SG54269A1 - Substituted benzothienylpiperazines their use as medicaments and processes for their preparation - Google Patents

Substituted benzothienylpiperazines their use as medicaments and processes for their preparation

Info

Publication number: SG54269A1
Authority: SG; Singapore
Prior art keywords: hydrogen; alkylcarbonyl; hydroxy; integer; benzothienylpiperazines
Prior art date: 1995-03-17

Application number

SG1996006846A

Other languages

English (en)

Inventor

Nicholas J Hrib

John G Jurcak

Abdul E Murtlib

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-17

Filing date

1996-03-12

Publication date

1998-11-16

1996-03-12 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1998-11-16 Publication of SG54269A1 publication Critical patent/SG54269A1/en

Links

FYKGUURZJVYPQE-UHFFFAOYSA-N 1-(1-benzothiophen-2-yl)piperazine Chemical class C1CNCCN1C1=CC2=CC=CC=C2S1 FYKGUURZJVYPQE-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
-1 benzothienylcarbonyl Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG1996006846A 1995-03-17 1996-03-12 Substituted benzothienylpiperazines their use as medicaments and processes for their preparation SG54269A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41381895A	1995-03-17	1995-03-17

Publications (1)

Publication Number	Publication Date
SG54269A1 true SG54269A1 (en)	1998-11-16

Family

ID=23638775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996006846A SG54269A1 (en)	1995-03-17	1996-03-12	Substituted benzothienylpiperazines their use as medicaments and processes for their preparation

Country Status (23)

Country	Link
US (1)	US5801176A (de)
EP (1)	EP0732332B1 (de)
JP (1)	JPH093060A (de)
KR (1)	KR100402510B1 (de)
CN (1)	CN1082959C (de)
AT (1)	ATE211137T1 (de)
AU (1)	AU700077B2 (de)
CA (1)	CA2171695A1 (de)
CZ (1)	CZ80496A3 (de)
DE (1)	DE69618050T2 (de)
DK (1)	DK0732332T3 (de)
ES (1)	ES2170177T3 (de)
HU (1)	HUP9600665A3 (de)
IL (1)	IL117519A (de)
NO (1)	NO315652B1 (de)
NZ (1)	NZ286186A (de)
PL (1)	PL182310B1 (de)
PT (1)	PT732332E (de)
RO (1)	RO117453B1 (de)
RU (1)	RU2157371C2 (de)
SG (1)	SG54269A1 (de)
TW (1)	TW328957B (de)
ZA (1)	ZA962075B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703083A (en) *	1996-04-15	1997-12-30	Neurogen Corporation	N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
EP1106605A4 (de) *	1999-06-24	2005-12-07	Toray Industries	Antagonisten des andrenergen-alpha1b-rezeptors
GB0117531D0 (en) *	2001-02-16	2001-09-12	Aventis Pharm Prod Inc	Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
EP1688412A3 (de) *	2001-02-16	2006-08-16	Aventis Pharmaceuticals, Inc.	Neue heterocyclische Amide-Derivate und ihre Verwendung als dopamine D3-Rezeptor-Liganden
ES2275853T3 (es) *	2001-02-16	2007-06-16	Aventis Pharmaceuticals Inc.	Derivados heterociclicos de urea y su uso como ligandos de receptores de dopamina d3.
US20040116522A1 (en) *	2001-03-30	2004-06-17	Yutaka Yamagata	Medicinal solutions
TWI320783B (en)	2005-04-14	2010-02-21	Otsuka Pharma Co Ltd	Heterocyclic compound
AR055203A1 (es) *	2005-08-31	2007-08-08	Otsuka Pharma Co Ltd	Derivados de benzotiofeno con propiedades antipsicoticas
CN105985314A (zh) *	2015-02-05	2016-10-05	苏州旺山旺水生物医药有限公司	布瑞哌唑类似物的制备方法
PT4082616T (pt) *	2019-12-24	2025-12-02	Sumitomo Pharma Co Ltd	Derivado de amida ácida alifática
JP7655885B2 (ja) *	2021-06-30	2025-04-02	住友ファーマ株式会社	脂肪族酸アミド誘導体を含有する医薬組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ209876A (en) *	1983-10-17	1988-03-30	Duphar Int Res	Piperazines and pharmaceutical compositions
EP0316723B1 (de) *	1987-11-20	1992-09-30	Hoechst-Roussel Pharmaceuticals Incorporated	3-[4(1-Substituierte-4-Piperazinyl)butyl]-4-Thiazolidinone, Verfahren zu deren Herstellung und ihre Anwendung als Arzneimittel
US5001130A (en) *	1988-02-18	1991-03-19	Bristol-Myers Company	Psychotropic heterobicycloalkylpiperazine derivatives
US4780466A (en) *	1988-03-17	1988-10-25	Hoechst-Roussel Pharmaceuticals, Inc.	Arylpiperazinylalkoxy derivatives of cyclic imides
US5776963A (en) *	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4968792A (en) *	1989-09-25	1990-11-06	American Home Products Corporation	Psychotropic benzisothiazole derivatives
US5143923B1 (en) *	1991-04-29	1993-11-02	Hoechst-Roussel Pharmaceuticals Incorporated	Benzoisothiazole-and benzisoxazole-3-carboxamides
RU2024520C1 (ru) *	1991-10-08	1994-12-15	Институт органической химии Уральского отделения РАН	10-метокси-5- метил-6- (1',1'- диоксидо-2'- метахлорфенилазо -3'- гидрокси -4'-метоксибензо(в)тиофен- 7-ил) -5h-3,4,6,7- тетрагидрофуро [4.3.2-q] [3]бензазоцин, обладающий антидепрессивным действием
GB9202915D0 (en) *	1992-02-12	1992-03-25	Wellcome Found	Chemical compounds
US5240927A (en) *	1992-05-19	1993-08-31	Hoechst-Roussel Pharmaceuticals Incorporated	Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
GB9302622D0 (en) *	1993-02-10	1993-03-24	Wellcome Found	Heteroaromatic compounds
US5395835A (en) *	1994-03-24	1995-03-07	Warner-Lambert Company	Naphthalamides as central nervous system agents
GB9410031D0 (en) *	1994-05-19	1994-07-06	Merck Sharp & Dohme	Therapeutic agents

