SG167671A1 - Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide - Google Patents

Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

Info

Publication number: SG167671A1
Authority: SG; Singapore
Prior art keywords: cyclobuten; aminobenzamide; dioxo; furanyl; propyl
Prior art date: 2003-04-18

Application number

SG200717017-8A

Other languages

English (en)

Inventor

Jianguo Yin

Xiaoyong Fu

Shuyi Zhang

Timothy L Mcallister

Agnes S Kim-Meade

Jason L Winters

Anantha Sudhakar

Doris P Schumacher

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-18

Filing date

2004-04-16

Publication date

2011-01-28

2004-04-16 Application filed by Schering Corp filed Critical Schering Corp

2011-01-28 Publication of SG167671A1 publication Critical patent/SG167671A1/en

Links

PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical compound NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Furan Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SG200717017-8A 2003-04-18 2004-04-16 Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide SG167671A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46377303P	2003-04-18	2003-04-18

Publications (1)

Publication Number	Publication Date
SG167671A1 true SG167671A1 (en)	2011-01-28

Family

ID=33310818

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200717017-8A SG167671A1 (en)	2003-04-18	2004-04-16	Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide

Country Status (13)

Country	Link
US (3)	US7071342B2 (de)
EP (2)	EP1615903B1 (de)
JP (2)	JP4440917B2 (de)
CN (3)	CN100448860C (de)
AR (1)	AR044027A1 (de)
AT (1)	ATE457307T1 (de)
CA (1)	CA2522748C (de)
DE (1)	DE602004025458D1 (de)
ES (1)	ES2338657T3 (de)
MX (1)	MXPA05011183A (de)
SG (1)	SG167671A1 (de)
WO (1)	WO2004094398A2 (de)
ZA (3)	ZA200508129B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040106794A1 (en) *	2001-04-16	2004-06-03	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
RU2388756C2 (ru) *	2004-01-30	2010-05-10	Шеринг Корпорейшн	Кристаллические полиморфные формы лиганда схс-хемокинового рецептора
KR20090024248A (ko)	2006-06-12	2009-03-06	쉐링 코포레이션	Ｃｘｃｒ2의 선택적 길항제 또는 ｃｘｃｒ1과 ｃｘｃｒ2 둘다의 선택적 길항제의 약제학적 제형 및 조성물, 및 염증성 질환을 치료하기 위한 이의 사용방법
CN101932553A (zh) *	2007-07-03	2010-12-29	先灵公司	合成1,2-取代的3,4-二氧代-1-环丁烯化合物的方法和中间体
JP2010532357A (ja) *	2007-07-05	2010-10-07	シェーリングコーポレイション	１，２−置換３，４−ジオキソ−１−シクロブテン化合物における制御された結晶サイズのための方法
KR20130087387A (ko)	2010-06-16	2013-08-06	데이진 가부시키가이샤	고리형 카르보디이미드 화합물의 중간체의 제조 방법
WO2012147897A1 (ja) *	2011-04-25	2012-11-01	住友化学株式会社	アミン化合物の製造方法
TWI724056B (zh)	2015-11-19	2021-04-11	美商卡默森屈有限公司	Ｃｘｃｒ２抑制劑
TWI734715B (zh)	2015-11-19	2021-08-01	美商卡默森屈有限公司	趨化因子受體調節劑
WO2019067332A1 (en)	2017-09-27	2019-04-04	Merck Sharp & Dohme Corp.	COMPOSITIONS AND METHODS FOR TREATING CANCER THROUGH A COMBINATION OF PROGRAMMED DEATH ANTIBODY ANTIBODIES (PD-1) AND A CXCR2 ANTAGONIST
EP3737366B1 (de)	2018-01-08	2026-02-25	ChemoCentryx, Inc.	Verfahren zur behandlung von generalisierter pustulöser psoriasis mit einem antagonisten von ccr6 oder cxcr2
TWI849253B (zh) *	2019-11-11	2024-07-21	美商富曼西公司	用於製備3-溴-1- (3-氯吡啶-2-基) -1h-吡唑-5-羧酸乙酯的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002076926A1 (en) *	2001-02-02	2002-10-03	Schering Corporation	3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
WO2002083624A1 (en) *	2001-04-16	2002-10-24	Schering Corporation	3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

