SG99594G - Angiostatic steroids - Google Patents

Angiostatic steroids

Info

Publication number: SG99594G
Authority: SG; Singapore
Prior art keywords: bond; alkyl; beta; integer; forms
Prior art date: 1985-10-23

Application number

SG99594A

Other languages

English (en)

Inventor

Paul A Aristoff

Harvey L Skulnick

Wendell Wierenga

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-23

Filing date

1994-07-21

Publication date

1994-10-28

1994-07-21 Application filed by Upjohn Co filed Critical Upjohn Co

1994-07-21 Priority to SG99594A priority Critical patent/SG99594G/en

1994-10-28 Publication of SG99594G publication Critical patent/SG99594G/en

Links

150000003431 steroids Chemical class 0.000 title abstract 2
230000000964 angiostatic effect Effects 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 7
125000003118 aryl group Chemical group 0.000 abstract 4
239000000460 chlorine Substances 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 4
229910052731 fluorine Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910019142 PO4 Inorganic materials 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
239000010452 phosphate Substances 0.000 abstract 2
-1 pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000168 pyrrolyl group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
- C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SG99594A 1985-10-23 1994-07-21 Angiostatic steroids SG99594G (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
SG99594A SG99594G (en)	1985-10-23	1994-07-21	Angiostatic steroids

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US79056485A	1985-10-23	1985-10-23
US81186685A	1985-12-20	1985-12-20
SG99594A SG99594G (en)	1985-10-23	1994-07-21	Angiostatic steroids

Publications (1)

Publication Number	Publication Date
SG99594G true SG99594G (en)	1994-10-28

Family

ID=27121047

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG99594A SG99594G (en)	1985-10-23	1994-07-21	Angiostatic steroids

Country Status (9)

Country	Link
EP (2)	EP0221705A1 (fr)
JP (1)	JP2545522B2 (fr)
AT (1)	ATE66002T1 (fr)
DE (1)	DE3680788D1 (fr)
ES (1)	ES2041245T3 (fr)
GR (1)	GR3002675T3 (fr)
HK (1)	HK129594A (fr)
SG (1)	SG99594G (fr)
WO (1)	WO1987002672A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5407926A (en) *	1987-12-29	1995-04-18	Alcon Laboratories, Inc.	Ophthalmic composition
US4876250A (en) *	1988-10-31	1989-10-24	Alcon Laboratories, Inc.	Methods for controlling ocular hypertension with angiostatic steroids
US5972922A (en) *	1990-06-11	1999-10-26	Alcon Laboratories, Inc.	Steroids which inhibit angiogenesis
DE69132048T2 (de) *	1990-06-11	2000-07-13	Alcon Laboratories Inc.(N.D.Ges.D.Staates Delaware), Forth Worth	Verwendung von Steroiden zur Inhibierung von Angiogenesis
EP1236470A3 (fr) *	1991-11-22	2004-09-01	Alcon Laboratories, Inc.	Stéroides angiostatiques
US5929111A (en) *	1996-12-18	1999-07-27	Alcon Laboratories, Inc.	A-seco steroids effective at treating ophthalmic pathological neovascularization and controlling intraocular pressure
US6596703B1 (en)	1997-07-11	2003-07-22	Jagotec Ag	Promotion of wound healing utilizing steroids having reduced deteriorous systemic side effects typical of glucocorticoids, mineralocorticoids and sex steroids
US6011023A (en) *	1997-08-27	2000-01-04	Alcon Laboratories, Inc.	Angiostatic steroids
EP4108248B1 (fr)	2013-03-29	2025-09-17	Biomed Valley Discoveries, Inc.	C. novyi pour le traitement de tumeurs solides chez des êtres humains
WO2015191602A2 (fr)	2014-06-09	2015-12-17	Biomed Valley Discoveries, Inc.	Polythérapies ciblant un stroma associé à une tumeur ou des cellules tumorales
WO2016123581A1 (fr)	2015-01-30	2016-08-04	Biomed Valley Discoveries, Inc.	Malonate cristallin c21h22c12n4o2
HK1244274A1 (zh)	2015-01-30	2018-08-03	生物医学谷探索股份有限公司	C21h22ci2n4o2的晶型
ES3039267T3 (en) *	2018-10-19	2025-10-20	Sage Therapeutics Inc	9(11)-unsaturated neuroactive steroids and their methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2868783A (en) *	1958-04-14	1959-01-13	Upjohn Co	11-oxygenated-17alpha, 21-dihydroxy-4-pregnen-20-ones and the 21-esters thereof
US3098085A (en) *	1958-07-04	1963-07-16	Ciba Geigy Corp	Process for the manufacture of 16alpha-methyl-allopregnanes substituted in the 21-position
US3083199A (en) *	1961-01-11	1963-03-26	Farmaceutici Italia	delta3-5alpha-steroids and 3alpha-hydroxy-5alpha-steroids and the preparation thereof
US3045033A (en) *	1961-05-10	1962-07-17	Schering Corp	Water soluble cyclophosphate esters of steroids and process for preparing same
US3402173A (en)	1965-03-19	1968-09-17	Syntex Corp	18-lower alkyl pregnanes and derivatives
US3780177A (en)	1967-06-16	1973-12-18	Warner Lambert Co	17-butyrate,21-ester derivatives of 6alpha,9alpha-difluoroprednisolone,compositions and use
DE2257132C3 (de) *	1972-11-18	1982-05-13	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Reduktion von 3-Ketosteroiden
US3980778A (en)	1973-10-25	1976-09-14	The Upjohn Company	Anti-inflammatory steroid
EP0001737B1 (fr) *	1977-10-26	1981-01-07	Schering Aktiengesellschaft	17-Alpha-(3-iodobenzoyloxy)-9-alpha-chloro-4-prégnène-3.20-diones, leurs D-homo analogues et procédé pour leur préparation
US4318853A (en) *	1980-01-31	1982-03-09	The Upjohn Company	9β,11β-Epoxy-5β-corticoids
ZA817929B (en) *	1980-12-22	1982-10-27	Upjohn Co	5alpha-and 5beta-androstane-17beta-carboxylates
US4456602A (en) *	1982-08-23	1984-06-26	The Upjohn Company	Amine containing ester prodrugs of corticosteroids
US4443440A (en) *	1982-08-30	1984-04-17	The Upjohn Company	Amine containing ester prodrugs of corticosteroids
US4469689A (en) *	1983-03-30	1984-09-04	The Upjohn Company	Sulfonate containing ester prodrugs of corticosteroids
US4588718A (en) *	1984-03-28	1986-05-13	The Upjohn Company	Carboxy containing ester prodrugs of corticosteroids
CA1310009C (fr) *	1984-03-28	1992-11-10	John Mark Braughler	Promedicaments de type esters steroidiques