1996
- 1996-03-11 PT PT96103772T patent/PT732332E/pt unknown
- 1996-03-11 DE DE69618050T patent/DE69618050T2/de not_active Expired - Fee Related
- 1996-03-11 EP EP96103772A patent/EP0732332B1/de not_active Expired - Lifetime
- 1996-03-11 DK DK96103772T patent/DK0732332T3/da active
- 1996-03-11 AT AT96103772T patent/ATE211137T1/de not_active IP Right Cessation
- 1996-03-11 ES ES96103772T patent/ES2170177T3/es not_active Expired - Lifetime
- 1996-03-12 SG SG1996006846A patent/SG54269A1/en unknown
- 1996-03-13 CA CA002171695A patent/CA2171695A1/en not_active Abandoned
- 1996-03-14 PL PL96313251A patent/PL182310B1/pl unknown
- 1996-03-14 AU AU48113/96A patent/AU700077B2/en not_active Ceased
- 1996-03-14 ZA ZA9602075A patent/ZA962075B/xx unknown
- 1996-03-14 HU HU9600665A patent/HUP9600665A3/hu unknown
- 1996-03-15 NZ NZ286186A patent/NZ286186A/en unknown
- 1996-03-15 CZ CZ96804A patent/CZ80496A3/cs unknown
- 1996-03-15 NO NO19961077A patent/NO315652B1/no not_active IP Right Cessation
- 1996-03-15 RO RO96-00568A patent/RO117453B1/ro unknown
- 1996-03-15 RU RU96104547/04A patent/RU2157371C2/ru not_active IP Right Cessation
- 1996-03-15 CN CN96103608A patent/CN1082959C/zh not_active Expired - Fee Related
- 1996-03-15 JP JP8058707A patent/JPH093060A/ja not_active Abandoned
- 1996-03-16 KR KR1019960007100A patent/KR100402510B1/ko not_active Expired - Fee Related
- 1996-03-17 IL IL11751996A patent/IL117519A/xx not_active IP Right Cessation
- 1996-05-15 TW TW085105712A patent/TW328957B/zh active
1997
- 1997-06-06 US US08/870,988 patent/US5801176A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HUP9600665A2 (en)	1997-10-28
JPH093060A (ja)	1997-01-07
NZ286186A (en)	1997-07-27
ATE211137T1 (de)	2002-01-15
CN1139108A (zh)	1997-01-01
TW328957B (en)	1998-04-01
NO961077D0 (no)	1996-03-15
NO961077L (no)	1996-09-18
RO117453B1 (ro)	2002-03-29
AU700077B2 (en)	1998-12-17
CA2171695A1 (en)	1996-09-18
IL117519A (en)	2000-08-31
HU9600665D0 (en)	1996-05-28
CZ80496A3 (en)	1996-10-16
DK0732332T3 (da)	2002-04-15
RU2157371C2 (ru)	2000-10-10
PL182310B1 (pl)	2001-12-31
PL313251A1 (en)	1996-09-30
DE69618050D1 (de)	2002-01-31
DE69618050T2 (de)	2002-07-11
KR960034201A (ko)	1996-10-22
EP0732332A1 (de)	1996-09-18
HUP9600665A3 (en)	1998-08-28
KR100402510B1 (ko)	2004-03-18
AU4811396A (en)	1996-09-26
ES2170177T3 (es)	2002-08-01
IL117519A0 (en)	1996-07-23
EP0732332B1 (de)	2001-12-19
NO315652B1 (no)	2003-10-06
ZA962075B (en)	1997-12-31
PT732332E (pt)	2002-06-28
CN1082959C (zh)	2002-04-17
US5801176A (en)	1998-09-01