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US2791613A (en) *	1953-08-24	1957-05-07	Columbia Southern Chem Corp	Metahaloaniline production using copper oxide-chromic oxide catalysts
CH691112A5 (de)	1995-03-14	2001-04-30	Sumitomo Chemical Co	Verfahren zur Herstellung von Kristallen eines Schwefelsäuresalzes des 3-Amino-2-hydroxyacetophenons mit hoher Schüttdiche und verbesserten Fliesseigenschaften .
ZA991105B (en) *	1998-03-04	2000-02-11	Searle & Co	Synthesis of chiral beta-amino acids.
US20030204085A1 (en) *	2001-02-02	2003-10-30	Taveras Arthur G.	3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists
US20040106794A1 (en) *	2001-04-16	2004-06-03	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
WO2003080053A1 (en)	2002-03-18	2003-10-02	Schering Corporation	Combination treatments for chemokine-mediated diseases
US12284102B2 (en)	2022-09-01	2025-04-22	Dell Products, L.P.	Detection of collaboration sessions and other workloads in a heterogenous computing platform

2004
- 2004-04-16 DE DE602004025458T patent/DE602004025458D1/de not_active Expired - Lifetime
- 2004-04-16 CN CNB2004800165225A patent/CN100448860C/zh not_active Expired - Fee Related
- 2004-04-16 JP JP2006501278A patent/JP4440917B2/ja not_active Expired - Fee Related
- 2004-04-16 EP EP04759956A patent/EP1615903B1/de not_active Expired - Lifetime
- 2004-04-16 CN CN2008101738953A patent/CN101514193B/zh not_active Expired - Fee Related
- 2004-04-16 AR ARP040101294A patent/AR044027A1/es not_active Application Discontinuation
- 2004-04-16 SG SG200717017-8A patent/SG167671A1/en unknown
- 2004-04-16 CN CN200810173891.5A patent/CN101514168B/zh not_active Expired - Fee Related
- 2004-04-16 WO PCT/US2004/011882 patent/WO2004094398A2/en not_active Ceased
- 2004-04-16 EP EP09014248.0A patent/EP2168956B8/de not_active Expired - Lifetime
- 2004-04-16 US US10/826,456 patent/US7071342B2/en not_active Expired - Lifetime
- 2004-04-16 MX MXPA05011183A patent/MXPA05011183A/es active IP Right Grant
- 2004-04-16 AT AT04759956T patent/ATE457307T1/de not_active IP Right Cessation
- 2004-04-16 ES ES04759956T patent/ES2338657T3/es not_active Expired - Lifetime
- 2004-04-16 CA CA2522748A patent/CA2522748C/en not_active Expired - Fee Related
2005
- 2005-10-07 ZA ZA200508129A patent/ZA200508129B/en unknown
2006
- 2006-05-09 US US11/430,687 patent/US7462740B2/en not_active Expired - Lifetime
2008
- 2008-01-16 ZA ZA200800487A patent/ZA200800487B/en unknown
- 2008-01-16 ZA ZA200800486A patent/ZA200800486B/en unknown
- 2008-10-17 US US12/253,356 patent/US7910775B2/en not_active Expired - Lifetime
2009
- 2009-12-01 JP JP2009273993A patent/JP5202503B2/ja not_active Expired - Fee Related

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002076926A1 (en) *	2001-02-02	2002-10-03	Schering Corporation	3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
WO2002083624A1 (en) *	2001-04-16	2002-10-24	Schering Corporation	3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands

