SI9300140A - N-t-butyl-androst-3,5-diene-17(beta)-carboxamide-3-carboxylic acid polymorph a - Google Patents

N-t-butyl-androst-3,5-diene-17(beta)-carboxamide-3-carboxylic acid polymorph a Download PDF

Info

Publication number: SI9300140A
Authority: SI; Slovenia
Prior art keywords: common; polymorph; butyl; androst; diene
Prior art date: 1992-03-24

Application number

SI19939300140A

Other languages

English (en)

Slovenian (sl)

Inventor

Neil Howard Baine

Neville Lewis Holder

Donald Nathaniel Kline

Robert Lee Webb

Gary Edward Zuber

Original Assignee

Smithkline Beecham Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-24

Filing date

1993-03-23

Publication date

1993-09-30

1993-03-23 Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation

1993-09-30 Publication of SI9300140A publication Critical patent/SI9300140A/sl

Links

238000000034 method Methods 0.000 claims abstract description 10
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 39
150000001875 compounds Chemical class 0.000 claims description 17
239000000725 suspension Substances 0.000 claims description 11
239000002904 solvent Substances 0.000 claims description 9
238000002329 infrared spectrum Methods 0.000 claims description 6
238000002955 isolation Methods 0.000 claims description 6
238000002360 preparation method Methods 0.000 claims description 6
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 4
238000003756 stirring Methods 0.000 claims description 4
238000002441 X-ray diffraction Methods 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
239000002244 precipitate Substances 0.000 claims 1
238000002425 crystallisation Methods 0.000 description 5
230000008025 crystallization Effects 0.000 description 5
238000001157 Fourier transform infrared spectrum Methods 0.000 description 3
238000002835 absorbance Methods 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
238000001556 precipitation Methods 0.000 description 3
238000001665 trituration Methods 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
238000000634 powder X-ray diffraction Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
229910000661 Mercury cadmium telluride Inorganic materials 0.000 description 1
241001311547 Patina Species 0.000 description 1
208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
MCMSPRNYOJJPIZ-UHFFFAOYSA-N cadmium;mercury;tellurium Chemical compound [Cd]=[Te]=[Hg] MCMSPRNYOJJPIZ-UHFFFAOYSA-N 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
229940011051 isopropyl acetate Drugs 0.000 description 1
GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SI19939300140A 1992-03-24 1993-03-23 N-t-butyl-androst-3,5-diene-17(beta)-carboxamide-3-carboxylic acid polymorph a SI9300140A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929206413A GB9206413D0 (en)	1992-03-24	1992-03-24	N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a

Publications (1)

Publication Number	Publication Date
SI9300140A true SI9300140A (en)	1993-09-30

Family

ID=10712749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI19939300140A SI9300140A (en)	1992-03-24	1993-03-23	N-t-butyl-androst-3,5-diene-17(beta)-carboxamide-3-carboxylic acid polymorph a

Country Status (29)

Country	Link
EP (1)	EP0633892B1 (da)
JP (1)	JP2736169B2 (da)
CN (1)	CN1078723A (da)
AP (1)	AP403A (da)
AT (1)	ATE180490T1 (da)
AU (1)	AU669522B2 (da)
BG (1)	BG99062A (da)
BR (1)	BR9306139A (da)
CA (1)	CA2132535A1 (da)
CZ (1)	CZ286266B6 (da)
DE (1)	DE69325094T2 (da)
DK (1)	DK0633892T3 (da)
ES (1)	ES2134260T3 (da)
FI (1)	FI114709B (da)
GB (1)	GB9206413D0 (da)
GR (1)	GR3030779T3 (da)
HU (1)	HUT68120A (da)
IL (1)	IL105102A (da)
MA (1)	MA22841A1 (da)
MX (1)	MX9301656A (da)
NO (1)	NO943547L (da)
NZ (1)	NZ252008A (da)
OA (1)	OA10100A (da)
PL (1)	PL172523B1 (da)
RU (1)	RU94041839A (da)
SI (1)	SI9300140A (da)
SK (1)	SK113894A3 (da)
WO (1)	WO1993019081A1 (da)
ZA (1)	ZA932014B (da)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors
IL104602A (en) *	1992-02-07	1997-07-13	Smithkline Beecham Corp	Process for the preparation of 3-carbonylandrostadiene- 17-carboxamides and intermediates for this process