Publication	Publication Date	Title
PH23607A (en)	1989-09-11	Amide derivatives and pharmaceutical composition containing said compounds
IL110151A0 (en)	1994-10-07	Amide and urea derivatives and pharmaceutical compositions containing the same
EP0417584A3 (en)	1992-02-26	N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments
ZA935276B (en)	1994-04-18	3-(hydroxybenzylidenyl)-indolin-2-ones processes for their preparation and pharmaceutical compositions containing them
MXPA00006605A (es)	2004-12-09	Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
MY114548A (en)	2002-11-30	New arylglycineamide derivatives, processes for the manufacture thereof and pharmaceutical compositions containing these compounds
NZ307505A (en)	2000-09-29	Arylglycinamide derivatives, methods of producing these substances and pharmaceutical compositions containing such compounds
IL107961A0 (en)	1994-04-12	Phenoxy- and phenoxyalkyl-piperidines and pharmaceutical compositions containing them
IL117519A0 (en)	1996-07-23	Substituted benzothienylpiperazines their use as medicaments and processes for their preparation
GB9305295D0 (en)	1993-05-05	Therapeutic compounds
ZA89389B (en)	1989-10-25	Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
HUT46536A (en)	1988-11-28	Process for producing antianxietive pharmaceutical compositions
GR3034023T3 (en)	2000-11-30	Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
DE3787844D1 (de)	1993-11-25	Thioester und dessen Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Ischämie und von Reperfusion-Syndromen.
HUT50354A (en)	1990-01-29	Process for producing new s-adenosylmethionine decarboxilase inhibitors
EP1142883A4 (de)	2002-08-21	Heterozyklische verbindungen und medikamentzusammensetzungen die diese enthalten
AU625238B2 (en)	1992-07-02	Anti-psychotic piperidylbenzimidazole compounds
HU895648D0 (en)	1990-01-28	Process for the preparation of n,n-disubstituted diaryl-alkancarboxylic acid amide derivatives and pharmaceutical compositions containing such compounds
IL78780A (en)	1990-02-09	1,3-oxathiane-4-phenyl-5-alkenyl derivatives,their preparation and pharmaceutical compositions containing them
GR3017280T3 (en)	1995-11-30	Aminoalkylchromones, process for their preparation and compositions containing them.
DE69226443D1 (de)	1998-09-03	N-(mercaptoacyl)aminosäure, ihre herstellung, ihre therapeutische verwendung und sie enthaltende pharmazeutische zusammensetzungen
IE890161L (en)	1989-07-20	2-Amino Acetamide Derivatives