1986
- 1986-10-16 EP EP86308031A patent/EP0221705A1/fr active Pending
- 1986-10-16 EP EP86906631A patent/EP0245357B1/fr not_active Expired - Lifetime
- 1986-10-16 DE DE8686906631T patent/DE3680788D1/de not_active Expired - Lifetime
- 1986-10-16 JP JP61505818A patent/JP2545522B2/ja not_active Expired - Lifetime
- 1986-10-16 WO PCT/US1986/002189 patent/WO1987002672A1/fr not_active Ceased
- 1986-10-16 ES ES198686906631T patent/ES2041245T3/es not_active Expired - Lifetime
- 1986-10-16 AT AT86906631T patent/ATE66002T1/de not_active IP Right Cessation
1991
- 1991-09-10 GR GR91401286T patent/GR3002675T3/el unknown
1994
- 1994-07-21 SG SG99594A patent/SG99594G/en unknown
- 1994-11-17 HK HK129594A patent/HK129594A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE66002T1 (de)	1991-08-15
HK129594A (en)	1994-11-25
EP0245357A1 (fr)	1987-11-19
ES2041245T3 (es)	1993-11-16
JPS63501292A (ja)	1988-05-19
EP0245357B1 (fr)	1991-08-07
JP2545522B2 (ja)	1996-10-23
DE3680788D1 (de)	1991-09-12
EP0221705A1 (fr)	1987-05-13
WO1987002672A1 (fr)	1987-05-07
GR3002675T3 (en)	1993-01-25

Publication	Publication Date	Title
SG99594G (en)	1994-10-28	Angiostatic steroids
ES8305786A1 (es)	1983-04-16	"procedimiento de preparacion de nuevos derivados esteroides sustituidos en 11b".
IT1213029B (it)	1989-12-07	Chelati di ioni metallici paramagnetici.
ES467430A1 (es)	1979-08-16	Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos.
GB1488903A (en)	1977-10-19	X-ray contrast media
GB1411211A (en)	1975-10-22	Flameproofing of linear polyesters
ES482005A1 (es)	1980-09-01	Procedimiento para preparar una composicion tensioactiva de-alcoxi-bis (trialcoxisiloxi)- silano.
DE69203551D1 (de)	1995-08-24	Biologisch abbaubarer Copolyester von 4-Hydroxyprolin und diesen enthaltende pharmazeutische Zusammensetzung.
GB1393616A (en)	1975-05-07	Preparation of piperidine-spiro-hydantoin derivatives
ES8405420A1 (es)	1984-06-16	Nuevo proceso para la preparacion de esteres de esteroides.
ES437423A1 (es)	1977-04-16	Procedimiento para la preparacion de nuevas piridobenzodia- zepinonas.
GB1466028A (en)	1977-03-02	Phosphonic acid esters containing a heterocyclic ring and having flame retardant properties
ES440723A1 (es)	1977-07-01	Procedimiento para la produccion de nuevos compuestos orga- nicos.
IE40883L (en)	1975-07-15	Amidoxime pharmaceuticals
WO2002048250A2 (fr)	2002-06-20	Stabilisants et plastifiants de thiol organiques exempts de metaux destines a des polymeres halogenes
ES382485A1 (es)	1972-12-01	Un procedimiento para la preparacion de acidos alquenoicos sustituidos.
ES347684A1 (es)	1969-06-01	Un procedimiento para la preparacion de nuevos esteres de testoterona.
GB1421075A (en)	1976-01-14	Bis basic esters of tricyclic ompounds
US3539529A (en)	1970-11-10	Polyvinylchloride stabilized compositions
GB938815A (en)	1963-10-09	Iodine-containing benzoic acid derivatives
GB1479424A (en)	1977-07-13	Flame resistant polyamide compositions
US2933465A (en)	1960-04-19	Vinyl chloride resins stabilized with titanium chelates
ES368120A1 (es)	1971-05-01	Procedimiento para la preparacion de derivados de 14 alfa, 17 alfa, 17 alfa-metilendioxipregnano.
JPS56120699A (en)	1981-09-22	177aminoo166hydroxysteroid of novel androstane and estrane* its derivative and its drug composition
ES469513A1 (es)	1978-12-01	Procedimiento para preparar nuevos derivados de pregn-4-eno.