES2531084T3 (es) 2015-03-10
CO5700735A2 (es) 2006-11-30
EP1620396A1 (fr) 2006-02-01
MXPA05011073A (es) 2005-12-12
AU2008202278A1 (en) 2008-11-20
RU2369598C2 (ru) 2009-10-10
AU2004230245A1 (en) 2004-10-28
US20060199854A1 (en) 2006-09-07
BRPI0409471B8 (pt) 2021-05-25
PL1620396T3 (pl) 2015-05-29
AU2004230245B2 (en) 2008-02-21
ECSP056093A (es) 2006-03-01
MA27765A1 (fr) 2006-02-01
IL170887A (en) 2013-06-27
NZ542899A (en) 2009-02-28
DK1620396T3 (en) 2015-02-23
CA2520128C (fr) 2012-02-07
CA2520128A1 (fr) 2004-10-28
EP1620396B1 (fr) 2014-12-03
WO2004092127A1 (fr) 2004-10-28
CY1116008T1 (el) 2017-01-25
BRPI0409471A (pt) 2006-05-02
TW200510299A (en) 2005-03-16
BRPI0409471B1 (pt) 2015-11-03
HRP20150163T1 (xx) 2015-03-27
IS2979B (is) 2017-09-15

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