1992
- 1992-03-24 GB GB929206413A patent/GB9206413D0/en active Pending
1993
- 1993-03-18 IL IL10510293A patent/IL105102A/xx not_active IP Right Cessation
- 1993-03-18 AP APAP/P/1993/000497A patent/AP403A/en active
- 1993-03-22 ZA ZA932014A patent/ZA932014B/xx unknown
- 1993-03-23 SI SI19939300140A patent/SI9300140A/sl unknown
- 1993-03-23 MA MA23136A patent/MA22841A1/fr unknown
- 1993-03-24 MX MX9301656A patent/MX9301656A/es unknown
- 1993-03-24 CN CN 93103518 patent/CN1078723A/zh active Pending
- 1993-03-24 DE DE69325094T patent/DE69325094T2/de not_active Expired - Fee Related
- 1993-03-24 EP EP93911567A patent/EP0633892B1/en not_active Expired - Lifetime
- 1993-03-24 ES ES93911567T patent/ES2134260T3/es not_active Expired - Lifetime
- 1993-03-24 AU AU40448/93A patent/AU669522B2/en not_active Ceased
- 1993-03-24 CA CA002132535A patent/CA2132535A1/en not_active Abandoned
- 1993-03-24 BR BR9306139A patent/BR9306139A/pt not_active Application Discontinuation
- 1993-03-24 CZ CZ19942319A patent/CZ286266B6/cs not_active IP Right Cessation
- 1993-03-24 NZ NZ252008A patent/NZ252008A/en unknown
- 1993-03-24 PL PL93305206A patent/PL172523B1/pl unknown
- 1993-03-24 DK DK93911567T patent/DK0633892T3/da active
- 1993-03-24 WO PCT/US1993/002974 patent/WO1993019081A1/en not_active Ceased
- 1993-03-24 AT AT93911567T patent/ATE180490T1/de not_active IP Right Cessation
- 1993-03-24 JP JP5516858A patent/JP2736169B2/ja not_active Expired - Fee Related
- 1993-03-24 RU RU94041839/04A patent/RU94041839A/ru unknown
- 1993-03-24 SK SK1138-94A patent/SK113894A3/sk unknown
- 1993-03-24 HU HU9402740A patent/HUT68120A/hu unknown
1994
- 1994-09-20 OA OA60561A patent/OA10100A/en unknown
- 1994-09-23 NO NO943547A patent/NO943547L/no unknown
- 1994-09-23 FI FI944414A patent/FI114709B/fi active
- 1994-09-26 BG BG99062A patent/BG99062A/xx unknown
1999
- 1999-07-14 GR GR990401866T patent/GR3030779T3/el unknown

Also Published As

Publication number	Publication date
HUT68120A (en)	1995-05-29
AP9300497A0 (en)	1993-04-30
CA2132535A1 (en)	1993-09-30
HU9402740D0 (en)	1994-12-28
DK0633892T3 (da)	2000-04-10
OA10100A (en)	1996-12-18
EP0633892B1 (en)	1999-05-26
ZA932014B (en)	1994-09-22
EP0633892A1 (en)	1995-01-18
MA22841A1 (fr)	1993-10-01
SK113894A3 (en)	1995-04-12
AU669522B2 (en)	1996-06-13
JPH07505370A (ja)	1995-06-15
ATE180490T1 (de)	1999-06-15
FI944414L (fi)	1994-09-23
CZ231994A3 (en)	1995-01-18
RU94041839A (ru)	1996-08-10
IL105102A0 (en)	1994-08-26
WO1993019081A1 (en)	1993-09-30
CZ286266B6 (cs)	2000-03-15
BG99062A (en)	1995-08-28
NO943547D0 (no)	1994-09-23
BR9306139A (pt)	1998-06-23
DE69325094T2 (de)	1999-11-18
NZ252008A (en)	1996-06-25
EP0633892A4 (en)	1995-05-17
JP2736169B2 (ja)	1998-04-02
CN1078723A (zh)	1993-11-24
GB9206413D0 (en)	1992-05-06
IL105102A (en)	1997-02-18
ES2134260T3 (es)	1999-10-01
FI944414A0 (fi)	1994-09-23
DE69325094D1 (de)	1999-07-01
PL172523B1 (pl)	1997-10-31
GR3030779T3 (en)	1999-11-30
MX9301656A (es)	1994-02-28
FI114709B (fi)	2004-12-15
AP403A (en)	1995-08-24
NO943547L (no)	1994-09-23
AU4044893A (en)	1993-10-21

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