Also Published As

Publication number	Publication date
ZA200800487B (en)	2009-08-26
CN101514168A (zh)	2009-08-26
EP2168956B1 (de)	2013-03-20
WO2004094398A3 (en)	2005-03-03
CN101514168B (zh)	2014-02-26
US7462740B2 (en)	2008-12-09
EP1615903B1 (de)	2010-02-10
EP1615903A2 (de)	2006-01-18
ES2338657T3 (es)	2010-05-11
US7071342B2 (en)	2006-07-04
CA2522748C (en)	2011-06-28
ATE457307T1 (de)	2010-02-15
US20090048458A1 (en)	2009-02-19
CA2522748A1 (en)	2004-11-04
EP2168956A2 (de)	2010-03-31
ZA200508129B (en)	2008-04-30
ZA200800486B (en)	2009-07-29
WO2004094398A2 (en)	2004-11-04
CN100448860C (zh)	2009-01-07
JP4440917B2 (ja)	2010-03-24
JP2010053139A (ja)	2010-03-11
US20040209946A1 (en)	2004-10-21
DE602004025458D1 (de)	2010-03-25
EP2168956B8 (de)	2013-05-01
JP5202503B2 (ja)	2013-06-05
CN101514193B (zh)	2012-12-19
CN1805947A (zh)	2006-07-19
HK1078315A1 (en)	2006-03-10
CN101514193A (zh)	2009-08-26
US20060205961A1 (en)	2006-09-14
US7910775B2 (en)	2011-03-22
EP2168956A3 (de)	2010-07-14
JP2006523616A (ja)	2006-10-19
MXPA05011183A (es)	2005-12-14
AR044027A1 (es)	2005-08-24

Publication	Publication Date	Title
SG167671A1 (en)	2011-01-28	Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)-(5-methyl-2- furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide
IL157478A0 (en)	2004-03-28	Method for the synthesis of 2', 3'-didehydronucleosides
HUP0304041A3 (en)	2005-08-29	Compounds useful as intermediates
EE05216B1 (et)	2009-10-15	Pregabaliini asmmeetriline sntees
WO2005107462A3 (en)	2006-05-04	Crystalline polymorphic forms of monosodium n-[8-(2-hydroxybenzoyl)amino]caprylate
EP1352965A4 (de)	2004-03-31	Verfahren zur herstellung einer amidverbindung unter verwendung eines mikrobiellen katalysators
HUP0400053A3 (en)	2006-01-30	New process for synthesis of 4-phenylbutyric acid
HRP20040920A2 (en)	2005-02-28	Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine
AU2003295684A8 (en)	2004-06-15	Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids
IL176131A0 (en)	2006-10-05	Practical, cost-effective synthesis of ubiquinones
ITMI20000026A0 (it)	2000-01-13	Procedimento per la produzione di gas di sintesi
AU2002331595A1 (en)	2003-03-03	Novel vasoconstrictor cannabinoid analogs
GB0302465D0 (en)	2003-03-05	"13C-labelled synthesis"
GB0112322D0 (en)	2001-07-11	Synthesis of chiral intermediates
GB0115588D0 (en)	2001-08-15	Novel compounds for use as photoinitiators
AU2002305242A1 (en)	2002-11-11	Synthesis of carbamate through low pressure heterogeneous oxidative carbonylation of amines
EP1701937A4 (de)	2007-05-02	Stabile polymorphe von (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamid
IL164044A0 (en)	2005-12-18	New crystalline forms of (2S)-N-5-Äamino(inino)methylÜ-2-thienylmethyl-1-(2R)-2-Ä(carboxsymethyl)aminoÜ-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide-nh2o
PL1644340T3 (pl)	2009-04-30	N-[({4-podstawione związki piperazyn-1-ylo}sulfonylometylo)alkilo]-n-hydroksyformamidowe jako inhibitory metaloproteinazy
IL161642A0 (en)	2004-09-27	IMPROVED PURIFICATION OF 4,4'(5')-DI-t-BUTYLCYCLOHEXANO-18-CROWN-6
GB0225106D0 (en)	2002-12-11	Synthesis of 3 hydroxy-5 -steroids
EP1391198A4 (de)	2005-04-27	Neuer sphingolipid-synthese-hemmer
IL175742A0 (en)	2006-09-05	Insecticidal n-(heteroarylalkyl) alkanediamine derivatives
GB0207770D0 (en)	2002-05-15	Asymmetric synthesis of glycidic amides
ITVR20020007U1 (it)	2003-07-31	Capo d'abbigliamento, particolarmente per karting