SK11242002A3 - Zlúčenina, spôsob prípravy zlúčeniny, farmaceutický prostriedok a spôsob liečenia rakoviny - Google Patents

Zlúčenina, spôsob prípravy zlúčeniny, farmaceutický prostriedok a spôsob liečenia rakoviny Download PDF

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Publication number
SK11242002A3
SK11242002A3 SK1124-2002A SK11242002A SK11242002A3 SK 11242002 A3 SK11242002 A3 SK 11242002A3 SK 11242002 A SK11242002 A SK 11242002A SK 11242002 A3 SK11242002 A3 SK 11242002A3
Authority
SK
Slovakia
Prior art keywords
val
allo
thr
kahalalide
ile
Prior art date
Application number
SK1124-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Fernando Albericio
Ernest Giralt
Jos� Carlos Jimenez
Angel Lopez
Ignacio Manzanares
Ignacio Rodrigues
Miriam Royo
Original Assignee
Pharma Mar, S. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar, S. A. filed Critical Pharma Mar, S. A.
Publication of SK11242002A3 publication Critical patent/SK11242002A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
SK1124-2002A 2000-02-09 2001-02-09 Zlúčenina, spôsob prípravy zlúčeniny, farmaceutický prostriedok a spôsob liečenia rakoviny SK11242002A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds
PCT/GB2001/000576 WO2001058934A2 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds

Publications (1)

Publication Number Publication Date
SK11242002A3 true SK11242002A3 (sk) 2003-06-03

Family

ID=9885232

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1124-2002A SK11242002A3 (sk) 2000-02-09 2001-02-09 Zlúčenina, spôsob prípravy zlúčeniny, farmaceutický prostriedok a spôsob liečenia rakoviny

Country Status (27)

Country Link
US (2) US7482429B2 (de)
EP (3) EP2258715A1 (de)
JP (1) JP5188665B2 (de)
KR (1) KR100871489B1 (de)
CN (2) CN101597326B (de)
AT (1) ATE371667T1 (de)
AU (1) AU783542B2 (de)
BG (1) BG65926B1 (de)
BR (1) BR0108213A (de)
CA (1) CA2399187C (de)
CY (1) CY1106992T1 (de)
CZ (1) CZ304258B6 (de)
DE (1) DE60130192T2 (de)
DK (1) DK1254162T3 (de)
ES (1) ES2292558T3 (de)
GB (1) GB0002952D0 (de)
HU (1) HUP0301817A3 (de)
IL (2) IL150981A0 (de)
MX (1) MXPA02007760A (de)
NO (1) NO331847B1 (de)
NZ (1) NZ520488A (de)
PL (1) PL207121B1 (de)
PT (1) PT1254162E (de)
RU (1) RU2280039C2 (de)
SK (1) SK11242002A3 (de)
UA (1) UA76949C2 (de)
WO (1) WO2001058934A2 (de)

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US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
HUP0600031A3 (en) 2000-10-31 2012-02-28 Pharma Mar Kahalalide formulations and their use
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
CN100396696C (zh) * 2004-04-23 2008-06-25 中国科学院海洋研究所 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用
WO2009052379A2 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Improved antitumoral treatments
AU2009209541A1 (en) * 2008-01-30 2009-08-06 Pharma Mar, S.A. Improved antitumoral treatments
CN101965192A (zh) * 2008-03-07 2011-02-02 法马马有限公司 改善的抗肿瘤治疗
CN103641891B (zh) * 2013-05-23 2017-03-22 深圳翰宇药业股份有限公司 一种制备Kahalalide F的方法
KR102279993B1 (ko) 2015-09-23 2021-07-21 엑스더블유파마 리미티드 감마-하이드록시부티르산의 전구체 및 이의 조성물 및 용도
BR112019020464A2 (pt) 2017-03-30 2020-04-28 Xw Laboratories Inc. compostos derivados de heteroarila bicíclica, composição farmacêutica compreendendo os ditos compostos, adesivo transdérmico compreendendo a dita composição e uso terapêutico dos compostos e composição
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
EP3856719B1 (de) 2018-09-30 2023-06-07 XWPharma Ltd. Verbindungen als neuronale histaminrezeptor-3-antagonisten und deren verwendungen
TW202547822A (zh) 2019-12-20 2025-12-16 香港商凱瑞康寧有限公司 ４－纈胺醯氧基丁酸的合成方法
EP4167971A1 (de) 2020-06-18 2023-04-26 XWPharma Ltd. Granulate mit kontrollierter freisetzung von wasserlöslichen pharmazeutischen wirkstoffen
EP4167966A1 (de) 2020-06-18 2023-04-26 XWPharma Ltd. Pharmazeutische granulate wasserlöslicher pharmazeutischer wirkstoffe
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
CN119970650A (zh) 2020-10-05 2025-05-13 凯瑞康宁生物工程有限公司 γ-羟基丁酸衍生物的修饰释放组合物
EP4308086B1 (de) 2021-03-19 2025-10-15 XWPharma Ltd. Pharmakokinetik von formulierungen mit kombinierter freisetzung eines gamma-hydroxybuttersäurederivats
AU2023257266A1 (en) * 2022-04-21 2024-08-22 Zevra Therapeutics, Inc. Gamma-hydroxybutyrate delivering compounds and processes for making and using them

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US4943533A (en) * 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
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SK281143B6 (sk) * 1991-03-06 2000-12-11 Merck Patent Gesellschaft Mit Beschr�Nkter Haftung Chimérická monoklonálna protilátka, expresné vektory a farmaceutický prostriedok
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UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
AU2001255575B2 (en) * 2000-04-28 2006-08-31 The Trustees Of The University Of Pennsylvania Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
US6440465B1 (en) * 2000-05-01 2002-08-27 Bioderm, Inc. Topical composition for the treatment of psoriasis and related skin disorders
HUP0600031A3 (en) 2000-10-31 2012-02-28 Pharma Mar Kahalalide formulations and their use
US20050054555A1 (en) 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds

Also Published As

Publication number Publication date
MXPA02007760A (es) 2002-10-23
WO2001058934A2 (en) 2001-08-16
EP2258715A1 (de) 2010-12-08
CA2399187C (en) 2011-04-19
BR0108213A (pt) 2003-03-05
CA2399187A1 (en) 2001-08-16
WO2001058934A3 (en) 2002-03-21
EP1829889A3 (de) 2007-09-26
CY1106992T1 (el) 2012-09-26
IL150981A0 (en) 2003-02-12
NO20023749L (no) 2002-10-07
IL150981A (en) 2013-05-30
BG107020A (bg) 2003-05-30
US20040214755A1 (en) 2004-10-28
CN1422278A (zh) 2003-06-04
PL356800A1 (en) 2004-07-12
RU2002123877A (ru) 2004-01-10
KR20020092951A (ko) 2002-12-12
US20080318849A1 (en) 2008-12-25
PL207121B1 (pl) 2010-11-30
DE60130192T2 (de) 2008-05-21
JP2003522198A (ja) 2003-07-22
AU3208601A (en) 2001-08-20
EP1254162B1 (de) 2007-08-29
RU2280039C2 (ru) 2006-07-20
CN101597326B (zh) 2014-07-09
KR100871489B1 (ko) 2008-12-05
HUP0301817A2 (hu) 2003-09-29
DE60130192D1 (de) 2007-10-11
GB0002952D0 (en) 2000-03-29
ES2292558T3 (es) 2008-03-16
PT1254162E (pt) 2007-12-03
ATE371667T1 (de) 2007-09-15
CZ304258B6 (cs) 2014-02-05
US7482429B2 (en) 2009-01-27
DK1254162T3 (da) 2008-01-02
HUP0301817A3 (en) 2011-10-28
NO20023749D0 (no) 2002-08-08
AU783542B2 (en) 2005-11-10
EP1254162A2 (de) 2002-11-06
EP1829889A2 (de) 2007-09-05
NZ520488A (en) 2005-03-24
UA76949C2 (en) 2006-10-16
HK1047290A1 (en) 2003-02-14
JP5188665B2 (ja) 2013-04-24
CZ20022740A3 (cs) 2003-01-15
CN101597326A (zh) 2009-12-09
BG65926B1 (bg) 2010-05-31
NO331847B1 (no) 2012-04-23

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